Research Foci
- Biologische Systeme
- Zellkulturstudien
- Zelluläre Barrieren
- Lebensmittelinhaltsstoffe und ihre Biotransformation
CV
Academic Education
- Promotionsstudium (Dr. rer. nat.) unter Betreuung von Herrn Prof. Dr. Hans-Ulrich Humpf
- Studium Lebensmittelchemie (B. Sc./M. Sc.) WWU Münster
Positions
- Akademischer Rat am Institut für Lebensmittelchemie der WWU Münster
- Wissenschaftlicher Mitarbeiter am Institut für Lebensmittelchemie der WWU Münster
Function or Membership
- Mitglied in der Gesellschaft Deutscher Chemiker GDCh und Lebensmittelchemischen Gesellschaft (LChG)
Teaching
- Seminar: Gentechnik und Biotechnologie/Biochemische und molekularbiologische Analytik [126220]
- [ – | Wed, – | ]
- Seminar: Molekulare Sensorik [126218]
- [ – | Wed, – | ]
- Seminar: Institutsseminar [126233]
(in cooperation with Florian Hübner, Hans-Ulrich Humpf, Melanie Esselen and Benedikt Cramer)- [Thu, – | ]
- Seminar: Aktuelle Forschung [126229]
(in cooperation with Florian Hübner, Hans-Ulrich Humpf, Melanie Esselen and Benedikt Cramer)- [ – | Thu, – | ]
- Practical: Biochemische und molekularbiologische Analytik [126221]
- [Mon – Fri | ad hoc]
- Seminar: Institutsseminar [124233]
(in cooperation with Florian Hübner, Hans-Ulrich Humpf, Melanie Esselen and Benedikt Cramer)- Seminar: Aktuelle Forschung [124229]
(in cooperation with Florian Hübner, Hans-Ulrich Humpf, Melanie Esselen and Benedikt Cramer)- Practical: Mikrobiologische Übungen für Lebensmittelchemiker [124216]
- Practical: Toxikologische Analysen [124223]
(in cooperation with Florian Hübner)- Presentation: Vortrag zur Bachelorarbeit [124219]
(in cooperation with Michael Lange-Aperdannier, Hans-Ulrich Humpf, Florian Hübner, Melanie Esselen and Benedikt Cramer)
Research Articles (Journals)
- Bieß, N, Behrens, M, Humpf, H-U, and Gerdemann, A. . “Elucidation of Sulforaphane‐Mediated Effects on the Cellular Human Metabolome Using Metabolic Profiling.” Molecular Nutrition and Food Research 70 (1). doi: 10.1002/mnfr.70373.
- Gerdemann, A, Behrens, M, Günther, G, Ghallab, A, Hengstler, JG., Humpf, H-U, and Esselen, M. . “A simplified LC–MS-based method for sensitive analysis of DNA adducts utilizing accessible in vitro metabolism models.” Archives of Toxicology 99: 4021–4034. doi: 10.1007/s00204-025-04125-w.
- Brückner, L, Neuendorff, F, Hadenfeldt, K, Behrens, M, Cramer, B, and Humpf, H. . “Thermal Stability and Matrix Binding of Citrinin in the Thermal Processing of Starch-Rich Foods.” Toxins 17 (2): 86–86. doi: 10.3390/toxins17020086.
- Keuter, Lucas, Wolbeck, Alessa, Kasimir, Matthias, Schuermann, Lina, Behrens, Matthias, and Humpf, Hans-Ulrich. . “Structural Impact of Steroidal Glycoalkaloids: Barrier Integrity, Permeability, Metabolism, and Uptake in Intestinal Cells.” Molecular Nutrition and Food Research 68 (6). doi: 10.1002/mnfr.202300639.
- Fischle, A, Schreiber, U, Haupt, V, Schimang, F, Schürmann, L, Behrens, M, Hübner, F, Esselen, M, Kalinin, DV, and Kalinina, SA. . “Biological evaluation of semi-synthetic isoindolinone isomers produced by Stachybotrys chartarum.” Frontiers in Fungal Biology 5. doi: 10.3389/ffunb.2024.1494795.
- Gerdemann, A, Broenhorst, M, Behrens, M, Humpf, HU, and Esselen, M. . “Polyphenols Cause Structure Dependent Effects on the Metabolic Profile of Human Hepatocarcinogenic Cells.” Molecular Nutrition and Food Research 67 (21): e2300052–e2300052. doi: 10.1002/mnfr.202300052.
- Kleinehr, J, Schöfbänker, M, Daniel, K, Günl, F, Mohamed, FF, Janowski, J, Brunotte, L, Boergeling, Y, Liebmann, M, Behrens, M, Gerdemann, A, Klotz, L, Esselen, M, Humpf, HU, Ludwig, S, and Hrincius, ER. . “Glycolytic interference blocks influenza A virus propagation by impairing viral polymerase-driven synthesis of genomic vRNA.” PLoS Pathogens 19 (7): e1010986.. doi: 10.1371/journal.ppat.1010986.
- Patnana, P.K., Liu, L., Frank, D., Nimmagadda, S., Behrens, M., Ahmed, H., Xie, X., Liebmann, M., Wei, L., Gerdemann, A., Thivakaran, A., Humpf, H.U., Klotz, L., Dugas, M., Varghese, J., Trajkovic-Arsic, M., Siveke, J.T., Hanenberg, H., Opalka, B., Dührsen, U., Reinhardt, H.C., Guenther, U., von, Bubnoff N., and Khandanpour, C. . “Dose-dependent expression of GFI1 alters metabolism in the haematopoietic progenitors and MLL::AF9-induced leukaemic cells.” British Journal of Haematology 202 (5): 1033–1048. doi: 10.1111/bjh.18939.
- Gerdemann, A, Cramer, B, Degen, GH, Veerkamp, J, Günther, G, Albrecht, W, Behrens, M, Esselen, M, Ghallab, A, Hengstler, JG, and Humpf, H-U. . “Comparative metabolism of aflatoxin B1 in mouse, rat and human primary hepatocytes using HPLC–MS/MS.” Archives of Toxicology 97 (12): 3179–3196. doi: 10.1007/s00204-023-03607-z.
- Kasimir, M, Wolbeck, A, Behrens, M, and Humpf, H. . “Intestinal Metabolism of Selected Steroidal Glycoalkaloids in the Pig Cecum Model.” ACS Omega 8 (20): 18266–18274. doi: 10.1021/acsomega.3c01990.
- Behrens, Matthias. . “Release of Small Phenolic Metabolites from Isotopically Labeled 13C Lignin in the Pig Cecum Model.” Journal of Agricultural and Food Chemistry 70 (27): 8317–8325. doi: 10.1021/acs.jafc.2c02836.
- Hahn, M., Lindemann, V., Behrens, M., Mulac, D., Langer, K., Esselen, M., and Humpf, H.-U. . “Permeability of dopamine D2 receptor agonist hordenine across the intestinal and blood-brain barrier in vitro.” PloS one 17 (6): e0269486–e0269486. doi: 10.1371/journal.pone.0269486.
- Gerdemann, A, Behrens, M, Esselen, M, and Humpf, HU. . “Metabolic profiling as a powerful tool for the analysis of cellular alterations caused by 20 mycotoxins in HepG2 cells.” Archives of Toxicology 96 (11): 2983–2998. doi: 10.1007/s00204-022-03348-5.
- Kasimir, M, Hahn, M, Westkamp, I, Karentzopoulos, A, Behrens, M, Hövelmann, Y, and Humpf, H. . “Intestinal Absorption and Metabolism of the Tomato Imidazole Alkaloids N-Caprylhistamine-β-glucoside and N-Caprylhistamine.” Journal of Agricultural and Food Chemistry 70: 1562–1570. doi: 10.1021/acs.jafc.1c08047.
- Lindemann, V, Jagels, A, Behrens, M, Hübner, F, and Humpf, HU. . “In Vitro Metabolism of Phenylspirodrimanes Derived from the Indoor Fungus Stachybotrys.” Toxins 14 (6): 395. doi: 10.3390/toxins14060395.
- Müller, L, Keuter, L, Bücksteeg, D, Uebel, T, Wilken, M, Schürmann, L, Behrens, M, Humpf, H, and Esselen, M. . “Metabolic conjugation reduces in vitro toxicity of the flavonoid nevadensin.” Food and Chemical Toxicology 164: 113006. doi: 10.1016/j.fct.2022.113006.
- Jürgens, FM, Behrens, M, Humpf, H-U, Robledo, SM, and Schmidt, TJ. . “In Vitro Metabolism of Helenalin Acetate and 11α,13-Dihydrohelenalin Acetate: Natural Sesquiterpene Lactones from Arnica.” Metabolites 12: 88.. doi: 10.3390/metabo12010088.
- Barth, C., Spreen, H., Mulac, D., Keuter, L., Behrens, M., Humpf, H.-U., and Langer, K. . “Spacer length and serum protein adsorption affect active targeting of trastuzumab-modified nanoparticles.” Biomaterials and Biosystems 5: 100032. doi: 10.1016/j.bbiosy.2021.100032.
- Jürgens, Michaela Franziska, Behrens, Matthias, Humpf, Hans-Ulrich, Robledo, M.Sara, and Schmidt, J.Thomas. . “In Vitro Metabolism of Helenalin Acetate and 11α,13-Dihydrohelenalin Acetate: Natural Sesquiterpene Lactones from Arnica.” Metabolites 12 (1): 88. doi: 10.3390/metabo12010088.
- Behrens, M, Hüwel, S, Galla, H-J, and Humpf, H-U. . “Efflux at the Blood-Brain Barrier Reduces the Cerebral Exposure to Ochratoxin A, Ochratoxin α, Citrinin and Dihydrocitrinone.” Toxins 13 (5): 327.. doi: 10.3390/toxins13050327.
- Spreen, H., Behrens, M., Mulac, D., Humpf, H., and Langer, K. . “Identification of main influencing factors on the protein corona composition of PLGA and PLA nanoparticles.” European journal of pharmaceutics and biopharmaceutics 163: 212–222.
- Kasimir, Matthias, Behrens, Matthias, Schulz, Mareike, Kuchenbuch, Henning, Focke, Christine, and Humpf, Hans-Ulrich. . “Intestinal Metabolism of α- and β‑Glucosylated Modified Mycotoxins T‑2 and HT‑2 Toxin in the Pig Cecum Model.” Journal of Agricultural and Food Chemistry 68 (19). doi: 10.1021/acs.jafc.0c00576.
- Marques, LMM, Behrens, M, Kalinina, S, Rottkord, U, Adhikari, A, (S), Shrestha RL, Humpf, H, and Lopes, NP. . “Govaniadine Evaluation of Cytotoxicity and Permeability in Cell Culture.” Revista Brasileira de Farmacognosia 30 (3): 374–380. doi: 10.1007/s43450-020-00066-w.
- Krug, I, Behrens, M, Esselen, M, and Humpf, HU. . “Transport of enniatin B and enniatin B1 across the blood-brain barrier and hints for neurotoxic effects in cerebral cells.” PloS one 13(5). doi: 10.1371/journal.pone.0197406.
- Behrens, M, Hüwel, S, Galla, H, and Humpf, H. . “Blood-Brain Barrier Effects of the Fusarium Mycotoxins Deoxynivalenol, 3 Acetyldeoxynivalenol, and Moniliformin and Their Transfer to the Brain.” PloS one 10 (11): 1–20. doi: 10.1371/journal.pone.0143640.