Schematic representation of an antibody-modified nanoparticle system for drug targeting application
Schematic representation of an antibody-modified nanoparticle system for drug targeting application

Pharmaceutical technology / Nanostructured dosage forms

The Langer working group is interested in the research field of pharmaceutical / medical nanotechnology, which will be further expanded in the coming years. Nanostructured carrier systems for various drug classes are developed, which actively affect the body distribution of the transported substances in terms of “drug targeting”. As medical application, tumor therapy as well as a diagnostic usage of the systems are in the main focus. For this purpose, on the basis of different starting materials of natural and synthetic origin drug carrier systems are developed, whereas the carrier’s surface properties are optimized regarding a target cell interaction and a prevented accumulation of non-target cells. A particular focus of future work is on the scaling of the preparation methods aiming at preparations, which can be obtained on the pilot-plant scale and thus find access to clinical applications.

Relevant preliminary work:

  1. Light-responsive nanoparticles based on new polycarbonate polymers as innovative drug delivery systems for photosensitizers in PDT
    Anderski J, Mahlert L, Sun J, Birnbaum W, Mulac D, Schreiber S, Herrmann F, Kuckling D, Langer K.  Int. J. Pharm. 557, 182-191 (2019)
  2. Mucus-penetrating nanoparticles: Promising drug delivery systems for the photodynamic therapy of intestinal cancer
    Anderski J, Mahlert L, Mulac D, Langer K. Eur. J. Pharm. Biopharm. 129, 1-9 (2018)
  3. Modifying plasmid-loaded HSA-nanoparticles with cell penetrating peptides - cellular uptake and enhanced gene delivery
    Mesken J, Iltzsche A, Mulac D, Langer K. Int. J. Pharm. 522, 198-209 (2017)