Research Foci
- Gentoxische Pflanzeninhaltsstoffe (Testsysteme: Mikrokern-Test, Comet Assay, HPRT-Test)
- Zellkulturstudien - Toxizität und Metabolismus
- Post-translationale Proteinmodifikationen durch sekundäre Pflanzenstoffe
- Bioanalytik (ELISA, Durchflusszytometrie, Western Blot, RealTime PCR, Fluoreszenzmikroskopie)
CV
Honors
- Top Viewed Article – ChemSusChem (Wiley)
- Goldener Brendel – Fachschaft Chemie der Universität Münster
- Kurt-Täufel-Preis des jungen Wissenschaftlers – Lebensmittelchemische Gesellschaft (LChG) - Fachgruppe in der Gesellschaft Deutscher Chemiker (GDCh)
External Functions
Teaching
- Lecture: Grundlagen der Toxikologie [124221]
- [ – | Tue, – | | LC 1]
- Lecture: Lebensmittelchemie und -technologie I [124211]
- [ – | Mon, – | | LC 1]
- [ – | Wed, – | | LC 1]
- Seminar: Aktuelle Forschung [124229]
(in cooperation with Florian Hübner, Hans-Ulrich Humpf, Matthias Behrens and Benedikt Cramer)- [ – | Thu, – | | LC 1]
- Seminar: Institutsseminar [124233]
(in cooperation with Florian Hübner, Hans-Ulrich Humpf, Matthias Behrens and Benedikt Cramer)- [Thu, – | ]
- Seminar: Aktuelle Lebensmittelchemie [124230]
- [Mon – Fri | ad hoc]
- Seminar/Tutorial: Literaturseminar für Doktoranden [124234]
(in cooperation with Hans-Ulrich Humpf)- [Mon – Fri | ad hoc]
- Introduction to academic work: Anleitung zu selbständigen wissenschaftlichen Arbeiten - AK Esselen [124231]
- [Mon – Fri | ad hoc]
- Presentation: Vortrag zur Bachelorarbeit [124219]
(in cooperation with Michael Lange-Aperdannier, Hans-Ulrich Humpf, Florian Hübner, Benedikt Cramer and Matthias Behrens)- [ – | Single Course]
- Lecture: Lebensmittelchemie und -technologie I
- Lecture: Kosmetische Mittel
- Lecture: Lebensmittelchemie und -technologie II
- Lecture: Biochemie der Ernährung
(in cooperation with Hans-Ulrich Humpf)- Seminar: Aktuelle Lebensmittelchemie
- Seminar: Institutsseminar
(in cooperation with Florian Hübner, Hans-Ulrich Humpf, Matthias Behrens and Benedikt Cramer)- Seminar: Aktuelle Forschung
(in cooperation with Florian Hübner, Hans-Ulrich Humpf, Matthias Behrens and Benedikt Cramer)- Seminar/Tutorial: Literaturseminar für Doktoranden
(in cooperation with Hans-Ulrich Humpf)- Seminar/Tutorial: Literaturseminar für Doktoranden
(in cooperation with Hans-Ulrich Humpf)- Introduction to academic work: Anleitung zu selbständigen wissenschaftlichen Arbeiten - AK Esselen
Articles
- Muschiol, EC, Tölke, LS, Lechtenfeld, CT, Kuczius, T, Winter, M, Nowak, S, and Esselen, M. . “Effects of electrochemical ageing of lithium-ion battery electrolyte on its in vitro genotoxicity: a special focus on sultones.” Archives of Toxicology 100: 1589–1602. doi: 10.1007/s00204-025-04246-2.
- Leopold, Maike, Peiffer, Felix, Muschiol, Elisabeth, Wölke, Christian, Peng, Yan, Brüning, Kai, Nowak, Sascha, Esselen, Melanie, Winter, Martin, and Cekic-Laskovic, Isidora. . “Importance of fluorine in high voltage electrolytes for LNMO||SiGr cell chemistry.” Small 21 (25) 2505254. doi: 10.1002/smll.202505254.
- Gerdemann, A, Behrens, M, Günther, G, Ghallab, A, Hengstler, JG., Humpf, H-U, and Esselen, M. . “A simplified LC–MS-based method for sensitive analysis of DNA adducts utilizing accessible in vitro metabolism models.” Archives of Toxicology 99: 4021–4034. doi: 10.1007/s00204-025-04125-w.
- Hassan, R., Gerdemann, A., Cramer, B., Hobloss, Z., Myllys, M., González, D., Albrecht, W., Veerkamp, J., Friebel, A., Hoehme, S., Esselen, M., Degen, G., Humpf, H., Hengstler, J., and Ghallab, A. . “Integrated data from intravital imaging and HPLC–MS/MS analysis reveal large interspecies differences in AFB1 metabolism in mice and rats.” Archives of Toxicology 98 (4): 1081–1093. doi: 10.1007/s00204-024-03688-4.
- Muschiol, Elisabeth, Tölke, Louisa, Lechtenfeld, Christian, Nowak, Sascha, and Esselen, Melanie. . “P13-16 Studies on the toxicology of electrolyte additives – mechanisms and changes during cycling.” Toxicology Letters 399 (2): S215–S2156. doi: 10.1016/j.toxlet.2024.07.532.
- Gerdemann, A, Broenhorst, M, Behrens, M, Humpf, HU, and Esselen, M. . “Polyphenols Cause Structure Dependent Effects on the Metabolic Profile of Human Hepatocarcinogenic Cells.” Molecular Nutrition and Food Research 67 (21): e2300052–e2300052. doi: 10.1002/mnfr.202300052.
- Kleinehr, J, Schöfbänker, M, Daniel, K, Günl, F, Mohamed, FF, Janowski, J, Brunotte, L, Boergeling, Y, Liebmann, M, Behrens, M, Gerdemann, A, Klotz, L, Esselen, M, Humpf, HU, Ludwig, S, and Hrincius, ER. . “Glycolytic interference blocks influenza A virus propagation by impairing viral polymerase-driven synthesis of genomic vRNA.” PLoS Pathogens 19 (7): e1010986.. doi: 10.1371/journal.ppat.1010986.
- Gerdemann, A, Cramer, B, Degen, GH, Veerkamp, J, Günther, G, Albrecht, W, Behrens, M, Esselen, M, Ghallab, A, Hengstler, JG, and Humpf, H-U. . “Comparative metabolism of aflatoxin B1 in mouse, rat and human primary hepatocytes using HPLC–MS/MS.” Archives of Toxicology 97 (12): 3179–3196. doi: 10.1007/s00204-023-03607-z.
- Muschiol, Elisabeth, Lechtenfeld, Christian-Timo, and Esselen, Melanie. . “In vitro Mutagenicity of Sulfur-Containing Additives.” contributed to the Baccara Power Day, Münster.
- Hahn, M., Lindemann, V., Behrens, M., Mulac, D., Langer, K., Esselen, M., and Humpf, H.-U. . “Permeability of dopamine D2 receptor agonist hordenine across the intestinal and blood-brain barrier in vitro.” PloS one 17 (6): e0269486–e0269486. doi: 10.1371/journal.pone.0269486.
- Gerdemann, A, Behrens, M, Esselen, M, and Humpf, HU. . “Metabolic profiling as a powerful tool for the analysis of cellular alterations caused by 20 mycotoxins in HepG2 cells.” Archives of Toxicology 96 (11): 2983–2998. doi: 10.1007/s00204-022-03348-5.
- Alfke, J, and Esselen, M. . “Cellular Uptake of Epigallocatechin Gallate in Comparison to Its Major Oxidation Products and Their Antioxidant Capacity In Vitro.” Antioxidants 11 (9). doi: 10.3390/antiox11091746.
- Maisuls, I., Boisten, F., Hebenbrock, M., Alfke, J., Schürmann, L., Jasper-Peter, B., Hepp, A., Esselen, M., Müller, J., and Strassert, C.A. . “Monoanionic C^N^N Luminophores and Monodentate C-Donor Co-Ligands for Phosphorescent Pt(II) Complexes: A Case Study Involving Their Photophysics and Cytotoxicity.” Inorganic Chemistry 61 (24): 9195–9204. doi: 10.1021/acs.inorgchem.2c00753.
- Alfke, Julian, Kampermann, Uta, and Esselen, Melanie. . “HPLC-MS/MS Quantification of Flavan-3-ols, Xanthines, and Epigallocatechin-3-Gallate Oxidation Products in Tea Samples and New Insights into Their Cytotoxicity.” ACS Food Science & Technology 2 (5): 925–935. doi: 10.1021/acsfoodscitech.2c00065.
- Gerhard, MN, Schymanski, D, Ebner, I, Esselen, M, Stahl, T, and Humpf, HU. . “Can the presence of additives result in false positive errors for microplastics in infant feeding bottles?” Food Additives and Contaminants: Part A: Chemistry, Analysis, Control, Exposure and Risk Assessment 39 (1): 185–197. doi: 10.1080/19440049.2021.1989498.
- Müller, L, Keuter, L, Bücksteeg, D, Uebel, T, Wilken, M, Schürmann, L, Behrens, M, Humpf, H, and Esselen, M. . “Metabolic conjugation reduces in vitro toxicity of the flavonoid nevadensin.” Food and Chemical Toxicology 164: 113006. doi: 10.1016/j.fct.2022.113006.
- Kubot, Maximilian, Frankenstein, Lars, Muschiol, Elisabeth, Klein, Sven, Esselen, Melanie, Winter, Martin, Nowak, Sascha, and Kasnatscheew, Johannes. . “Lithium Difluorophosphate Electrolyte Additive: a Boon for good High Voltage Li Ion Batteries, but a Bane for high Thermal Stability and low Toxicity: Towards a Synergistic Dual-Additive Approach with Fluoroethylene Carbonate to Circumvent this Dilemma.” ChemSusChem 16 (6) e202202189. doi: 10.1002/cssc.202202189.
- Müller, L, Schütte, LRF, Bücksteeg, D, Alfke, J, Uebel, T, and Esselen, M. . “Topoisomerase poisoning by the flavonoid nevadensin triggers DNA damage and apoptosis in human colon carcinoma HT29 cells.” Archives of Toxicology 95 (12): 3787–3802. doi: 10.1007/s00204-021-03162-5.
- Lünne, F, Köhler, J, Stroh, C, Müller, L, Daniliuc, CG, Mück-Lichtenfeld, C, Würthwein, EU, Esselen, M, Humpf, HU, and Kalinina, SA. . “Insights into Ergochromes of the Plant Pathogen <i>Claviceps purpurea</i>.” Journal of Natural Products 84 (10): 2630–2643. doi: 10.1021/acs.jnatprod.1c00264.
- Müller, L, Weever, F, Hübner, F, Humpf, HU, and Esselen, M. . “Characterization of Oligomeric Proanthocyanidin-Enriched Fractions from <i>Aronia melanocarpa</i> (Michx.) Elliott via High-Resolution Mass Spectrometry and Investigations on Their Inhibitory Potential on Human Topoisomerases.” Journal of Agricultural and Food Chemistry 69 (37): 11053–11064. doi: 10.1021/acs.jafc.1c04761.
- Alfke, J, Kampermann, U, Kalinina, S, and Esselen, M. . “Isolation and structural elucidation of dimeric epigallocatechin-3-gallate autoxidation products and their antioxidant capacity.” European Food Research and Technology 247: 2961–2975. doi: 10.1007/s00217-021-03846-3.
- Hermes, L, Römermann, J, Cramer, B, and Esselen, M. . “Quantitative Analysis of β-Asarone Derivatives in <i>Acorus calamus</i> and Herbal Food Products by HPLC-MS/MS.” Journal of Agricultural and Food Chemistry 69 (2): 776–782. doi: 10.1021/acs.jafc.0c05513.
- Hermes, L, Römermann, J, Cramer, B, and Esselen, M. . “Quantitative Analysis of β-Asarone Derivatives in Acorus calamus and Herbal Food Products by HPLC-MS/MS.” Journal of Agricultural and Food Chemistry Online ahead of print. doi: 10.1021/acs.jafc.0c05513.
- Hermes, Lena, Römermann, Jannis, Cramer, Benedikt, and Esselen, Melanie. . “Phase II metabolism of asarone isomers in vitro and in humans using HPLC-MS/MS and HPLC-QToF/MS.” Foods 10 (9): 2032.. doi: 10.3390/foods10092032.
- Uebel, T, Hermes, L, Haupenthal, S, Müller, L, and Esselen, M. . “α‐Asarone, β‐asarone, and γ‐asarone: Current status of toxicological evaluation.” Journal of Applied Toxicology 2020: 1–14. doi: 10.1002/jat.4112.
- Hermes, L, Haupenthal, S, Uebel, T, and Esselen, M. . “DNA double strand break repair as cellular response to genotoxic asarone isomers considering phase I metabolism.” Food and Chemical Toxicology 2020. doi: 10.1016/j.fct.2020.111484.
- Uebel, T, Wilken, M, Vu, Chi H, and Esselen, M. . “In vitro combinatory cytotoxicity of hepatocarcinogenic asarone isomers and flavonoids.” Toxicology in Vitro 60: 19–26. doi: 10.1016/j.tiv.2019.04.029.
- Schultheis, J, Beckmann, D, Mulac, D, Müller, L, Esselen, M, and Düfer, M. . “Nrf2 activation protects mouse beta cells from glucolipotoxicity by restoring mitochondrial function and physiological redox balance.” Oxidative medicine and cellular longevity 2019. doi: 10.1155/2019/7518510.
- Hermes, L, Haupenthal, S, and Esselen, M. . “DNA repair mechanisms involved in cellular response of to genotoxic asarone isomers.” contribution to the DGDR-Jahrestagung, Karlsruhe
- Hermes, L, Haupenthal, S, and Esselen, M. . “Genotoxic asarone isomers influence DNA strand break repair.” contribution to the 46th EEMGS/30th GUM meeting, Potsdamm
- Zielinski, A, and Esselen, M. . “Genotoxic Properties of Prostaglandins and Cyclopentenone Prostaglandines derived from Arachidonic Acid.” contribution to the 46th EEMGS/30th GUM meeting, Potsdamm
- Zielinski, A, and Esselen, M. . “Gentoxische Effekte von Prostaglandinen und Cyclopentenonprostaglandinen aus Arachidonsäure.” contribution to the LChG Regionalverband NRW, Arbeitstagung 2018, Essen
- Müller, L, Uebel, T, and Esselen, M. . “Einfluss von Alkenylbenzenen auf die Expression von Phase II-Enzymen in humanen Leberkarzinomzellen.” contribution to the LChG Regionalverband NRW Arbeitstagung, Essen
- Pöppelmann, T, Alfke, J, and Esselen, M. . “Einfluss von (-)-Epigallocatechin-3-gallat auf Histondeactylasen und apoptoseassoziierter Enzyme in humanen Kolonkarzinomzellen.” contribution to the 47. Deutscher Lebensmittelchemikertag, Berlin
- Jagels, A, Hövelmann, Y, Zielinski, A, Esselen, M, Köhler, J, Hübner, F, and Humpf, HU. . “Stachybotrychromenes A-C: novel cytotoxic meroterpenoids from Stachybotrys sp.” Mycotoxin Res. 34: 179–185.
- Krug, I, Behrens, M, Esselen, M, and Humpf, HU. . “Transport of enniatin B and enniatin B1 across the blood-brain barrier and hints for neurotoxic effects in cerebral cells.” PloS one 13(5). doi: 10.1371/journal.pone.0197406.
- Groh, IAM, and Esselen, M. . “The Alkenylbenzene Methyleugenol and Selected Oxidative Metabolites Affect the DNA-Damage Signaling Pathway and Induce Apoptosis in Human Colon Tumor HT29 Cells.” Food Toxicol. 2017: 267–265.
- Haupenthal, S, Berg, K, Gründken, M, Vallicotti, S, Hemgesberg, M, Sak, K, Schrenk, D, and Esselen, M. . “In vitro genotoxicity of carcinogenic asarone isomers.” Food and Function 2017. doi: 10.1039/c6fo01701k.
- Pöppelmann, T, and Esselen, M. . “(-)-Epigallocatechin-3- gallate (EGCG) acts as a modulator of post-translational protein modifications of histone deacetylases.” contribution to the Frühjahrstagung, Deutsche Gesellschaft für Pharmakologie und Toxikologie, Heidelberg
- Pöppelmann, T, and Esselen, M. . “(-)-Epigallocatechingallat als Modulator post-translationaler Proteinmodifikationen von Histondeacetylasen in vitro.” contribution to the Regionalverbandes NRW LChG, Münster
- Esselen, M, and Schrenk, D. . “Other Process-Generated Toxicants in Foods.” in CHEMICAL CONTAMINANTS AND RESIDUES IN FOOD, edited by D Schrenk and A Cartus. Woodhead Publishing Limited.
- Haupenthal, S, Uebel, T, and Esselen, M. . “Angriffspunkt DNA - Zelluläre Schadensantwort auf natürliche Lebensmittelkanzerogene.” Labor and More 06.16.
- Uebel, T, Vu, Chi H, and Esselen, M. . “Development of a long-term cytotoxicity in vitro cell model using naturally occurring alkenylbenzenes.” contribution to the Industriesymposium FoChIn, Münster
- Zielinski, A, and Esselen, M. . “Zytotoxizität von langkettigen, mehrfach ungesättigten Fettsäuren und ihren oxidativen Metaboliten.” contribution to the GDCh, LChG "Deutscher Lebensmittelchemikertag", München, Deutschland
- Pöppelmann, T, and Esselen, M. . “(-)-Epigallocatechingallat als Modulator post-translationaler Proteinmodifikation von Histondeacetylasen.” contribution to the GDCh - LChG "Deutscher Lebensmittelchemikertag", München, Deutschland
- Uebel, T, Haupenthal, S, Groh, IAM, and Esselen, M. . “Profiling DNA damage response concerning cellular gene and protein phosphorylation status after phenylpropene incubation.” contribution to the Symposium „DNA damage response, genetic instability and cancer“, Mainz
- Zielinski, Alexa, Solecki, Gergely Morten, and Esselen, Melanie. . “Zelluläre Wirkmechanismen von nicht enzymatischen Oxidationsprodukten von mehrfach ungesättigten Fettsäuren (PUFA).” contribution to the Arbeitstagung des Regionalverbands Nordrhein-Westfalen der Lebensmittelchemischen Gesellschaft, Mönchengladbach
- Pöppelmann, Tobias, Groh, Isabel Anna Maria, and Esselen, Melanie. . “Einfluss von (-)-Epigallocatechingallat auf die SUMO- und HDAC-Expressionin vitro.” contribution to the Arbeitstagung des Regionalverbands Nordrhein-Westfalen der Lebensmittelchemischen Gesellschaft, Mönchengladbach
- Haupenthal, S, Vallicotti, S, and Hemgesberg, Mand Esselen M. . “The alkaline comet assay as a method to investigate the DNA strand breaking effect of phenylpropanoids in mammalian cells.” contribution to the CAW 2015 - 11th International Comet Assay Workshop, Antwerpen doi: 10.3389/conf.fgene.2015.01.00037.
- Haben, Melina, Cramer, Benedikt, Hickert, Sebastian, Eisenbrand, Gerhard, and Esselen, Melanie. . “Beitrag eines Acrylamid-Niacin-Adduktes zur Reduzierung des Acrylamid-Gehaltes im Lebensmittel.” in Lebensmittelchmie
- Haben, Melina, Eisenbrand, Gerhard, and Esselen, Melanie. . “Impact of an acrylamide-niacin adduct on the cellular redox status of human colon carcinoma cells.” in Naunyn-Schmiedeberg's Archives of Pharmacology
- Berg, Kerstin, Esselen, Melanie, and Schrenk, Dieter. . “Determination of the mutagenicity of α- , β-and γ-asarone.” in Naunyn-Schmiedeberg's Archives of Pharmacology
- Haupenthal, Sabrina, Groh, Isabel Anna Maria, Berg, Kerstin, Schrenk, Dieter, and Esselen, Melanie. . “DNA-damaging effects of phenylpropanoids in hamster lung fibroblast V79 cells.” in Naunyn-Schmiedeberg's Archives of Pharmacology Springer.
- Uebel, Thomas, Heyer, Melanie, Vallicotti, Sabrina, Esselen, and Melanie. . “Phenylpropanoids induce oxidative DNA strand breaks in mammalian cells.” in Naunyn-Schmiedeberg's Archives of Pharmacology Springer.
- Groh, I., Rudakovski, O., Gründken, M., Schroeter, A., Marko, D., and Esselen, M. . “Methyleugenol and oxidative metabolites induce DNA damage and interact with human topoisomerases.” Archives of Toxicology null (null). doi: 10.1007/s00204-015-1625-3.
- Esselen, M. . “Trendbericht Lebensmittelchemie 2013: Natürliche kanzerogene Lebensmittelinhaltsstoffe aus der Klasse der Phenylpropanoide.” Nachrichten aus der Chemie 03/2014.
- Esselen, M, and Barth, S. . “Food-Borne Topoisomerase Inhibitors: Risk or Benefit.” in Advances in Molecular Toxicology, edited by JC Fishbein and JM Heilman.
- Groh, IA, Chen, C, Lüske, C, Cartus, AT, and Esselen, M. . “Plant polyphenols and oxidative metabolites of the herbal alkenylbenzene methyleugenol suppress histone deacetylase activity in human colon carcinoma cells.” Journal of Nutrition and Metabolism 2013: 821082.. doi: 10.1155/2013/821082.
- Esselen, M, Barth, SW, Winkler, S, Baechler, S, Briviba, K, Watzl, B, Skrbek, S, and Marko, D. . “Anthocyanins suppress the cleavable complex formation by irinotecan and diminish its DNA-strand-breaking activity in the colon of Wistar rats.” Carcinogenesis 34 (4): 835–40. doi: 10.1093/carcin/bgs398.
- Solecki, GM, Groh, IA, Kajzar, J, Haushofer, C, Scherhag, A, Schrenk, D, and Esselen, M. . “Genotoxic properties of cyclopentenone prostaglandins and the onset of glutathione depletion.” Chemical Research in Toxicology 26 (2): 252–61. doi: 10.1021/tx300435p.
- Groh, IA, Cartus, AT, Vallicotti, S, Kajzar, J, Merz, KH, Schrenk, D, and Esselen, M. . “Genotoxic potential of methyleugenol and selected methyleugenol metabolites in cultured Chinese hamster V79 cells.” Food and Function 3 (4): 428–36. doi: 10.1039/c2fo10221h.
- Esselen, M, and Schrenk, D. . “Toxicants in foods generated by non-thermal processes.” in Chemical contaminants and residues in food, edited by Dieter Schrenk.
- Esselen, M, Boettler, U, Teller, N, Bachler, S, Hutter, M, Rufer, CE, Skrbek, S, and Marko, D. . “Anthocyanin-rich blackberry extract suppresses the DNA-damaging properties of topoisomerase I and II poisons in colon carcinoma cells.” Journal of Agricultural and Food Chemistry 59 (13): 6966–73. doi: 10.1021/jf200379c.
- Esselen, M, Fritz, J, Hutter, M, Teller, N, Baechler, S, Boettler, U, Marczylo, TH, Gescher, AJ, and Marko, D. . “Anthocyanin-rich extracts suppress the DNA-damaging effects of topoisomerase poisons in human colon cancer cells.” Molecular Nutrition and Food Research 55 Suppl 1: S143–53. doi: 10.1002/mnfr.201000315.
- Barth, SW, Briviba, K, Watzl, B, Jäger, N, Marko, D, and Esselen, M. . “In vivo bioassay to detect irinotecan-stabilized DNA/topoisomerase I complexes in rats.” Biotechnology Journal 5 (3): 321–7. doi: 10.1002/biot.200900174.
- Pelka, J, Gehrke, H, Esselen, M, Türk, M, Crone, M, Bräse, S, Muller, T, Blank, H, Send, W, Zibat, V, Brenner, P, Schneider, R, Gerthsen, D, and Marko, D. . “Cellular uptake of platinum nanoparticles in human colon carcinoma cells and their impact on cellular redox systems and DNA integrity.” Chemical Research in Toxicology 22 (4): 649–59. doi: 10.1021/tx800354g.
- Esselen, M, Fritz, J, Hutter, M, and Marko, D. . “Delphinidin modulates the DNA-damaging properties of topoisomerase II poisons.” Chemical Research in Toxicology 22 (3): 554–64. doi: 10.1021/tx800293v.
- Fritz, J, Roth, M, Holbach, P, Esselen, M, and Marko, D. . “Impact of delphinidin on the maintenance of DNA integrity in human colon carcinoma cells.” Journal of Agricultural and Food Chemistry 56 (19): 8891–6. doi: 10.1021/jf801522x.
- Fridrich, D, Teller, N, Esselen, M, Pahlke, G, and Marko, D. . “Comparison of delphinidin, quercetin and (-)-epigallocatechin-3-gallate as inhibitors of the EGFR and the ErbB2 receptor phosphorylation.” Molecular Nutrition and Food Research 52 (7): 815–22. doi: 10.1002/mnfr.200800026.
- Kern, M, Fridrich, D, Reichert, J, Skrbek, S, Nussher, A, Hofem, S, Vatter, S, Pahlke, G, Rüfer, C, and Marko, D. . “Limited stability in cell culture medium and hydrogen peroxide formation affect the growth inhibitory properties of delphinidin and its degradation product gallic acid.” Molecular Nutrition and Food Research 51 (9): 1163–72. doi: 10.1002/mnfr.200700004.
- Kern, M, Pahlke, G, Balavenkatraman, KK, Böhmer, FD, and Marko, D. . “Apple polyphenols affect protein kinase C activity and the onset of apoptosis in human colon carcinoma cells.” Journal of Agricultural and Food Chemistry 55 (13): 4999–5006. doi: 10.1021/jf063158x.
- Fridrich, D, Kern, M, Pahlke, G, Volz, N, Will, F, Dietrich, H, and Marko, D. . “Apple polyphenols diminish the phosphorylation of the epidermal growth factor receptor in HT29 colon carcinoma cells.” Molecular Nutrition and Food Research 51 (5): 594–601. doi: 10.1002/mnfr.200600189.
- Fridrich, D, Kern, M, Fritz, J, Pahlke, G, Köhler, N, Winterhalter, P, and Marko, D. . “The epidermal growth factor receptor and human topoisomerases represent potential cellular targets of oligomeric procyanidins.” Molecular Nutrition and Food Research 51 (2): 192–200. doi: 10.1002/mnfr.200600186.
- Kern, M, Pahlke, G, Ngiewih, Y, and Marko, D. . “Modulation of key elements of the Wnt pathway by apple polyphenols.” Journal of Agricultural and Food Chemistry 54 (19): 7041–6. doi: 10.1021/jf0606611.
- Pahlke, G, Ngiewih, Y, Kern, M, Jakobs, S, Marko, D, and Eisenbrand, G. . “Impact of quercetin and EGCG on key elements of the Wnt pathway in human colon carcinoma cells.” Journal of Agricultural and Food Chemistry 54 (19): 7075–82. doi: 10.1021/jf0612530.
- Fritz, J, Kern, M, Pahlke, G, Vatter, S, and Marko, D. . “Biological activities of malvidin, a red wine anthocyanidin.” Molecular Nutrition and Food Research 50 (4-5): 390–5. doi: 10.1002/mnfr.200500228.
- Kern, M, Tjaden, Z, Ngiewih, Y, Puppel, N, Will, F, Dietrich, H, Pahlke, G, and Marko, D. . “Inhibitors of the epidermal growth factor receptor in apple juice extract.” Molecular Nutrition and Food Research 49 (4): 317–28. doi: 10.1002/mnfr.200400086.
Supervised Doctoral Studies
- Pöppelmann, Tobias (): Impact of polyphenols on post translational modifications of Sumo-1 target proteins
- Supervisors
- Humpf, Hans-Ulrich
- Zielinski, Alexa (): Cellular mechanism of not enzymatic oxidation products of poly unsaturated fatty acids.
- Supervisors
- Humpf, Hans-Ulrich
- Kalinina Svetlana (): Penicillium spp. as a Source of Secondary Metabolites: Structure Elucidation, Occurrence in Food, Cytotoxicity, and Biological Activity
- Further Supervisors
- Humpf, Hans-Ulrich
- Wünsch, Bernhard
- Uebel, Thomas (): Impact of phenyl propanoids on cellular redox status.
- Supervisors
- Humpf, Hans-Ulrich
- Pajaziti, Betina (): Endokrine Fibroblasten-Wachstumsfaktoren als Regulatoren der beta-Zellfunktion und beta-Zellviabilität
- Supervisors
- Düfer, Martina
- Hempel, Georg
- Esselen, Melanie
- Hempel, Georg
- Müller, Dolores (): Pilotstudie zur Bioverfügbarkeit und biologischen Aktivität anthocyanreicher Heidelbeerextrakte in verkapselter und unverkapselter Form im Menschen
- Supervisors
- Richling, Elke
- Esselen, Melanie
- Teresa Röhrig (): In vitro Studien zum Einfluss von Extrakten aus Kaffee, Artischocke, Ingwer, Erdbeerbaum und Tee auf die Phosphodiesterase-Aktivität
- Haupenthal, Sabrina (): Beeinflussung der DNA-Integrität durch Metaboliten natürlicher kanzerogener Phenylpropanoide.
- Further Supervisor
- Humpf, Hans-Ulrich
- Haben, Melina (): Wirkmechanistische Untersuchungen zu zellulären Aktivitäten von Maillard-Produkten traditioneller chinesischer Lebensmittel und Lebensmittelmodelverbindungen
- Supervisors
- Richling, Elke
- Berg, Kerstin (): Untersuchungen zur Gentoxizität der Asarone
- Supervisors
- Schrenk, Dieter
- Esselen, Melanie
- Kunsmann, Lisa (): Charakterisierung von Membranvesikeln enterohämorrhagischer Escherichia coli
- Further Supervisors
- Humpf, Hans-Ulrich
- Karch, Helge
- Messer, Anastasia (): Crosstalk zwischen murinen myeloiden Zellen und fremdstoffmetabolisierenden Hepatomzellen durch Liganden des Ahr-Signalweges
- Supervisors
- Schrenk, Dieter
- Esselen, Melanie
- Seibel, Tom (): Metabolitenmuster im Blut und Genexpressionsmuster von Aryl-Hydrocarbon-Rezeptor-defizienten- und Wildtyp-Mäusen
- Supervisors
- Dieter, Schrenk
- Melanie, Esselen
- Cartus, Alexander Thomas (): Metabolismus der Phenylpropene Methyleugenol, (E)-Methylisoeugenol sowie alpha-, beta- und gamma-Asaron
- Supervisors
- Schrenk, Dieter
- Esselen, Melanie
- Groh, Isabel Anna Maria (): Wirkmechanismen zur Gentoxizität von Methyleugenol und ausgewählter oxidativer Metaboliten sowie zur posttranslationalen Histondeacetylase-Modifizierung durch Polyphenole
- Supervisors
- Schrenk, Dieter
- Ufelmann, Helena (): Toxikologische Relevanz des Vorkommens von Desmethyl-Varianten der Mycrocystine und des Nodularins in Gewässern und Nahrungsergänzungsmittel
- Supervisors
- Schrenk, Dieter
- Esselen, Melanie
- Schantz, Markus (): Biologische Wirksamkeit eines Heidelbeerextrakts (Vaccinium myrtillus L.) im Vergleich zu verkapselten Präparaten: Antioxidative Wirksamkeit und Modulation der intestinalen Verfügbarkeit der Anthocyane
- Supervisors
- Richling, Elke
- Esselen, Melanie