Welcome to the Collaborative Research Center 1348

The precise spatial and temporal organization of cellular differentiation, essential for organismal development and physiology, depends on the correct formation and function of cellular interfaces. These interfaces facilitate the efficient transfer of materials and information between cells, through the dynamic assembly of molecular platforms at the plasma membrane. Such platforms integrate external and internal signals and transduce mechanical forces, guiding development and ensuring correct responses to physiological and pathophysiological changes. The Collaborative Research Center (CRC) 1348 focuses on understanding how these dynamic cellular interfaces are formed and how they control decision-making in cells and tissues.

We have developed a comprehensive strategy combining molecular modeling, structural biology, biochemistry, organic synthesis, genetics, cellular and developmental biology. This approach aims to unravel the molecular mechanisms governing cellular interactions and responses in individual cells as well as in multicellular organisms. Leveraging advances in high-resolution imaging, optogenetics, single-cell technologies, synthetic biology, and engineering, CRC 1348 aims to not only understand but also to precisely manipulate dynamic processes at the plasma membrane. Our goal is to provide a deep understanding of the molecular principles that govern cellular interface formation and function, setting the foundation for future efforts to recreate biological complexity from the bottom up.

Exciting seminar with Giorgos Pyrowolakis about "From Patterning Signals to ECM Remodeling in Epithelial Morphogenesis".
Click here for more information.

Neue Techniken zur gezielten Veränderung der Erbinformation („genome editing“) eröffnen spannende, aber auch umstrittene Möglichkeiten in Medizin, Pflanzen- und Tierzüchtung. Besonders das CRISPR/Cas9-Verfahren sorgt hier für Aufsehen: Es erlaubt, Erbgut schnell, präzise und vergleichsweise einfach zu verändern. So können DNA-Bausteine eingefügt, entfernt oder angepasst werden. Wegen seiner einfachen Anwendung wird CRISPR weltweit intensiv in der Forschung genutzt. Der Vortrag erklärt, wie das Verfahren funktioniert, wo es heute schon eingesetzt wird und welche Chancen und Risiken es für die Zukunft birgt.

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How to get to the CRC 1348?

The CRC 1348 office is located in the Multiscale Imaging Center (MIC). Our seminars take place in the MIC auditorium.

• Arrival by public transport

  From Münster central station (Münster Westf Hbf) you can reach the MIC by bus in around 30 minutes.

  Bus stops:

  • Schreiberstraße: bus line 5, every 15 minutes from Münster Westf Hbf/bus platform B1 – bus line 11, every 20 minutes from Münster Westf Hbf/bus platform C1
  • Mendelstraße: bus line 2, every 30 minutes from Münster Westf Hbf/bus platform C1
  • P + R Coesfelder Kreuz: bus line 12, every 20 minutes from Münster Westf Hbf/bus platform C1

  (Status as of November 2023)

• Arrival by plane

  • Airport Düsseldorf (DUS): Several train connections to Münster central station (Münster Westf Hbf), travel time approximately 1,5 hours
  • Airport Münster-Osnabrück (FMO): Small airport, bus connection to Münster central station (Münster Westf Hbf), bus line S50, leaving every 60 minutes, travel time approximately 30 minutes

  (Status as of November 2023)