Markus Damme (University of Kiel)

Moving or not - lysosomal traffic jam in the axon

Host: Christian Klämbt

Lysosomes are degradative organelles of eukaryotic cells that mediate the catabolism of various metabolites, including proteins, oligosaccharides, and complex lipids, to lower molecular weight metabolites that can be reused for biosynthetic processes. In neurons, lysosomes are critical for the last steps of autophagy, mediating the degradation of protein aggregates. Lysosomes are dynamic organelles transported via microtubules and microtubule-binding motor proteins throughout the cell. Different motor-cargo adaptor complexes have been described, connecting lysosomes with both dynein and kinesin. The presence of lysosomes in the axon of neurons is just emerging, and mechanisms regulating their transport in the axon are still poorly understood. I will give an overview of different mouse models and our recent work on axonal trafficking defects of lysosomes in the axon.

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