Publications

 

  • 2022

    Shvarev D., Schoppe J., König C., Perz A., Fuellbrunn N, Kiontke S., Langemeyer L., Januliene D., Schnelle K., Kümmel D., Fröhlich F., Möller A., Ungermann C. (2022)
    Structure of the lysosomal membrane fusion machinery.
    Elife 11,  doi: 10.7554/eLife.80901

    Gollwitzer P., Grützmacher N., Wilhelm S., Kümmel D., Demetriades C. (2022)
    A Rag GTPase Dimer Code Defines the Regulation of mTORC1 by Amino Acids.
    Nat Cell Biol, 24:1394-1406, doi: 10.1038/s41556-022-00976-y

    Marchetti G.M., Füsser F., Singh R.K., Brummel M., Koch O., Kümmel D., §Hippler M. (2022)
    Structural analysis revealed a novel conformation of the NTRC reductase domain from Chlamydomonas reinhardtii.
    J Struct Biol, 214, doi: 10.1016/j.jsb.2021.107829

    Peters A., Herrmann E., Cornelissen N.V., Klöcker N., Kümmel D., Rentmeister A. (2022)
    Visible-light Removable Photocaging Groups Accepted by MjMAT Variant: Structural Basis and Compatibility with DNA and RNA Methyltransferases.
    Chembiochem, 23, doi: 10.1002/cbic.202100437

    Klink B.U., Herrmann E., Antoni C., Langemeyer L., Kiontke S., Gatsogiannis C., Ungermann C., Raunser S., Kümmel D. (2022)
    Structure of the Mon1-Ccz1 complex reveals molecular basis of membrane binding for Rab7 activation.
    Proc Natl Acad Sci USA, 119, doi: 10.1073/pnas.2121494119

  • 2021

    Fitzian K., Brückner, A., Brohée, L., Zech, R., Antoni, C., Kiontke, S., Gasper, R., Linard Matos, A.L., Beel S., Wilhelm S., Gerke V., Ungermann C., Nellist M., Raunser S., Demetriades C., Oeckinghaus A., Kümmel D. (2021)
    TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation
    Mol Cell, doi:10.1016/j.molcel.2021.04.019

    Hoffmann S., Terhorst T.M.E., Singh R.K., Kümmel D., Pietrokovski S., Mootz H.D. (2021)
    Biochemical and structural characterization of an unusual and naturally split class 3 intein.
    Chembiochem, 22, 364-373. doi:10.1002/cbic.202000509

    Michailidou F., Klöcker N., Cornelissen N., Singh R.K., Peters A., Ovcharenko A., Kümmel D., Rentmeister A. (2021)
    Engineered SAM synthetases for enzymatic generation of AdoMet analogs with photocaging groups and reversible DNA modification in cascade reactions.
    Angew Chem Int Ed Engl, 60, 480-485. doi:10.1002%2Fanie.202012623

  • 2020

    Lynagh T., Kiontke S., Meyhoff-Madsen M., Gless B.H., Johannesen J., Kattelmann S., Christiansen A., Dufva M., Laustsen A.H., Devkota K., Olsen C.A., Kümmel D., Pless S.A., Lohse B. (2020)
    Peptide Inhibitors of the ?-Cobratoxin-Nicotinic Acetylcholine Receptor Interaction.
    J Med Chem, 63, 13709?13718. doi:10.1021/acs.jmedchem.0c01202

    Hansmann P., Brückner A., Kiontke S., Berkenfeld B., Seebohm G., Brouillard P., Vikkula M., Jansen F.E., Nellist M., Oeckinghaus A., Kümmel D. (2020).
    Structural analysis of the TSC2 GAP domain: mechanistic insight into catalysis and pathogenic mutations.
    Structure, 28: 933-942. doi:10.1016/j.str.2020.05.008

    Escobar-Hoyos L.F., Penson A., Kannan R., Cho H ., Pan C-H., Singh R.K., Hobbs G.A., Luo, R, Lecomte N., Babu S., Pan F.C., Alonso-Curbelo D., Morris J.P., Askan G., Grbovic-Huezo O., Ogrodowski P., Bermeo J., Saglimbeni J., Cruz C.D., Ho Y-J., Lawrence S.A., Melchor J.P., Goda G.A., Bai K., Pastore A., Hogg S.J., Raghavan S., Bailey P., Chang D.K., Biankin A., Shroyer K.R., Wolpin B.M., Aguirre A.J., Ventura A., Taylor B., Der C.J., Dominguez D., Kümmel D., Oeckinghaus A., Lowe S., Bradley R. Abdel-Wahab O., Leach S.D. (2020)
    Altered RNA splicing by mutant p53 activates oncogenic RAS signaling in pancreatic cancer.
    Cancer Cell, 38: 198-211. doi: 10.1016/j.ccell.2020.05.010

    Langemeyer L., Borchers A.-C., Herrmann E., Füllbrunn N., Han Y., Perz A., Auffarth K., Kümmel D., Ungermann C. (2020).
    A conserved and regulated mechanism drives endosomal Rab transition.
    Elife 9: e56090   doi: 10.7554/eLife.56090

    Dufner Almeida L.G., Nanhoe S., Zonta, A., Hosseinzadeh M., Kom-Gortat R., Elfferich P., Schaaf G., Kenter A., Kümmel D., Migone N., Povey S., Ekong R., Nellist M. (2020).
    Comparison of the functional and structural characteristics of rare TSC2 variants with clinical and genetic findings.
    Hum. Mutat. 41: 759-773  doi: 10.1002/humu.23963

  • 2019

    Ungermann C., Kümmel D. (2019)
    Structure of membrane tethers and their role in fusion.
    Traffic, 20:479-490  doi: 10.1111/tra.12655

  • 2018

    Lürick A., Kümmel D., and Ungermann C. (2018)
    Multisubunit tethers in membrane fusion.
    Curr. Biol. 28, R417-R420.

    Gao J., Langemeyer L., Kümmel D., Reggiori F., Ungermann C. (2018)
    Molecular mechanism to target the endosomal Mon1-Ccz1 GEF complex to the pre-autophagosomal structure.
    Elife e31145.

    Fernández M.L., Quartino P.Y., Arce-Bejarano R., Fernández J., Camacho L.F., Gutiérrez J.M., Kümmel D., Fidelio G., Lomonte B. (2018)
    Intravascular hemolysis induced by phospholipases A2 from the venom of the Eastern coral snake, Micrurus fulvius: functional profiles of hemolytic and non-hemolytic isoforms.
    Toxicol Lett. 286: 39-47

    Langemeyer L., Perz A., Kümmel D., Ungermann C. (2018)
    A Guanine nucleotide exchange factor (GEF) limits Rab GTPase driven membrane fusion.
    J. Biol. Chem. 293: 731-739.

  • 2017

    Hellinger R., Thell K., Vasileva M., Muhammad T., Gunasekera S., Kümmel D., Göransson U., Becker C.W., Gruber C.W. (2017)
    Chemical Proteomics for Target Discovery of Head-to-Tail Cyclized Mini-Proteins.
    Front Chem. 5, 73

    Kiontke, S., Langemeyer, L., Kuhlee, A., Schuback, S., Raunser, S., Ungermann, C., Kümmel, D. (2017)
    Architecture and mechanism of the late endosomal Rab7-like Ypt7 guanine nucleotide exchange factor complex Mon1-Ccz1.
    Nat Commun, 8: 10.1038/ncomms14034.

  • 2016

    Zech, R., Kiontke, S., Mueller, U., Oeckinghaus, A., Kümmel, D. (2016)
    Structure of the Tuberous Sclerosis Complex 2 (TSC2) N-terminus Provides Insight into Complex Assembly and Tuberous Sclerosis Pathogenesis.
    J Biol Chem, 291: 20008-20020

  • 2015

    Krishnakumar S.S., Li F., Coleman J., Schauder C.M., Kümmel D., Pincet F., Rothman J.E., Reinisch K.M. (2015)
    Re-visiting the trans insertion model for complexin clamping.
    Elife, e04463

    Lürick, A., Kuhlee, A., Bröcker, C., Kümmel, D., Raunser, S., Ungermann, C. (2015)
    The Habc Domain of the SNARE Vam3 Interacts with the HOPS Tethering Complex to Facilitate Vacuole Fusion.
    J Biol Chem, 290: 5405-5413.

  • 2014

    Behrmann, H., Lürick, A., Kuhlee, A., Balderhaar, H.K., Bröcker, C., Kümmel D, Engelbrecht-Vandre, S., Gohlke, U., Raunser, S., Heinemann, U., Ungermann, C. (2014)
    Structural identification of the Vps18 β-propeller reveals a critical role in the HOPS complex stability and function.
    J Biol Chem, 289: 33503-33512

    Kümmel, D., Ungermann, C. (2014)
    Principles of membrane tethering and fusion in endosome and lysosome biogenesis.
    Curr Opin Cell Biol, 29C: 61-66

    Cho, R.W., Kümmel, D., Li, F., Baguley, S.W., Coleman, J., Rothman, J.E., Littleton, J.T. (2014)
    Genetic analysis of the Complexin trans-clamping model for cross-linking SNARE complexes in vivo.
    Proc Natl Acad Sci USA, 111(28):10317-10322

    Li, F., Kümmel, D., Coleman, J., Reinisch, K.M., Rothman, J.E., Pincet, F. (2014)
    A half-zippered SNARE complex represents a functional intermediate in membrane fusion.
    J. Am. Chem. Soc., 136:3456-3464

  • 2013

    Krishnakumar, S.S., Kümmel, D., Jones, S.J., Radoff, D.T., Reinisch, K.M., Rothman, J.E. (2013)
    Conformational dynamics of calcium-triggered activation of fusion by synaptotagmin.
    Biophys. J., 105:2507-2516

    Shen, D., Yuan, H., Hutagalung, A., Verma, A., Kümmel, D., Wu, X., Reinisch, K., McNew, J.A., Novick, P. (2013)
    The synaptobrevin homologue Snc2p recruits the exocyst to secretory vesicles by binding to Sec6p.
    J. Cell Biol., 202:509-526