Prof. Dr. Thomas Budde

Institute of Physiology I
Robert-Koch-Str. 27a
D-48149 Münster

Phone: +49 (0)251 / 83 – 55533
Fax: +49 (0)251 / 83 – 55551

Research Areas

The main scientific questions addressed in our lab are: What are the cellular and molecular mechanisms underlying the typical activity states of thalamic neurons during sleep and arousal? And why do physiological sleep oscillations (like spindling) in some patients suffering from absence epilepsy change into pathophysiological spike-and-wave discharges? To answer these questions, I am combining electrophysiological (patch clamp, extracellular recording), molecular biological (RT-PCR, in situ hybridization), immunological (immunohistochemisitry, Western blot), imaging (Ca2+ imaging), and computational modelling techniques.
Fig.: Electrophysiological setup suitable for patch clamp experiments in brain slices.

Selected Publications

T. Broicher, H.-J. Bidmon, B. Kamuf, P. Coulon, A. Gorji, H.-C. Pape,  E.-J. Speckmann & T. Budde (2010). Thalamic afferent activation of supragranular layers in auditory cortex in vitro: a voltage sensitive dye study. Neurosci. 165: 371-85.

V. Rankovic, P. Ehling, P. Coulon, P. Landgraf, M. R. Kreutz, T. Munsch* & T. Budde* (2010). Intracellular Ca2+ release-dependent inactivation of Ca2+ currents in thalamocortical relay neurons. Europ. J. Neurosci 31: 439–449. *equal contribution

S. Bittner, N. Bobak, A. M. Herrmann, K. Göbel, P. Meuth, K. G. Höhn, M.-P. Stenner, T. Budde, H. Wiendl* & S. G. Meuth* (2010). The potassium channel K2P5.1 (TASK2) as a new target for multiple sclerosis. Annals of Neurology 68: 58-69. *equal contribution

N. Decher*, A. K. Streit*, M. Rapedius, M. F. Netter, S. Marzian, P. Ehling, G. Schlichthörl, T. Craan, V. Renigunta, A. Köhler, R. C. Dodel, R. Navarro-Pollanco, R. Preisig-Müller, G. Klebe, T. Budde, T. Baukrowitz & J. Daut (2010). RNA editing modulates the binding of drugs and highly unsaturated fatty acids to the open pore of Kv potassium channels. EMBO J. 29: 2101-13. *equal contribution

P. Ehling*, S. Bittner*, N. Bobak, T. Schwarz, H. Wiendl, T. Budde, C. Kleinschnitz & S. G. Meuth (2010). Two pore domain potassium channels in cerebral ischemia: a focus on K2P9.1 (TASK3, KCNK9). Experimental & Translational Stroke Medicine 2: 14. *equal contribution

D. Hagenfeld, T. Schulz, P. Ehling, T. Budde, U. Schumacher & P. Prehm (2010). Depolarisation of the membrane potential by hyaluronan. J. Cell. Biochem 111: 858-864.

Academic CV

1981-1982 Civil engineering, Ruhr-Universität Bochum, Germany
1982-1990 Diploma, Biology, Ruhr-Universität Bochum, Germany Dissertation title: The cAMP-dependent regulation of calcium release from sarcoplasmic reticulum in isolated heart muscle cells
1990-1993 Ph.D., Natural sciences, Ruhr-Universität Bochum, Germany Dissertation title: Characterization of membrane conductances in neurons acutely isolated from the rat lateral geniculate nucleus
17.03.2000 Habilitation and venia legendi in Physiology, Otto-von-Guericke-Universität Magdeburg.
Dissertation title: Subcellular mechanisms of functional regulation in identified neurons of the brain
17.04.2007 Nomination as non-ordinary professor by the dean of the Medical Faculty of the Westfälische Wilhelms-Universität Münster