Publications
Publications
Publications
© Judith Stepper

Below you can find publications of work that has been carried out within the Research Training Group Chembion.

  • 2024

    • L. Vinnenberg, N. Rychlik, T. Oniani, B. Williams, J. A. White, S. Kovac, S. G. Meuth, T. Budde, P. Hundehege. Assessing neuroprotective effects of diroximel fumarate and siponimod via modulation of pacemaker channels in an experimental model of remyelination, Exp. Neurol. 2024, 371, 114572. doi: 10.1016/j.expneurol.2023.114572.
    • L.M. Todesca, M. Gerke, E. E. Bulk, M. Bachmann, A. Rudersdorf, L. Antonutto, S. Pillozzi, M. Düfer, I. Szabo, A. Schwab. Targeting KCa3.1 channels to overcome erlotinib resistance in non-small cell lung cancer cells. Cell Death Discov. 2024 10, 2. doi: 10.1038/s41420-023-01776-5.
    • A. Dombovski, R. Steigerwald, N. Ritter, P. Disse, G. Goerges, J. Osthues, I. Aymanns, C. Dilkaute, J. Schreiber, M. Düfer, G. Seebohm, B. Wünsch, J. Jose. A novel fluorescent labeling compound for GluN2A containing N-methyl-D-aspartate receptors identified by Autodisplay-based screening. J. Pharm. Anal., 2024. doi: 10.1016/j.jpha.2024.01.013.

  • 2023

    • I. Thale, S. Maskri, L. Grey, L. M. Todesca, T. Budde, I. Maisuls, C. A. Strassert, O. Koch, A. Schwab, B. Wünsch. Imaging of KCa3. 1 channels in tumor cells with PET and small‐molecule fluorescent probes. ChemMedChem. 2023, 18(2):e202200551. doi: 10.1002/cmdc.202200551.
    • N. Rychlik, P. Hundehege, T. Budde. Influence of inflammatory processes on thalamocortical activity. Biol. Chem. 2023, 404(4):303-310. doi: 10.1515/hsz-2022-0215.
    • B. Soret, J. Hense, S. Lüdtke, I. Thale, A. Schwab, M. Düfer. Pancreatic KCa3.1 channels in health and disease. Biol. Chem. 2023, 404(4):339-353. doi: 10.1515/hsz-2022-0232.
      † These authors contributed equally to this work
    • M. Korff, R. Steigerwald, E. Bechthold, D. Schepmann, J. A. Schreiber, S. G. Meuth, G. Seebohm, B. Wünsch. Chemical, pharmacodynamic and pharmacokinetic characterization of the GluN2B receptor antagonist 3-(4-phenylbutyl),2,3,4,5-tetrahydro-1H-3-benzazepine-1,7-diol – starting point for PET tracer development. Biol. Chem. 2023, 404(4):279-289. doi: 10.1515/hsz-2022-0222.
    • L. Korn, A. M. Speicher, C. B. Schroeter L. Gola, T. Kaehne, A. Engler, P. Disse, J. Fernández-Orth, J. Csatári, M. Naumann, G. Seebohm, S. G. Meuth, H. R. Schöler, H. Wiendl, S. Kovac†, M. Pawlowski†. MAPT genotype-dependent mitochondrial aberration and ROS production trigger dysfunction and death in cortical neurons of patients with hereditary FTLD. Redox. Biol. 2023, 59:102597. doi: 10.1016/j.redox.2022.102597.                                                            
      † These authors contributed equally to this work
    • T. Schierling, B. Tosi, C. Eisenhardt, S. Reining, C. G. Daniliuc, C. Brenker, T. Strünker, B. Wünsch. Synthesis and functional characterization of novel RU1968-derived CatSper inhibitors with reduced stereochemical complexity. ACS Pharmacol. Transl. Sci. 2023, 6(1)115–127. doi: 10.1021/acsptsci.2c00188.
    • H. Kapell, L. Fazio, J. Dyckow, S. Schwarz, A. Cruz-Herranz, C. Mayer, J. Campos, E. D´Este, W. Möbius, C. Cordano, A.-K. Pröbstel, M. Gharagozloo, A. Zulji, V. Narayanan Naik, A.-K. Delank, M. Cerina, T. Müntefering, C. Lerma-Martin, J. K. Sonner, J. H. Sin, P. Disse, N. Rychlik, K. Sabeur, M. Chavali, R. Srivastava, M. Heidenreich, K. C. Fitzgerald, G. Seebohm, C. Stadelmann, B. Hemmer, M. Platten, T. J. Jentsch, M. Engelhardt, T. Budde, K.-A. Nave, P. A. Calabresi, M. A. Friese, A. J. Green, C. Acuna, D. H. Rowitch, S. G. Meuth, L. Schirmer. Neuron-oligodendrocyte potassium shuttling at nodes of Ranvier protects against inflammatory demyelination. J. Clin. Invest. 2023, 133(7):e164223. doi: 10.1172/JCI164223.† These authors contributed equally to this work 
    • H. Noguera Hurtado, A. Gresch, M. Düfer. NMDA receptors – regulatory function and pathophysiological significance for pancreatic beta cells. Biol. Chem. 2023, 404(4):311-324. doi: 10.1515/hsz-2022-0236.
    • T. Loeck, A. Schwab. The role of the Na+/Ca2+-exchanger (NCX) in cancer-associated fibroblasts. Biol. Chem. 2023, 404(4):325-337. doi: 10.1515/hsz-2022-0253.
    • P. Disse, I. Aymanns, N. Ritter, L. Korn, H. Wiendl, M. Pawlowski, S. Kovac, S. G. Meuth, T. Budde, N. Strutz-Seebohm, B. Wünsch, G. Seebohm. A novel NMDA receptor test model based on hiPSC-derived neural cells. Biol. Chem. 2023, 404(4): 267-277. doi: 10.1515/hsz-2022-0216.
    • M. Dellin, I. Rohrbeck, P. Asrani, J. A. Schreiber, N. Ritter, F. Glorius, B. Wünsch, T. Budde, L. Temme, T. Strünker, B. Stallmeyer, F. Tüttelmann, S. G. Meuth, M. Spehr, J. Matschke, A. Steinbicker, C. Gatsogiannis, R. Stoll, N. Strutz-Seebohm, G. Seebohm. The second PI(3,5)P2 binding site in the S0 helix of KCNQ1 stabilizes PIP2-at the primary PI1 site with potential consequences on intermediate-to-open state transition. Biol. Chem. 2023, 404(4):241-254. doi: 10.1515/hsz-2022-0247.
    • A. Labbaf, M. Dellin, M. Komadowski, D. Chetkovich, N. Decher, H.-C. Pape, G. Seebohm, T. Budde, M. Zobeiri. Characterization of Kv1.2-mediated outward current in TRIP8b-deficient mice. Biol. Chem. 2023, 404(4): 291-302. doi: 10.1515/hsz-2023-0116.
    • E. Bechthold, L. Grey, E. Diamant, J. Schmidt, R. Steigerwald, F. Zhao, K. B. Hansen, L. Bunch, R. P. Clausen, B. Wünsch. In vitro ADME characterization of a very potent 3-acylamino-2-aminopropionic acid-derived GluN2C-NMDA receptor agonist and its ester prodrugs. Biol. Chem2023, 404(4): 255-265. doi: 10.1515/hsz-2022-0229.
    • C. Schroeter, C. Nelke, M. Schewe, L. Spohler, A. Herrmann, T. Müntefering, N. Huntemann, M. Kuzikov, P. Gribbon, S. Albrecht, S. Bock, P. Hundehege, L. Neelsen, T. Baukrowitz, G. Seebohm, B. Wünsch, S. Bittner, T. Ruck, T. Budde, S. G. Meuth. Validation of TREK1 ion channel activators as an immunomodulatory and neuroprotective strategy in neuroinflammation. Biol. Chem. 2023, 404(4):355-375. doi: 10.1515/hsz-2022-0266.
    • T. Lange, T. Depmeier, T. Strünker, M. Lehr. HPLC fluorescence assay for measuring the activity of NAPE-PLD and the action of inhibitors affecting this enzyme. J. Pharm. Biomed. Anal2023, 229:115354. doi: 10.1016/j.jpba.2023.115354.
    • M .Patberg, T. Oniani, P. Disse, S. Peischard, L. Vinnenberg, M. Zobeiri, M. N. Romanelli, L. Epping, H. Wiendl, S. G. Meuth, P. Hundehege, G. Seebohm, T. Budde, A. Junker. Optimized synthesis and pharmacological evaluation of HCN channel inhibitor EC18. Arch. Pharm. 2023, e2200665. doi: 10.1002/ardp.202200665.
    • M. M. Audero, T. Carvalho, F. A.  Ruffinatti, T. Loeck, M. Yassine, G. Chinigò, A. Folcher, V. Farfariello, A. Schwab, S. J. Reshkin, R. A. Cardone, N. Prevarskaya, A. Fiorio Pla. Acidic tumor microenvironment promotes epithelial-to-mesenchymal transition to select more aggressive PDAC cell phenotypes. Cancers 2023, 15: 2572. doi: 10.3390/cancers15092572.
    • N. Ritter, P. Disse, B. Wünsch, G. Seebohm, N. Strutz-Seebohm. Pharmacological potential of 3-benzazepines in NMDAR-linked pathophysiological processes. Biomedicines 2023, 11(5): 1367. doi:10.3390/biomedicines11051367.
    • M. Wojciechowski, J. Schreiber, J. Jose. A novel flow cytometry-based assay for the identification of HCN4 CNBD ligands. Pharmaceuticals 2023, 16(5): 710. doi: 10.3390/ph16050710.
    • Y. Tong, Y. Lee, X. Liu, J. L. Childs-Disney, B. M. Suresh, R. I. Benhamou, C. Yang, W. Li, M. G. Costales, H. S. Haniff, S. Sievers, D. Abegg, T. Wegner, T. O. Paulisch, E. Lekah, M. Grefe, G. Crynen, M. Van Meter, T. Wang, Q. M. R. Gibaut, J. L. Cleveland, A. Adibekian, F. Glorius, H. Waldmann, M. D. Disney. Programming inactive RNA-binding small molecules into bioactive degraders. Nature 2023, 618, 169-179. doi: 10.1038/s41586-023-06091-8.
    • T. Loeck, M. Rugi, L. M. Todesca, B. Soret, I. Neumann, S. Schimmelpfennig, K. Najder, Z. Pethő, V. Farfariello, N. Prevarskaya, A. Schwab. The context-dependent role of the Na+/Ca2+-exchanger (NCX) in pancreatic stellate cell migration. Pflugers Arch. – Eur. J. Physiol. 2023, 475: 1225–1240. doi: 10.1007/s00424-023-02847-3.

    • M. Korff, J. Lüken, J. Schmidt, D. Schepmann, G. Goerges, N. Ritter, P. Disse, JA Schreiber, G Seebohm, B Wünsch. Negative allosteric modulators of NMDA receptors with GluN2B subunit: synthesis of β-aminoalcohols by epoxide opening and subsequent rearrangement. Org. Biomol. Chem. 2023, 21(37):7616-7638. doi: 10.1039/d3ob01208e. 

    • N. Ritter, P. Disse, I. Aymanns, L. Mücher, J. A. Schreiber, C. Brenker, T. Strünker, D. Schepmann, T. Budde, N. Strutz-Seebohm, S. M. Ametamey, B. Wünsch, G. Seebohm. Downstream allosteric modulation of NMDA receptors by 3-benzazepine derivatives. Mol. Neurobiol. 2023, online. doi: 10.1007/s12035-023-03526-1.

    • J. Lüken, G. Goerges, N. Ritter, P. Disse, J. A. Schreiber, J. Schmidt, B. Frehland, D. Schepmann, G. Seebohm, B. Wünsch. Indazole as phenol bioisostere: structure-affinity-relationships of GluN2B selective NMDA receptor antagonists. J. Med. Chem. 2023, 66: 11573 – 11588. doi: 10.1021/acs.jmedchem.3c01161.

    • M. Korff, A. Chaudhary, Y. Li, X. Zhou, C. Zhao, J. Rong, J. Chen, Z. Xiao, N. H. Elghazawy, W. Sippl, A. T. Davenport, J. B. Daunais, L. Wang, C. Abate, H. Ahmed, R. Crowe, T. J. Schmidt, S. H. Liang, S. M. Ametamey, B. Wünsch, A. Haider. Synthesis and biological evaluation of enantiomerically pure (R)- and (S)-[18F]OF-NB1 for imaging the GluN2B subunit-containing NMDA receptors. J. Med. Chem. 2023, accepted. doi: 10.1021/acs.jmedchem.3c0144.

    • T. Wegner†, A. Dombovski†, K. Gesing, A. Köhrer, M. Elinkmann, U. Karst, F. Glorius, J. Jose. Combining lipid-mimicking-enabled transition metal and enzyme mediated catalysis at the cell surface of E. coli. Chem. Sci. 2023. doi: 10.1039/D3SC02960C.
      † These authors contributed equally to this work

    • RT. Ngomba, A. Lüttjohann, A. Dexter, S. Ray, G. van Luijtelaar. The Metabotropic Glutamate 5 Receptor in Sleep and Wakefulness: Focus on the Cortico-Thalamo-Cortical Oscillations. Cells 2023, 12(13):1761. doi: 10.3390/cells12131761.

  • 2022

    • T. O. Paulisch, L. Mai, F. Strieth-Kalthoff, M.J. James, C. Henkel, D.M. Guldi, F. Glorius. Dynamic kinetic sensitization of β-dicarbonyl compounds - access to medium-sized rings by De Mayo-type ring expansion. Angew. Chem. Int. Ed. 2022, 61(5):e202112695. doi: 10.1002/anie.202112695.
    • E. Bechthold, J. A. Schreiber, N. Ritter, D. Schepmann, C. Daniliuc, G. Seebohm, B. Wünsch. Synthesis and biological evaluation of conformationally restricted GluN2B ligands derived from eliprodil. Eur. J. Med. Chem. 2022, 237:114359. doi: 10.1016/j.ejmech.2022.114359.
    • M. Korff, T. O. Paulisch, F. Glorius, N. L. Doltsinis, B. Wünsch. Photocatalytic isomerization of (E)-anethole to (Z)-anethole. Molecules. 2022, 27(16):5342. doi: 10.3390/molecules27165342.
    • E. Bechthold, J. A. Schreiber, N. Ritter, L. Grey, D. Schepmann, C. Daniliuc, R. González-Cano, F. R. Nieto, G. Seebohm, B. Wünsch. Synthesis of tropane-based σ1 receptor antagonists with antiallodynic activity. Eur. J. Med. Chem. 2022, 230:114113. doi: 10.1016/j.ejmech.2022.114113.
    • S. Peischard, M. Möller, P. Disse, T. H. Ho, A. O. Verkerk, N. Strutz-Seebohm, T. Budde, S. G. Meuth, P. A. Schweizer, S. Morris, L. Mücher, V. Eisner, D. Thomas, K. Klingel, K. Busch, G. Seebohm. Virus-induced inhibition of cardiac pacemaker channel HCN4 triggers bradycardia in human-induced stem cell system. Cell. Mol. Life Sci. 2022, 79(8):440. doi: 10.1007/s00018-022-04435-7.
    • T. Depmeier, T. Lange, W. Hanekamp, T. Strünker, M. Lehr. HPLC fluorescence assay for measuring the activity of diacylglycerol lipases and the action of inhibitors thereof. Anal. Biochem. 2022, 657:114889. doi: 10.1016/j.ab.2022.114889. 
    • T. Oniani, L. Vinnenberg, R. Chaudhary, J. A. Schreiber, K. Riske, B. Williams, H. C. Pape, J. A. White, A. Junker, G. Seebohm, S. G. Meuth, P. Hundehege, T. Budde, M. Zobeiri. Effects of axonal demyelination, inflammatory cytokines and divalent cation chelators on thalamic HCN channels and oscillatory bursting. Int. J. Mol. Sci. 2022, 23(11):6285. doi: 10.3390/ijms23116285.

                † These authors contributed equally to this work

    • S. Fuest, C. Post, S. T. Balbach, S. Jabar, I. Neumann, S. Schimmelpfennig, S. Sargin, E. Nass, T. Budde, S. Kailayangiri, B. Altvater, A. Ranft, W. Hartmann, U. Dirksen, C. Rössig, A. Schwab, Z. Pethő. Relevance of abnormal KCNN1 expression and osmotic hypersensitivity in Ewing sarcoma. Cancers. 2022, 14(19):4819. doi: 10.3390/cancers14194819.

                † These authors contributed equally to this work

    • C. P. Konken, K. Heßling, I. Thale, S. Schelhaas, J. Dabel, S. Maskri, E. Bulk, T. Budde, O. Koch, A. Schwab, B. Wünsch. Imaging of the calcium activated potassium channel 3.1 (KCa3. 1) in vivo using a senicapoc‐derived positron emission tomography tracer. Arch. Pharm. 2022, 355(12):e2200388. doi: 10.1002/ardp.202200388. 
    • H. Huang, P. Bellotti, J. Erchinger, T. O. Paulisch, F. Glorius. Radical carbonyl umpolung arylation via dual catalysis. J. Am. Chem. Soc. 2022, 144,1899-1909. doi: 10.1021/jacs.1c12199.
    • L. Epping, C. B. Schroeter, C. Nelke, S. Bock, L. Gola, N. Ritter, A. M. Herrmann, S. Räuber, A. Henes, J. Fernandez-Orth, W. Neuhaus, S. Bittner, T. Budde, M. Platten, S. Kovac, G. Seebohm, T. Ruck, M. Cerina, S. G. Meuth. Activation of non-classical NMDA receptors by glycine impairs barrier function of brain endothelial cells. Cell. Mol. Life Sci. 2022, 79(9):479. doi: 10.1007/s00018-022-04502-z.
    • R. Steigerwald, T. H. Chou, H. Furukawa, B. Wünsch. GluN2A-selective NMDA receptor antagonists: mimicking the U-shaped bioactive conformation of TCN-201 by a [2.2]paracyclophane system. ChemMedChem. 2022, 17(21):e202200484. doi: 10.1002/cmdc.202200484.
    • E. Bulk, L. M. Todesca, M. Bachmann, I. Szabo, M. Rieke, A. Schwab. Functional expression of mitochondrial KCa3.1 channels in non-small cell lung cancer cells. Pflügers Arch. 2022, 474(11):1147-1157. doi: 10.1007/s00424-022-02748-x.
    • M. F. Caliandro, F. Schmalbein, L. M. Todesca, M. Mörgelin, M. Rezaei, J. Meißner, I. Siepe, J. Grosche, A. Schwab, J. A. Eble. A redox-dependent thiol-switch and a Ca2+ binding site within the hinge region hierarchically depend on each other in α7β1 integrin regulation. Free Radic. Biol. Med. 2022, 187:38-49. doi: 10.1016/j.freeradbiomed.2022.05.013.
    • C. B. Schroeter, L. Rolfes, K. S. S. Gothan, J. Gruchot, A. M. Herrmann, S. Bock, L. Fazio, A. Henes, V. Narayanan, S. Pfeuffer, C. Nelke, S. Räuber, N. Huntemann, E. Duarte-Silva, V. Dobelmann, P. Hundehege, H. Wiendl, K. Raba, P. Küry, D. Kremer, T. Ruck, T. Müntefering, T. Budde, M. Cerina, S. G. Meuth. Cladribine treatment improves cortical network functionality in a mouse model of autoimmune encephalomyelitis. J. Neuroinflammation. 2022, 19(1):270. doi: 10.1186/s12974-022-02588-7.
    • L. Oster†, J. Schröder†, M. Rugi, S. Schimmelpfennig, S. Sargin, A. Schwab, K. Najder. Extracellular pH controls chemotaxis of neutrophil granulocytes by regulating LTB4 production and Cdc42 signaling. J. Immunol. 2022, 209(1):136-144. doi: 10.4049/jimmunol.2100475.

                † These authors contributed equally to this work

    • J. A. Schreiber, M. Möller, M. Zaydman, L. Zhao, Z. Beller, S. Becker, N. Ritter, P. Hou, J. Shi, J. Silva, E. Wrobel, N. Strutz-Seebohm, N. Decher, N. Schmitt, S. G. Meuth, M. Düfer, B. Wünsch, J. Cui, G. Seebohm. A benzodiazepine activator locks Kv7.1 channels open by electro-mechanical uncoupling. Commun. Biol. 2022, 5(1):301. doi: 10.1038/s42003-022-03229-8.

                † These authors contributed equally to this work 

    • R. Kleinmans, T. Pinkert, S. Dutta, T. O. Paulisch, H. Keum, C. G. Daniliuc, F. Glorius. Intermolecular [2π+2σ]-photocycloaddition enabled by triplet energy transfer. Nature2022, 605(7910):477-482. doi: 10.1038/s41586-022-04636-x.
  • 2021

    • E. Bechthold, J. A. Schreiber, K. Lehmkuhl, B. Frehland, D. Schepmann, F. A. Bernal, C. Daniliuc, I. Álvarez, C. Val Garcia, T. J. Schmidt, G. Seebohm, B. Wünsch. Ifenprodil stereoisomers: synthesis, absolute configuration, and correlation with biological activity. J. Med. Chem. 2021, 64(2):1170-1179. doi: 10.1021/acs.jmedchem.0c01912.
    • J. Menke, J. Massa, O. Koch. Natural product scores and fingerprints extracted from artificial neural networks. Comput. Struct. Biotechnol. J. 2021, 19:4593-4602. doi: 10.1016/j.csbj.2021.07.032.
    • A. Gresch, H. Noguera Hurtado, L. Wörmeyer, V. De Luca, R. Wiggers, G. Seebohm, B. Wünsch, M. Düfer. Selective inhibition of NMDA receptors with GluN2B subunit protects β cells against stress-induced apoptotic cell death. J. Pharmacol Exp. Ther. 2021, 379(3):235-244. doi: 10.1124/jpet.121.000807.

                † These authors contributed equally.

    • J. Menke, S. Maskri, O. Koch. Computational ion channel research: from the application of artificial intelligence to molecular dynamics simulations. Cell. Physiol. Biochem. 2021, 55(S3):14-45. doi: 10.33594/000000336.
    • L. M. Todesca, S. Maskri, K. Brömmel, I. Thale, B. Wünsch, O. Koch, A. Schwab. Targeting Kca3.1 channels in cancer. Cell. Physiol. Biochem. 2021, 55(S3):131-144. doi: 10.33594/000000374.
    • H. Wang, P. Bellotti, X. Zhang, T. O. Paulisch, F. Glorius. A base-controlled switch of SO2 reincorporation in photocatalyzed radical difunctionalization of alkenes. Chem. 2021, 7(12):3412-3424. doi: 10.1016/j.chempr.2021.10.007.
    • S. Kriegler, T. O. Paulisch, T. Wegner, F. Glorius, R. Winter. Bipolar imidazolium-based lipid analogues for artificial archaeosomes. Langmuir. 2021, 37(41):11996-12006. doi: 10.1021/acs.langmuir.1c01565.

                 † These authors contributed equally.

    • J.-H. Ye, P. Bellotti, T. O. Paulisch, C. G. Daniliuc, F. Glorius. Visible-light-induced cycloaddition of α-ketoacylsilanes with imines: facile access to β-lactams. Angew. Chem. Int. Ed. 2021, 60(24):13671-13676. doi: 10.1002/anie.202102451.
    • N. Ritter, M. Korff, A. Markus, D. Schepmann, G. Seebohm, J. A. Schreiber, B. Wünsch. Deconstruction - reconstruction: analysis of the crucial structural elements of GluN2B-selective, negative allosteric NMDA receptor modulators with 3-benzazepine scaffold. Cell. Physiol. Biochem. 2021, 55(S3):1-13. doi: 10.33594/000000335.
    • J. K. Jeschke, C. Biagioni, T. Schierling, I. V. Wagner, F. Börgel, D. Schepmann, A. Schüring, A. E. Kulle, P. M. Holterhus, M. von Wolff, B. Wünsch, V. Nordhoff, T. Strünker, C. Brenker. The action of reproductive fluids and contained steroids, prostaglandins, and Zn2+ on CatSper Ca2+ channels in human sperm. Front. Cell Dev. Biol. 2021, 9:699554. doi: 10.3389/fcell.2021.699554.
    • R. Rajan, D. Schepmann, R. Steigerwald, J. A. Schreiber, E. El-Awaad, J. Jose, G. Seebohm, B. Wünsch. [2.2]Paracyclophane-based TCN-201 analogs as GluN2A-selective NMDA receptor antagonists. ChemMedChem. 2021, 16(20):3201-3209. doi: 10.1002/cmdc.202100400.
    • E. Bulk, L. M. Todesca, A. Schwab. Ion channels in lung cancer. Rev. Physiol. Biochem. Pharmacol. 2021, 181:57-79. doi: 10.1007/112_2020_29.
    • M. Chamlali, S. Kouba, L. Rodat-Despoix, L. M. Todesca, Z. Pethö, A. Schwab, H. Ouadid-Ahidouch. Orai3 calcium channel regulates breast cancer cell migration through calcium-dependent and -independent mechanisms. Cells. 2021, 10(12):3487. doi: 10.3390/cells10123487.
    • F. Glaser, P. Hundehege, E. Bulk, L. M. Todesca, S. Schimmelpfennig, E. Nass, T. Budde, S. G. Meuth, A. Schwab. KCa channel blockers increase effectiveness of the EGF receptor TK inhibitor erlotinib in non-small cell lung cancer cells (A549). Sci Rep. 2021, 11(1):18330. doi: 10.1038/s41598-021-97406-0.
    • M. Patberg, A. Isaak, F. Fusser, N. V. Ortiz Zacarias, L. Vinnenberg, J. Schulte, L. Michetti, L. Grey, C. van der Horst, P. Hundehege, O. Koch, L. H. Heitman, T. Budde, A. Junker. Piperazine squaric acid diamides, a novel class of allosteric P2X7 receptor antagonists. Eur. J. Med. Chem. 2021, 226:113838. doi: 10.1016/j.ejmech.2021.113838.
    • L. Vinnenberg, S. Bock, P. Hundehege, T. Ruck, S. G. Meuth. Impact of diverse ion channels on regulatory T cell functions. Cell. Physiol. Biochem. 2021, 55(S3):145-156. doi: 10.33594/000000375.
    • M. Cerina, L. Fazio, S. G. Meuth. Electrophysiological measurements for brain network characterisation in rodents. In: Groppa S., G. Meuth, S. (eds) Translational Methods for Multiple Sclerosis Research. Neuromethods, vol 166. Humana, New York, NY. 2021, doi: 10.1007/978-1-0716-1213-2_9.
    • A. Schwab, T. Loeck, K. Najder-Nalepa. STIM2: Redox-sensor and effector of the (tumor) microenvironment. Cell Calcium. 2021, 94:102335. doi: 10.1016/j.ceca.2020.102335.
    • J. Menke, O. Koch. Using domain-specific fingerprints generated through neural networks to enhance ligand-based virtual screening. J. Chem. Inf. Model. 2021, 61(2):664-675. doi: 10.1021/acs.jcim.0c01208.
    • J. Menke, J. Massa, O. Koch. Natural product scores and fingerprints extracted from artificial neural networks. Comput. Struct. Biotechnol. J. 2021, 19:4593-4602. doi: 10.1016/j.csbj.2021.07.032.
    • V. Hofschröer, K. Najder, M. Rugi, R. Bouazzi, M. Cozzolino, A. Arcangeli, G. Panyi, A. Schwab. Ion channels orchestrate pancreatic ductal adenocarcinoma progression and therapy. Front. Pharmacol. 2021, 11:586599. doi: 10.3389/fphar.2020.586599.
    • D. Ilari, S. Maskri, D. Schepmann, J. Köhler, C. G. Daniliuc, O. Koch, B. Wünsch. Diastereoselective synthesis of conformationally restricted KOR agonists. Org. Biomol. Chem. 2021, 19, 4082-4099. doi: 10.1039/D1OB00398D.
  • 2020

    • H. Renner, M. Grabos, K. J. Becker, T. E. Kagermeier, J. Wu, M. Otto, S. Peischard, D. Zeuschner, Y. TsyTsyura, P. Disse, J. Klingauf, S. A. Leidel, G. Seebohm, H. R. Schöler, J. M. Bruder. A fully automated high-throughput workflow for 3D-based chemical screening in human midbrain organoids. Elife. 2020, 9:e52904. doi: 10.7554/eLife.52904.
    • L. Temme, E. Bechthold, J. A. Schreiber, S. Gawaskar, D. Schepmann, D. Robaa, W. Sippl, G. Seebohm, B. Wünsch. Negative allosteric modulators of the GluN2B NMDA receptor with phenylethylamine structure embedded in ring-expanded and ring-contracted scaffolds, Eur. J. Med. Chem. 2020, 190:112138. doi: 10.1016/j.ejmech.2020.112138.
    • K. Brömmel, S. Maskri, I. Maisuls, C. P. Konken, M. Rieke, Z. Pethő, C. A. Strassert, O. Koch, A. Schwab, B. Wünsch. Synthesis of small-molecule fluorescent probes for the in vitro imaging of calcium-activated potassium channel KCa3.1. Angew. Chem. Int. Ed. 2020, 59(21):8277-8284. doi: 10.1002/anie.202001201.
    • K. Brömmel, S. Maskri, E. Bulk, Z. Pethő, M. Rieke, T. Budde, O. Koch, A. Schwab, B. Wünsch. Co-staining of KCa3.1 channels in NSCLC cells with a small-molecule fluorescent probe and antibody-based indirect immunofluorescence. ChemMedChem. 2020, 15(24):2462-2469. doi: 10.1002/cmdc.202000652.
    • T. O. Paulisch, S. Bornemann, M. Herzog, S. Kudruk, L. Roling, A. L. Linard Matos, H.-J. Galla, V. Gerke, R. Winter, F. Glorius. An imidazolium‐based lipid analogue as gene transfer agent. Chem. Eur. J. 2020, 26(71):17176-17182. doi: 10.1002/chem.202003466. 
    • S. Bornemann, M. Herzog, L. Roling, T. O. Paulisch, D. Brandis, S. Kriegler, H.-J. Galla, F. Glorius, R. Winter. lnteraction of imidazolium-based lipids with phospholipid bilayer membranes of different complexity. Phys. Chem. Chem. Phys. 2020, 22, 9775-9788. doi: 10.1039/D0CP00801J.

                † These authors contributed equally.

    • J. L. Schwarz, R. Kleinmans, T. O. Paulisch, F. Glorius. 1,2-Amino alcohols via Cr/photoredox dual-catalyzed addition of α‑amino carbanion equivalents to carbonyls. J. Am. Chem. Soc. 2020, 142(5):2168-2174. doi: 10.1021/jacs.9b12053.
    • E. Bollmann, J. A. Schreiber, N. Ritter, S. Peischard, H. T. Ho, B. Wünsch, T. Strünker, S. G. Meuth, T. Budde, N. Strutz-Seebohm, G. Seebohm. 4,4'-Diisothiocyanato-2,2'-stilbenedisulfonic acid (DIDS) modulates the activity of KCNQ1/KCNE1 channels by an interaction with the central pore region. Cell. Physiol. Biochem. 2020, 54(2):321-332. doi: 10.33594/000000222.
    • Z. Pethő, K. Najder, T. Carvalho, R. McMorrow, L. M. Todesca, M. Rugi, E. Bulk, A. Chan, CWGM Löwik, S. J. Reshkin, A. Schwab. pH-channeling in cancer: How pH-dependence of cation channels shapes cancer pathophysiology. Cancers. 2020, 12(9):2484. doi: 10.3390/cancers12092484.
    • K. Najder, M. Rugi, M. Lebel, J. Schröder, L. Oster, S. Schimmelpfennig, S. Sargin, Z. Pethő, E. Bulk, A. Schwab. Role of the intracellular sodium homeostasis in chemotaxis of activated murine neutrophils. Front. Immunol. 2020, 11:2124. doi: 10.3389/fimmu.2020.02124.
  • 2019

    • J. A. Schreiber, D. Schepmann, B. Frehland, S. Thum, M. Datunashvili, T. Budde, M. Hollmann, N. Strutz-Seebohm, B. Wünsch, G. Seebohm. A common mechanism allows selective targeting of GluN2B subunit-containing N-methyl-D-aspartate receptors. Commun Biol 2019, 2, 420. doi: 10.1038/s42003-019-0645-6.

    This work was awarded with the PHOENIX Pharmazie Wissenschaftspreis 2020.