Beteiligung an „Cells in Motion“

  • Forschungsinteressen: molecular and cellular physiology of the thalamocortical system; cellular imaging; electrophysiology; analysis of neuronal network function, oscillations and connectivity; neuroinflammation; ion channel function

      Projekt FF-2014-05: Signalwege der TREK1-vermittelten Migration von T Lymphozyten über die Blut-Hirn-Schranke
           (Stefan Bittner, Thomas Budde, Petra Ehling, Sven Meuth, Heinz Wiendl, Projektzeitraum: 07/2014 - 06/2016)

  • Publikationen im Forschungsschwerpunkt „Zelldynamik und Bildgebung“

    2019

    Hundehege P, Cerina M, Eichler S, Thomas C, Herrmann AM, Gobel K, Muntefering T, Fernandez-Orth J, Bock S, Narayanan V, Budde T, Speckmann E-J, Wiendl H, Schubart A, Ruck T, Meuth SG. The next-generation sphingosine-1 receptor modulator BAF312 (siponimod) improves cortical network functionality in focal autoimmune encephalomyelitis. Neural Regen Res 2019;14: 1950-1960. Abstract
    van Alst TM, Wachsmuth L, Datunashvili M, Albers F, Just N, Budde T, Faber C. Anesthesia differentially modulates neuronal and vascular contributions to the BOLD signal. Neuroimage 2019;195: 89-103. Abstract
    Zobeiri M, Chaudhary R, Blaich A, Rottmann M, Herrmann S, Meuth P, Bista P, Kanyshkova T, Luttjohann A, Narayanan V, Hundehege P, Meuth SG, Romanelli MN, Urbano FJ, Pape H-C, Budde T, Ludwig A. The Hyperpolarization-Activated HCN4 Channel is Important for Proper Maintenance of Oscillatory Activity in the Thalamocortical System. Cereb Cortex 2019;29: 2291-2304. Abstract
    Zobeiri M, van Luijtelaar G, Budde T, Sysoev IV. The Brain Network in a Model of Thalamocortical Dysrhythmia. Brain Connect 2019;9: 273-284. Abstract

    2018

    Datunashvili M, Chaudhary R, Zobeiri M, Luttjohann A, Mergia E, Baumann A, Balfanz S, Budde B, van Luijtelaar G, Pape H-C, Koesling D, Budde T. Modulation of Hyperpolarization-Activated Inward Current and Thalamic Activity Modes by Different Cyclic Nucleotides. Front Cell Neurosci 2018;12: 369. Abstract
    Eichinger P, Herrmann AM, Ruck T, Herty M, Gola L, Kovac S, Budde T, Meuth SG, Hundehege P. Human T cells in silico: Modelling dynamic intracellular calcium and its influence on cellular electrophysiology. J Immunol Methods 2018;461: 78-84. Abstract

    2017

    Leist M, Rinne S, Datunashvili M, Aissaoui A, Pape H-C, Decher N, Meuth SG, Budde T. Acetylcholine-dependent upregulation of TASK-1 channels in thalamic interneurons by a smooth muscle-like signalling pathway. J Physiol 2017;595: 5875-5893. Abstract
    Storck H, Hild B, Schimmelpfennig S, Sargin S, Nielsen N, Zaccagnino A, Budde T, Novak I, Kalthoff H, Schwab A. Ion channels in control of pancreatic stellate cell migration. Oncotarget 2017;8: 769-784. Abstract

    2015

    Bista P, Pawlowski M, Cerina M, Ehling P, Leist M, Meuth P, Aissaoui A, Borsotto M, Heurteaux C, Decher N, Pape H-C, Oliver D, Meuth SG, Budde T. Differential phospholipase C-dependent modulation of TASK and TREK two-pore domain K+ channels in rat thalamocortical relay neurons. J Physiol 2015;593: 127-144. Abstract
    Ehling P, Cerina M, Budde T, Meuth SG, Bittner S. The CNS under pathophysiologic attack--examining the role of K(2)p channels. Pflugers Arch 2015;467: 959-972. Abstract
    Ehling P, Melzer N, Budde T, Meuth SG. CD8(+) T Cell-Mediated Neuronal Dysfunction and Degeneration in Limbic Encephalitis. Front Neurol 2015;6: 163. Abstract

    2014

    Kanyshkova T, Ehling P, Cerina M, Meuth P, Zobeiri M, Meuth SG, Pape H-C, Budde T. Regionally specific expression of high-voltage-activated calcium channels in thalamic nuclei of epileptic and non-epileptic rats. Mol Cell Neurosci 2014;61: 110-122. Abstract

    2013

    Bittner S, Ruck T, Schuhmann MK, Herrmann AM, Moha ou Maati H, Bobak N, Gobel K, Langhauser F, Stegner D, Ehling P, Borsotto M, Pape H-C, Nieswandt B, Kleinschnitz C, Heurteaux C, Galla H-J, Budde T, Wiendl H, Meuth SG. Endothelial TWIK-related potassium channel-1 (TREK1) regulates immune-cell trafficking into the CNS. Nat Med 2013;19: 1161-1165. Abstract
    Ehling P, Cerina M, Meuth P, Kanyshkova T, Bista P, Coulon P, Meuth SG, Pape H-C, Budde T. Ca(2+)-dependent large conductance K(+) currents in thalamocortical relay neurons of different rat strains. Pflugers Arch 2013;465: 469-480. Abstract
    Ehling P, Gob E, Bittner S, Budde T, Ludwig A, Kleinschnitz C, Meuth SG. Ischemia-induced cell depolarization: does the hyperpolarization-activated cation channel HCN2 affect the outcome after stroke in mice?. Exp Transl Stroke Med 2013;5: 16. Abstract
    Gobel K, Wedell J-H, Herrmann AM, Wachsmuth L, Pankratz S, Bittner S, Budde T, Kleinschnitz C, Faber C, Wiendl H, Meuth SG. 4-Aminopyridine ameliorates mobility but not disease course in an animal model of multiple sclerosis. Exp Neurol 2013;248: 62-71. Abstract