Welcome to the Collaborative Research Center 1348
Accurate timing for differentiation of cells and their precise spatial integration into a complex organism require constant communication across cellular interfaces. Exchange of information and signals mostly occurs via assembly and disassembly of molecular platforms that serve as cellular decision-making hubs. To understand the dynamic organization and decision-making processes at cellular interfaces this collaborative research center will follow an integrated research approach, combining projects at two levels:
First we will decipher the formation of particular plasma membrane domains in isolated cells and at interfaces between neighboring cells. Second we will study the functional consequences of selected cellular interfaces in the context of the organisms. Our studies employ state-of-the-art high-resolution imaging modalities and utilize the advantages offered by genetic model organisms. We will then integrate both levels of analyses by incorporating the mechanistic insights gained from simpler model systems into a multicellular context to gain a better understanding of how specific properties of cellular interfaces are used to shape and regulate complex tissue structures within organisms.
SFB 1348 Seminar
October 10, 2024
Exciting seminar with Alba Silipo about "Carbohydrates as keywords in the molecular dialogue". Click here for more information.
SFB 1348 Seminar
October 31, 2024
Exciting seminar with Ruben Bierings about "Exocytosis of Weibel-Palade bodies: how to unpack a vascular emergency kit". Click here for more information.
Mitochondrien: Dynamische Kraftwerke der Zelle
Vortrag mit Prof. Dr. Busch am 11.11.2024
Mitochondrien, auch bekannt als Kraftwerke der Zelle, sind dynamischer als normalerweise dargestellt. Nicht nur verändert sich ihre Form in Anpassung an Anforderungen der Zelle, auch ihre Innenarchitektur kann sich anpassen. Auf dem molekularen Niveau ist ebenfalls eine verblüffende Plastizität vorhanden: Enzyme, die bei der Bereitstellung von ATP, der Energiewährung der Zelle, zusammenarbeiten, können sich zu großen Superkomplexen vereinen. All diese Prozesse wiederum sind äußerst anfällig gegenüber Mutationen in den involvierten Genen. So kann der Verlust einer von 46 Untereinheiten, die den Atmungskomplex I bilden, dazu führen, dass der Gesamtkomplex nur noch partiell zusammengebaut wird und der Zusammenbau von Superkomplexes insgesamt gestört wird. Die gegenwärtige Forschung untersucht, wie solche Störungen zum Prozess des Alterns oder zum Fortschreiten neurodegenerativer Krankheiten beiträgt. Im Vortrag werden diese Punkte kurz angerissen.
CRC 1348 Meeting 2025
May 7-9 2025, Münster
Please mark your calenders - our SFB1348 meeting at "Cellular interfaces across scales: from molecules to tissue dynamics" will take place from May 7-9, 2025. More information will follow soon.
How to get to the CRC 1348?
The CRC 1348 office is located in the Multiscale Imaging Center (MIC). Our seminars take place in the MIC auditorium.
Arrival by public transport
From Münster central station (Münster Westf Hbf) you can reach the MIC by bus in around 30 minutes.
Bus stops:
- Schreiberstraße: bus line 5, every 15 minutes from Münster Westf Hbf/bus platform B1 – bus line 11, every 20 minutes from Münster Westf Hbf/bus platform C1
- Mendelstraße: bus line 2, every 30 minutes from Münster Westf Hbf/bus platform C1
- P + R Coesfelder Kreuz: bus line 12, every 20 minutes from Münster Westf Hbf/bus platform C1
(Status as of November 2023)
Arrival by plane
- Airport Düsseldorf (DUS): Several train connections to Münster central station (Münster Westf Hbf), travel time approximately 1,5 hours
- Airport Münster-Osnabrück (FMO): Small airport, bus connection to Münster central station (Münster Westf Hbf), bus line S50, leaving every 60 minutes, travel time approximately 30 minutes
(Status as of November 2023)