The current research of Prof. Dr. M. Esselen focuses genotoxic and mutagenic effects and combinatory toxicity of carcinogenic plant compounds. Further, the group is interested in cell culture studies to investigate the impact of flavonoids on key elements of cellular signaling cascades such as Nrf-2 pathway. Apoptosis or DNA-topology. The third focus include in vitro toxicity of cyclopentenone prostaglandins.