Publications
2025
Richens, J.H.*, Dmitrieva, M.*, Zenner, H.L., Muschalik, N., Butler, R., Glashauser, J., Camelo, C., Luschnig, S., Munro, S., Rittscher, J., and St Johnston, D. (2025). MSP-tracker: A versatile vesicle tracking software tool used to reveal the spatial control of polarized secretion in Drosophila epithelial cells. PLoS Biology 23(4): e3003099. doi.org/10.1371/journal.pbio.3003099.
Jacobs, T., Isasti Sanchez, J., Reger, S., and Luschnig, S. (2025). Rho/Rok-dependent regulation of actomyosin contractility at tricellular junctions restricts epithelial permeability in Drosophila. Current Biology 35(6): 1181-1196. doi.org/10.1016/j.cub.2025.01.043.
2024
Schleutker, R., and Luschnig, S. (2024). Palmitoylation of proteolipid protein M6 promotes tricellular junction assembly in epithelia of Drosophila. Journal of Cell Science 137(6): jcs261916. doi.org/10.1242/jcs.261916.
Luschnig, S. (2024). Flies Use Blood Cells to Take a Deep Breath. Nature d41586-024-01649–6. doi.org/10.1038/d41586-024-01649-6.
2023
Glashauser, J.*, Camelo, C.*, Hollmann, M., Backer, W., Jacobs, T., Isasti Sanchez, J., Schleutker, R., Förster, D., Berns, N., Riechmann, V., and Luschnig, S. (2023). Acute manipulation and real-time visualization of membrane trafficking and exocytosis in Drosophila. Developmental Cell 58(8): 709-723.e7. doi.org/10.1016/j.devcel.2023.03.006.
Chandran, L., Backer, W., Schleutker, R., Kong, D., Beati, S.A.H., Luschnig, S.#, and Müller, H.-A.J.# (2023). Src42A is required for E-cadherin dynamics at cell junctions during Drosophila axis elongation. Development 150 (2): dev201119. doi.org/10.1242/dev.201119.
2022
Labbaf, Z., Petratou, K., Ermlich, L., Backer, W., Tarbashevich, K., Reichman-Fried, M., Luschnig, S., Schulte-Merker, S., and Raz, E. (2022). A robust and tunable system for targeted cell ablation in developing embryos. Developmental Cell 57(16): 2026-2040.e5. doi.org/10.1016/j.devcel.2022.07.008.
Gass, M., Borkowsky, S., Lotz, M.-L., Siwek, R., Schröter, R., Nedvetsky, P., Luschnig, S., Rohlmann, A., Missler, M., and Krahn, M.P. (2022). PI(4,5)P2 controls slit diaphragm formation and endocytosis in Drosophila nephrocytes. Cellular and Molecular Life Sciences 79(5): 248. doi.org/10.1007/s00018-022-04273-7
Camelo, C., Körte, A., Jacobs, T., and Luschnig, S. (2022). Tracheal tube fusion in Drosophila involves release of extracellular vesicles from multivesicular bodies. Journal of Cell Science 135(3): jcs259590. doi.org/10.1242/jcs.259590.
2021
Isasti-Sanchez, J., Münz-Zeise, F., Lancino, M., and Luschnig, S. (2021). Transient opening of tricellular vertices controls paracellular transport through the follicle epithelium during Drosophila oogenesis. Developmental Cell 56, 1083-1099.e5. doi.org/10.1016/j.devcel.2021.03.021. Highlighted by minireview in the same issue.
Camelo, C.# and Luschnig, S.# (2021). Cells into tubes: Molecular and physical principles underlying lumen formation in tubular organs. In Cellular Networks in Development. Current Topics in Developmental Biology (143) pp. 37–74. doi.org/10.1016/bs.ctdb.2020.09.002.
2020
Gross-Thebing, S., Truszkowski, L., Tenbrinck, D., Sánchez-Iranzo, H., Camelo, C., Westerich, K.J., Singh, A., Maier, P., Prengel, J., Lange, P., Hüwel, J., Gaede, F., Sasse, R., Vos, B.E., Betz, T., Matis, M., Prevedel, R., Luschnig, S., Diz-Muñoz, A., Burger, M., and Raz, E. (2020). Using migrating cells as probes to illuminate features in live embryonic tissues. Science Advances (6), eabc5546. doi.org/10.1126/sciadv.abc5546.
Wittek, A., Hollmann, M., Schleutker, R., and Luschnig, S. (2020). The transmembrane proteins M6 and Anakonda cooperate to initiate tricellular junction assembly in epithelia of Drosophila. Current Biology (30): 4254–4262.e4255. doi.org/10.1016/j.cub.2020.08.003.
2019
Sauerwald, J., Backer, W., Matzat, T., Schnorrer, F., and Luschnig, S. (2019). Matrix metalloproteinase 1 modulates invasive behavior of tracheal branches during entry into Drosophila flight muscles. eLife pii: e48857. doi.org/10.7554/eLife.48857.
Caviglia, S., Flores-Benitez, D., Lattner, J., Luschnig, S., and Brankatschk, M. (2019). Rabs on the fly: Functions of Rab GTPases during development Small GTPases 10(2): 89-98. doi.org/10.1080/21541248.2017.1279725.
2018
Loison, O., Weitkunat, M., Kaya-Çopur, A., Nascimento Alves, C., Matzat, T., Spletter, M.L., Luschnig, S., Brasselet, S., Lenne, P.-F. and Schnorrer, F. (2018). Polarization-resolved microscopy reveals a muscle myosin motor-independent mechanism of molecular actin ordering during sarcomere maturation PLoS Biology 16(4):e2004718. doi.org/10.1371/journal.pbio.2004718.
Nelson, J.O., Förster, D., Frizzell, K., Luschnig, S., and Metzstein, M.M. (2018). Multiple Nonsense-Mediated mRNA Processes Require Smg5 in Drosophila Genetics 209(4): 1073-1084. doi.org/10.1534/genetics.118.301140.
Beati, H., Peek, I., Hordowska, P., Honemann-Capito, M., Glashauser, J., Renschler, F., Kakanj, P., Ramrath, A., Leptin, M., Luschnig, S., Wiesner, S., and Wodarz, A. (2018). The adherens junction-associated LIM domain protein Smallish regulates epithelial morphogenesis. Journal of Cell Biology 217(3): 1079–1095. doi.org/10.1083/jcb.201610098.
2017
Sauerwald, J., Soneson, C., Robinson, M.D., and Luschnig, S. (2017). Faithful mRNA splicing depends on the Prp19 complex subunit faint sausage and is required for tracheal branching morphogenesis in Drosophila. Development 144(4): 657-663. doi.org/10.1242/dev.144535
2016
Misra, T., Baccino Calace, M., Meyenhofer, T., Rodriguez-Crespo, D., Akarsu, H., Armenta-Calderón, R., Gorr, T.A., Frei, C., Cantera, R., Egger, B., and Luschnig, S. (2016). A genetically encoded biosensor for visualizing hypoxia responses in vivo. Biology Open 6(2): 296-304. doi.org/10.1242/bio.018226.
Caviglia, S., Brankatschk, M., Fischer, E., Eaton, S., and Luschnig, S. (2016). Staccato/Unc-13-4 controls secretory lysosome-mediated lumen fusion during epithelial tube anastomosis. Nature Cell Biology 18(7): 727–739. doi.org/10.1038/ncb3374.
De Lella Ezcurra, A.L., Bertolin, A.P., Kim, K., Katz, M.J., Gándara, L., Misra, T., Luschnig, S., Perrimon, N., Melani, M., and Wappner, P. (2016). miR-190 enhances HIF-dependent responses to hypoxia in Drosophila by inhibiting the prolyl-4-hydroxylase Fatiga. PLoS Genetics 12, e1006073. doi.org/10.1371/journal.pgen.1006073.
2015
Byri, S., Misra, T., Syed, Z.A., Bätz, T., Shah, J., Boril, L., Glashauser, J., Aegerter-Wilmsen, T., Matzat, T., Moussian, B., Uv, A., and Luschnig, S. (2015). The triple-repeat protein Anakonda controls epithelial tricellular junction formation in Drosophila. Developmental Cell 33(5): 535-48. doi.org/10.1016/j.devcel.2015.03.023.
2014
Bätz, T., Förster, D., and Luschnig, S. (2014). The transmembrane protein Macroglobulin complement-related is essential for septate junction formation and epithelial barrier function in Drosophila. Development 141(4): 899-908. doi.org/10.1242/dev.102160.
Caviglia, S#. and Luschnig, S. (2014)#. Tube fusion: making connections in branched tubular networks. Seminars in Cell and Developmental Biology 31: 82-90. doi.org/10.1016/j.semcdb.2014.03.018.
Luschnig, S. and Uv, A. (2014). Luminal matrices: An inside view on organ morphogenesis. Experimental Cell Research 321(1): 64-70. doi.org/10.1016/j.yexcr.2013.09.010.
2013
Caviglia, S. and Luschnig, S. (2013). The ETS domain transcriptional repressor Anterior open inhibits MAP Kinase and Wingless signaling to couple tracheal cell fate with branch identity. Development 140(6): 1240-1249. doi.org/10.1242/dev.087874.
2012
Förster, D. and Luschnig, S. (2012). Src42A-dependent polarized cell shape changes mediate epithelial tube elongation in Drosophila. Nature Cell Biology 14(5): 526–534. doi.org/10.1038/ncb2456.
Armbruster, K. and Luschnig, S. (2012). The Drosophila Sec7 domain Guanine Nucleotide Exchange Factor protein Gartenzwerg localizes at the cis-Golgi and is essential for epithelial tube expansion. Journal of Cell Science, 125(5): 1318–1328. doi.org/10.1242/jcs.096263.
2011
Grillo, M., Furriols, M., Casanova, J., and Luschnig, S. (2011). Control of germline torso expression by the BTB/POZ domain protein Pipsqueak is required for embryonic terminal patterning in Drosophila. Genetics 187(2): 513-21. doi.org/10.1534/genetics.110.121624.
2010
Stein, D., Charatsi, I., Zhang, Z., Cho, Y.S., Nguyen, J., Delotto, R., Luschnig, S.#, and Moussian, B.# (2010). Localization and Activation of the Drosophila Protease Easter Requires the Saposin-Like ER Protein Seele. Current Biology 20(21): 1953-58. doi.org/10.1016/j.cub.2010.09.069.
Förster, D., Armbruster, K., and Luschnig, S. (2010). Sec24-dependent secretion drives cell-autonomous expansion of tracheal tubes in Drosophila. Current Biology 20(1): 62-68. doi.org/10.1016/j.cub.2009.11.062.
2009
Kim, S., Gailite, I., Moussian, B., Luschnig, S., Goette, M., Fricke, K., Honemann-Capito, M., Grubmüller, H., and Wodarz, A. (2009). Kinase-activity-independent functions of atypical protein kinase C in Drosophila. Journal of Cell Science 122(Pt 20): 3759-71. doi.org/10.1242/jcs.052514.
2008
Grieder, N.C., Caussinus, E., Parker, D.S., Cadigan, K., Affolter, M., and Luschnig, S. (2008). gammaCOP is required for apical protein secretion and epithelial morphogenesis in Drosophila melanogaster. PLoS ONE 19;3(9): e3241. doi.org/10.1371/journal.pone.0003241.
Haecker, A., Bergman, M., Neupert, C., Moussian, B., Luschnig, S., Aebi, M., and Mannervik, M. (2008). Wollknäuel is required for embryo patterning and encodes the Drosophila ALG5 UDP-glucose:dolichyl-phosphate glucosyltransferase. Development 135: 1745-1749. doi.org/10.1242/dev.020891.
Muraro, N.I., Weston, A. J., Gerber, A.P., Luschnig, S., Moffat, K.G., and Baines, R.A. (2008). Pumilio binds para mRNA and requires Nanos and Brat to regulate sodium current in Drosophila motoneurons. Journal of Neuroscience 28(9): 2099-109. doi.org/10.1523/JNEUROSCI.5092-07.2008.
2007
Haecker, A., Qi, D., Lilja, T., Moussian, B., Andrioli, L.P., Luschnig, S., and Mannervik, M. (2007). Drosophila brakeless interacts with atrophin and is required for tailless-mediated transcriptional repression in early embryos. PLoS Biology 5(6): e145. doi.org/10.1371/journal.pbio.0050145.
2006
Gerber, A.P., Luschnig, S., Krasnow, M.A., Brown, P.O., and Herschlag, D. (2006). Genome-wide identification of mRNAs associated with the translational regulator PUMILIO in Drosophila melanogaster. Proc Natl Acad Sci USA 103(12): 4487–4492. doi.org/10.1073/pnas.0509260103. F1000 rating 6.
Luschnig, S., Bätz, T., Armbruster, K., and Krasnow, M.A (2006). serpentine and vermiform encode matrix proteins with chitin binding and deacetylation domains that limit tracheal tube length in Drosophila. Current Biology 16(2):186-94. doi.org/10.1016/j.cub.2005.11.072
2005
Devine, W.P., Lubarsky, B., Shaw, K., Luschnig, S., Messina, L., and Krasnow, M.A. (2005). Requirement for chitin biosynthesis in epithelial tube morphogenesis. Proc Natl Acad Sci USA 102: 17014-17019. doi.org/10.1073/pnas.0506676102. F1000 rating 10.
2004
Bartoszewski, S., Luschnig, S., Desjeux, I., Grosshans, J., and Nüsslein-Volhard, C. (2004). Drosophila p24 homologues eclair and baiser are necessary for the activity of the maternally expressed Tkv receptor during early embryogenesis. Mechanisms of Development 121(10): 1259-73. doi.org/10.1016/j.mod.2004.05.006.
Luschnig, S., Moussian, B., Krauss, J., Desjeux, I., Perkovic, J., and Nüsslein-Volhard, C. (2004). An F1 genetic screen for maternal-effect mutations affecting embryonic pattern formation in Drosophila melanogaster. Genetics 167(1): 325-42. doi.org/10.1534/genetics.167.1.325.
2003
Charatsi, I., Luschnig, S., Bartoszewski, S., Nüsslein-Volhard, C., and Moussian, B. (2003). Krapfen/dMyd88 is required for the establishment of dorsoventral pattern in the Drosophila embryo. Mechanisms of Development 120(2): 219-226. doi.org/10.1016/S0925-4773(02)00410-0.
Ghabrial, A.*, Luschnig, S.*, Metzstein, M.M.*, and Krasnow, M.A. (2003). Branching morphogenesis of the Drosophila tracheal system. Annual Review in Cell and Developmental Biology 19: 623-47. doi.org/10.1146/annurev.cellbio.19.031403.160043.
2002
Schnorrer, F., Luschnig, S., Koch, I., and Nüsslein-Volhard, C. (2002). Gamma-tubulin37C and gamma-tubulin ring complex protein 75 are essential for bicoid RNA localization during Drosophila oogenesis. Developmental Cell (5): 685-96. doi.org/10.1016/S1534-5807(02)00301-5. F1000 rating 9.
2000
Luschnig, S., Krauss, J., Bohmann, K., Desjeux, I., and Nüsslein-Volhard, C. (2000). The Drosophila SHC adaptor protein is required for signaling by a subset of receptor tyrosine kinases. Molecular Cell 5(2): 231-41. doi.org/10.1016/S1097-2765(00)80419-0.