Forschungsschwerpunkte
- Mykotoxine
- Instrumentelle Analytik (HPLC-MS/MS, HPLC-HRMS, GC-MS)
- Humanes Biomonitoring
- Einfluss der Lebensmittelverarbeitung auf Mykotoxine
Vita
Akademische Ausbildung
- Kollegiat der International Research Training Group Münster/D - Nagoya/J (IRTG-MS/NG)
- Dissertation (Prof. Dr. H.-U. Humpf), Lehrstuhl für Lebensmittelchemie der WWU Münster
- Forschungsaufenthalt an der Nagoya University, Nagoya, Japan, Department of Chemistry (Prof. Dr. D. Uemura)
Beruflicher Werdegang
- Akademischer Rat am Institut für Lebensmittelchemie der WWU Münster, Leiter der Serviceeinheit "Instrumentelle Analytik und Spektroskopie"
- Post-Doc am Institut für Lebensmittelchemie der WWU Münster (Prof. Dr. H.-U. Humpf)
Preise
- Stockmeyer Wissenschaftspreis – Heinrich-Stockmeyer-Stiftung
Mitgliedschaften und Aktivitäten in Gremien
- Mitglied im Editorial Board der Zeitschrift "Mycotoxin Research"
- Mitglied der §64-LFGB Arbeitssgruppe "Mykotoxine" beim Bundesamt für Verbraucherschutz und Lebensmittelsicherheit
-
Lehre
- Praktikum: Instrumentelle Lebensmittel- und Futtermittelanalytik
(zusammen mit Dr. Florian Hübner)
[wöchentlich | Dr. Benedikt Cramer] - Seminar: Instrumentelle Lebensmittel- und Futtermittelanalytik
[ - | | wöchentlich | Mo. | LC 1 | Dr. Benedikt Cramer] - Seminar: Aktuelle Forschung
(zusammen mit Dr. Svetlana Kalinina, Dr. Matthias Behrens, Prof. Dr. Hans-Ulrich Humpf, Prof. Dr. Melanie Esselen, Dr. Florian Hübner)
[ - | | wöchentlich | Do. | Dr. Svetlana Kalinina] - Seminar: Institutsseminar
(zusammen mit Dr. Matthias Behrens, Prof. Dr. Hans-Ulrich Humpf, Prof. Dr. Melanie Esselen, Dr. Florian Hübner)
[ | wöchentlich | Do. | Dr. Benedikt Cramer] - Vortrag: Vortrag zur Bachelorarbeit [122219]
(zusammen mit Dr. Michael Lange-Aperdannier, Dr. Matthias Behrens, Prof. Dr. Melanie Esselen, Prof. Dr. Hans-Ulrich Humpf, Dr. Florian Hübner)
[ - | LC 1 | Dr. Michael Lange-Aperdannier] - Praktikum: Instrumentelles Messtechnikpraktikum [122234]
- Seminar: Instrumentelle Analytik [122225]
[ - | | wöchentlich | Fr. | LC 3 | Dr. Benedikt Cramer]
[ - | | wöchentlich | Mo. | LC 3 | Dr. Benedikt Cramer] - Seminar: Institutsseminar [122232]
(zusammen mit Dr. Matthias Behrens, Prof. Dr. Melanie Esselen, Prof. Dr. Hans-Ulrich Humpf, Dr. Florian Hübner)
[ | wöchentlich | Do. | Dr. Benedikt Cramer] - Seminar: Aktuelle Forschung [122228]
(zusammen mit Dr. Svetlana Kalinina, Dr. Matthias Behrens, Prof. Dr. Melanie Esselen, Prof. Dr. Hans-Ulrich Humpf, Dr. Florian Hübner)
[ - | | wöchentlich | Do. | LC 3 | Dr. Svetlana Kalinina] - Praktikum: Instrumentelle Lebensmittel- und Futtermittelanalytik [120205]
(zusammen mit Dr. Florian Hübner) - Seminar: Aktuelle Forschung [120230]
(zusammen mit Dr. Svetlana Kalinina, Dr. Matthias Behrens, Prof. Dr. Hans-Ulrich Humpf, Prof. Dr. Melanie Esselen, Dr. Florian Hübner) - Seminar: Institutsseminar [120218]
(zusammen mit Dr. Matthias Behrens, Dr. Eva-Maria Niehaus, Prof. Dr. Hans-Ulrich Humpf, Prof. Dr. Melanie Esselen, Dr. Florian Hübner) - Seminar: Instrumentelle Lebensmittel- und Futtermittelanalytik [120204]
- Praktikum: Instrumentelle Lebensmittel- und Futtermittelanalytik
Publikationen
- . . ‘Developments in mycotoxin analysis: an update for 2020-2021.’ World Mycotoxin Journal 15, Nr. 1: 3–25. doi: 10.3920/WMJ2021.2752.
- . . ‘Mycotoxins in Serum and 24-h Urine of Vegans and Omnivores from the Risks and Benefits of a Vegan Diet (RBVD) Study.’ Molecular Nutrition and Food Research 66, Nr. 6. doi: 10.1002/mnfr.202100874.
- . . ‘Detection of Mycotoxins in Highly Matrix-Loaded House-Dust Samples by QTOF-HRMS, IM-QTOF-HRMS, and TQMS: Advantages and Disadvantages.’ Analytical Chemistry 94, Nr. 10: 4209–4217. doi: 10.1021/acs.analchem.1c04254.
- . . ‘Development and application of a competitive enzyme immunoassay for the detection of penitrem A in fungal mycelium: Evidence for frequent occurrence of multiple indole-containing mycotoxins in mouldy foods.’ Food Control 132: 108558. doi: 10.1016/j.foodcont.2021.108558.
- . . ‘Quantitative Analysis of β-Asarone Derivatives in Acorus calamus and Herbal Food Products by HPLC-MS/MS.’ Journal of Agricultural and Food Chemistry Online ahead of print. doi: 10.1021/acs.jafc.0c05513.
- . . ‘Current and future perspectives of mycotoxin research — report from the 42nd Mycotoxin Workshop (Online conference).’ Mycotoxin Research 37, Nr. 4: 275–278. doi: 10.1007/s12550-021-00439-7.
- . . ‘Phase II metabolism of asarone isomers in vitro and in humans using HPLC-MS/MS and HPLC-QToF/MS.’ Foods 10, Nr. 9: 2032. doi: 10.3390/foods10092032.
- . . ‘Determination of urinary mycotoxin biomarkers using a sensitive online solid phase extraction‐uhplc‐ms/ms method.’ Toxins 13, Nr. 6. doi: 10.3390/toxins13060418.
- . . ‘Dried urine spots as sampling technique for multi-mycotoxin analysis in human urine.’ Mycotoxin Research 37, Nr. 2: 129–140. doi: 10.1007/s12550-021-00423-1.
- . . ‘Subcellular spatio-temporal intravital kinetics of aflatoxin B1 and ochratoxin A in liver and kidney.’ Archives of Toxicology 95, Nr. 6: 2163–2177. doi: 10.1007/s00204-021-03073-5.
- . . ‘Artificial vs natural Stachybotrys infestation—Comparison of mycotoxin production on various building materials.’ Indoor Air 30, Nr. 6: 1268–1282. doi: 10.1111/ina.12705.
- . . ‘Developments in mycotoxin analysis: An update for 2018-19.’ World Mycotoxin Journal 13, Nr. 1: 3–24. doi: 10.3920/WMJ2019.2535.
- . . ‘Mycotoxins in blood and urine of Swedish adolescents—possible associations to food intake and other background characteristics.’ Mycotoxin Research 36, Nr. 2: 193–206. doi: 10.1007/s12550-019-00381-9.
- . . ‘Occurrence of the ochratoxin A degradation product 2′R-ochratoxin a in coffee and other food: An update.’ Toxins 11, Nr. 6: 329. doi: 10.3390/toxins11060329.
- . . ‘Matrix binding of T-2 toxin: structure elucidation of reaction products and indications on the fate of a relevant food-borne toxin during heating.’ Mycotoxin Research 35, Nr. 3: 261–270. doi: 10.1007/s12550-019-00350-2.
- . . ‘Human Study on the Kinetics of 2′R-Ochratoxin A in the Blood of Coffee Drinkers.’ Molecular Nutrition and Food Research 63, Nr. 4: 1801026. doi: 10.1002/mnfr.201801026.
- . . Thermal reactions and the formation of degradation products of T-2 and HT-2 toxin during processing of oats.: American Chemical Society. doi: 10.1021/bk-2019-1306.ch007.
- . . ‘Identification of ochratoxin-N-acetyl-L-cysteine as a new ochratoxin A metabolite and potential biomarker in human urine.’ Mycotoxin Research 2020, Nr. 36: 1–10. doi: 10.1007/s12550-019-00360-0.
- . . ‘Exploring secondary metabolite profiles of stachybotrys spp. By LC-MS/MS.’ Toxins 11, Nr. 3: 133. doi: 10.3390/toxins11030133.
- . . ‘Developments in mycotoxin analysis: An update for 2017-2018.’ World Mycotoxin Journal 12, Nr. 1: 3–29. doi: 10.3920/WMJ2018.2398.
- 10.1016/j.enzmictec.2017.08.005. . ‘In vitro biosynthesis of 3-mercaptolactate by lactate dehydrogenases.’ Enzyme and Microbial Technology 108, Nr. null: 1–10. doi:
- . . ‘Auranthine, a Benzodiazepinone from Penicillium aurantiogriseum: Refined Structure, Absolute Configuration, and Cytotoxicity.’ Journal of Natural Products 81, Nr. 10: 2177–2186. doi: 10.1021/acs.jnatprod.8b00187.
- . . ‘Interaction of ochratoxin A and its thermal degradation product 2'R-ochratoxin A with human serum albumin.’ Toxins 10, Nr. 7. doi: 10.3390/toxins10070256.
- . . ‘Glucosylation of T-2 and HT-2 toxins using biotransformation and chemical synthesis: Preparation, stereochemistry, and stability.’ Mycotoxin Research 34, Nr. 3: 159–172. doi: 10.1007/s12550-018-0310-9.
- . . ‘Detection of the Cytotoxic Penitrems A-F in Cheese from the European Single Market by HPLC-MS/MS.’ Journal of Agricultural and Food Chemistry 66, Nr. 5: 1264–1269. doi: 10.1021/acs.jafc.7b06001.
- . . ‘Interaction of 2'R-ochratoxin A with serum albumins: Binding site, effects of site markers, thermodynamics, species differences of albumin-binding, and influence of albumin on its toxicity in MDCK cells.’ Toxins 10, Nr. 9. doi: 10.3390/toxins10090353.
- . . ‘Developments in mycotoxin analysis: An update for 2016-2017.’ World Mycotoxin Journal 11, Nr. 1: 5–32. doi: 10.3920/WMJ2017.2250.
- . . ‘Immunochemical Analysis of Paxilline and Ergot Alkaloid Mycotoxins in Grass Seeds and Plants.’ Journal of Agricultural and Food Chemistry 66, Nr. 1: 315–322. doi: 10.1021/acs.jafc.7b05580.
- ‘Enniatin B and ochratoxin A in the blood serum of workers from the waste management setting.’ Mycotoxin Research 34, Nr. 2: 85–90. doi: 10.1007/s12550-017-0302-1. .
- 10.1007/s12550-017-0290-1. . ‘Alternaria toxins in South African sunflower seeds: cooperative study.’ Mycotoxin Research 33, Nr. 4: 309–321. doi:
- In Chemical Contaminants and Residues in Food: Second Edition, edited by , 51–66. Elsevier Inc. doi: 10.1016/B978-0-08-100674-0.00003-5. . ‘Applications of High-Performance Liquid Chromatography-Mass Spectrometry Techniques for the Analysis of Chemical Contaminants and Residues in Food.’
- ‘Detection of the tremorgenic mycotoxin paxilline and its desoxy analog in ergot of rye and barley: a new class of mycotoxins added to an old problem.’ Analytical and Bioanalytical Chemistry 409, Nr. 21: 5101–5112. doi: 10.1007/s00216-017-0455-y. .
- ‘Impact of Mechanical and Thermal Energies on the Degradation of T-2 and HT-2 Toxins during Extrusion Cooking of Oat Flour.’ Journal of Agricultural and Food Chemistry 65, Nr. 20: 4177–4183. doi: 10.1021/acs.jafc.7b01484. .
- ‘Influence of environmental factors on the production of penitrems A–F by Penicillium crustosum.’ Toxins 9, Nr. 7. doi: 10.3390/toxins9070210. .
- 10.1007/s00216-017-0279-9. . ‘Multi-mycotoxin analysis using dried blood spots and dried serum spots.’ Analytical and Bioanalytical Chemistry 409, Nr. 13: 3369–3382. doi:
- 10.1007/s12550-016-0263-9. . ‘Fate of deoxynivalenol and deoxynivalenol-3-glucoside during cereal-based thermal food processing: a review study.’ Mycotoxin Research 33, Nr. 1: 79–91. doi:
- 10.1007/s12550-016-0261-y. . ‘Evidence of ochratoxin A conjugates in urine samples from infants and adults.’ Mycotoxin Research 33, Nr. 1: 39–47. doi:
- 10.1007/s00216-016-0047-2. . ‘Localization of ergot alkaloids in sclerotia of Claviceps purpurea by matrix-assisted laser desorption/ionization mass spectrometry imaging.’ Analytical and Bioanalytical Chemistry 409, Nr. 5: 1221–1230. doi:
- ‘Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry imaging of ochratoxin A and fumonisins in mold-infected food.’ Rapid Communications in Mass Spectrometry 30, Nr. 23: 2508–2516. doi: 10.1002/rcm.7733. .
- ‘Determination of exposure to the alternaria mycotoxin tenuazonic acid and its isomer allo-tenuazonic acid in a German population by stable isotope dilution HPLC-MS3 .’ Journal of Agricultural and Food Chemistry 64, Nr. 34: 6641–6647. doi: 10.1021/acs.jafc.6b02735. .
- ‘Analysis of ochratoxin A in dried blood spots - Correlation between venous and finger-prick blood, the influence of hematocrit and spotted volume.’ Journal of Chromatography B 1020, Nr. null: 158–164. doi: 10.1016/j.jchromb.2016.03.026. .
- 10.1007/s12550-015-0233-7. . ‘Survey of Alternaria toxin contamination in food from the German market, using a rapid HPLC-MS/MS approach.’ Mycotoxin Research 32, Nr. 1: 7–18. doi:
- . . ‘Structure elucidation and in vitro cytotoxicity of ochratoxin α amide, a new degradation product of ochratoxin A.’ Mycotoxin Research 31, Nr. 2: 83–90. doi: 10.1007/s12550-014-0218-y.
- ‘Detection and Quantitative Analysis of the Non-cytotoxic allo-Tenuazonic Acid in Tomato Products by Stable Isotope Dilution HPLC-MS/MS.’ Journal of Agricultural and Food Chemistry 63, Nr. 50: 10879–10884. doi: 10.1021/acs.jafc.5b04812. .
- 10.1007/s12550-015-0221-y. . ‘A new approach using micro HPLC-MS/MS for multi-mycotoxin analysis in maize samples.’ Mycotoxin Research 31, Nr. 2: 109–115. doi:
- ‘A comparative study of the human urinary mycotoxin excretion patterns in Bangladesh, Germany, and Haiti using a rapid and sensitive LC-MS/MS approach.’ Mycotoxin Research 31, Nr. 3: 127–136. doi: 10.1007/s12550-015-0223-9. .
- . . ‘Determination of mycotoxin exposure in Germany using an LC-MS/MS multibiomarker approach.’ Molecular Nutrition and Food Research 58, Nr. 12: 2368. doi: 10.1002/mnfr.201400406.
- ‘Biomonitoring using dried blood spots: Detection of ochratoxin A and its degradation product 2'R-ochratoxin A in blood from coffee drinkers*.’ Molecular Nutrition and Food Research 59, Nr. 9: 1837–1843. doi: 10.1002/mnfr.201500220. .
- . „Beitrag eines Acrylamid-Niacin-Adduktes zur Reduzierung des Acrylamid-Gehaltes im Lebensmittel .“ präsentiert auf der Deutscher Lebensmittelchemikertag, Karlsruhe, .
- . . ‘Matrix binding of ochratoxin A during roasting.’ Journal of Agricultural and Food Chemistry 61, Nr. 51: 12737. doi: 10.1021/jf403984x.
- . . ‘H2 unimolecular elimination in electrospray ionization mass spectrometry from erythraline, a spirocyclic alkaloid.’ European Journal of Mass Spectrometry 19, Nr. 5: 350. doi: 10.1255/ejms.1243.
- . . ‘HPLC-MS/MS-analysis of Mycotoxins: Current applications and future perspectives.’ Journal of Plant Pathology 1, Nr. SUPPL: S1.39.
- . . ‘Large-scale synthesis of isotopically labeled 13C 2-tenuazonic acid and development of a rapid HPLC-MS/MS method for the analysis of tenuazonic acid in tomato and pepper products.’ Journal of Agricultural and Food Chemistry 61, Nr. 1: 120. doi: 10.1021/jf305138k.
- . . ‘Systematic approach for structure elucidation of polyphenolic compounds using a bottom-up approach combining ion trap experiments and accurate mass measurements.’ Journal of Agricultural and Food Chemistry 60, Nr. 45: 11274. doi: 10.1021/jf3030369.
- ‘Wavelength-dependent degradation of ochratoxin and citrinin by light in vitro and in vivo and its implications on Penicillium.’ Toxins 4, Nr. 12: 1535–1551. doi: 10.3390/toxins4121535. .
- ‘In vitro Metabolism of Grandisin, a Lignan with Anti-chagasic Activity.’ Planta Medica 78, Nr. 18: 1939–1941. doi: 10.1055/s-0032-1327876. .
- ‘Intestinal metabolism of T-2 toxin in the pig cecum model.’ Mycotoxin Research 28, Nr. 3: 191–198. doi: 10.1007/s12550-012-0134-y. .
- ‘Applications of HPLC-MS techniques for the analysis of chemical contaminants and residues in food.’ In Chemical Contaminants and Residues in Food, edited by , 62–78. Elsevier Inc. doi: 10.1533/9780857095794.1.62. .
- ‘Analysis of the Fusarium mycotoxin moniliformin in cereal samples using 13C 2-moniliformin and high-resolution mass spectrometry.’ Journal of Agricultural and Food Chemistry 60, Nr. 14: 3586–3591. doi: 10.1021/jf300323d. .
- 10.1002/rcm.5075. . ‘Re-examination of the anion derivatives of isoflavones by radical fragmentation in negative electrospray ionization tandem mass spectrometry: Experimental and computational studies.’ Rapid Communications in Mass Spectrometry 25, Nr. 14: 2020–2026. doi:
- ‘Impact of physicochemical parameters on the decomposition of deoxynivalenol during extrusion cooking of wheat grits.’ Journal of Agricultural and Food Chemistry 59, Nr. 23: 12480–12485. doi: 10.1021/jf2038604. .
- . . ‘Total synthesis and cytotoxicity evaluation of all ochratoxin A stereoisomers.’ Bioorganic and Medicinal Chemistry 18, Nr. 1: 343–357. doi: 10.1016/j.bmc.2009.10.050.
- . . ‘Aromatic hydroxylation is a major metabolic pathway of the mycotoxin zearalenone in vitro.’ Molecular Nutrition and Food Research 53, Nr. 9: 1123–1133. doi: 10.1002/mnfr.200800584.
- . . ‘Identification and in vitro cytotoxicity of ochratoxin a degradation products formed during coffee roasting.’ Journal of Agricultural and Food Chemistry 56, Nr. 14: 5673–5681. doi: 10.1021/jf801296z.
- . . ‘Stable isotope dilution analysis of the Fusarium mycotoxin zearalenone.’ Journal of Agricultural and Food Chemistry 55, Nr. 21: 8353–8358. doi: 10.1021/jf0717283.
- . . ‘Thermal degradation of the Fusarium mycotoxin deoxynivalenol.’ Journal of Agricultural and Food Chemistry 54, Nr. 17: 6445–6451. doi: 10.1021/jf061008g.
- . . ‘New Monascus metabolites: Structure elucidation and toxicological properties studied with immortalized human kidney epithelial cells.’ Molecular Nutrition and Food Research 50, Nr. 3: 314–321. doi: 10.1002/mnfr.200500229.
- . . ‘Stable isotope dilution analysis of the Fusarium mycotoxins deoxynivalenol and 3-acetyldeoxynivalenol.’ Molecular Nutrition and Food Research 50, Nr. 3: 251–260. doi: 10.1002/mnfr.200500230.
- . . ‘Synthesis of stable isotope labeled 3-acetyldeoxynivalenol.’ Molecular Nutrition and Food Research 49, Nr. 12: 1151–1153. doi: 10.1002/mnfr.200500153.
Dr. Benedikt Cramer
Professur für Lebensmittelchemie (Prof. Humpf)
