Research Foci
- Studies on the thermal stability, biosynthesis, toxicity and (intestinal) metabolism of mycotoxins.
- Development of human biomonitoring methods (HBM) for exposure assessment of mycotoxins and detection of nutritional biomarkers.
- Metabolomics- and proteomics-based approaches to characterise cellular responses upon exposure to mycotoxins and other food constituents
- transfer of food constituents across the intestinal barrier (Caco-2 model) as well as the blood-brain-barrier.
- Studies on the occurrence and significance of mycotoxins in indoor environments
CV
Academic Education
- Habilitation und Erlangung der Venia legendi im Fachgebiet "Lebensmittelchemie"
- Forschungsaufenthalt an der Emory University, Atlanta, USA, Department of Biochemistry bei Herrn Prof. Dr. A.H. Merrill
- 2. Ausbildungsphase für Lebensmittelchemiker am Landesuntersuchungsamt in Erlangen, Staatsprüfung für Lebensmittelchemiker
- Dissertation am Lehrstuhl für Lebensmittelchemie der Universität Würzburg bei Prof. Dr. P. Schreier
Positions
- Dean of the Faculty for Chemistry and Pharmacy at the Westfälischen Wilhelms-Universität Münster
- Managing Direktor of the Institute of Food Chemistry
- W3-Full-Professor for Food Chemistry and Director of the Institute of Food Chemistry at the University of Münster
- C3-Professor of Food Chemistry at the University of Münster
- Wissenschaftlicher Assistent und seit 01.10.2000 Oberassistent am Lehrstuhl für Lebensmittelchemie der Universität Würzburg
- Post-doc an der Columbia University, New York, Department of Chemistry bei Prof. Dr. K. Nakanishi
- Wissenschaftlicher Mitarbeiter am Lehrstuhl für Lebensmittelchemie der Universität Würzburg
Honors
- Josef-Schormüller-Stipendium – Lebensmittelchemische Gesellschaft (LChG) - Fachgruppe in der Gesellschaft Deutscher
- Studienabschluss-Stipendium – Fonds der Chemischen Industrie (FCI)
- Stockmeyer Wissenschaftspreis 2002 – Heinrich-Stockmeyer-Stiftung
- Peter B. Czedik-Eysenberg-Preis – GÖCH - Gesellschaft Österreichischer Chemiker - Arbeitsgruppe Lebensmittel, Kosmetik und Gebrauchsgegenstände
External Functions
- German Research Foundation (DFG) (Member of the DFG Review Board "Biological Chemistry and Food Chemistry" for the subject Food Chemistry)
- Springer-Nature (Editor in Chief of the journal Mycotoxin Research)
- Federal Institute for Risk Assessment (BfR) (BfR Commission for Contaminants in the Food Chain, Member)
- Society for Mycotoxin Research (President)
- Wiley-VCH (Editor in Chief of the journal "Molecular Nutrition and Food-Research")
- Mitglied in der der Senatskommission der Deutschen Forschungsgemeinschaft zur gesundheitlichen Bewertung von Lebensmitteln (SKLM)
- Präsident der Gesellschaft für Mykotoxinforschung e.V.
- Federal Institute for Risk Assessment (BfR) (of the Expert Commission "Contaminants and other undesirable substances in the food chain", Member)
- Associate Editor der Zeitschrift "Molecular Nutrition and Food-Research", Wiley-VCH
- Mitglied der Gesellschaft für Mykotoxinforschung e.V.
- Member of the American Chemical Society
- Mitglied in der Gesellschaft Deutscher Chemiker GDCh
Appointments
- Ruf auf eine W3-Professur für Lebensmittelchemie an der Universität Münster
University of Münster, Lebensmittelchemie (W3) – accepted - Ruf auf eine C4-Professur für Lebensmittelchemie, Universität Hamburg
Universität Hamburg, Lebensmittelchemie (C4) – rejected - Ruf auf eine C4-Professur für Lebensmittelchemie, Universität Halle-Wittenberg
University of Halle-Wittenberg, Lebensmittelchemie (C4) – rejected - Ruf auf eine C3-Professur für Lebensmittelchemie an der Universität Münster
University of Münster, Lebensmittelchemie (C3) – accepted - Ruf auf eine C3-Professur für Lebensmittelchemie, Universität Hohenheim
University of Hohenheim, Lebensmittelchemie (C3) – rejected
Teaching
- Vorlesung: Specialised Food Chemistry I [128216]
[ - | | wöchentlich | Mi | LC 1 | Prof. Dr. Hans-Ulrich Humpf] - Vorlesung: Biochemistry of Nutrition [128219]
(in cooperation with Dr. Svetlana Kalinina, Prof. Dr. Melanie Esselen)
[ - | | wöchentlich | Di | LC 1 | Dr. Svetlana Kalinina]
[ - | | wöchentlich | Do | LC 1 | Dr. Svetlana Kalinina] - Seminar: Institutsseminar [128233]
(in cooperation with Dr. Benedikt Cramer, Dr. Matthias Behrens, Prof. Dr. Melanie Esselen, Dr. Florian Hübner)
[ | wöchentlich | Do | Dr. Benedikt Cramer] - Seminar: Seminar Specialised Food Chemistry (Analysis of Isotopes and Enantiomers, Combined Spectral Analysis and Hyphenated Techniques in Food Analysis) [128217]
[ - | | wöchentlich | Fr. | LC 1 | Prof. Dr. Hans-Ulrich Humpf] - Seminar: Seminar Masterthesis [128229]
(in cooperation with Dr. Benedikt Cramer, Dr. Matthias Behrens, Prof. Dr. Melanie Esselen, Dr. Florian Hübner)
[ - | | wöchentlich | Do | LC 3 | Dr. Benedikt Cramer] - Anleitung zum wissenschaftlichen Arbeiten: Anleitung zu selbständigen wissenschaftlichen Arbeiten - AK Humpf [128231]
[n. V. | Prof. Dr. Hans-Ulrich Humpf] - Literaturseminar für Doktoranden [128232]
(in cooperation with Prof. Dr. Melanie Esselen)
[n. V. | Prof. Dr. Hans-Ulrich Humpf] - Vorlesung: Specialised Food Chemistry II [126221]
- Seminar: Seminar Masterthesis [126230]
(in cooperation with Dr. Benedikt Cramer, Dr. Matthias Behrens, Prof. Dr. Melanie Esselen, Dr. Florian Hübner) - Seminar: Institutsseminar [126233]
(in cooperation with Dr. Benedikt Cramer, Dr. Matthias Behrens, Prof. Dr. Melanie Esselen, Dr. Florian Hübner) - Anleitung zum wissenschaftlichen Arbeiten: Anleitung zu selbständigen wissenschaftlichen Arbeiten - AK Humpf [126232]
- Vortrag: Vortrag zur Bachelorarbeit [126220]
(in cooperation with Dr. Benedikt Cramer, Dr. Michael Lange-Aperdannier, Dr. Matthias Behrens, Prof. Dr. Melanie Esselen, Dr. Florian Hübner) - Literaturseminar für Doktoranden [126233]
(in cooperation with Prof. Dr. Melanie Esselen)
- Vorlesung: Specialised Food Chemistry I [128216]
Publications
- 10.1038/s41598-024-55920-x. . ‘Antagonistic properties against Fusarium sporotrichioides and glycosylation of HT-2 and T-2 toxins by selected Trichoderma strains.’ Scientific Reports 14, № 1. doi:
- 10.1007/s00204-024-03688-4. . ‘Integrated data from intravital imaging and HPLC–MS/MS analysis reveal large interspecies differences in AFB1 metabolism in mice and rats.’ Archives of Toxicology 98, № 4: 1081–1093. doi:
- 10.1021/acs.jafc.3c07465. . ‘Co-occurrence of T-2 and HT-2 Mycotoxins and α and β Anomers of Their Glucosides in Wheat and Oat Grains.’ Journal of Agricultural and Food Chemistry 72, № 6: 3150–3159. doi:
- 10.1007/s00204-024-03726-1. . ‘Commentary of the SKLM to the EFSA opinion on risk assessment of N-nitrosamines in food.’ Archives of Toxicology 98, № 6. doi:
- . . ‘Co-occurrence of T-2 and HT-2 Mycotoxins and α and β Anomers of Their Glucosides in Wheat and Oat Grains.’ Journal of Agricultural and Food Chemistry 72, № 6. doi: 10.1021/acs.jafc.3c07465.
- . . ‘Human Intervention Study: Alkylresorcinol Metabolites as Potential Biomarkers for Grain Intake and the Occurrence of Alkylresorcinols in Commonly Consumed Foods in the German Retail Sector.’ ACS Omega 9, № 22. doi: 10.1021/acsomega.4c00733.
- . . ‘Incorporation of the histone variant H2A.Z counteracts gene silencing mediated by H3K27 trimethylation in Fusarium fujikuroi.’ Epigenetics and Chromatin 17, № 1. doi: 10.1186/s13072-024-00532-y.
- . . ‘Integrated data from intravital imaging and HPLC-MS/MS analysis reveal large interspecies differences in AFB1 metabolism in mice and rats.’ Archives of Toxicology 1. doi: 10.1007/s00204-024-03688-4.
- . . ‘Role of albumin in the metabolism and excretion of ochratoxin A.’ Mycotoxin Research 1. doi: 10.1007/s12550-024-00538-1.
- . . ‘Structural Impact of Steroidal Glycoalkaloids: Barrier Integrity, Permeability, Metabolism, and Uptake in Intestinal Cells.’ Molecular Nutrition and Food Research 68, № 6. doi: 10.1002/mnfr.202300639.
- . . ‘Surface Display and Engineering of Laccase CotA for Increased Growth of Pseudomonas putida on Lignin.’ ChemCatChem 16, № 4. doi: 10.1002/cctc.202301055.
- 10.1016/j.fgb.2024.103892. . ‘Tools to make Stachybotrys chartarum genetically amendable: Key to unlocking cryptic biosynthetic gene clusters.’ Fungal Genetics and Biology 172. doi:
- 10.1111/bjh.18939. . ‘Dose-dependent expression of GFI1 alters metabolism in the haematopoietic progenitors and MLL::AF9-induced leukaemic cells.’ British Journal of Haematology 202, № 5: 1033–1048. doi:
- contributed to the DPhG Annual Meeting, Tübingen, . ‘Role of stabilizers in protein adsorption patterns of PLGA nanoparticles.’
- . . ‘Comparative metabolism of aflatoxin B1 in mouse, rat and human primary hepatocytes using HPLC–MS/MS.’ Archives of Toxicology 97, № 12: 3179–3196. doi: 10.1007/s00204-023-03607-z.
- 10.1016/j.toxicon.2023.107160. . ‘Degradation products of aflatoxin M1 (AFM1) formed by high voltage atmospheric cold plasma (HVACP) treatment.’ Toxicon 230. doi:
- 10.1007/s00217-023-04374-y. . ‘Determination of furan and alkylfuran in breakfast cereals from the European market and their correlation with acrylamide levels.’ European Food Research and Technology 2023. doi:
- 10.1007/s00204-023-03491-7. . ‘Maternal exposure to multiple mycotoxins and adverse pregnancy outcomes: a prospective cohort study in rural Bangladesh.’ Archives of Toxicology 97, № 6: 1795–1812. doi:
- . . ‘Polyphenols Cause Structure Dependent Effects on the Metabolic Profile of Human Hepatocarcinogenic Cells.’ Molecular Nutrition and Food Research 67, № 21: e2300052. doi: 10.1002/mnfr.202300052.
- . . ‘Glycolytic interference blocks influenza A virus propagation by impairing viral polymerase-driven synthesis of genomic vRNA.’ PLoS Pathogens 19, № 7: e1010986. doi: 10.1371/journal.ppat.1010986.
- . . ‘Permeability of dopamine D2 receptor agonist hordenine across the intestinal and blood-brain barrier in vitro.’ PloS one 17, № 6: e0269486. doi: 10.1371/journal.pone.0269486.
- . . ‘Metabolic conjugation reduces in vitro toxicity of the flavonoid nevadensin.’ Food and Chemical Toxicology 164: 113006. doi: 10.1016/j.fct.2022.113006.
- . . ‘Mycotoxins in Serum and 24-h Urine of Vegans and Omnivores from the Risks and Benefits of a Vegan Diet (RBVD) Study.’ Molecular Nutrition and Food Research 66, № 6. doi: 10.1002/mnfr.202100874.
- . . ‘Detection of Mycotoxins in Highly Matrix-Loaded House-Dust Samples by QTOF-HRMS, IM-QTOF-HRMS, and TQMS: Advantages and Disadvantages.’ Analytical Chemistry 94, № 10: 4209–4217. doi: 10.1021/acs.analchem.1c04254.
- . . ‘In Vitro Metabolism of Helenalin Acetate and 11α,13-Dihydrohelenalin Acetate: Natural Sesquiterpene Lactones from Arnica.’ Metabolites 12: 88. doi: 10.3390/metabo12010088.
- 10.1016/j.bbiosy.2021.100032. . ‘Spacer length and serum protein adsorption affect active targeting of trastuzumab-modified nanoparticles.’ Biomaterials and Biosystems 5: 100032. doi:
- 10.1007/s00204-022-03361-8. . ‘Hypoalbuminemia affects the spatio-temporal tissue distribution of ochratoxin A in liver and kidneys: consequences for organ toxicity.’ Archives of Toxicology 96, № 11: 2967–2981. doi:
- 10.1007/s00204-022-03395-y. . ‘Inhibition of cytochrome P450 enhances the nephro- and hepatotoxicity of ochratoxin A.’ Archives of Toxicology 96, № 12: 3349–3361. doi:
- . . ‘In Vitro Metabolism of Helenalin Acetate and 11α,13-Dihydrohelenalin Acetate: Natural Sesquiterpene Lactones from Arnica.’ Metabolites 12, № 1: 88. doi: 10.3390/metabo12010088.
- . . ‘Metabolic profiling as a powerful tool for the analysis of cellular alterations caused by 20 mycotoxins in HepG2 cells.’ Archives of Toxicology 96, № 11: 2983–2998. doi: 10.1007/s00204-022-03348-5.
- 10.1007/s00204-022-03288-0. . ‘Assessment of multiple mycotoxin exposure and its association with food consumption: a human biomonitoring study in a pregnant cohort in rural Bangladesh.’ Archives of Toxicology 96, № 7: 2123–2138. doi:
- . . ‘Salivary nitrate/nitrite and acetaldehyde in humans: potential combination effects in the upper gastrointestinal tract and possible consequences for the in vivo formation of N-nitroso compounds-a hypothesis.’ Archives of Toxicology 96, № 6: 1905–1914. doi: 10.1007/s00204-022-03296-0.
- . . ‘Analysis of mold and mycotoxins in naturally infested indoor building materials.’ Mycotoxin Research 2022. doi: 10.1007/s12550-022-00461-3.
- 10.1007/s12550-022-00462-2. . ‘From the laboratory bench to the lecture hall: latest findings from mycotoxin research presented at the 43rd Mycotoxin Workshop.’ Mycotoxin Research 2022. doi:
- . . ‘C Lignin in the Pig Cecum Model.’ Journal of Agricultural and Food Chemistry 70, № 27: 8317–8325. doi: 10.1021/acs.jafc.2c02836.
- . . ‘.In Vitro Metabolism of Phenylspirodrimanes Derived from the Indoor Fungus Stachybotrys.’ Toxins 14, № 6: 395. doi: 10.3390/toxins14060395.
- . . ‘Detection of Mycotoxins in Highly Matrix-Loaded House-Dust Samples by QTOF-HRMS, IM-QTOF-HRMS, and TQMS: Advantages and Disadvantages.’ Analytical Chemistry 94, № 10: 4209–4217. doi: 10.1021/acs.analchem.1c04254.
- . . ‘Can the presence of additives result in false positive errors for microplastics in infant feeding bottles?’ Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 39, № 1: 185–197. doi: 10.1080/19440049.2021.1989498.
- . . ‘Current and future perspectives of mycotoxin research — report from the 42nd Mycotoxin Workshop (Online conference).’ Mycotoxin Research 37, № 4: 275–278. doi: 10.1007/s12550-021-00439-7.
- ‘Studies on the formation of a protein corona on colloidal drug carriers.’ contributed to the EMBO practical course – targeted proteomics: Experimental design and data analysis., CRG – Centre de Regulació Genòmica, online, .
- ‘Nanoparticle matrix and incubation medium – main influencer of the protein corona?’ contributed to the DPhG Annual Meeting, Leipzig online, .
- . . ‘Determination of urinary mycotoxin biomarkers using a sensitive online solid phase extraction‐uhplc‐ms/ms method.’ Toxins 13, № 6. doi: 10.3390/toxins13060418.
- . ‘Identification of main influencing factors on the protein corona composition of PLGA and PLA nanoparticles.’ European journal of pharmaceutics and biopharmaceutics 163: 212–222.
- . . ‘Dried urine spots as sampling technique for multi-mycotoxin analysis in human urine.’ Mycotoxin Research 37, № 2: 129–140. doi: 10.1007/s12550-021-00423-1.
- . . ‘Subcellular spatio-temporal intravital kinetics of aflatoxin B1 and ochratoxin A in liver and kidney.’ Archives of Toxicology 95, № 6: 2163–2177. doi: 10.1007/s00204-021-03073-5.
- . . ‘Chemoenzymatic synthesis of 2,6-disubsttuted tetrahydropyrans with high 1 receptor affinity, antitumor and analgesic activity.’ European Journal of Medicinal Chemistry 219: 113443. doi: 10.1016/j.ejmech.2021.113443.
- . . ‘Natural Compounds Isolated from Stachybotrys chartarum Are Potent Inhibitors of Human Protein Kinase CK2.’ Molecules 26, № 15: 4453. doi: 10.3390/molecules26154453.
- . . ‘Insights into Ergochromes of the Plant Pathogen Claviceps purpurea.’ Journal of Natural Products 84, № 10: 2630–2643. doi: 10.1021/acs.jnatprod.1c00264.
- . . ‘Primary Human Colon Epithelial Cells (pHCoEpiCs) Do Express the Shiga Toxin (Stx) Receptor Glycosphingolipids Gb3Cer and Gb4Cer and Are Largely Refractory but Not Resistant towards Stx.’ International Journal of Molecular Sciences (IJMS) 22, № 18: 10002. doi: 10.3390/ijms221810002.
- . . ‘Primary Human Renal Proximal Tubular Epithelial Cells (pHRPTEpiCs): Shiga Toxin (Stx) Glycosphingolipid Receptors, Stx Susceptibility, and Interaction with Membrane Microdomains.’ Toxins 13, № 8: 529.
- . . ‘Efflux at the Blood-Brain Barrier Reduces the Cerebral Exposure to Ochratoxin A, Ochratoxin α, Citrinin and Dihydrocitrinone.’ Toxins 13, № 5: 327. doi: 10.3390/toxins13050327.
- . . ‘Shiga Toxin (Stx)-Binding Glycosphingolipids of Primary Human Renal Cortical Epithelial Cells (pHRCEpiCs) and Stx-Mediated Cytotoxicity.’ Toxins 13, № 2: 139. doi: 10.3390/toxins13020139.
- . . ‘Mass Spectrometry–Based Analysis of Urinary Biomarkers for Dietary Tomato Intake.’ Molecular Nutrition & Food Research 64.
- . . ‘Identification of a novel N-caprylhistamine-β-glucoside from tomato fruits and LC-MS/MS-based food screening for imidazole alkaloids.’ Food Chemistry 312.
- . . ‘Mycotoxins in blood and urine of Swedish adolescents—possible associations to food intake and other background characteristics.’ Mycotoxin Research 36, № 2: 193–206. doi: 10.1007/s12550-019-00381-9.
- . . ‘Acylated 1H-1,2,4-Triazol-5-amines Targeting Human Coagulation Factor XIIa and Thrombin: Conventional and Microscale Synthesis, Anticoagulant Properties, and Mechanism of Action.’ Journal of Medicinal Chemistry 63, № 21: 13159–13186. doi: 10.1021/acs.jmedchem.0c01635.
- . . ‘Govaniadine Evaluation of Cytotoxicity and Permeability in Cell Culture.’ Revista Brasileira de Farmacognosia 30, № 3: 374–380. doi: 10.1007/s43450-020-00066-w.
- . . ‘Artificial vs natural Stachybotrys infestation—Comparison of mycotoxin production on various building materials.’ Indoor Air 30, № 6: 1268–1282. doi: 10.1111/ina.12705.
- . . ‘Metabolomics Study on Pathogenic and Non-pathogenic E. coli with Closely Related Genomes with a Focus on Yersiniabactin and Its Known and Novel Derivatives.’ Metabolites 10, № 6: 221. doi: 10.3390/metabo10060221.
- . . ‘Intestinal Metabolism of α- and β‑Glucosylated Modified Mycotoxins T‑2 and HT‑2 Toxin in the Pig Cecum Model.’ Journal of Agricultural and Food Chemistry 68, № 19. doi: 10.1021/acs.jafc.0c00576.
- . . ‘Real-time interaction analysis of Shiga toxins and membrane microdomains of primary human brain microvascular endothelial cells.’ Glycobiology 30, № 3: 174–185. doi: 10.1093/glycob/cwz091.
- . . ‘Matrix binding of T-2 toxin: structure elucidation of reaction products and indications on the fate of a relevant food-borne toxin during heating.’ Mycotoxin Research 35, № 3: 261–270. doi: 10.1007/s12550-019-00350-2.
- . . ‘Human Study on the Kinetics of 2′R-Ochratoxin A in the Blood of Coffee Drinkers.’ Molecular Nutrition and Food Research 63, № 4: 1801026. doi: 10.1002/mnfr.201801026.
- . . Thermal reactions and the formation of degradation products of T-2 and HT-2 toxin during processing of oats. Washington, D.C.: American Chemical Society. doi: 10.1021/bk-2019-1306.ch007.
- . . ‘Identification of ochratoxin-N-acetyl-L-cysteine as a new ochratoxin A metabolite and potential biomarker in human urine.’ Mycotoxin Research 2020, № 36: 1–10. doi: 10.1007/s12550-019-00360-0.
- . . ‘Exploring secondary metabolite profiles of stachybotrys spp. By LC-MS/MS.’ Toxins 11, № 3: 133. doi: 10.3390/toxins11030133.
- . . ‘Large-Scale Screening of Foods for Glucose-Derived β-Carboline Alkaloids by Stable Isotope Dilution LC–MS/MS.’ Journal of Agricultural and Food Chemistry 67: 3890–3899.
- . . ‘Detection of Novel Cytotoxic Imidazole Alkaloids in Tomato Products by LC-MS/MS.’ Journal of Agricultural and Food Chemistry 67: 3670–3678.
- . . ‘Identification of potential human urinary biomarkers for tomato juice intake by mass spectrometry-based metabolomics.’ European Journal of Nutrition 59: 685–697.
- . . ‘Interaction of Dihydrocitrinone with Native and Chemically Modified Cyclodextrins.’ Molecules 24, № 7: 1328. doi: 10.3390/molecules24071328.
- . ‘Effect of nanoparticle size and PEGylation on the protein corona of PLGA nanoparticles.’ Eur. J. Pharm. Biopharm. 2019: 70–80.
- . ‘Serum type and concentration both affecting the protein corona composition of PLGA nanoparticles.’ Beilstein J. Nanotechnol. 10: 1002–1015.
- . . ‘Occurrence of the ochratoxin A degradation product 2′R-ochratoxin a in coffee and other food: An update.’ Toxins 11, № 6: 329. doi: 10.3390/toxins11060329.
- . . ‘Structural Insights into Escherichia coli Shiga Toxin (Stx) Glycosphingolipid Receptors of Porcine Renal Epithelial Cells and Inhibition of Stx-Mediated Cellular Injury Using Neoglycolipid-Spiked Glycovesicles.’ Microorganisms 7, № 11: 582. doi: 10.3390/microorganisms7110582.
- . ‘Stachybotrychromenes A-C: novel cytotoxic meroterpenoids from Stachybotrys sp.’ Mycotoxin Res. 34: 179–185.
- 10.1371/journal.pone.0197406. . ‘Transport of enniatin B and enniatin B1 across the blood-brain barrier and hints for neurotoxic effects in cerebral cells.’ PloS one 13(5). doi:
- . . ‘Interaction of ochratoxin A and its thermal degradation product 2'R-ochratoxin A with human serum albumin.’ Toxins 10, № 7. doi: 10.3390/toxins10070256.
- . . ‘Glucosylation of T-2 and HT-2 toxins using biotransformation and chemical synthesis: Preparation, stereochemistry, and stability.’ Mycotoxin Research 34, № 3: 159–172. doi: 10.1007/s12550-018-0310-9.
- . . ‘Detection of the Cytotoxic Penitrems A-F in Cheese from the European Single Market by HPLC-MS/MS.’ Journal of Agricultural and Food Chemistry 66, № 5: 1264–1269. doi: 10.1021/acs.jafc.7b06001.
- . . ‘Interaction of 2'R-ochratoxin A with serum albumins: Binding site, effects of site markers, thermodynamics, species differences of albumin-binding, and influence of albumin on its toxicity in MDCK cells.’ Toxins 10, № 9. doi: 10.3390/toxins10090353.
- . . ‘Immunochemical Analysis of Paxilline and Ergot Alkaloid Mycotoxins in Grass Seeds and Plants.’ Journal of Agricultural and Food Chemistry 66, № 1: 315–322. doi: 10.1021/acs.jafc.7b05580.
- . . ‘Interaction of 2′R-ochratoxin A with Serum Albumins: Binding Site, Effects of Site Markers, Thermodynamics, Species Differences of Albumin-binding, and Influence of Albumin on Its Toxicity in MDCK Cells.’ Toxins 10, № 9: 353. doi: 10.3390/toxins10090353.
- 10.3390/toxins10070256. . ‘Interaction of Ochratoxin A and Its Thermal Degradation Product 2′R-Ochratoxin A with Human Serum Albumin.’ Toxins 10, № 7: 256. doi:
- 10.1016/j.enzmictec.2017.08.005. . ‘In vitro biosynthesis of 3-mercaptolactate by lactate dehydrogenases.’ Enzyme and Microbial Technology 108, № null: 1–10. doi:
- 10.1007/s12550-017-0302-1. . ‘Enniatin B and ochratoxin A in the blood serum of workers from the waste management setting.’ Mycotoxin Research 34, № 2: 85–90. doi:
- 10.1007/s00204-016-1799-3. . ‘Structure–activity relationship of ochratoxin A and synthesized derivatives: importance of amino acid and halogen moiety for cytotoxicity.’ Archives of Toxicology 91, № 3: 1461–1471. doi:
- 10.1002/mnfr.201600629. . ‘Short-term biomarkers of apple consumption.’ Molecular Nutrition and Food Research 61, № 3. doi:
- 10.1093/glycob/cww090. . ‘Shiga toxin glycosphingolipid receptors and their lipid membrane ensemble in primary human blood-brain barrier endothelial cells.’ Glycobiology 27, № 1: 99–109. doi:
- 10.1007/s12550-016-0263-9. . ‘Fate of deoxynivalenol and deoxynivalenol-3-glucoside during cereal-based thermal food processing: a review study.’ Mycotoxin Research 33, № 1: 79–91. doi:
- 10.1007/s12550-016-0261-y. . ‘Evidence of ochratoxin A conjugates in urine samples from infants and adults.’ Mycotoxin Research 33, № 1: 39–47. doi:
- 10.1007/s00216-016-0047-2. . ‘Localization of ergot alkaloids in sclerotia of Claviceps purpurea by matrix-assisted laser desorption/ionization mass spectrometry imaging.’ Analytical and Bioanalytical Chemistry 409, № 5: 1221–1230. doi:
- 10.1007/s12550-017-0290-1. . ‘Alternaria toxins in South African sunflower seeds: cooperative study.’ Mycotoxin Research 33, № 4: 309–321. doi:
- 10.1016/B978-0-08-100674-0.00003-5. . ‘Applications of High-Performance Liquid Chromatography-Mass Spectrometry Techniques for the Analysis of Chemical Contaminants and Residues in Food.’ In Chemical Contaminants and Residues in Food: Second Edition, edited by , 51–66. Amsterdam: Elsevier. doi:
- 10.1021/acs.jafc.7b01484. . ‘Impact of Mechanical and Thermal Energies on the Degradation of T-2 and HT-2 Toxins during Extrusion Cooking of Oat Flour.’ Journal of Agricultural and Food Chemistry 65, № 20: 4177–4183. doi:
- 10.3390/toxins9070210. . ‘Influence of environmental factors on the production of penitrems A–F by Penicillium crustosum.’ Toxins 9, № 7. doi:
- 10.1007/s00216-017-0279-9. . ‘Multi-mycotoxin analysis using dried blood spots and dried serum spots.’ Analytical and Bioanalytical Chemistry 409, № 13: 3369–3382. doi:
- 10.1002/cbic.201600691. . ‘A Fungal N-Dimethylallyltryptophan Metabolite from Fusarium fujikuroi.’ ChemBioChem 18, № 10: 899–904. doi:
- 10.1093/glycob/cwx048. . ‘Colocalization of receptors for Shiga toxins with lipid rafts in primary human renal glomerular endothelial cells and influence of D-PDMP on synthesis and distribution of glycosphingolipid receptors.’ Glycobiology 27, № 10: 947–965. doi:
- 10.1007/s00204-016-1855-z. . ‘Dual effectiveness of Alternaria but not Fusarium mycotoxins against human topoisomerase II and bacterial gyrase.’ Archives of Toxicology 91, № 4: 2007–2016. doi:
- 10.3390/toxins9040126. . ‘Establishment of the inducible Tet-on system for the activation of the silent trichosetin gene cluster in Fusarium fujikuroi.’ Toxins 9, № 4. doi:
- 10.3389/fmicb.2016.02144. . ‘Lack of the COMPASS component Ccl1 reduces H3K4 trimethylation levels and affects transcription of secondary metabolite genes in two plant-pathogenic fusarium species.’ Frontiers in Microbiology 7, № null. doi:
- 10.3390/toxins9110338. . ‘Shiga toxin glycosphingolipid receptors in human Caco-2 and HCT-8 colon epithelial cell lines.’ Toxins 9, № 11. doi:
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- . . ‘Acetonitrile: the better extractant for the determination of T-2 and HT-2 toxin in cereals using an immunoaffinity-based cleanup?’ European Food Research and Technology 228, № 4: 519–529. doi: 10.1007/s00217-008-0959-y.
- . . ‘Effect of ochratoxin A on cell survival and collagen homeostasis in human mesangial cells in primary culture.’ Food and Chemical Toxicology 47, № 1: 209–213. doi: 10.1016/j.fct.2008.11.001.
- . . ‘Effects of a Fusarium toxin-contaminated triticale, either untreated or treated with sodium metabisulphite (Na2S2O5, SBS), on weaned piglets with a special focus on liver function as determined by the C-13-methacetin breath test.’ Archives of Animal Nutrition 62, № 4: 263–286. doi: 10.1080/17450390802214167.
- . . ‘Investigation on asparagus spears during the main harvest byFusarium spp.- infections and contamination by Fumonisin B1 | Spargelstangenuntersuchungen zur Haupterntezeit auf Infektionen mitFusarium spp. und Kontaminationen mit Fumonisin B1.’ Mycotoxin Research 24: 88–97. doi: 10.1007/BF02985286.
- . . ‘Enterohemorrhagic Escherichia coli hemolysin delivery to target cells.’ International Journal of Medical Microbiology 298: 84.
- . . ‘Identification and in vitro cytotoxicity of ochratoxin a degradation products formed during coffee roasting.’ Journal of Agricultural and Food Chemistry 56, № 14: 5673–5681. doi: 10.1021/jf801296z.
- . . ‘Determination of T-2 and HT-2 toxins in cereals including oats after immunoaffinity cleanup by liquid chromatography and fluorescence detection.’ Journal of Agricultural and Food Chemistry 56, № 13: 4968–4975. doi: 10.1021/jf800316m.
- . . ‘Effects of the mycotoxin deoxynivalenol on human primary hepatocytes.’ Molecular Nutrition and Food Research 52, № 7: 830–839. doi: 10.1002/mnfr.200700439.
- . . ‘Association between tortilla consumption and human urinary fumonisin B1 levels in a Mexican population.’ Cancer Epidemiology, Biomarkers and Prevention 17, № 3: 688–694. doi: 10.1158/1055-9965.EPI-07-2534.
- . . ‘Deconjugation and degradation of flavonol glycosides by pig cecal microbiota characterized by fluorescence in situ hybridization (FISH).’ Journal of Agricultural and Food Chemistry 56, № 6: 2281–2290. doi: 10.1021/jf073444o.
- . . ‘Hydrolyzed fumonisins HFB1 and HFB2 are acylated in vitro and in vivo by ceramide synthase to form cytotoxic N-acyl-metabolites.’ Molecular Nutrition and Food Research 51: 1120–1130. doi: 10.1002/mnfr.200700118.
- . . ‘Subtypes of the plasmid-encoded serine protease EspP in Shiga toxin-producing Escherichia coli: distribution, secretion, and proteolytic activity.’ Applied and Environmental Microbiology 73, № 20: 6351–6359. doi: 10.1128/AEM.00920-07.
- . . ‘Cytotoxicity, metabolism and cellular uptake of the mycotoxin deoxynivalenol in human proximal tubule cells and lung fibroblasts in primary culture.’ Toxicology 240, № 1-2: 48–59. doi: 10.1016/j.tox.2007.07.016.
- . . ‘Stable isotope dilution analysis of the Fusarium mycotoxin zearalenone.’ Journal of Agricultural and Food Chemistry 55, № 21: 8353–8358. doi: 10.1021/jf0717283.
- . . ‘Hydrolyzed fumonisins HFB1 and HFB2 are acylated in vitro and in vivo by ceramide synthase to form cytotoxic N-acyl-metabolites.’ Molecular Nutrition and Food Research 51, № 9: 1120–1130. doi: 10.1002/mnfr.200700118.
- . . ‘Long-term effects of ochratoxin A on fibrosis and cell death in human proximal tubule or fibroblast cells in primary culture.’ Toxicology 232, № 1-2: 57–67. doi: 10.1016/j.tox.2006.12.008.
- . . ‘Analysis of sphingolipids in potatoes (Solanum tuberosum L.) and sweet potatoes (Ipomoea batatas (L.) Lam.) by reversed phase high-performance liquid chromatography electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS).’ Molecular Nutrition and Food Research 50, № 12: 1201–1211. doi: 10.1002/mnfr.200600140.
- . . ‘Analysis of sphingolipids in potatoes (Solanum tuberosum L.) and sweet potatoes (Ipomoea batatas (L.) Lam.) by reversed phase high-performance liquid chromatography electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS).’ Molecular Nutrition and Food Research 50: 1201–1211. doi: 10.1002/mnfr.200600140.
- . . ‘Metabolism of quercetin and rutin by the pig caecal microflora prepared by freeze-preservation.’ Molecular Nutrition and Food Research 50, № 8: 686–695. doi: 10.1002/mnfr.200600016.
- . . ‘Thermal degradation of the Fusarium mycotoxin deoxynivalenol.’ Journal of Agricultural and Food Chemistry 54, № 17: 6445–6451. doi: 10.1021/jf061008g.
- . . ‘Cytotoxic and antimitotic effects of N-containing Monascus metabolites studied using immortalized human kidney epithelial cells.’ Molecular Nutrition and Food Research 50, № 4-5: 406–412. doi: 10.1002/mnfr.200500238.
- . . ‘A new solid phase extraction clean-up method for the determination of 12 type A and B trichothecenes in cereals and cereal-based food by LC-MS/MS.’ Molecular Nutrition and Food Research 50, № 3: 261–269. doi: 10.1002/mnfr.200500234.
- . . ‘New Monascus metabolites: Structure elucidation and toxicological properties studied with immortalized human kidney epithelial cells.’ Molecular Nutrition and Food Research 50, № 3: 314–321. doi: 10.1002/mnfr.200500229.
- . . ‘Stable isotope dilution analysis of the Fusarium mycotoxins deoxynivalenol and 3-acetyldeoxynivalenol.’ Molecular Nutrition and Food Research 50, № 3: 251–260. doi: 10.1002/mnfr.200500230.
- . . ‘Use of the pig caecum model to mimic the human intestinal metabolism of hispidulin and related compounds.’ Molecular Nutrition and Food Research 50, № 1: 78–86. doi: 10.1002/mnfr.200500144.
- . . ‘Synthesis of stable isotope labeled 3-acetyldeoxynivalenol.’ Molecular Nutrition and Food Research 49, № 12: 1151–1153. doi: 10.1002/mnfr.200500153.
- . . ‘Investigation on contamination of asparagus spears (Asparagus officinalis L.) with Fusarium proliferatum (Matsushima) Nirenberg during main harvest | Untersuchungen zum endophytischen Befall von Fusarium proliferatum (Matsushima) Nirenberg in geernteten Stangen von Spargel (Asparagus officinalis L.).’ Gesunde Pflanzen 57, № 2-3: 53–58. doi: 10.1007/s10343-005-0065-z.
- . . ‘Investigation on contamination of asparagus spears (Asparagus officinalis L.) with Fusarium proliferatum (Matsushima) Nirenberg during main harvest | Untersuchungen zum endophytischen Befall von Fusarium proliferatum (Matsushima) Nirenberg in geernteten Stangen von Spargel (Asparagus officinalis L.).’ Gesunde Pflanzen 57: 53–58. doi: 10.1007/s10343-005-0065-z.
- . . ‘Isolation and structural elucidation of thermal degradation products of the Fusarium mycotoxin nivalenol | Isolierung und Strukturaufklärung von thermischen Abbauprodukten des Mykotoxins Nivalenol.’ Mycotoxin Research 21: 15–17. doi: 10.1007/BF02954807.
- . . ‘Isolation and structural elucidation of thermal degradation products of the Fusarium mycotoxin nivalenol.’ Mycotoxin Research 21: 15–17. doi: 10.1007/BF02954807.
- . . ‘Combinatory effects of citrinin and ochratoxin A in immortalized human proximal tubule cells.’ Mycotoxin Research 21: 176–181. doi: 10.1007/BF02959258.
- . . ‘Determination of 12 type A and B trichothecenes in cereals by liquid chromatography-electrospray ionization tandem mass spectrometry.’ Journal of Agricultural and Food Chemistry 53, № 23: 8904–8910. doi: 10.1021/jf051501c.
- . . ‘Metabolism of anthocyanins and their phenolic degradation products by the intestinal microflora.’ Bioorganic & Medicinal Chemistry 13, № 17: 5195–5205. doi: 10.1016/j.bmc.2005.05.003.
- . . ‘Comparison of different clean-up procedures for the analysis of deoxynivalenol in cereal-based food and validation of a reliable HPLC method.’ Chromatographia 62, № 1-2: 41–48. doi: 10.1365/s10337-005-0576-x.
- . . ‘Occurrence of fumonisins B-1 and B-2 in asparagus from Shandong province, P.R. China.’ Food additives and contaminants 22, № 7: 673–676. doi: 10.1080/02652030500133016.
- . . ‘Structural elucidation and analysis of thermal degradation products of the Fusarium mycotoxin nivalenol.’ Molecular Nutrition and Food Research 49, № 4: 309–316. doi: 10.1002/mnfr.200400092.
- . . ‘New applications of the CD Exciton chirality method. Stereochemical assignment of organic compounds containing carboxylic acid groups.’ Chemical Monthly / Monatshefte für Chemie 136, № 3: 397–410. doi: 10.1007/s00706-004-0277-4.
- . . ‘Quantitative analysis of Fusarium mycotoxins in maize using accelerated solvent extraction before liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry.’ Food additives and contaminants 21: 678–692. doi: 10.1080/02652030410001711304.
- . . ‘Effects of thermal food processing on the chemical structure and toxicity of fumonisin mycotoxins.’ Molecular Nutrition and Food Research 48, № 4: 255–269. doi: 10.1002/mnfr.200400033.
- . . ‘Quantitative analysis of Fusarium mycotoxins in maize using accelerated solvent extraction before liquid chromatography atmospheric pressure chemical ionization tandem mass spectrometry.’ Food additives and contaminants 21, № 7: 678–692. doi: 10.1080/02652030410001711304.
- . . ‘Bound fumonisin B1: Analysis of fumonisin-B1 glyco and amino acid conjugates by liquid chromatography-electrospray ionization-tandem mass spectrometry.’ Journal of Agricultural and Food Chemistry 51: 5567–5573. doi: 10.1021/jf0344338.
- . . ‘Induction of apoptosis in cultured human proximal tubule cells by fumonisins and fumonisin metabolites.’ Toxicology and Applied Pharmacology 192, № 2: 146–153. doi: 10.1016/S0041-008X(03)00262-X.
- . . ‘Bound fumonisin B-1: Analysis of fumonisin-B-1 glyco and amino acid conjugates by liquid chromatography-electrospray ionization-tandem mass spectrometry.’ Journal of Agricultural and Food Chemistry 51, № 18: 5567–5573. doi: 10.1021/jf0344338.
- . . ‘New Monascus metabolites with a pyridine structure in red fermented rice.’ Journal of Agricultural and Food Chemistry 51, № 18: 5493–5496. doi: 10.1021/jf030213i.
- . . ‘Fumonisins and fumonisin analogs as inhibitors of ceramide synthase and inducers of apoptosis.’ Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 1585, № 2-3: 188–192. doi: 10.1016/S1388-1981(02)00340-2.
- . . ‘Analyses of red fermented rice (angkak) and report of a new Monascus metabolite.’ Mycotoxin Research 18: 212–216. doi: 10.1007/BF02946098.
- . . ‘Analysis of Fumonisin B1 in Fusarium proliferatum-infected asparagus spears and garlic bulbs from Germany by liquid chromatography-electrospray ionization mass spectrometry.’ Journal of Agricultural and Food Chemistry 50: 2778–2781. doi: 10.1021/jf0115037.
- . . ‘Insights into the Modulation of Ceramide Metabolism by Naturally Occurring and Synthetic Sphingolipid Analogs as Monitored by Electrospray Tandem Mass.’ In Ceramide Signaling, edited by , 1–8. Basel : Springer International Publishing.
- . . ‘Liquid chromatography/electrospray ionisation-mass spectrometry method for the quantification of sphingosine and sphinganine in cell cultures exposed to fumonisins.’ Journal of Chromatography B 780, № 1: 137–144. doi: 10.1016/S1570-0232(02)00440-3.
- . . ‘New Monascus metabolite isolated from red yeast rice (angkak, red koji).’ Journal of Agricultural and Food Chemistry 50, № 14: 3999–4002. doi: 10.1021/jf020023s.
- . . ‘Analysis of fumonisin B-1 in Fusarium proliferatum-infected asparagus spears and garlic bulbs from Germany by liquid chromatography - Electrospray ionization mass spectrometry.’ Journal of Agricultural and Food Chemistry 50, № 10: 2778–2781. doi: 10.1021/jf0115037.
- . . ‘Absolute configuration of 3-hydroxy acids formed by Stenotrophomonas maltophilia: Application of multidimensional gas chromatography and circular dichroism spectroscopy.’ Chirality 14, № 1: 51–58. doi: 10.1002/chir.10029.
- . . ‘Determination of N-(carboxymethyl)fumonisin B1 in corn products by liquid chromatography/electrospray ionization-mass spectrometry.’ Journal of Agricultural and Food Chemistry 49: 2146–2151. doi: 10.1021/jf001429c.
- . . ‘Enantioselective epoxidation with chiral MnIII(salen) catalysts: Kinetic resolution of aryl-substituted allylic alcohols.’ Journal of Organic Chemistry 66: 5796–5800. doi: 10.1021/jo010350j.
- . . ‘Molecular and electronic structure of (2,2′-bidipyrrinato)nickel(II) complexes.’ European Journal of Inorganic Chemistry 10: 2549–2556. doi: 10.1002/1099-0682(200109)2001:10<2549::AID-EJIC2549>3.0.CO;2-7.
- . . ‘Formation of Fumonisin artefacts in thermal treated food.’ Mycotoxin Research 17: 116–119. doi: 10.1007/BF03036725.
- . . ‘Induction of Apoptosis in Cultured Human Proximal Tubule Cells by Fumonisins and Fumonisin Metabolites.’ Mycotoxin Research 17A: 107–111. doi: 10.1016/S0041-008X(03)00262-X.
- . . ‘A new one-step strategy for the stereochemical assignment of acyclic 2-and 3-sulfanyl-1-alkanols using the CD exciton chirality method.’ Journal of Organic Chemistry 66, № 24: 8160–8164. doi: 10.1021/jo010768h.
- . . ‘Molecular and electronic structure of (2,2 '-bidipyrrinato)nickel(II) complexes.’ European Journal of Inorganic Chemistry , № 10: 2549–2556. doi: 10.1002/1099-0682(200109)2001:102549::AID-EJIC2549>3.0.CO;2-7.
- . . ‘Enantioselective epoxidation with chiral Mn-III(salen) catalysts: Kinetic resolution of aryl-substituted allylic alcohols.’ Journal of Organic Chemistry 66, № 17: 5796–5800. doi: 10.1021/jo010350j.
- . . ‘Combined synthetic/CD strategy for the stereochemical assignment of the tricarballylic acid side chains of fumonisin B-1.’ Journal of Organic Chemistry 66, № 11: 3678–3681. doi: 10.1021/jo0000630.
- . . ‘Determination of N-(carboxymethyl)fumonisin B-1 in corn products by liquid chromatography/electrospray ionization-mass spectrometry.’ Journal of Agricultural and Food Chemistry 49, № 5: 2146–2151. doi: 10.1021/jf001429c.
- . . ‘Toxicity assessment of fumonisins using the brine shrimp (Artemia salina) bioassay.’ Food and Chemical Toxicology 38, № 12: 1097–1102. doi: 10.1016/S0278-6915(00)00112-5.
- . . ‘Microscale determination of the absolute configuration of α-aryl- substituted alcohols by the CD exciton chirality method.’ Journal of Organic Chemistry 65: 186–190. doi: 10.1021/jo991424i.
- . . ‘Synthesis of optically active α-methylene β-lactams through lipase-catalyzed kinetic resolution.’ Journal of Organic Chemistry 65: 4919–4922. doi: 10.1021/jo0003089.
- . . ‘The brine shrimp (Artemia salina) bioassay: A simple method to assess the toxicity of fumonisin mycotoxins.’ Mycotoxin Research 16: 83. doi: 10.1007/BF02942988.
- . . ‘Synthesis of optically active alpha-methylene beta-lactams through lipase-catalyzed kinetic resolution.’ Journal of Organic Chemistry 65, № 16: 4919–4922. doi: 10.1021/jo0003089.
- . . ‘2-Naphthol as a powerful chromophore for the configurational assignment of carboxylic acid groups via the CD exciton chirality method.’ Tetrahedron: Asymmetry 11, № 8: 1741–1747. doi: 10.1016/S0957-4166(00)00116-6.
- . . ‘Microscale determination of the absolute configuration of alpha-aryl-substituted alcohols by the CD exciton chirality method.’ Journal of Organic Chemistry 65, № 1: 186–190. doi: 10.1021/jo991424i.
- . . ‘Rapid determination of fumonisin FB1 in corn products by high-performance liquid chromatography-electrospray mass spectrometry.’ European Food Research and Technology 209, № 5: 348–351. doi: 10.1007/s002170050507.
- . . ‘Simultaneous determination of fumonisin B-1 and hydrolyzed fumonisin B-1 in corn products by liquid chromatography/electrospray ionization mass spectrometry.’ Journal of Agricultural and Food Chemistry 47, № 12: 5078–5083. doi: 10.1021/jf990046f.
- . . ‘Determination of ochratoxin A in beer by high-performance liquid chromatography.’ Chromatographia 49, № 9-10: 543–546. doi: 10.1007/BF02467756.
- . . ‘Rapid determination of fumonisin FB1 in corn products by high-performance liquid chromatography-electrospray mass spectrometry.’ European Food Research and Technology 209: 348–351. doi: 10.1007/s002170050507.
- . . ‘Simultaneous determination of fumonisin B1 and hydrolyzed fumonisin B1 in corn products by liquid chromatography/electrospray ionization mass spectrometry.’ Journal of Agricultural and Food Chemistry 47: 5078–5083. doi: 10.1021/jf990046f.
- . . ‘Absolute Configurational Assignment of Acyclic Hydroxy Carboxylic Acids: A New Strategy in Exciton-Coupled Circular Dichroism.’ Journal of Organic Chemistry 63, № 2: 322–325.
- . . ‘Assigning the absolute configuration of fumonisins by the circular dichroism exciton chirality method.’ Tetrahedron: Asymmetry 9, № 9: 1549–1556. doi: 10.1016/S0957-4166(98)00123-2.
- . . ‘Dioxygenation of Long-Chain Alkadien(trien)ylphenols by Soybean Lipoxygenase.’ Journal of Agricultural and Food Chemistry 46, № 8: 2951–2956. doi: 10.1021/jf980196a.
- . . ‘Synthesis of optically active α-hydroxy acids by kinetic resolution through lipase-catalyzed enantioselective acetylation.’ European Journal of Organic Chemistry , № 9: 2013–2018. doi: 10.1002/(SICI)1099-0690(199809)1998:92013::AID-EJOC2013>3.0.CO;2-S.
- . . ‘α hydroxylation of carboxylic acids with molecular oxygen catalyzed by the α oxidase of peas (Pisum sativum): A novel biocatalytic synthesis of enantiomerically pure (R)-2-hydroxy acids.’ Journal of the American Chemical Society 120, № 43: 11044–11048. doi: 10.1021/ja981252r.
- . . ‘Acylation of naturally occurring and synthetic 1-deoxysphinganines by ceramide synthase: Formation of N-palmitoyl-aminopentol produces a toxic metabolite of hydrolyzed fumonisin, AP1, and a new category of ceramide synthase inhibitor.’ Journal of Biological Chemistry 273: 19060–19064. doi: 10.1074/jbc.273.30.19060.
- . . ‘Column liquid chromatography-electrospray ionisation-tandem mass spectrometry for the analysis of ochratoxin.’ Journal of Chromatography A 818: 260–264. doi: 10.1016/S0021-9673(98)00594-9.
- . . ‘Fumonisine in Lebensmitteln: Empfindlicher und selektiver Nachweis mittels HPLC-MS/MS.’ GIT 42, № 2: 84–85.
- . . ‘High-Performance Liquid Chromatography-Electrospray Ionisation-Tandem Mass Spectrometry (HPLC-ESI-MS/MS) for the Analysis of Ochratoxin.’ J. Chromatogr. 818, № 2: 260–264.
- . . ‘N-Palmitoyl-HFB1: A New Metabolite of Hydrolyzed Fumonisin (HFB1) in Rat Liver Microsomes.’ Rev. Méd. Vét 149, № 6: 576.
- . . ‘Acylation of naturally occurring and synthetic 1-deoxysphinganines by ceramide synthase. Formation of N-palmitoyl-aminopentol produces a toxic metabolite of hydrolyzed fumonisin, AP1, and a new category of ceramide synthase inhibitor.’ Journal of Biological Chemistry 273, № 30: 19060–19064. doi: 10.1074/jbc.273.30.19060.
- . . ‘A new exciton-coupled circular dichroism method for assigning the absolute configuration in acyclic α- and β-hydroxy carboxylic acids.’ Tetrahedron: Asymmetry 8, № 1: 11–14. doi: 10.1016/S0957-4166(96)00490-9.
- . . ‘Application of atmospheric pressure ionization HPLC-MS-MS for the analysis of natural products.’ Chromatographia 45: 127–132. doi: 10.1007/BF02505549.
- . . ‘Configurational assignment of optically active hydroperoxy homoallylic alcohols and the corresponding diols by circular dichroism and multidimensional gas chromatography.’ Chirality 9, № 1: 69–74. doi: 10.1002/(SICI)1520-636X(1997)9:169::AID-CHIR13>3.3.CO;2-W.
- . . ‘Enzymatic Resolution of Chiral 2-Hydroxy Carboxylic Acids by Enantioselective Oxidation with Molecular Oxygen Catalyzed by the Glycolate Oxidase from Spinach (Spinacia oleracea).’ Journal of Organic Chemistry 62, № 22: 7844–7849.
- . . ‘Exciton-coupled circular dichroism (ECCD) in acyclic hydroxylated dienes: A sensitive method for the direct stereochemical assignment of lipoxygenase products.’ Chirality 9, № 5-6: 563–567. doi: 10.1002/(SICI)1520-636X(1997)9:5/6563::AID-CHIR25>3.3.CO;2-5.
- . . ‘The configurational assignment of the optically active 5-(1-hydro- peroxyethyl)-3-ethoxycarbonyl-2-methylfuran and its alcohol by exciton- coupled circular dichroism (ECCD).’ Tetrahedron: Asymmetry 8, № 21: 3555–3558. doi: 10.1016/S0957-4166(97)00515-6.
- . . ‘1-Naphthoic acid: A new type of asymmetric chromophore for exciton-coupled circular dichroism (ECCD).’ Tetrahedron: Asymmetry 7, № 6: 1543–1546. doi: 10.1016/0957-4166(96)00176-0.
- . . ‘Horseradish peroxidase (HRP)-catalysed enantioselective reduction of racemic hydroperoxy homoallylic alcohols: A novel enzymatic method for the preparation of optically active, unsaturated diols and hydroperoxy alcohols.’ Chemical communications , № 24: 2701–2702. doi: 10.1039/cc9960002701.
- . . ‘Identification and determination of fumonisin FB1 and FB2 in corn and corn products by high-performance liquid chromatography - Electrospray-ionization tandem mass spectrometry (HPLC-ESI-MS-MS).’ Chromatographia 43, № 3-4: 124–128. doi: 10.1007/BF02292939.
- . . ‘Identification and determination of fumonisin FB1 and FB2 in corn and corn products by high-performance liquid chromatography - Electrospray-ionization tandem mass spectrometry (HPLC-ESI-MS-MS).’ Chromatographia 43: 124–128. doi: 10.1007/BF02292939.
- . . ‘A new approach in exciton-coupled circular dichroism (ECCD)--insertion of an auxiliary stereogenic center.’ Chirality 7, № 3: 128. doi: 10.1002/chir.530070304.
- . . ‘Allylic and homoallylic exciton coupled CD: A sensitive method for determining the absolute stereochemistry of natural products.’ Journal of Organic Chemistry 60, № 11: 3539–3542. doi: 10.1021/jo00116a048.
- . . ‘A new approach in exciton‐coupled circular dichroism (ECCD)—insertion of an auxiliary stereogenic center.’ Chirality 7: 128–135. doi: 10.1002/chir.530070304.
- . . ‘Absolute stereochemistry of natural 3,4-dihydroxy-beta-ionone glycosides by the CD exciton chirality method.’ Journal of Natural Products 57, № 12: 1762–1765. doi: 10.1021/np50114a027.
- . . ‘Absolute stereochemistry of natural 3,4-Dihydroxy-β-ionone glycosides by the cd exciton chirality method.’ Journal of Natural Products 57: 1762–1765. doi: 10.1021/np50114a027.
- . . ‘Natural Precursor of Isomeric Vitispiranes from Plant Tissues: 3,4-Dihydroxy-7,8-dihydro-β-ionol β-D-glucoside.’ In Progress in Flavour Precursor Studies, edited by , 283–285. N/A: Sonstiger Verlag / other publisher.
- . . ‘3,4-dhydroxy-7,8-dihydro-β-ionol β-D-gucopyranoside: Natural precursor of isomeric vitispiranes from gooseberry (Ribes uva crispa L.) and whitebeam (Sorbus aria) leaves.’ Journal of Agricultural and Food Chemistry 40, № 11: 2060–2062. doi: 10.1021/jf00023a006.
- . . ‘3-Hydroxy-5,6-epoxy-β-ionol β-D-Glucopyranoside and 3-hydroxy-7,8-dihydro-β-ionol β-d-glucopyranoside: New C13 norisoprenoid glucoconjugates from sloe tree (prunus spinosa l.) leaves.’ Journal of Agricultural and Food Chemistry 40, № 10: 1898–1901. doi: 10.1021/jf00022a034.
- . . ‘3-Hydroxy-5,6-epoxy-β-ionol β-D-Glucopyranoside and 3-Hydroxy-7,8-dihydro-β-ionol β-D-Glucopyranoside: New C13 Norisoprenoid Glucoconjugates from Sloe Tree (Prunus spinosa L.) Leaves.’ Journal of Agricultural and Food Chemistry 40: 1898–1901. doi: 10.1021/jf00022a034.
- . . ‘3,4-Dihydroxy-7,8-dihydro-β-ionone β-d-glucopyranoside: natural precursor of 2,2,6,8-tetramethyl-7,l 1-dioxatricyclote.[6.2.1.0]-ene (Riesling Acetal) and l,l,6-trimethyl-l,2-dihydronaphthalene in red currant (Ribes rubrum L.) leaves.’ Journal of Agricultural and Food Chemistry 39, № 10: 1833–1835. doi: 10.1021/jf00010a029.
- . . ‘Bound aroma compounds from the fruit and the leaves of blackberry (Rubus laciniata, L.).’ Journal of Agricultural and Food Chemistry 39, № 10: 1830–1832. doi: 10.1021/jf00010a028.
- . . ‘3,4- Dihydroxy-7,8-dihydro-β-ionone β-D-Glucopyranoside: Natural Precursor of 2,2,6,8-Tetramethyl-7,11-dioxatricyclo[6.2.1.01,6]undec-4-ene (Riesling Acetal) and 1,1,6-Trimethyl-1,2-dihydronaphthalene in Red Currant (Ribes rubrum L.) Leaves.’ Journal of Agricultural and Food Chemistry 39: 1833–1835. doi: 10.1021/jf00010a029.
Supervised Doctoral Studies
Lins, Anika Untersuchungen zur Proteincorona an kolloidalen Arzneistoffträgern. Laabs, Moritz Entwicklung, Charakterisierung und Testung von Lecithin-gecoateten Nanopartikeln zur Überwindung der Blut-Hirn-Schranke. Franziska Michaela Jürgens Investigation of pharmacokinetic properties of antileishmanial Sesquiterpene lactones from Arnica montana L. (Thesis written in German) Wünsch, Angelika Imitation von Lipoproteinen als nanopartikuläre Arzneistoffträgersysteme Dr. Krug, Isabel Doris In vitro-Untersuchungen zu den Effekten ausgewählter Mykotoxine und mariner Biotoxine an der Blut-Hirn-Schranke Dr. Sueck, Franziska Vorkommen, Proteinaffinität, Metabolismus und biologische Halbwertszeit der Mykotoxine 2’R-Ochratoxin A und Ochratoxin A beim Menschen Dr. Wagner (geb. Ferse), Ines Isolierung und Strukturaufklärung neuer Monascus-Sekundärmetabolite in Rotschimmelreis sowie Synthese von Ochratoxin A-Derivaten zur Untersuchung der StrukturWirkungs-Beziehung Dr. Kuchenbuch (geb. Schmidt), Henning Sören Investigations on the stability and degradation of T-2 toxin during thermal food processing Dr. Hickert, Sebastian Rudolf Investigation on Alternaria mycotoxins with focus on tenuazonic acid and studies oin the potential of micro-HPLC-MS/MS and MALDI-Imaging mass spectrometry for mycotoxin analysis Dr. Saenger (geb. Kemme), Theresa Studien zum Nachweis ernährungsbedingter Biomarker im Humanurin Kalinina Svetlana Penicillium spp. as a Source of Secondary Metabolites: Structure Elucidation, Occurrence in Food, Cytotoxicity, and Biological Activity Dr. Bergmann, Dominik Stabilisotopenmarkierte Darstellung des Mykotoxins Citrinin und seines Hauptmetaboliten Dihydrocitrinon sowie Synthese von Aminoglykosid-Derivaten Dr. Uebel, Thomas Impact of aserone isomers on cellular redox status and the onset of DNA-integrity Dr. Rottkord, Ulrike Struktur-Wirkungs-Beziehungen zur Toxizität von Ochratoxin A und kombinatorische Effekte mit Citrinin Dr. Arndt, Birgit Studies on the secondary metabolism of Fusarium fujikuroi Korte, Robin Analysis and Characterization of Food Allergens: A Mass Spectrometric Approach Haupenthal, Sabrina Beeinflussung der DNA-Integrität durch Metaboliten natürlicher kanzerogener Phenylpropanoide. Dr. Dopstadt, Julian Das Potential des Mutterkornpilzes Claviceps purpurea zur Produktion neuer Sekundärmetaboliten Dr. Rösler, Sarah M. Complex Regulation of Secondary Metabolism in the Phytopathogenic Fungus Fusarium fujikuroi Dr. Lichtenwald, Marina Molecular and phenotypical analysis of biofilm formation of enterohaemorrhagiuc Eschericia coli Meyer, Sören Instrumentelle Analytik (LC/ICPMS/MS) und toxikologische Charakterisierung von Arsenolipiden Dr. Gerding, Johannes Biomarkerbasierte Abschätzung der humanen Mykotoxinexposition und Untersuchung des Metabolismus ausgewählter Mykotoxine Schnieders, Annika Investigation of natural products as MHC-II loading enhancers with the HLA-DR1 serotype as an example (Thesis written in German) Kunsmann, Lisa Charakterisierung von Membranvesikeln enterohämorrhagischer Escherichia coli Dr. Hummel, Marlene Allergene Proteine in Gewürzen: Massenspektro-metrische Identifizierung und Charakterisierung von 2S Albuminen aus Senf und Sesam Bittner, Andrea Matrix-gebundene Ochratoxin A-Rückstände in thermisch behandelten Lebensmitteln: Strukturaufklärung, Analytik und Bioverfügbarkeit Bittner, Katharina Studien zum Vorkommen, zur systemischen Absorption und zum Metabolismus von Polyphenolen Dr. von Bargen, Katharina Walburga Identifizierung und Strukturaufklärung neuer Sekundärmetaboliten aus Fusarium fujikuroi sowie Untersuchungen zur Biosynthese und Analytik Bargen, Christoph Authentifizierung und Strukturaufklärung von Lebensmittelinhaltsstoffen mittels massenspektrometrischer Methoden am Beispiel von Proteinen und Polyphenolen Unterberg, Marlies Etablierung eines LC/FTMS basierten Testsystems zur Quantifizierung der epigenetische Effekte von Arsenverbindungen Hemmersbach, Sarah Intestinal absorption of flavonoids and metabolites in the Caco-2 model Pieper, Imke Organoquecksilberspezies und der zelluläre DNA-Schadensresponse Lepski, Silke Charakterisierung und massenspektrometrische Nachweis von Nussallergenen Weiss, André Funktionale Charakterisierung der Serinprotease-Autotransporter EspPα und Espl aus enterohämorrhagischen Escherichia coli Weidner, Maria Untersuchungen zur Toxizität und zum Metabolismus von Fusarium-Mykotoxinen in humanen Primärzellen Studt, Lena Effects of biotic and abiotic factors on the production of Fusarium-mycotoxins by phytophathogenic Fusarium-isolates Leffers, Larissa Bioverfügbarkeit, Metabolismus und Toxizität von Arsenozuckern Dr. Brezina, Ulrike Determination of zearalenone, deoxynivalenol and their metabolites in physiological samples of pigs with LC-MS/MS: Development of multi-mycotoxin methods and verification through a dose-response feeding study Lohrey, Lilia Darstellung der stabilisotopenmarkierten Mykotoxine Moniliformin und Tenuazonsäure sowie Synthese von bioaktiven Arylthiazolen mittels direkter Fusarin-Analoga Engemann, Anna Intestinaler Metabolismus von Lebensmittelinhaltsstoffen im Schweine-Caecum-Modell Dr. Havermann, Susannah Aktivierung des ARE durch Flavonole und Hydroxyzimtsäurederivate: Untersuchungen in Zellkultursystemen und C. elegans Kleigrewe, Karin Vorkommen von Fusarin-C-Mykotoxinen in Lebensmitteln und Strukturaufklärung neuer Fusarin-Analoga Dr. Diederich, Johannes Manganspeziation in biologischen Proben Fraske, Andrea Studien zur systemischen Absorption und zum Metabolismus von Anthocyanen im Tiermodell Schwein Dr. Riedel, Sylvia Modulation of lipid metabolism as a possible tool to prevent carcinoigenoic effects of fumonisin B1 Dr. Ehlers, Susan Analytik von Perfluoralkylsäuren in verschiedenen Matrices zur Klärung der Toxikokinetik in Tierarten die der Lebensmittelgewinnung dienen Dr. Bevanda-Franjic, Marijane In vitro-Studien von Anthocyanen im Caco-2-Modellsystem Rzeppa, Sebastian Isolierung, Strukturaufklärung und Analytik von Procyanidinen sowie Kinetikstudien im Tiermodell am Schwein Blaas, Nina Untersuchungen zur massenspektrometrischen Charakterisierung von Sphingophospholipiden in humaner Milch und pflanzlichen Lebensmitteln Mulac, Dennis Zellkulturstudien zur Cytotoxizität, zur Aufnahme und zum Transportmechanismus von Mutterkornalkaloiden Hübner, Florian Darstellung der stabilisotopen-markierten Mykotoxine Fumonisin B1 und Alternariol Dr. Betz, Josefine Struktur-Funktions-Analysen von Shiga Toxin-Rezeptoren mikro- und makrovaskulärer humaner Endothelzellen Dr. Neue, Kristina Elucidation of N-glycosylation by unspecific proteolysis in combination with ZIC-HILIC SPE and de novo sequencing of IgG primary structures by use of direct nanoESI Q-Tof mass spectrometry Dr. Harrer, Henning Uwe Michael Die Bedeutung des Sphingolipidstoffwechsels für die toxikologische Wirkungsweise der Fumonisin-Mykotoxine Dr. Franzmann, Carolin Untersuchungen zum Vorkommen, zur Stabilität und zum thermischen Abbau von Mutterkornalkaloiden in Roggen und Roggenprodukten Dr. Nollen, Maike Cora Untersuchungen zur indirekten Genotoxizität von Arsenit und seinem Metabolit monomethylarsonige Säure Wiemann, Philipp Regulation of secondary metabolism in phytophathogenic Fusarium spp. Dr. van 't Slot, Gordon Untersuchungen zum intestinalen Metabolismus von pflanzlichen Lebensmittelinhaltsstoffen Dr. Fischbeck, Anne Vorkommen von Sphingomyelin in der menschlichen Ernährung und seine Bedeutung bei entzündlichen Darmerkrankungen im Tiermodell Dr. Trebstein, Anke Analytik von Mykotoxinen der Gattung Fusarium mittels Hochleistungsflüssigchromatographie mit Fluoreszenzdetektion und Tandem-Massenspektrometrie Dr. Beyer, Marita Produktion, Analytik und Abbau bedeutender Trichothecen-Mykotoxine Brockmeyer, Jens Structure and function of the plasmid-encoded bacterial serine protease autotransporter EspP from Shiga toxin-producing Escherichia coli Dr. Aldick, Thomas Stabilität und Aktivität von freiem und vesikulärem Hämolysin aus enterohämorrhagischen Escherichia coli Cramer, Benedikt Thermischer Abbau und Analytik der Mykotoxine Ochratoxin A und Zearalenon Dr. Königs, Maika Untersuchungen zur Cytotoxizität und zum Metabolismus von Fusarientoxinen in humanen Primärzellen Dr. Rose, Ina Katrin Metabolismus von Flavonoiden durch die intestinale Mikroflora im Schweine-Caecum-Modell Dr. Klötzel, Marianna Entwicklung von Analyseverfahren zur empfindlichen Bestimmung von Fusarientoxinen in Lebensmitteln Dr. Bartke, Nana Untersuchungen zum Vorkommen von Sphingolipiden in pflanzlichen Lebensmitteln Dr. Knecht, Anja Monascus-Sekundärmetabolite: Neue Verbindungen und Untersuchungen zur biologischen Aktivität Dr. Bretz, Michael Ewald Produktion, Analytik und Abbau ausgewählter Fusarientoxine
Professor Dr. Hans-Ulrich Humpf
Professur für Lebensmittelchemie (Prof. Humpf)