© Meuth

Topics of research

Research interests include the study of autoimmune inflammation, ion channels in inflammation and degeneration, neuroimmune interactions, and cellular electrophysiology.

ChemBIon project description

Glutamate-mediated excitotoxicity and neurodegeneration are pathophysiological hallmarks of diverse inflammatory disorders of the central nervous system (CNS), including multiple sclerosis (MS). N-methyl-D-aspartate (NMDA) receptors play a pivotal role in the mediation of neuronal glutamate excitotoxicity leading to cellular damage and apoptotic cell death. Current treatment approaches targeting NMDA receptors are unspecific and associated with severe adverse events due to the broad and important functions of these receptors in the CNS. In collaboration with B. Wünsch we recently found an ameliorative effect of a novel subunit-specific NMDA receptor antagonist in experimental autoimmune encephalomyelitis (EAE), a mouse model for MS. The antagonist, WMS-1410 (WMS), specifically binds to GluN2B NMDA receptors, leading to a reduced infiltration of auto-aggressive immune cells into the spinal cord.
The goal of this project: The goal of this project is to investigate the WMS mode of action in autoimmune neuro-inflammation.

  • Curriculum vitae



    Study of Medicine, Otto-von-Guericke University, Magdeburg, Germany


    Promoted member of the DFG Group “Biological basics of disorders of the nervous system”


    Postgrad. academic studies, Neurobiol., Otto-von-Guericke University (OvGU), Magdeburg


    Dr. med. (summa cum laude), Inst. of Physiology, OvGU, Magdeburg


    PhD Thesis (summa cum laude), Inst. of Physiology, OvGU, Magdeburg


    Open Univ. degree “Master of Health Business Administration”, Univ. Nürnberg-Erlangen, Germany



    Assistant physician and Postdoc (Research group “Multiple Sclerosis and Neurimmunology”), Department of Neurology and Policlinic, University Hospital Würzburg (Prof. Dr. K.V. Toyka)


     Stay abroad, UT Southwestern Medical Center, Dallas, Texas, USA


    Assistant physician, Clinic of Psychiatry, Psychotherapy und Psychosomatic medicine, Lohr am Main, Germany (Prof. Dr. G. Jungkunz)


    Visiting scientist, Department of Neurology and Policlinic, University Hospital Würzburg, Germany; Research group “Multiple Sclerosis and Neuroimmunology” (Prof. Dr. H. Wiendl)


    Senior physician, Department of Neurology, Division of Inflammatory Diseases of the Nervous System and Neurology, University Hospital Münster, Germany (Prof. Dr. H. Wiendl)


    Professor (W3) for Neuropathophysiol., Inst. of Physiol. I, Westphalian Wilhelms-Univ. Münster


    Admission as medical specialist for Neurology (Medical Board Westfalen-Lippe)

    Since 04/2013

    Vice-chair, Department of Neurology, University Hospital Münster

    Since 03/2016

    Director, Institute of Translational Neurology, University Hospital Münster

    Since 01/2017

    Vice Dean for research / Deputy Dean, Faculty of Medicine, Münster

    Since 03/2019

    Acting Dean, Faculty of Medicine, Münster