Forschungsschwerpunkte
  • PET/CT- und PET/MRT-Bildgebung
  • Bewegungskorrektur in der PET
  • Pharmakokinetische Modellierung in PET/CT und PET/MRT
Vita

Akademische Ausbildung

Habilitation in Medizinischer Physik, WWU Münster
Promotion, Dr. rer. medic., Studium der Medizinwissenschaften, Klinik für Nuklearmedizin, WWU (Betreuer: Univ.-Prof. Dr. med. M. Schäfers)
Diplom in Physik, WWU Münster (Betreuer: Univ.-Prof. Dr. rer. nat. T. Kuhn)
Studium der Physik und Mathematik, WWU Münster

Beruflicher Werdegang

Postdoc in der Klinik für Nuklearmedizin (UKM)
Postdoc im European Institute for Molecular Imaging (EIMI)

Preise

Philips-Preis für für Medizinische Physik – Deutsche Gesellschaft für Medizinische Physik

  • Publikationen

    2026

    Backhaus P, Cazzamalli S, Oehler S, Buther F, Brosch-Lenz J, Landau F, Breyholz H-J, Claesener M, Migliorini F, Ciamarone A, Georgiev T, Mock J, Ventura D, Barca C, Schiefelbein L, Hermann S, Schafers K, Gierse F, Bernemann C, Schlack K, Bogemann M, Puca E, Schindler P, Neri D, Rahbar K, Schrader AJ, Seifert KE, Schafers M. Translational and First-in-Human Positron Emission Tomography Targeting Prostatic Acid Phosphatase in Prostate Cancer Using the Ligand [(68)Ga]Ga-OncoACP3-DOTA. Eur Urol 2026;89: 305-310. Abstract
    Backhaus P, Cazzamalli S, Oehler S, Buther F, Brosch-Lenz J, Landau F, Breyholz H-J, Claesener M, Migliorini F, Ciamarone A, Georgiev T, Mock J, Ventura D, Barca C, Schiefelbein L, Hermann S, Schafers K, Gierse F, Bernemann C, Schlack K, Bogemann M, Puca E, Schindler P, Neri D, Rahbar K, Schrader AJ, Seifert KE, Schafers M. Translational and First-in-Human Positron Emission Tomography Targeting Prostatic Acid Phosphatase in Prostate Cancer Using the Ligand [(68)Ga]Ga-OncoACP3-DOTA. Eur Urol 2026;89: 305-310. Abstract
    Brosch-Lenz J, Buther F, Oehler S, Ciamarone A, Georgiev T, Schindler P, Landau F, Breyholz H-J, Ventura D, Rust M, Schlack K, Bogemann M, Puca E, Mock J, Cazzamalli S, Neri D, Rahbar K, Schrader AJ, Schafers M, Seifert KE, Backhaus P. Dynamics, Pharmacokinetics, and Dosimetry of First-in-Human [(68)Ga]Ga-OncoACP3-DOTA PET in Patients with Prostate Cancer. J Nucl Med 2026;67: 1079-1085. Abstract
    Brosch-Lenz J, Buther F, Oehler S, Ciamarone A, Georgiev T, Schindler P, Landau F, Breyholz H-J, Ventura D, Rust M, Schlack K, Bogemann M, Puca E, Mock J, Cazzamalli S, Neri D, Rahbar K, Schrader AJ, Schafers M, Seifert KE, Backhaus P. Dynamics, Pharmacokinetics, and Dosimetry of First-in-Human [(68)Ga]Ga-OncoACP3-DOTA PET in Patients with Prostate Cancer. J Nucl Med 2026;67: 1079-1085. Abstract
    Ventura D, Schafers M, Bobe S, Buther F, Brandt J, Stegger L, Bruggemann P, Roll W, Rahbar K, Schindler P, Backhaus P. FAP-targeted [(68)Ga]BED003-PET in different solid malignancies. Eur J Nucl Med Mol Imaging 2026;53: 4977-4987. Abstract
    Ventura D, Schafers M, Bobe S, Buther F, Brandt J, Stegger L, Bruggemann P, Roll W, Rahbar K, Schindler P, Backhaus P. FAP-targeted [(68)Ga]BED003-PET in different solid malignancies. Eur J Nucl Med Mol Imaging 2026;53: 4977-4987. Abstract
    Ventura D, Schafers M, Bobe S, Buther F, Brandt J, Stegger L, Bruggemann P, Roll W, Rahbar K, Schindler P, Backhaus P. FAP-targeted [(68)Ga]BED003-PET in different solid malignancies. Eur J Nucl Med Mol Imaging 2026;53: 4977-4987. Abstract

    2025

    Backhaus P, Cazzamalli S, Oehler S, Buther F, Brosch-Lenz J, Landau F, Breyholz H-J, Claesener M, Migliorini F, Ciamarone A, Georgiev T, Mock J, Ventura D, Barca C, Schiefelbein L, Hermann S, Schafers K, Gierse F, Bernemann C, Schlack K, Bogemann M, Puca E, Schindler P, Neri D, Rahbar K, Schrader AJ, Seifert KE, Schafers M. Translational and First-in-Human Positron Emission Tomography Targeting Prostatic Acid Phosphatase in Prostate Cancer Using the Ligand [(68)Ga]Ga-OncoACP3-DOTA. Eur Urol 2025Abstract
    Backhaus P, Seitzer K, Cazzamalli S, Oehler S, Migliorini F, Ciamarone A, Georgiev T, Mock J, Bögemann M, Breyholz HJ, Landau F, Büther F, Puca E, Neri D, Rahbar K, Schrader A, Schäfers M. A new theranostic target in prostate cancer: First results from prostatic acid phosphatase (ACP3) imaging with [68Ga]Ga-OncoACP3-DOTA PET in prostate cancer patients and comparison to [18F]F-PSMA-1007 2025;66
    Seifert KE, Schlack K, Cazzamalli S, Oehler S, boegemann M, Migliorini F, Ciamarone A, Georgiev T, Mock JC, Breyholz H-J, Ventura D, Landau F, Buether F, Puca E, Neri D, Rahbar K, Schrader AJ, Schäfers M, Backhaus P. Imaging and treatment of the prostatic acid phosphatase with [68Ga]Ga-OncoACP3-DOTA and [177Lu]Lu-OncoACP3-DOTA in prostate cancer patients. Annals of Oncology 2025;36: S1220-S1221. Abstract

    2024

    Ventura D, Dittmann M, Büther F, Schäfers M, Rahbar K, Hescheler D, Claesener M, Schindler P, Riemann B, Seifert R, Roll W. Diagnostic Performance of [(18)F]TFB PET/CT Compared with Therapeutic Activity [(131)I]Iodine SPECT/CT and [(18)F]FDG PET/CT in Recurrent Differentiated Thyroid Carcinoma. J Nucl Med 2024;65: 192-198. Abstract

    2023

    Cufe J, Gierse F, Schafers KP, Hermann S, Schafers MA, Backhaus P, Buther F. Dispersion-corrected extracorporeal arterial input functions in PET studies of mice: a comparison to intracorporeal microprobe measurements. EJNMMI Res 2023;13: 86. Abstract
    Cufe J, Gierse F, Schäfers KP, Hermann S, Schäfers MA, Backhaus P, Büther F. Dispersion-corrected extracorporeal arterial input functions in PET studies of mice: a comparison to intracorporeal microprobe measurements. EJNMMI Res 2023;13: 86. Abstract
    Galbiati A, Dorten P, Gilardoni E, Gierse F, Bocci M, Zana A, Mock J, Claesener M, Cufe J, Büther F, Schäfers K, Hermann S, Schäfers M, Neri D, Cazzamalli S, Backhaus P. Tumor-Targeted Interleukin 2 Boosts the Anticancer Activity of FAP-Directed Radioligand Therapeutics. J Nucl Med 2023Abstract

    2022

    Backhaus P, Burg MC, Asmus I, Pixberg M, Büther F, Breyholz H-J, Yeh R, Weigel SB, Stichling P, Heindel W, Bobe S, Barth P, Tio J, Schäfers M. Initial Results of FAPI-PET/MRI to Assess Response to Neoadjuvant Chemotherapy in Breast Cancer. J Nucl Med 2022Abstract
    Backhaus P, Burg MC, Roll W, Büther F, Breyholz H-J, Weigel S, Heindel W, Pixberg M, Barth P, Tio J, Schäfers M. Simultaneous FAPI PET/MRI Targeting the Fibroblast-Activation Protein for Breast Cancer. Radiology 2022;302: 39-47. Abstract
    Backhaus P, Gierse F, Burg MC, Büther F, Asmus I, Dorten P, Cufe J, Roll W, Neri D, Cazzamalli S, Millul J, Mock J, Galbiati A, Zana A, Schäfers KP, Hermann S, Weckesser M, Tio J, Wagner S, Breyholz H-J, Schäfers M. Translational imaging of the fibroblast activation protein (FAP) using the new ligand [(68)Ga]Ga-OncoFAP-DOTAGA. Eur J Nucl Med Mol Imaging 2022;49: 1822-1832. Abstract
    Noto B, Roll W, Zinken L, Rischen R, Kerschke L, Evers G, Heindel W, Schäfers M, Büther F. Respiratory motion correction in F-18-FDG PET/CT impacts lymph node assessment in lung cancer patients. EJNMMI Res 2022;12: 61. Abstract
    Vehof V, Büther F, Florian A, Drakos S, Chamling B, Kies P, Stegger L, Yilmaz A. Hybrid CMR- and FDG-PET-Imaging Gives New Insights Into the Relationship of Myocardial Metabolic Activity and Fibrosis in Patients With Becker Muscular Dystrophy. Front Cardiovasc Med 2022;9: 793972. Abstract

    2020

    Backhaus P, Büther F, Wachsmuth L, Frohwein L, Buchholz R, Karst U, Schäfers K, Hermann S, Schäfers M, Faber C. Toward precise arterial input functions derived from DCE-MRI through a novel extracorporeal circulation approach in mice. Magn Reson Med 2020;84: 1404-1415. Abstract
    Büther F, Jones J, Seifert R, Stegger L, Schleyer P, Schäfers M. Clinical Evaluation of a Data-Driven Respiratory Gating Algorithm for Whole-Body PET with Continuous Bed Motion. J Nucl Med 2020;61: 1520-1527. Abstract
    Pösse S, Büther F, Mannweiler D, Hong I, Jones J, Schäfers M, Schäfers KP. Comparison of two elastic motion correction approaches for whole-body PET/CT: motion deblurring vs gate-to-gate motion correction. EJNMMI Phys 2020;7Abstract

    2019

    Lassen ML, Beyer T, Berger A, Beitzke D, Rasul S, Büther F, Hacker M, Cal-Gonzalez J. Data-driven, projection-based respiratory motion compensation of PET data for cardiac PET/CT and PET/MR imaging. J Nucl Cardiol 2019Abstract

    2018

    Bolwin K, Czekalla B, Frohwein LJ, Büther F, Schäfers KP. Anthropomorphic thorax phantom for cardio-respiratory motion simulation in tomographic imaging. Phys Med Biol 2018;63: 035009. Abstract
    Büther F, Ernst I, Frohwein LJ, Pouw J, Schäfers KP, Stegger L. Data-driven gating in PET: Influence of respiratory signal noise on motion resolution. Med Phys 2018;45: 3205-3213. Abstract
    Frohwein LJ, Hess M, Schlicher D, Bolwin K, Büther F, Jiang X, Schäfers KP. PET attenuation correction for flexible MRI surface coils in hybrid PET/MRI using a 3D depth camera. Phys Med Biol 2018;63: 025033. Abstract

    2017

    Büther F, Noto B, Auf der Springe K, Allkemper T, Stegger L. An artefact of PET attenuation correction caused by iron overload of the liver in clinical PET-MRI. Eur J Hybrid Imag 2017;1
    Heß M, Büther F, Schäfers KP. Data-Driven Methods for the Determination of Anterior-Posterior Motion in PET. IEEE Trans Med Imaging 2017;36: 422-432. Abstract
    Noto B, Büther F, Auf der Springe K, Avramovic N, Heindel W, Schäfers M, Allkemper T, Stegger L. Impact of PET acquisition durations on image quality and lesion detectability in whole-body 68Ga-PSMA PET-MRI. EJNMMI Res 2017;7: 12. Abstract

    2016

    Büther F, Vehren T, Schäfers KP, Schäfers M. Impact of Data-driven Respiratory Gating in Clinical PET. Radiology 2016;281: 229-238. Abstract
    Büther F, Vrachimis A, Becker A, Stegger L. Impact of MR-safe headphones on PET attenuation in combined PET/MRI scans. EJNMMI Res 2016;6: 20. Abstract
    Reinartz G, Haverkamp U, Wullenkord R, Lehrich P, Kriz J, Büther F, Schäfers K, Schäfers M, Eich HT. 4D-Listmode-PET-CT and 4D-CT for optimizing PTV margins in gastric lymphoma : Determination of intra- and interfractional gastric motion. Strahlenther Onkol 2016;192: 322-332. Abstract

    2015

    Büther F. Bewegungsartefakte in PET/CT-Bildern und deren Korrekturen. Nuklearmediziner 2015;38: 249-258. Abstract
    Ersepke T, Büther F, Heß M, Schäfers KP. A contactless approach for respiratory gating in PET using continuous-wave radar. Med Phys 2015;42: 4911. Abstract
    Heß M, Büther F, Gigengack F, Dawood M, Schäfers KP. A dual-Kinect approach to determine torso surface motion for respiratory motion correction in PET. Med. Phys. 2015;42: 2276-2286. Abstract

    2014

    Kesner AL, Schleyer PJ, Büther F, Walter MA, Schäfers KP, Koo PJ. On transcending the impasse of respiratory motion correction applications in routine clinical imaging - a consideration of a fully automated data driven motion control framework. EJNMMI Phys 2014;1: 8. Abstract
    Schäfers KP, Bolwin K, Büther F, Hermann S, Jacobs AH, Kösters T, Kuhlmann M, Schäfers M, Viel T. High-Resolution Small Animal Imaging. In: Comprehensive Biomedical Physics 2014;Elsevier, Oxford: 181-211. Abstract

    2013

    Büther F, Ernst I, Hamill J, Eich HT, Schober O, Schäfers M, Schäfers KP. External radioactive markers for PET data-driven respiratory gating in positron emission tomography. Eur J Nucl Med Mol Imaging 2013;40: 602-614. Abstract
    Fieseler M, Kugel H, Gigengack F, Kösters T, Büther F, Quick HH, Faber C, Jiang X, Schäfers KP. A dynamic thorax phantom for the assessment of cardiac and respiratory motion correction in PET/MRI: A preliminary evaluation. Nucl Instrum Methods Phys Res A 2013;702: 59-63. Abstract

    2010

    Büther F, Ernst I, Dawood M, Kraxner P, Schäfers M, Schober O, Schäfers KP. Detection of respiratory tumour motion using intrinsic list mode-driven gating in positron emission tomography. Eur J Nucl Med Mol Imaging 2010;37: 2315-2327. Abstract
    Dawood M, Brune C, Büther F, Jiang X, Burger M, Schober O, Schäfers M, Schäfers KP. A continuity equation based optical flow method for cardiac motion correction in 3 D PET data. Lect Notes Comput Sc 2010;6326: 88-97. Abstract
    Ernst L, Büther F, Dawood M, Moustakis C, Willich N, Schäfers K, Boelling T. Listmode based PET/CT planning for motion detection in high precision radiotherapy. Strahlenther Onkol 2010;186: 13-14.

    2009

    Büther F, Dawood M, Stegger L, Wübbeling F, Schäfers M, Schober O, Schäfers KP. List mode-driven cardiac and respiratory gating in PET. J Nucl Med 2009;50: 674-681. Abstract
    Dawood M, Büther F, Schober O, Schäfers M, Schäfers KP. Wieviele respiratorische Gates? Einfluss der Anzahl an Gates auf atemgetriggerte PET Aufnahmen. Nuklearmedizin 2009;48: A23.
    Dawood M, Büther F, Stegger L, Jiang X, Schober O, Schäfers M, Schäfers KP. Optimal number of respiratory gates in positron emission tomography: a cardiac patient study. Med Phys 2009;36: 1775-1784. Abstract
    Ernst I, Büther F, Dawood M, Kraxner P, Moustakis C, Bolling T, Schober O, Schäfers K, Willich N. PET/CT for movement detection in high precision radiotherapy. Strahlenther Onkol 2009;185: 35-36.

    2008

    Dawood M, Büther F, Jiang X, Schäfers KP. Respiratory motion correction in 3-D PET data with advanced optical flow algorithms. IEEE Trans.Med.Imaging 2008;27: 1164-1175. Abstract
    Dawood M, Kösters T, Fieseler M, Büther F, Jiang X, Schäfers KP. Motion Correction on Dual ECG and Respiratory Gated 0440 3D Cardiac PET/CT Data. lncs 2008: 155-162.

    2007

    Büther F, Stegger L, Dawood M, Range F, Schäfers M, Fischbach R, Wichter T, Schober O, Schäfers KP. Effective methods to correct contrast agent-induced errors in PET quantification in cardiac PET/CT. J Nucl Med 2007;48: 1060-1068. Abstract
    Dawood M, Büther F, Lang N, Schober O, Schäfers KP. Respiratory gating in positron emission tomography: a quantitative comparison of different gating schemes. Med Phys 2007;34: 3067-3076. Abstract
    Dawood M, Fieseler M, Büther F, Jiang X, Schäfers KP. A Multi-resolution Optical Flow Based Approach to Respiratory Motion Correction in 3D PET/CT Images. Lect Notes Comput Sc 2007: 314-322. Abstract

    2006

    Dawood M, Büther F, Lang N, Jiang X, Schäfers KP. Transforming Static CT in Gated PET/CT Studies to Multiple Respiratory Phases. ICPR 2006: 1026-1029. Abstract