Forschungsschwerpunkte
- Neue Sekundärmetaboliten (Mykotoxine) aus Stachybotrys, Claviceps, Fusarium und Penicillium spp.
- Strukturaufklärung
- Synthese von Naturstoffen
Vita
Akademische Ausbildung
- Short research stay (Postdoctoral Researcher), Department of Applied Genetics and Cell Biology, Institute of Microbial Genetics - University of Natural Resources and Life Sciences, Austria - Group of Prof. J. Strauss, Dr. L. Studt-Reinhold "Genetic engineering of Fusarium and Stachybotrys spp."
- Postdoctoral Researcher (Fungal Genetics and Biology), Institute of Food Chemistry - University of Münster, Germany - Group of Prof. H.-U. Humpf in collaboration with Prof. P. Tudzynski "Pigment gene cluster in Claviceps purpurea"
- PhD, Institute of Food Chemistry, Fellow of International Graduate School of Chemistry - University of Münster, Germany - Group of Prof. H.-U. Humpf "Penicillium spp. as a Source of Secondary Metabolites: Structure Elucidation, Occurrence in Food, Cytotoxicity, and Biological Activity"
- Pharm.D., Licensed pharmacist, Perm State Pharmaceutical Academy, Russia
- Candidate of Sciences (Pharmaceutical Chemistry and Pharmacognosy), Department of Pharmacognosy and Botany - Perm State Pharmaceutical Academy, Russia - Group of Prof. V. M. Petrichenko "Development of natural drugs based on extracts from Verbascum nigrum"
- Diploma in Pharmacy (with highest honours), Studies of Pharmacy, Perm State - Pharmaceutical Academy, Russia
Beruflicher Werdegang
- Group Leader (Habilitation), Institute of Food Chemistry, University of Münster, Germany
- Postdoctoral Researcher and Dean assistant, Institute of Food Chemistry, University of Münster, Germany
- Research Assistant, Institute of Food Chemistry, University of Münster, Germany
- Research Associate, School of Pharmacy, Curtin University of Technology, Australia: Research work in the laboratory of Prof. A. Dolzhenko, Research topic: “Synthesis of biologically active triazolo-triazines
- Research and Teaching Assistant, Pharmaceutical Chemistry and Pharmacognosy Perm State Pharmaceutical Academy, Russia
Mitgliedschaften und Aktivitäten in Gremien
- Vereinigung für Allgemeine und Angewandte Mikrobiologie VAAM (Mitglied)
- Gesellschaft Deutscher Chemiker (GDCh), Lebensmittelchemische Gesellschaft (LChG) (Mitglied)
- Gesellschaft für Mykotoxinforschung e.V. (Mitglied)
- Gesellschaft für Chemische Technik und Biotechnologie e.V. (Mitglied)
- Deutsche Pharmazeutische Gesellschaft e.V. (Mitglied)
Artikel in Fachzeitschriften, Zeitungen oder Magazinen
- Atanasoff-Kardjalieff, A.K., Steinert, K., Bergander, K., S., Kalinina, und Studt-Reinhold, L. . „The Fusarium PKS16 gene cluster facilitates the biosynthesis of proliferapyrones.“ ChemBioChem 26 (7). doi: 10.1002/cbic.202401039.
- Atanasoff-Kardjalieff, Anna K., Berger, Harald, Steinert, Katharina, Janevska, Slavica, Ponts, Nadia, Humpf, Hans-Ulrich, Kalinina, Svetlana, und Studt-Reinhold, Lena. . „Incorporation of the histone variant H2A.Z counteracts gene silencing mediated by H3K27 trimethylation in <i>Fusarium fujikuroi</i>.“ Epigenetics and Chromatin 17 (1). doi: 10.1186/s13072-024-00532-y.
- Steinert, Katharina, Atanasoff-Kardjalieff, Anna K., Messner, Elias, Gorfer, Markus, Niehaus, Eva-Maria, Humpf, Hans-Ulrich, Studt-Reinhold, Lena, und Kalinina, Svetlana A. . „Tools to make Stachybotrys chartarum genetically amendable: Key to unlocking cryptic biosynthetic gene clusters.“ Fungal Genetics and Biology 172. doi: 10.1016/j.fgb.2024.103892.
- Fischle, A, Schreiber, U, Haupt, V, Schimang, F, Schürmann, L, Behrens, M, Hübner, F, Esselen, M, Kalinin, DV, und Kalinina, SA. . „Biological evaluation of semi-synthetic isoindolinone isomers produced by Stachybotrys chartarum.“ Frontiers in Fungal Biology 5. doi: 10.3389/ffunb.2024.1494795.
- Reinker, Marie, Kalinin, D.mitrii V., und Kalinina, Svetlana. . „Total synthesis of (±)-auranthine confirmed its refined structure.“ RSC Advances 14 (3). doi: 10.1039/D3RA07483H.
- Fischle, A., Lutsch, M., Hübner, F., Schäker-Hübner, L., Schürmann, L., Hansen, F.K., und S., Kalinina. . „Micro-scale screening of genetically modified Fusarium fujikuroi strain extends the apicidin family.“ Natural Products and Bioprospecting 14 (51). doi: 10.1007/s13659-024-00473-9.
- Imberg, L., Siutkina, A.I., Erbacher, C., Schmidt, J., Broekmans, D.F., Ovsepyan, R.A., Daniliuc, C.G., de Oliveira, E.G., Serafim, M.S. M., O´Donoghue, A., Pillaiyar, T., Panteleev, M.A., Poso, A., Kalinina, S., M., Bermudez, Nekipelov, K., G., Bendas, Karst, U., und Kalinin, D.V. . „Pyrazinyl-substituted aminoazoles as covalent inhibitors of thrombin: synthesis, structure, and anticoagulant properties.“ ACS Pharmacology & Translational Science 8 (1). doi: 10.1021/acsptsci.4c00515.
- Studt-Reinhold, L., Atanasoff-Kardjalieff, A.K., Berger, H., Petersen, C., Bachleitner, S., Sulyok, M., Fischle, A., Kalinina, S., und Søndergaard, T.E. . „H3K27me3 is vital for fungal development and secondary metabolite gene silencing, and substitutes for the loss of H3K9me3 in the plant pathogen Fusarium proliferatum.“ PLOS Genetics 12 (3). doi: 10.1371/journal.pgen.1011075.
- Siutkina, A.I., Kalinina, S., Liu, R., Heitman, L.H., Junker, A., Daniliuc, C.G., und Kalinin, D.V. . „Microwave-assisted synthesis, structure, and preliminary biological evaluation of novel 6-methoxy-5,6- dihydro-5-azapurines.“ ACS Omega 8 (15). doi: 10.1021/acsomega.3c00765.
- Atanasoff-Kardjalieff, A.K., Seidl, B., Steinert, K., Daniliuc, C.G., Schumacher, R., Humpf, H.-U., Kalinina, S., und Studt, L. . „Biosynthesis of the Isocoumarin derivatives fusamarins is mediated by the PKS8 gene cluster in Fusarium.“ ChemBioChem 24 (6). doi: 10.1002/cbic.202200342.
- Lünne, F, Köhler, J, Stroh, C, Müller, L, Daniliuc, CG, Mück-Lichtenfeld, C, Würthwein, EU, Esselen, M, Humpf, HU, und Kalinina, SA. . „Insights into Ergochromes of the Plant Pathogen <i>Claviceps purpurea</i>.“ Journal of Natural Products 84 (10): 2630–2643. doi: 10.1021/acs.jnatprod.1c00264.
- Alfke, J, Kampermann, U, Kalinina, S, und Esselen, M. . „Isolation and structural elucidation of dimeric epigallocatechin-3-gallate autoxidation products and their antioxidant capacity.“ European Food Research and Technology 247: 2961–2975. doi: 10.1007/s00217-021-03846-3.
- Kalinina, S, Cramer, B, und Humpf, H. . „Current and future perspectives of mycotoxin research — report from the 42nd Mycotoxin Workshop (Online conference).“ Mycotoxin Research 37 (4): 275–278. doi: 10.1007/s12550-021-00439-7.
- Kalinina, S, Cramer, B, und Humpf, H-U. . „Current and future perspectives of mycotoxin research — report from the 42nd Mycotoxin Workshop (Online conference).“ Mycotoxin Research 37: 275–278. doi: 10.1007/s12550-021-00439-7.
- Schmid, R, Petras, D, Nothias, L-F, Wang, M, Aron, AT, Jagels, A, Tsugawa, H, Rainer, J, Garcia-Aloy, M, Dührkop, K, Korf, A, Pluskal, T, Kameník, Z, Jarmusch, AK, Caraballo-Rodríguez, AM, Weldon, KC, Nothias-Esposito, M, Aksenov, AA, Bauermeister, A, Orio, AA, Grundmann, CO, Vargas, F, Koester, I, Gauglitz, JM, Gentry, EC, Hövelmann, Y, Kalinina, S, Pendergraft, MA, Panitchpakdi, M, Tehan, R, Gouellec, A, Aleti, G, Russo, HM, Arndt, B, Hübner, F, Hayen, H, Zhi, H, Raffatellu, M, Prather, KA, Aluwihare, LI, Böcker, S, McPhail, KL, Humpf, H-U, Karst, U, und Dorrestein, PC. . „Ion identity molecular networking for mass spectrometry-based metabolomics in the GNPS environment.“ Nature Communications 2021. doi: 10.1038/s41467-021-23953-9.
- Atanasoff-Kardjalieff, AK, Lünne, F, Kalinina, S, Strauss, J, Humpf, H-U, und Studt, L. . „Biosynthesis of Fusapyrone Depends on the H3K9 Methyltransferase, FmKmt1, in Fusarium mangiferae.“ Frontiers in Fungal Biology 2021. doi: 10.3389/ffunb.2021.671796.
- Lünne, F, Köhler, J, Stroh, C, Müller, L, Daniliuc, CG, Mück-Lichtenfeld, C, Würthwein, E-U, Esselen, M, Humpf, H-U, und Kalinina, S*. . „Insights into Ergochromes of the Plant Pathogen Claviceps purpurea.“ Journal of Natural Products 2021. doi: 10.1021/acs.jnatprod.1c00264.
- Korff, M, Imberg, L, Will, JM, Buckreis, N, Kalinina, SA, Wenzel, BM, Kastner, GA, Daniliuc, CG, Barth, M, Ovsepyan, RA, Butov, KR, Humpf, HU, Lehr, M, Panteleev, MA, Poso, A, Karst, U, Stenmetzer, T, Bendas, G, und Kalinin, DV. . „Acylated 1H-1,2,4-Triazol-5-amines Targeting Human Coagulation Factor XIIa and Thrombin: Conventional and Microscale Synthesis, Anticoagulant Properties, and Mechanism of Action.“ Journal of Medicinal Chemistry 63 (21): 13159–13186. doi: 10.1021/acs.jmedchem.0c01635.
- Lünne, F, Niehaus, E-M, Lipinski, S, Kunigkeit, J, Kalinina, S, und Humpf, H-U. . „Identification of the polyketide synthase PKS7 responsible for the production of lecanoric acid and ethyl lecanorate in Claviceps purpurea.“ Fungal Genetics and Biology 2020. doi: 10.1016/j.fgb.2020.103481.
- Korff, M, Imberg, L, Will, JM, Bückreiß, N, Kalinina, SA, Wenzel, BM, Kastner, GA, Daniliuc, CG, Barth, M, Ovsepyan, RA, Butov, KR, Humpf, H, Lehr, M, Panteleev, MA, Poso, A, Karst, U, Steinmetzer, T, Bendas, G, und Kalinin, DV. . „Acylated 1H-1,2,4-Triazol-5-amines Targeting Human Coagulation Factor XIIa and Thrombin: Conventional and Microscale Synthesis, Anticoagulant Properties, and Mechanism of Action.“ Journal of Medicinal Chemistry 63 (21): 13159–13186. doi: 10.1021/acs.jmedchem.0c01635.
- Marques, LMM, Behrens, M, Kalinina, S, Rottkord, U, Adhikari, A, (S), Shrestha RL, Humpf, H, und Lopes, NP. . „Govaniadine Evaluation of Cytotoxicity and Permeability in Cell Culture.“ Revista Brasileira de Farmacognosia 30 (3): 374–380. doi: 10.1007/s43450-020-00066-w.
- Kalinina, SA, Jagels, A, Hickert, S, Mauriz, Marques LM, Cramer, B, und Humpf, H. . „Detection of the Cytotoxic Penitrems A–F in Cheese from the European Single Market by HPLC-MS/MS.“ Journal of Agricultural and Food Chemistry 66 (5): 1264–1269. doi: 10.1021/acs.jafc.7b06001.
- Kalinina, S, Kalinin, D, Hövelmann, Y, Daniliuc, CG, Mück-Lichtenfeld, C, Cramer, B, und Humpf, H-U. . „Auranthine, a Benzodiazepinone from Penicillium aurantiogriseum: Refined Structure, Absolute Configuration, and Cytotoxicity.“ Journal of Natural Products 2018. doi: 10.1021/acs.jnatprod.8b00187.
- Niehaus, E-M, Kim, H-K, Münsterkötter, M, Janevska, S, Arndt, B, Kalinina, S, Houterman, PM, Ahn, I-P, Alberti, I, Tonti, S, Kim, D-W, Sieber, CM K, Humpf, H-U, Yun, S-Y, Güldener, U, und Tudzynski, B. . „Comparative genomics of geographically distant Fusarium fujikuroi isolates revealed two distinct pathotypes correlating with secondary metabolite profiles.“ PLoS Pathogens 2017. doi: 10.1371/journal.ppat.1006670.
- Kalinina, S, Jagels, A, Cramer, B, Geisen, R, und Humpf, H-U. . „Influence of Environmental Factors on the Production of Penitrems A–F by Penicillium crustosum.“ Toxins 2017. doi: 10.3390/toxins9070210.
- Kalinina, S, Kalinin, DV, und Dolzhenko, AV. . „A One-Pot, Three-Component, Microwave-Promoted Synthesis of 2-Amino-Substituted 7-Amino-1,2,4-triazolo[1,5-a][1,3,5]triazines.“ Tetrahedron Letters 2013. doi: 10.1002/chin.201403197.
- Kalinin, DV, Pantsurkin, VI, Syropyatov, BY, Kalinina, S, Rudakova, IP, Vakhrin, MI, und Dolzhenko, AV. . „Synthesis, local anaesthetic and antiarrhythmic activities of N-alkyl derivatives of proline anilides.“ European Journal of Medicinal Chemistry 2013. doi: 10.1016/j.ejmech.2013.02.003.
- Dolzhenko, AV, Kalinina, S, und Kalinin, D. . „A novel multicomponent microwave-assisted synthesis of 5-aza-adenines.“ RSC Advances 2013. doi: 10.1039/c3ra41932k.
- Kalinina, S, Elkina, O, Kalinin, DV, Syropyatov, BY, und Dolzhenko, AV. . „Diuretic activity and toxicity of some Verbascum nigrum extracts and fractions.“ Pharmaceutical Biology 2013. doi: 10.3109/13880209.2013.822001.
- Kalinin, DV, Kalinina, SA, und Dolzhenko, AV. . „A New Synthesis of Amino Substituted Azolo[1,3,5]triazines via Reaction of N1,N1-Dimethyl-N2-azolylformamidines with Cyanamide.“ Heterocycles 2013. doi: 10.3987/COM-12-12601.
- Dolzhenko, AV, Kalinin, D, und Kalinina, S. . „Fused Heterocyclic Systems with s-Triazine Ring. Part 21. Synthesis of Novel Trichloromethyl Substituted Azolo[1,3,5]triazines.“ Heterocycles 2012. doi: 10.3987/COM-12-12542.