Priv. Doz. Dr. Nermin Seda Kehr

Priv. Doz. Dr. Nermin Seda Kehr

Busso-Peus-Straße 10, Raum 110.114
48149 Münster

T: +49 251 83 34462

  • Curriculum Vitae

    Feb. 02th 2022

    The National Scientific Qualification as Full Professor in Bioengineering
    The Ministry of Education, University and Research, Italy
    Apr. 15th 2021 Venia Legendi in Organic Chemistry
    University of Münster
    Since July. 2015 Independent group leader (DFG-temporary position)
    University of Münster/Institute of Physics and Center for Soft Nanoscience (SoN), Germany
    Sep. 2018 - Dec. 2018 Invited Visiting scientist
    Research group of Prof. Khademhosseini, University of California, Los Angeles (UCLA), USA
    June 2014 - July 2015 Senior scientist
    Research group of Prof. Fuchs, University of Münster/Institute of Physics, Germany
    Mar. 2013 – May. 2014 Senior scientist
    Research group of Prof. Galla, University of Münster/Instiute of Biochemistry, Germany
    Jun. 2011 - Aug. 2011 Visiting scientist
    Research group of Prof.  Langer, Massachusetts Institute of Technology, USA
    Oct. 2012 – Feb. 2013 Senior scientist
    Research group of Prof. De Cola, University of Strasbourg/Institut de Science et d'Ingénierie Supramoléculaires, France
    Jan. 2009 – Sep. 2012 Senior scientist
    Research group of Prof. De Cola, University of Münster/Institute of Physics, Germany
    Jan. 2008 – Dec. 2008 Postdoctoral researcher
    Research group of Prof. De Cola, University of Münster/Institute of Physics, Germany
    Jan. 2007 - Dec. 2007 Postdoctoral researcher
    Research group of Prof. Ravoo, University of Münster/Institute of Organic Chemistry, Germany
    Sept. 2006 - Dec. 2006 Postdoctoral researcher
    Department of Mass spectrometry, University of Münster/Institute of Organic Chemistry, Germany
    2003 - 2005 PhD Education
    University of Münster/Institute of Organic Chemistry, Germany; Supervisor: Prof. Dieter Hoppe
    “(-)-Sparteine-Induced Enantioselective Homoaldol Reactions and Their Applications”
    July 14th, 2005 Promotion: Doktor der Naturwissenschaft (magna cum laude)

     

  • Publications

    3D-Printed Oxygen-Carrying Nanocomposite Hydrogels for Enhanced Cell Viability under Hypox-ic and Normoxic Conditions
    Motealleh A, Schäfer A. H ,Fromm O, Kehr N. S.

    Biomacromolecules, 2021, doi.org/10.1021/acs.biomac.1c01067

    Functional Nanomaterials and 3D-Printable Nanocomposite Hydrogels for Enhanced Cell Proliferation and for the Reduction of Bacterial Biofilm Formation
    Motealleh A, Kart D, Czieborowski M, Kehr N. S.
    ACS Appl. Mater. Interfaces 2021, 13, 43755

    3D Printed Step-gradient Composite Hydrogels for Directed Migration and Osteogenic Differentiation of Human Bone Marrow-derived Mesenchymal Stem Cells
    Motealleh A, Schulten A, Kehr N. S.
    Nano Select, 2021, DOI: 10.1002/nano.202100113

    Step-gradient Composite Hydrogels for Local Drug Delivery and Directed Cell Migration
    Motealleh A, Kehr N. S.
    Adv. NanoBiomed Res. 1, 2021, 202000114

    Bifunctional nanomaterials for simultaneously improving cell adhesion and affecting bacterial biofilm formation on silicon-based surfaces
    Motealleh A, Dorri P, Czieborowski M, Philipp B, Kehr N. S.
    Biomed. Mater., 2021, 16, 025013

    Recent Advances in Injectable Hydrogels for Controlled and Local Drug Delivery
    Rizzo F, Kehr N. S.
    Adv. Healthcare Mater. 2021, 2001341

    Directed Vertical Cell Migration via Bifunctionalized Nanomaterials in 3D Step-gradient Nanocomposite Hydrogels
    Motealleh A, Kehr N. S.
    Biomater. Sci., 2020, 8, 5628

    Injectable oxygen-generating nanocomposite hydrogels with prolonged oxygen delivery for enhanced cell proliferation under hypoxic and normoxic conditions Motealleh A, Kehr N. S.
    J. Mater. Chem. B., 2020, 8, 4195-4201

    Injectable Polymer/Nanomaterial Composites for the Fabrication of Three-Dimensional Biomaterial Scaffolds
    Motealleh A, Dorri P, Kehr N. S.
    Biomed. Mater, 2020, 15, 045021

    Bifunctional Nanomaterials for Enhanced Cell Proliferation and for the Reduction of Bacterial Bioluminescence/Fitness
    Motealleh A, Czieborowski M, Philipp B, Nowak S, Kehr N. S.
    Adv. Mater. Interfaces, 2020, 7, 2000086.

    Periodic Mesoporous Organosilica-Based Nanocomposite Hydrogels for Enhanced Cell Adhesion in 3D Hydrogel Network
    Kehr N. S.
    Journal of Applied Biological Sciences, 2019, 13, 133-137

    Functional Nanomaterials on 2D Surfaces and in 3D Nanocomposite Hydrogels for Biomedical Applications
    Tutar R, Motealleh A, Khademhosseini A, Kehr N. S.
    Adv. Func. Mater, 2019, 1904344

    3D Printing of Step-Gradient Nanocomposite Hydrogels for Controlled Cell Migration
    Motealleh A, Celebi-Saltik B, Ermis N, Nowak S, Khademhosseini A, Kehr N. S
    Biofabrication, 2019, 11, 045015

    Self Assembled Monolayers of Chiral Periodic Mesoporous Organosilica as Stimuli Responsive Local Drug Delivery System
    Motealleh A, Dorri P, Kehr N.S.
    J. Mater. Chem. B., 2019, 7, 2362-2371

    Advances in Controlled Oxygen-Generating Biomaterials for Tissue Engineering and Regenerative Therapy
    Ashammakhi N, Darabi M, Kehr N.S., Erdem A, Shau-Kai Hu, Dokmeci M, Nasr A, Khademhosseini A 
    Biomacromolecules, 2019, 11, 56.

    Stimuli-responsive Local Drug Molecule Delivery to Adhered Cells in a 3D Nanocomposite Scaffold
    Motealleh A, de Marco R, Kehr N.S.
    J. Mater. Chem. B., 2019, 7, 3716-3723

    3D Bioprinting of Triphasic Nanocomposite Hydrogels and Scaffolds for Cell Adhesion and Migration
    A. Motealleh, P. Dorri, A. H. Schäfer, and N. S. Kehr
    Biofabrication, 2019, 32, 035022

    Chirality-Dependent Cell Adhesion and Enrichment in Janus Nanocomposite Hydrogels
    Motealleh A, Hermes H, Jose J, Kehr N.S.
    Nanomedicine 2018, 14, 247 - 256

    Highly fluorescent water soluble spirobifluorene dye with large Stokes shift: synthesis, characterization and bio-applications
    Schlüter F, Riehemann K, Kehr N.S., Quici S, Daniliuc C.G., Rizzo F
    Chem. Commun. 2018, 54, 642 - 645

    Janus Nanocomposite Hydrogels for Chirality-Dependent Cell Adhesion and Migration
    Motealleh A, Kehr N.S.
    ACS Appl. Mater. Interfaces. 2017, 9, 33674 – 33682

    Janus Enantiomorphous Nanomaterial Assembly on Substrate Surfaces for Chirality-Dependent Cell Adhesion
    Kehr N.S.
    Colloids Surf. B, 2017, 159, 125

    Chirality-Dependent Cellular Uptake of Chiral Nanocarriers and Intracellular Delivery of Different Amounts of Guest Molecules
    Kehr N.S., Jose J
    Appl. Surf. Sci. 2017, 425, 432 – 439

    Nanocomposite (Janus) paper as 3D cell culture system
    Kehr N.S., Motealleh A
    Colloids Surf. B, 2017, 156, 236 – 242

    Microcontact Printing of (Bio)Molecules on Self-Assembled Monolayers of Zeolites L and Surface Mediated Drug Delivery
    Kehr N.S.
    Adv. Porous Mater. 2017, 5, 1 – 9

    Nanocomposite Hydrogels and Their Applications in Tissue Engineering
    Motealleh A, Kehr N.S.
    Adv. Healthcare Mater. 2017, 6, 16009388 (invited review article)

    Cell Growth on “Janus” Density Gradients of Bifunctional Zeolites
    Kehr N.S., Motealleh A, Schäfer A.H.
    ACS Appl. Mater. Interfaces. 2016, 8, 35081 – 35090

    Surface Mediated Stimuli Responsive Organic Molecules Delivery from Porous Carrier to Adhered Cells
    Ergün B, De Cola L, Galla H.-J., Kehr N.S.
    Adv. Healthcare Mater. 2016, 5, 1588 – 1592

    Enantiomorphous Periodic Mesoporous Organosilica based Nanocomposite Hydrogel Scaffolds for Cell Adhesion and Cell Enrichment
    Kehr N.S.
    Biomacromolecules, 2016, 17, 1117 – 1122

    Controlled Cell Growth and Cell Migration in PMOs/Alginate Nanocomposite Hydrogels
    Kehr N.S., Riehemann K
    Adv. Healthcare Mater. 2016, 5, 193 – 197

    Self-assembled monolayers of enantiomerically functionalized periodic mesoporous organosilicas and the effect of surface chirality on cell ladhesion
    behaviour
    Kehr N.S., Galla H.-J., Riehemann K, Fuchs H
    RSC Adv. 2015, 5, 5704 – 5710

    Self-assembled Monolayers and Nanocomposite Hydrogels of Functional Nanomaterials for Tissue Engineering Applications
    Kehr N.S., Atay S, Ergün B
    Macromol. Biosci. 2015, 15, 445 – 463 (invited review article)

    Spatial controlled channel entrances functionalisation of zeolites L
    Kehr N.S., Ergün B, Lülf H, De Cola L
    Adv. Mater, 2014, 26, 3248 − 3252

    Cell adhesion behaviour in 3D hydrogel scaffolds functionalized with D- or L-aminoacids
    Benson K, Galla H.-J., Kehr N.S.
    Macromol. Biosci. 2014, 14, 793 − 798

    When self-assembly meets biology: luminescent platinum complexes for imaging applications
    Mauro M, Aliprandi A, Septiadi D, Kehr N.S., De Cola L
    Chem Soc. Rev. 2014, 43, 4144 − 4166

    Fluorescent Modular Boron Systems Based on NNN- and ONO-Tridentate Ligands: Self-Assembly and Cell Imaging
    C. Glotzbach, U. Kauscher, J. Voskuhl, N. S. Kehr, M. C. A. Stuart, R. Fröhlich, H. J. Galla, B. J. Ravoo, K. Nagura K, Saito S, Yamaguchi S, Würthwein E.-U.
    J. Org. Chem. 2013, 78, 4410 − 4418

    Periodic Mesoporous Organosilica-Based Nanocomposite Hydrogels as Three-Dimensional Scaffolds
    Kehr N.S., Prasetyanto E.A., Benson K, Ergün B, Galstyan A., Galla H.-J.
    Angew. Chem. Int. Ed., 2013, 52, 1156 - 1160

    Bifunctional periodic mesoporous organosilicas and their self-assembled monolayers as biocompatible surfaces
    Benson K, Prasetyanto Y.E.A., Galla H.-J., Kehr N.S.
    Soft Matter, 2012, 5, 10845 - 10852

    Power Struggles between oligopeptides and Cyclodextrin Vesicles
    Versluis F, Voskuhl J, Stuart M.C.A., Kehr N.S., Ravoo B.J., Kros A
    Soft Matter, 2012, 8, 8770 - 8777

    Dendrimer-Modified Solid Supports: Nanostructured Materials with Potential Drug Allergy Diagnostic Applications
    Ruiz-Sanchez A.J., Montañez M.I., Mayorga C, Torres M.J., Kehr N.S., Vida Y, Collado D, Najera F, De Cola L, Perez-Inestrosa E
    Current Medical Chem., 2012, 19, 4952 - 4954

    Melanin-like Hydrogels Derived From Gallic Macromers
    O. Z. Fisher, B. L. Larson, D. Graupner, M. T. Nguyen-Kim, N. S. Kehr, L. De Cola, R. Langer*, D. G. Anderson
    Adv. Mater. 2012, 24, 3032-3036

    Cell Adhesion Behaviour on Enantiomerically Functionalized Zeolite L Monolayers
    El-Gindi J, Benson K, De Cola L, Galla H.-J., Kehr N.S.
    Angew. Chem. Int. Ed., 2012, 51, 3716-3720

    Click Chemistry on Self-assembled Monolayer of Zeolite L Crystals by Microcontact Printing - Applications in Nanobiotechnology
    Kehr N.S., El-Gindi J, Galla H.-J., De Cola L
    Mic. Mes. Mater., 2011, 144, 9-14

    Cell Adhesion and Cellular Patterning on a Self-Assembled Monolayer of Zeolite L Crystals
    Kehr N.S., Riehemann K, El-Gindi J, Schäfer A, Fuchs H, Galla H.-J., De Cola L
    Adv. Funct. Mater., 2010, 20, 2248-2254

    Asymmetric printing of molecules and zeolites on self assembled monolayers
    Kehr N.S., Schäfer A, Ravoo B.J., De Cola L
    Nanoscale, 2010, 2, 601–605

    Shape and Release Control of a Peptide Decorated Vesicle through pH Sensitive Orthogonal Supramolecular Interactions
    Verluis F, Tomatsu I, Kehr N.S., Fregonese C, Stuart M, Ravoo B.J., Koning R, Kros A
    J. Am. Chem. Soc., 2009, 131, 13186–13187

    (N-Arylaminomethyl)pyridine-N-oxides: Synthesis and characterization of potential ligand systems and the formation of their N,O-chelate aluminum complexes
    Nienkemper K, Kehr G, Kehr N.S., Fröhlich R, Erker G
    J. Org. Chem., 2008, 18, 3063- 3073

    Functionalized phosphorus analogues of the β-diketiminato ligand systems: bis(N-arylphosphinimino)acetonitrile-derived complexes of rhodium and iridium
    Spannoff K, Kehr G, Kehr N.S., Fröhlich R, Erker G
    Dalton Trans., 2008, 25, 3339-3344

    (Amidomethyl)pyridine zirconium and hafnium complexes: Synthesis and structural characterization
    Nienkemper K, Kehr G, Kehr N.S., Fröhlich R, Erker G
    J. Org. Chem., 2008, 693, 1572-1589

    Highly enantioselective reactions of configurationally labile epimeric diamine complexes of lithiated S-benzyl thiocarbamates
    Lange H, Bergander K, Fröhlich R, Kehr N.S., Nakamura S, Shibata N, Toru T, Hoppe D
    Chem. Asian J., 2008, 3, 88-101

    Formation and Structural and Dynamic Features of Atropisomeric η2-Iminoacyl Zirconium Complexes
    Spies P, Kehr G, Kehr N.S., Fröhlich R, Erker G
    Organometallics, 2007, 26, 5612-5620

    Polymer characterization by electrospray-mass-spectrometry - shifting the upper mass limit
    Kehr N.S., Luftmann H
    e-Polymers, 2007, 10

    Synthesis of enantioenriched and diastereomerically pure cis-fused bicyclic α-oxy-substituted γ-lactones via epoxidation of optically active homoaldol products
    Ünaldi N.S., Fröhlich R, Hoppe D
    Synthesis, 2005, 15, 2507−2520

    Enantio- and diastereoselective synthesis of highly substituted acylcyclopropanes from homoaldol products by stereospecific homoallylic cyclization
    Kalkoven R, Brandau S, Ünaldi N.S., Fröhlich R, Hoppe D
    Eur. J. Org. Chem., 2005, 21, 4571−4580

    Diastereoselective synthesis of enantioenriched, annulated tetrahydrofurans by simultaneous formation of the O-1-C-5 and the C-5-C-4 bonds
    Ünaldi S, Özlügedik M, Fröhlich R, Hoppe D
    Adv. Synth. Cat., 2005, 347, 1621−1626

    Synthesis of enantioenriched trans-fused bicyclo[4.4.0]-dec-3-enes and bicyclo[4.3.0]non-3-enes bearing a 1,5-lactone bridge
    Özlügedik M, Ünaldi S, Wibbeling B, Hoppe D
    Adv. Synth. Cat., 2005, 347, 1627−1631

    Organic synthesis via transition metal complexes, part 120. C-C insertion: Insertion of an alkyne into the C-C single bond between the carbene-carbon atom and the π - carbon atom of a Fischer carbene complex by an unprecedented metalla(di-π-methane) skeletal rearrangement
    Ünaldi S, Fröhlich R, Aumann R
    Chem. Eur. J., 2003, 9, 3000-3009

    The di-π-methane photorearrangement of 2,3-Disubstituted benzobarrelenes and benzonorbornadiene - substituent effects in regioselectivity
    R. Altundas, A. Dastan, S. Ünaldi, K. Guven, O. Uzun, M. Balci
    Eur. J. Org. Chem., 2002, 3, 526-533

    Substituent effect on regioselectivity in the di-π-methane rearrangement: synthesis of disubstituted benzobarrelene derivatives and their photochemistry
    Ünaldi S, M. Balci M
    Tetrahedron Lett., 2001, 42, 8365-8367

  • Teaching

    Teaching

    PolyNano Seminar (Master degree course), University of Münster, Germany (2021)

    Grundlagen-Modul-Chemie, Theoretische Übungen zum Organisch-Chemischen Kurs für Biowissenschaftler, (Barchelor degree course), University of Münster, Germany (2020)

    Grundlagen-Modul-Chemie, Theoretische Übungen zum Organisch-Chemischen Kurs für Biowissenschaftler, (Barchelor degree course), University of Münster, Germany (2019)

    Praktikum OC-II, Lehramt Chemie, (Barchelor degree course), University of Münster, Germany (2019)

    Polymers, (Master degree course), University of Münster, Germany (2019)

    Seminar zum Chemischen Praktikum OC-IIb, Lehramt Chemie, (Barchelor degree course), University of Münster, Germany (2019)

    Theoretical Exercises of the Organic Chemistry Course for Biosciences (Barchelordegree course), University of Münster, Germany (2018)

    Chemistry Training Seminar (Barchelor degree course), University of Münster, Germany (2018)

    PolyNano Course, (Master degree course), University of Münster Germany (2018)

    PolyNano Course, (Master degree course), University of Münster German (2017)

    PolyNano Seminar (Master degree course), University of Münster, Germany (2017)

    Chemistry Training Seminar (Barchelor degree course), University of Münster, Germany (2017)

    PolyNano Course, (Master degree course), University of Münster Germany (2016)

    PolyNano Seminar (Master degree course), University of Münster, Germany (2016)

    Biochemistry I, (Barchelor degree course), University of Münster Germany (2013)

     

    General Aspects of Nanoparticles (Master degree course), University of Münster, Germany (2011-2013)

     

    Structure of Materials (Barchelor degree course), University of Münster, Germany (2010-2012)

  • Invited lectures and conferences

    Invited lectures and conferences

    • Tissue Engineering and Regenerative Medicine International Society, the Nederlands (Nov. 2021):“3D Printing of Nanocomposite Hydrogels/Polymers for Local Drug Delivery Applications”
    • 9th NRW Nano Conference, Germany (Apr. 2021): Oral presentation
      “Injectable Nanocomposite Hydrogels/Polymers for Local Drug Delivery Applications”
    • Milan Polymer Days, (Jul 2020): “Injectable nanocomposite hydrogels for controlled cell migration and local drug delivery applications”
    • Sixth International Conference on Multifunctional, Hybrid and Nanomaterials, Spain, (Mar. 2019):"Janus, Triphasic, and Step-Gradient Nanocomposite Hydrogels for Controlled Cell Migration in 3D Network
    • Rimini Peptides, Italy (Jun. 2018): “Nanomaterials for cell-material interaction studies”.
    • Frontier Forum Meeting on NanoSciences, Croatia (May. 2017): “Arrays and Nanocomposite Hydrogels of Bifunctional Nanomaterials for Biomedical Applications”.
    • 29th Deutsche Zeolith-Tagung, Germany (Mar. 2017): “Bifunctional Zeolite L for Biomedical Applications”.
      Max Planck Institute of Colloids and Interfaces, Germany (Dec. 2016): “Cell-Material Interaction and Surface Mediated Controlled Drug Delivery”.
      University of Bologna, Italy (Feb. 2016): “Cell adhesion on self-assembled monolayers and nanocomposite hydrogels of functional porous nanomaterials”.
    • 2nd International Symposium on Nanoparticles/Nanomaterials and Applications, Portugal (Jan. 2016): “Self-assembled monolayers and nanocomposite hydrogels of enantiomorphous porous nanomaterials”.
    • Santa Barbara State University of California, USA (Feb. 2014): “Cell adhesion on functionalized 2D surfaces or in 3D scaffolds”.
    • Bilkent University, Turkey (May. 2013): “Functional porous nanoparticles for the generation of 2D surfaces and 3D scaffolds”.
    • TOBB University of Economics and Technology, Turkey (May 2013): “Generation of new 2D surfaces and 3D scaffolds”.
    • Tübitak Marmara research Center, Turkey (May 2013): “Functional porous nanoparticles and their applications”.
    • University of Jyväskylä and Aalto University, Finland (Nov.2012 ): “Functional porous nanoparticles for the generation of 2D surfaces and 3D scaffolds”.
    • University of Helsinki, Finland (Apr. 2012): “Silica based functional porous nanoparticles for biotechnological applications”.
    • Santa Barbara State University of California, USA (Feb. 2012): “Functional periodic mesoporous organosilicas as biocompatible surfaces”.
    • University of Toronto, Canada (Feb. 2012): ”Periodic mesoporous organosilica based materials for biotechnological applications”.
    • University of Nagoya, Japan (May. 2010): “Functionalization of Zeolite L Monolayers by Microcontact Chemistry and Their Application in Biotechnology”.
    • Santa Barbara State University of California, USA (Feb. 2010): “Functionalization of Zeolite L Nanocrystals by Microcontact Printing and Interaction of Zeolite L Nanocrystals with Biological Systems”.
    • University of Münster, Germany (Jul. 2009): “Interaction of Zeolite L Nanocrystals with Living Systems”.
    • Emory University, Atlanta, USA (Mar. 2009): “Interaction of Zeolite L Nanocrystals with Living Systems”.
    • Santa Barbara State University of California, USA (Mar. 2009): “Zeolite L Nanocrystals and Living Systems”.
    • Emory University, Atlanta, USA (Mar. 2008): “Synthesis of Amphiphilic Cyclodextrins and Recognization of Guest Molecules in Water”.
    • University of Toronto, Canada (Mar. 2008): “Formation of Bilayer Vesicles from Amphiphilic Cyclodextrins and Recogniztion of Guest Molecules in Water”.
    • Santa Barbara State University of California, USA (Mar. 2008): “Host-Guest interaction of Amphiphilic Cyclodextrin Vesicles and Guest Molecules in Water”.
    • University of Winsor, Ontario, Canada (Feb. 2007): “New Approach to Polymer Characterization by Electrospray-Mass Spectrometry”.
      Santa Barbara State University of California, USA (Feb. 2007): “Polymer Characterization by Electrospray-Mass Spectrometry-Shifting the Upper Mass Limit”.
    • Santa Barbara State University of California, USA (Feb. 2005): “Synthesis of Nonracemic, Chiral Homoenolate Reagents and Their Applications”.