Thiemo Daldrup

Institute of Physiology I
Robert-Koch-Str. 27a
D-48149 Münster

Phone: +49 (0) 251/83 55561
Fax.: +49 (0) 251/83 55551


Joined OCC in 2011

Research Project

Neuronal correlates of hippocampal activity at phasic and sustained fear in fear conditioned mice.

Regions of the ventral and dorsal hippocampus differentially contribute to processes of learning and memory. While animals with dorsal hippocampal lesions show deteriorations in cognitive functions like e.g. spatial memory (Morris et al., 1982; O’Keefe and Nadel, 1978; Gaskin and White, 2006), lesions in ventral hippocampus impair animals fear behavior in respective behavioral paradigms (e.g. “open-field”, “elevated-plus-maze”; Hock and Bunsey, 1998; McHugh et al., 2004; Kjelstrup et al., 2002; Pentowski et al., 2006). So far, distinct contributions of both brain regions to the processes of conditioned fear have not been investigated. Thus, the aim of this study is to investigate the neuronal correlates of hippocampal activity (field potential-, single cell recordings) in phasic and sustained fear after fear conditioning in mice.

PhD Committee

Prof. Dr. T. Budde
Prof. Dr. N. Sachser
Prof. Dr. H.-C. Pape


Lange, M. D.*, Daldrup, T.*, Remmers, F., Szkudlarek, H. J., Lesting, J., Guggenhuber, S., … Pape, H. C. (2017). Cannabinoid CB1 receptors in distinct circuits of the extended amygdala determine fear responsiveness to unpredictable threat. Molecular Psychiatry, Epub ahead of print.
*equal contribution

Daldrup T, Lesting J, Meuth P, Seidenbecher T, Pape H-C (2016) Neuronal correlates of sustained fear in the anterolateral part of the bed nucleus of stria terminalis. Neurobiology of Learning and Memory. 131: 137-146. doi:10.1016/j.nlm.2016.03.020

Daldrup T*, Remmes J*, Lesting J, Gaburro S, Fendt M, Meuth P, Kloke V, Pape H-C, Seidenbecher T (2015) Expression of freezing and fear-potentiated startle during sustained fear in mice. Genes Brain Behav 14:281–291. doi:10.1111/gbb.12211.
*equal contribution

Lesting J*, Daldrup T*, Narayanan V, Himpe C, Seidenbecher T, Pape H-C (2013) Directional theta coherence in prefrontal cortical to amygdalo-hippocampal pathways signals fear extinction. PLoS One 8:e77707. doi:10.1371/journal.pone.0077707.
*equal contribution

Conference Contributions

Folta K, Grube D, Rammsayer T, Keller K, Daldrup T, Treue S. (2009).
Learning-induced changes of an attentional check-up mechanism of interval timing in non-human primates.
German Neuroscience Society Meeting, Göttingen.  

Daldrup T, Folta K, Treue S. (2010).
Interval timing: Interference suppression in rhesus-monkeys and humans.
Primate Neurobiology Meeting, Tübingen.


*1981 Münster, Germany
2004-2005 studies in Landscape Ecology, University of Münster
2005-2008 studies in Biology, Justus-Liebig-University Gießen
2008 Bachelor Degree in Biology; Bachelor Thesis: “Impact of attentional distractors on non-human primates subjective time-perception: Effects of modality, position and behavioral relevance“; Supervisor: Prof. Dr. R. Lakes-Harlan, Justus-Liebig University, Gießen; Prof. Dr. K. Folta, German Primate Center, Göttingen
2008-2010 studies in Biology, University of Münster
2009 Research project “The tactile Morris’ Water-Maze: Influences of transcranial magnetstimulation (TMS) on rats’ learning behavior and cortical plasticity.” Dept. of Neurophysiology, Medical Faculty of Ruhr-University, Bochum
2009 Research project “Task-switch in the reversed-gap-paradigm: Mechanisms of attention and time processing in non-human primates.” Cognitive Neuroscience Laboratory, German Primate Center, Göttingen
2010 M.Sc. Degree (Biological Sciences); Master Thesis: “Interaction of attentional and prospective time-related processes in nonhuman primates: interference-induced modulation of subjective time perception”, Cognitive Neuroscience Laboratory, German Primate Center, Göttingen; Supervisor: Prof. Dr. K. Folta, University of Hildesheim
2011 Beginning of PhD research project, Institute of Physiology I, University of Münster