Topics of research
ChemBIon project description
In the last decades increasing knowledge about the role of ion channels in the immune system has revealed their importance for immune cell effector mechanisms, both in health and under pathophysiological conditions. Cellular ion-based mechanisms are elementary for basic functions of the immune system. Despite our advanced understanding about ion channels on lymphocytes, computer modelling of the electrophysiological behaviour of resting and activated human CD4+ T cells revealed a discrepancy in current amplitudes that might also point to a so far unknown, depolarizing ion conductance functionally affecting T cell electrophysiology. Until today, hyperpolarization-activated and cyclic nucleotide-gated (HCN) ion channels are well described on neurons and cardiomyocytes, but not much is known about their role on immune cells.
The goal of this project: Since HCN channels maintain a stable resting membrane potential and closely interact with other channels expressed on immune cells, we aim at investigating expression and function of HCN channels under physiological and pathophysiological conditions.
Scientific assistant at the Institute of Translational Neurology (Department of Neurology), Münster Germany
Scientific Manager at the Institute of Translational Neurology (Department of Neurology), Münster Germany
Responsible for animal welfare issues at the department of neurology, Münster Germany
01/2014 - 10/2018
Junior Group Leader– „CiM – Cells-in-Motion” Cluster of Excellence, DFG
01/2011 - 02/2016
Scientific assistant at the neurology clinic in Münster, Germany
07/2010 - 12/2010
Scientific assistant at the Institute of Physiology I (Neurophysiology), Westphalian Wilhelms-University Münster
PhD, Institute of Physiology I (Neurophysiology), Westphalian Wilhelms-University Münster (supervisor: Prof. Dr. Th. Budde)
10/2001 - 04/2006
Biology studies in Cologne, Germany; Diploma thesis at the Research Centre in Jülich Germany (Supervisor: Prof. Dr. A. Baumann)