Research topic

tba

Selected Publications

• Bertillot F, Hervé S, Drobjazko N, Kedei N, Gendi M, Hernandez MO, Kruse K, Pekcan Erkan E, Binner M, Punovuori K, Pellinen T, Ahtiainen M, Böhm J, Mecklin JP, Haglund C, Hagström J, iCAN, Nikolaev M, Gjorevski N, Lütolf M, Seppälä TT, Wickström SA, and Miroshnikova YA. Colorectal cancer heterogeneity co-evolves with tumor architecture to determine disease outcome. In revision, June 2025. doi: 10.1101/2025.08.11.669722.
• Hervé S, Scelfo A, Bersano-Marchisio G, Grison M, Vaidziulyte K, Deygas M, Nader G, Mace A-S, Gentili M, Williart A, Manel N, Piel M, Miroshnikova YA* (co-last/co-corresponding), Fachinetti D (co-last/co-corresponding)*. Chromosome mis-segregation triggers cell cycle arrest through a mechanosensitive nuclear envelope checkpoint. Nat Cell Biol. 2025 Jan;27(1):73-86. doi: 10.1038/s41556-024-01565-x.
• McCreery K, Stubb A, Stephens R, Cook A, Fursova NA, Kruse K, Michelbach A, Biggs LC, Keikhosrav A, Nykänen S, Pulkkanen R, Hydén-Granskog C, Zou J, Lackmann J-W, Niessen CM, Vuoristo S, Miroshnikova YA*(co-last/co-corresponding), and Wickström SA*(co-last/co-corresponding). Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells. Nat Cell Biol. 2025 Sep 29. doi: 10.1038/s41556-025-01767-x.
• Nava MM and Miroshnikova YA (co-first), Biggs LC, Whitefield DB, Vihinen H, Jokitalo E, García Arcos JM, Hoffmann B, Merkel R, Niessen CM, Noel Dahl K, and Wickström S.A. Heterochromatin-driven nuclear softening protects the genome against mechanical stress-induced damage. Cell. 2020 May 14;181(4):800817. doi: 10.1016/j.cell.2020.03.052.
• Miroshnikova YA, Le HQ, Schneider D, Thalheim T, Rübsam M, Bremicker N, Polleux AJ, Kamprad N, Tarantola M, Wang I, Balland M,  Niessen CN, Galle J, Wickström SA. A biomechanical network of adhesion forces and cell mechanics couples proliferation and differentiation to drive epidermal stratification. Nat Cell Biol. 2018 Jan;20(1):69-80. doi: 10.1038/s41556-017-0005-z.