Behavioral profiles are strongly shaped by the individual's whole-life experience. Many studies in human and rodents alike suggest that an accumulation of negative encounters over lifetime (allostatic load hypothesis) is particularly detrimental since it is considered to promote anxiety-like behavior. On the contrary, overall positive experiences are thought to facilitate learning and resilience leaving the individual less vulnerable to develop an anxiety-like phenotype. The more recent ‘match/mismatch hypotheses’ is taking life phases into consideration by suggesting that a non-conformity between a beneficial early life and an adverse later-life environment leads to an increase in anxiety levels. However, a wholistic lifetime approach in mice is needed to understand how these over lifetime acquired behavioral profiles not only in- or decrease the susceptibility of the expression of anxiety-related behaviors, but especially how they shape fear memory and extinction learning in the adult mouse. My main research focuses on the investigation of life history effects on fear memory and extinction learning in mice.
Prof. Hans-Christian Pape
Prof. Norbert Sachser
Dr. Thomas Seidenbecher
Remmes, J; Bodden, C; Richter, SH; Lesting, J; Sachser, N; Pape, HC, Seidenbecher, T (2016): Impact of Life History on Fear Memory and Extinction. Frontiers in Behavioral Neuroscience 10: 185. doi:10.3389/fnbeh.2016.00185
Daldrup T*, Remmes J*, Lesting J, Gaburro S, Fendt M, Meuth P, Kloke V, Pape H-C, Seidenbecher T (2015) Expression of freezing and fear-potentiated startle during sustained fear in mice. Genes Brain Behav 14:281–291. doi:10.1111/gbb.12211.
J. Remmes, C. Bodden, N. Sachser, H.-C.Pape, T. Seidenbecher (2015): Impact of life history on fear memory and extinction in mice. Poster Presentation 11th Meeting of the German Neuroscience Society, At Göttingen, Germany, Volume: T25-11B
J. Remmes, C. Bodden, N. Sachser, H.-C.Pape, T. Seidenbecher (2014): Impact of life history on fear memory and extinction in mice. Poster Presentation Neurovisionen 10; Forschungszentrum Jülich Germany
J. Remmes, C. Bodden, N. Sachser, H.-C.Pape, T. Seidenbecher (2014): Influence of life history on fear memory and extinction in mice. Poster Presentation, Radboud Summer School: “Stress & Cognition: From basic mechanisms to psychopathology”, Nijmegen, Netherlands
J. Remmes, M. Mattheisen, T. Mittelstaedt, K. Pernhorst, E.‐M. Eibel, A. Raabe, M. Alexander, S.Cichon, A. J. Becker, S. Schoch (2010): Genetic basis of Levetiracetam pharmacoresistance and side effects in human epilepsy. Poster Presentation, 3rd Annual Meeting of NGFN‐Plus and NGFN‐Transfer in the Program of Medical Genome Research, At Berlin, Germany
|2003-2011||Diploma studies in Biology at the University of Bonn|
|2007-2011||Student assistant, Department of Neuropathology and Epileptology, Universitäts Klinikum, Bonn|
|2011||Diploma student, Department of Neuropathology and Epileptology, Universitäts Klinikum, Bonn|
|2012||Research Associate at the Institute of Physiology 1, Münster|
|2013||Beginning of PhD research project at the Institute of Physiology 1, Münster|