PROJECT A09
Regulation and Execution of Vesicle Formation in WASH-mediated Endocytosis
Endocytosis is a key regulator of plasma membrane composition and function, whereas the extracellular matrix (ECM) controls cell-matrix adhesion, migration, cell polarization, and more. In this project, we will analyze the role of the ECM for endocytic membrane trafficking, and the induction and execution of an endocytic mechanism facilitated by the actin nucleation promoting factor WASH that is used by human papillomaviruses (HPV) for infection. In particular, we are interested in the recruitment of cellular factors regulating membrane bending and scission.
