Hui-Fen Chen
© Hiu-Fen Chen
Hui-Fen Chen
Translational Research Imaging Center
University Hospital of Psychiatry and Psychotherapy
Room Gebäude A16
Albert-Schweitzer-Campus 1
48149 Münster
T: +49 (0) 251/83 56279
F: +49 (0) 251/83 52067

Joined OCC in 2021

Research Project

My PhD project is focused on the investigation of sex differences in peripheral and spinal signaling pathways and changes in supraspinal networks relevant for pain-related behaviors following acute incisional and chronic neuropathic pain in mice. We propose a unique approach by combining a versatile set of behavioral outcomes, precise spatiotemporal optogenetic probing, supraspinal fMRI-based network analysis, as well as multiple in vitro assays to probe functional changes in a subset of spinal inhibitory neurons after both injuries.

Lots of evidences showed that male and female have different pain processing and expression due to distinct psychological, biological and social factors. However, the pain literature is indeed male-biased. Thus, we expect to describe sex differences longitudinally in distinct pain-related behaviors, the contribution of spinal GABAergic neurons, and changes in the supraspinal connectomes after INC and SNI in mice. Results from this project will serve as a basis for future project proposals (ERC and DFG) further investigating sex-specific mechanisms of acute and chronic pain.

PhD Committee

Prof. Dr. rer. nat. Cornelius Faber
Prof. Dr. med. Esther Pogatzki-Zahn
Prof. Dr. Helene Richter


Hsin-Yi Lai, Lun-De Liao, Chin-Teng Lin, Jui-Hsiang Hsu, Xin He, You-Yin Chen, Jyh-Yeong Chang, Hui-Fen Chen, Siny Tsang and Yen-Yu I Shih. Design, simulation and experimental validation of a novel flexible neural probe for deep brain stimulation and multichannel recording. J Neural Eng. 2012 Jun;9(3):036001

Conference Contributions

Szu-Ming Chen, Ming-Shiuan Chiue, Hui-Fen Chen, Jyh-Horng Chen and Ruey-Shyang Hseu. The effects of ganoderma lucidum on the cerebral blood flow and neurotransmitters in Alzheimimer’s disease rat model. The XXVth ICMRBS, 2012.

Yun-An Huang, Hui-Fen Chen, Ming-Shiuan Chiueh, Edzer L. Wu, Meng-Chi Hsieh, Tzi-Dar Chiueh, and Jyh-Horng Chen. 3D high resolution T2 and T2* rat brain imaging using Wideband MRI technique. The 21th ISMRM, 2013.

Hui-Fen Chen, Anna Fejtova, Seda Salar. The effect of C-terminal binding protein 1 deletion on excitatory synaptic transmission in the CA1 region of the hippocampus. The 7th International IZKF-Symposium, 2019.


*1984 Taipei, Taiwan
2002–2006 Bachelor B.Sc. in Entomology at the National Chung Hsing University, Taichung, Taiwan
2007-2008 Research assistant, Graduate Institute of Pharmaceutical Sciences, National Taiwan University, Taipei, Taiwan
2008-2009 Research assistant, Institute of Pharmacology, National Taiwan University, Taipei, Taiwan
2009-2010 Research assistant, Graduate Institute of Acupuncture Science, China Medical University, Taichung, Taiwan
2011-2014 Assistant technician, 7T Animal MRI Core Lab of Neurobiology and Cognitive Science Center, National Taiwan University, Taipei, Taiwan
2015-2018 M.Sc. in Developmental, Neural and Behavioral Biology at the University Göttingen, Göttingen, Germany
2018 Student assistant, Max Planck Institute for Biophysical Chemistry, Göttingen
2019 Beginning of PhD research project, Universitätsklinikum Erlangen, Erlangen
2020 PhD student at the University of Münster