Research Project

In the field of psychiatric research, the analysis of neuronal development and function plays an important role. Neuronal proteins are usually modified by molecular processes such as palmitoylation, which are essential for their correct function. The palmitoyl-acyltransferase ZDHHC7 reversibly binds palmitic acids to target proteins and mediates functions that are relevant for neuronal development, synaptic function and plasticity in the brain. Furthermore, ZDHHC7 has been indirectly associated with mental diseases, which often occur as a result of stress, via its targets.


In my research project, I investigate the role of ZDHHC7 in the sex-specific stress response of mice.

PhD Committee

Prof. Dr. Weiqi Zhang
Prof. Dr. Ralf Stanewsky
Prof. Dr. Cornelius Faber

Publications

Gorinski, N., Wojciechowski, D., Guseva, D., Abdel Galil, D., Mueller, F. E., Wirth, A., Thiemann, S., Zeug, A., Schmidt, S., Zareba-Kozioł, M., Wlodarczyk, J., Skryabin, B. V., Glage, S., Fischer, M., Al-Samir, S., Kerkenberg, N., Hohoff, C., Zhang, W., Endeward, V., & Ponimaskin, E. (2020). DHHC7-mediated palmitoylation of the accessory protein barttin critically regulates the functions of ClC-K chloride channels. The Journal of biological chemistry, 295(18), 5970–5983. https://doi.org/10.1074/jbc.RA119.011049

Redlich, R., Schneider, I., Kerkenberg, N., Opel, N., Leehr, E. J., Bauhaus, J., … Dannlowski, U. (2019). The role of BDNF methylation and Val 66 Met in amygdala reactivity during emotion processing. (April), 1–11. https://doi.org/10.1002/hbm.24825

Hohoff, C., Zhang, M., Ambreé, O., Kravchenko, M., Buchert, J., Kerkenberg, N., … Zhang, W.(2019). Deficiency of the palmitoyl acyltransferase ZDHHC7 impacts brain and behavior of mice in a sex-specific manner. 224(6), 2213–2230.https://doi.org/10.1007/s00429-019-01898-6

Conference Contributions

Kerkenberg, N., Wachsmuth, L., Schettler, C., Struffert, L., Siebert, L. M., Breuer, F., Ponimaskin, E., Faber, C., Baune, B. T., Hohoff, C., Zhang, W. (2020) Ongoing brain microstructural changes in adult mice and their modification by the palmitoyl acyltransferase ZDHHC7. Poster presented at the FENS 2020 Virtual Forum.

Hohoff, C., Zhang, M., Ambree, O., Kravchenko, M., Buschert, J., Kerkenberg, N., Schettler, C., vom Werth, K.L., Wewer, M.F.J., Schneider, I., Grotegerd, D., Wachsmuth, L., Faber, C., Skryabin, B.V., Brosius, J., Ponimaskin, E., Zhang, W. (2018). ZDHHC7-deficiency sex-specifically impacts brain and behavior of mice. Poster Presentation at the Small Animal MRI Symposium 2018, Muenster, Germany.

CV

*1992 Hamm, Germany
2011–2015

studies in Biomedical Engineering at the Hamm-Lippstadt University of Applied Sciences, Germany

2015-2018

studies in Biology at the University of Münster, Germany

Since 2018 PhD research project, Department of Psychiatry and Psychotherapy, University of Münster, Germany