Ehemalige - Prof. Dr. Bettina Tudzynski a.D.

Prof. Dr. Bettina Tudzynski a. D.
© WWU - AG Tudzynski
Prof. Dr. Bettina Tudzynski a. D.
 
Institut für Biologie und Biotechnologie der Pflanzen
Molecular Biology and Biotechnology of Fungi
bettina.tudzynski@uni-muenster.de
  • Curriculum Vitae

    • Study of biology at the Moscow State University 1970-1975
    • PhD at the Friedrich-Schiller-University in Jena 1980
    • Habilitation for Mikrobiology at the Friedrich-Schiller-Universität in Jena 1991
    • Re-habilitation at the University of Münster 1994
    • Group-leader in the Institute of Botany, University of Münster
    • Apl. Prof. 2006
    • Retired since 11/2017
  • Research

    • Signalling pathways involved in the interaction of the grey mold Botrytis cinerea with its host plant Phaseolus vulgaris
    • Physiology and molecular genetics of fungi
    • Secondary metabolism
    • multi-level regulation of gene expression
  • Projects

    • Signalling and regulation of gene expression in Botrytis cinerea in the interaction with its host plant Phaseolus vulgaris
    • Molecular determinants of host specificity of maize-, rice- and mango-pathogenic species of the genus Fusarium
    • The nitrogen regulation network in Fusarium fujikuroi: The role of AreA and interacting partners in regulating secondary metabolism
    • Identification and functional characterization of cryptic secondary metabolite gene clusters in Fusarium fujikuroi by molecular and epigenetic approaches
  • Publications

    2018

    Janevska S, Tudzynski B. (2018) Secondary metabolism in Fusarium fujikuroi: strategies to unravel the function of biosynthetic pathways. Appl Microbiol Biotechnol. 102:615-630. doi: 10.1007/s00253-017-8679-5. Review.

    Niehaus EM, Rindermann L, Janevska S, Münsterkötter M, Güldener U, Tudzynski B (2018) Analysis of the global regulator Lae1 uncovers a connection between Lae1 and the histone acetyltransferase HAT1 in Fusarium fujikuroi. Appl Microbiol Biotechnol. 102:279-295. doi: 10.1007/s00253-017-8590-0. Epub 2017 Oct 28.

    Janevska S, Baumann L, Sieber CMK, Münsterkötter M, Ulrich J, Kämper J, Güldener U, Tudzynski B. (2018) Elucidation of the two H3K36me3 histone methyltransferases Set2 and Ash1 in Fusarium fujikuroi unravels their different chromosomal targets and a major impact of Ash1 on genome stability. Genetics 208:153-171. doi: 10.1534/genetics.117.1119. Epub 2017 Nov 16.


    2017

    Studt L, Janevska S, Arndt B, Boedi S, Sulyok M, Humpf HU, Tudzynski B,  Strauss J (2017) Lack of the COMPASS component Ccl1 reduces H3K4 trimethylation levels and affects transcription of secondary metabolite genes in two plant-pathogenic Fusarium species. Frontier Microbiology,7:2144. doi: 10.3389/fmicb.2016.02144.

    Arndt B, Janevska S, Schmid R, Hübner F, Tudzynski B, Humpf HU (2017) A fungal N-dimethylallyltryptophan metabolite from Fusarium fujikuroi. ChemBioChem. 18:899-904. doi: 10.1002/cbic.201600691. Epub 2017 Apr 13.

    Pfannmüller A, Boysen J, Tudzynski B (2017) The molecular network of nitrate sensing and assimilation in Fusarium fujikuroi. Front. Microbiol. 8:381. doi: 10.3389/fmicb.2017.00381.

    Pfannmüller A, Leufken J, Studt L, Michielse CB, Sieber CMK, Güldener U, Hawat S, Hippler M, Fufezan C, and Tudzynski B (2017) Comparative transcriptome and proteome analysis reveals a global impact of the nitrogen regulators AreA and AreB on secondary metabolism in Fusarium fujikuroi. PLoS ONE 12(4): e0176194

    Janevska S, Arndt B, Baumann L, Apken LH, Maciel Mauriz Marques L, Humpf HU, Tudzynski B (2017) Establishment of the Inducible Tet-On System for the activation of the silent trichosetin gene cluster in Fusarium fujikuroi. Toxins. 9(4). pii: E126. doi: 10.3390/toxins9040126.

    Niehaus EM, Schumacher J, Burkhardt I, Rabe P, Spitzer E, Münsterkötter M, Güldener U, Sieber CMK, Dickschat JS and Tudzynski B (2017) The GATA-type transcription factor Csm1 regulates conidiation and secondary metabolism in Fusarium fujikuroi. Front. Microbiol. 8:1175. doi: 10.3389/fmicb.2017.01175.

    Niehaus EM, Kim HK, Münsterkötter M, Janevska S, Arndt B, Kalinina SA, Houterman PM, Ahn IP, Albert I, Tonti S, Kim DW, Sieber CMK, Humpf HU, Yun SH, Güldener U, Tudzynski B (2017) Comparative genomics of geographically distant Fusarium fujikuroi isolates revealed two distinct pathotypes correlating with secondary metabolite profiles. Plos Pathogens 13(10):e1006670. doi: 10.1371/journal.ppat.1006670.


    2016

    Studt L, Janevska S, Niehaus EM, Burkhardt I, Arndt B, Sieber CMK, Humpf HU, Dickschat JS, Tudzynski B. (2016) Two separate key enzymes and two pathway-specific transcription factors are involved in fusaric acid biosynthesis in Fusarium fujikuroi. Environ Microbiol. 18:936-956. doi: 10.1111/1462-2920.13150.

    Rösler SM, Sieber CMK, Humpf HU, Tudzynski B (2016) Interplay between pathway-specific and global regulation of the fumonisin gene cluster in the rice pathogen Fusarium fujikuroi. Appl Microbiol Biotechnol. 100: 5869-5882. doi: 10.1007/s00253-016-7426-7.

    Burkhardt T, Henrot, SM, Studt L, Rösler S, Christmann M, Tudzynski B, Dickschat JS (2016) Mechanistic characterisation of two sesquiterpene cyclases from the plant pathogenic fungus Fusarium fujikuroi. Angew. Chem. Int. Ed., 55: 8748-8751. doi:
    10.1002/anie.201603782
    .

    Studt L, Rösler SM, Burkhardt I, Arndt B, Freitag M, Humpf HU, Dickschat JS, Tudzynski B (2016) Knock-down of the methyltransferase Kmt6 relieves H3K27me3 and results in induction of cryptic and otherwise silent secondary metabolite gene clusters in Fusarium fujikuroi. Environ Microbiol. 18: 4037-4054. doi: 10.1111/1462-2920.13427.

    Rösler SM, Kramer K, Finkemeier I, Humpf HU, Tudzynski B. (2016) The SAGA complex in the rice pathogen Fusarium fujikuroi: structure and functional characterization. Molecular Microbiology. 102: 951-974. doi: 10.1111/mmi.13528.

    Niehaus EM, Studt L, von Bargen KW, Kummer W, Humpf HU, Reuter G, Tudzynski B. (2016) Sound of silence: The beauvericin cluster in Fusarium fujikuroi is controlled by cluster-specific and global regulators mediated by H3K27 modification. Environ Microbiol.18:4282-4302. doi: 10.1111/1462-2920.13576.

    Niehaus EM, Münsterkötter M, Proctor RH, Brown DW, Sharon A, Idan Y, Oren-Young L, Sieber CM, Novák O, Pěnčík A, Tarkowská D, Hromadová K, Freeman S, Maymon M, Elazar M, Youssef SA, El-Shabrawy ESM, Shalaby AA, Houterman P, Brock NL, Burkhardt I, Tsavkelova EM, Dickschat JS, Galuszka P, Güldener U, Tudzynski B (2016) Comparative ‘omics’ of the Fusarium fujikuroi species complex highlights differences in genetic potential and metabolite synthesis. Genome Biology and Evolution 8:3574-3599. doi: 10.1093/gbe/evw259.

    Janevska S, Arndt B, Niehaus EM, Burkhardt I, Rösler SM, Brock NL, Humpf HU, Dickschat JS, Tudzynski B (2016) Gibepyrone biosynthesis in the rice pathogen Fusarium fujikuroi is facilitated by a small polyketide synthase gene cluster. J Biol Chem 291:27403-27420. doi: 10.1074/jbc.M116.753053.


    2015

    von Bargen K, Niehaus EM, Krug I, Bergander K, Würthwein EU, Humpf, HU, Tudzynski, B (2015) Isolation and Structure Elucidation of the Products of the PKS19 Gene Cluster in Fusarium fujikuroi. J. Natural Products 78:1809-1815.

    Michielse CB, Studt L, Janevska S, Sieber CM, Arndt B, Espino JJ, Humpf HU, Güldener U, Tudzynski B. (2015) The global regulator FfSge1 is required for expression of secondary metabolite gene clusters but not for pathogenicity in Fusarium fujikuroi. Environ Microbiol. 17:2690-2708. doi: 10.1111/1462-2920.12592.

    Pfannmüller A, Wagner D, Sieber CM, Schönig B, Boeckstaens M, Marini AM, Tudzynski B. (2015) The general amino acid permease FfGap1 of Fusarium fujikuroi is sorted to the vacuole in a nitrogen-dependent, but Npr1 kinase-independent manner. PLoS One , 10(4):e0125487. doi: 10.1371/journal.pone.0125487.

    Schumacher J, Simon A, Cohrs KC, Traeger S, Porquier A, Dalmais B, Viaud M, Tudzynski B (2015) The VELVET Complex in the Gray Mold Fungus Botrytis cinerea: Impact of BcLAE1 on Differentiation, Secondary Metabolism, and Virulence. Mol Plant Microbe Interact. 28: 659-674.

    Arndt B, Studt L, Wiemann P, Osmanov H, Kleigrewe K, Köhler J, Krug I, Tudzynski B, Humpf HU (2015) Genetic engineering, high resolution mass spectrometry and nuclear magnetic resonance spectroscopy elucidate the bikaverin biosynthetic pathway in Fusarium fujikuroi. Fungal Genet Biol. 84:26-36.

    Hansen FT, Gardiner DM, Lysøe E, Fuertes PR, Tudzynski B, Wiemann P, Sondergaard TE, Giese H, Brodersen DE, Sørensen JL. (2015) An update to polyketide synthase and non-ribosomal synthetase genes and nomenclature in Fusarium. Fungal Genet Biol. 75:20-29.

    Tudzynski B, Studt L, Rojas CM (2015) Gibberellins in fungi, bacteria and lower plants- biosynthesis, function, and evolution. In: The gibberellins. Ann. Plant Rev. Vol. 49. Hedden P and Thomas SG (Eds) Wiley-Blackwell.