Prof. Dr. Rebekka LencerInstitute for Translational PsychiatryAlbert-Schweitzer-Campus 1 D - 48149 Münster Phone: +49 (0)251 / 83-52581 Fax: +49 (0)251 / 83-57128 Email: lencer@uni-muenster.de |
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Research Areas
- Neurocognition and sensorimotor processing in psychosis
- Neuropsychiatric disorders in (genetically determined) movement disorder
- Cortical networks for oculomotor function
- Defining neurophysiological intermediate phenotypes for genetic analyses
Fig.1-3: Visual exploration of daily live scenes
Selected Publications
Lencer R, Mills LJ, Alliey-Rodriguez N; Shafee R, Lee A, Reilly JL, Sprenger A, McDowell JE, McCarroll SA, Keshavan MS, Pearlson GD, Tamminga CA,Clementz BA, Gershon ES, Sweeney JA, Bishop JR (2017). Genome-wide association studies of smooth pursuit and antisaccade eye movements in psychotic disorders: findings from the B-SNIP study. Translational Psychiatry 7, e1249; doi:10.1038/tp.2017.210
Lencer R, Meermeier A, Silling K, Gremmler S, Lappe M (2017) Instability of visual error processing for sensorimotor adaptation in schizophrenia. European Archives of Psychiatry and Clinical Neuroscience 267(3):237-244.
Trillenberg P, Sprenger A, Talamo S, Herold K, Helmchen C, Verleger R, Lencer R (2017) Visual and non-visual motion information processing during pursuit eye tracking in schizophrenia and bipolar disorder. European Archives of Psychiatry and Clinical Neuroscience 267(3):225-235.
Lencer R, Sprenger A, Reilly JL, McDowelld JE, Rubin LH, Badner JA, Keshavan MS, Pearlson GD, Tamminga CA, Gershon ES, Clementz BA, Sweeney JA (2015) Pursuit eye movements as an intermediate phenotype across psychotic disorders: evidence from the B-SNIP study. Schizophrenia Research, 169(1-3): 326-333.
Lencer R, Nagel M, Sprenger A, Zapf S, Erdmann C, Heide W, Binkofski F (2004) Cortical mechanisms of smooth pursuit eye movements with target blanking. An fMRI study. European Journal of Neuroscience, 19 (5):1430-6.
Academic CV
| 1984-1990 | Studies of human medicine and romanistic at the Universities in Bochum and Berlin, stay abroad in Cadiz, Spain |
| 1990 | Medical state examination |
| 1993 | Promotion |
| 1994 | Full approbation |
| 1993–1998 | Member of the research group „Molecular genetic and phenotypic markers in families with multiple occurrence of psychosis“ and „Oculomotor performance and schizophrenia“, Leadership: Prof. V. Arolt, Prof. E. Schwinger, Prof. W. Heide, Lübeck |
| 1993-2000 | Assistent doctor at the department of Psychiatry und Psychotherapy, University of Lübeck |
| 1998–1999 | Assistent doctor at the department of Neurology, University of Lübeck |
| 1999 | Medical specialist for Psychiatry und Psychotherapy |
| since 1999 | Leader of the research group „Neurobiology of psychotic disorders“ |
| 2001 | Senior physician at the department of Psychiatry und Psychotherapy, University of Lübeck |
| 2007-2009 | Research Fellow at the Center for Cognitive Medicine, University of Illinois at Chicago, USA |
| 2010 | Professor of Psychiatry and Psychotherapy, University of Lübeck |
| 2010 | Leader of the research group “Perception and Action in Psychiatric Disorders”, University of Münster |
| since 2010 | Vice chair of the department of Psychiatry and Psychotherapy, University of Münster |
| 2014 | Professor of Psychiatry and Psychotherapy, University of Münster |
| since 2014 | Speaker of the Otto Creutzfeldt Center for Cognitive and Behavioral Neuroscience, WWU Münster |
| 2018 | Visiting professor Institute of Social Sciences and Psychology, Western Sydney University, Australia (5 weeks) |
Honours and Special Recognitions
| 1998 | Young Scientist Award (Winter Workshop on Schizophrenia (Prof. Stephen Hirsch, Prof. Timothy Crow, London) |
| 2002, 2006 | Senior Scientist Award (Winter Workshop on Schizophrenia (Prof. Stephen Hirsch, Prof. Timothy Crow, London) |
Research Database CRIS@WWU
Project
- mHealth psychoeducational intervention versus antipsychotic-induced effects – mPIVAS ()
EU-Project Hosted outside the University of Münster: EC - Lifelong Learning Programme: Leonardo da Vinci | Project Number: 2013-1-HR1-LEO04-032256
- mHealth psychoeducational intervention versus antipsychotic-induced effects – mPIVAS ()
Research Articles (Journals)
- Buschermöhle, Y., Höltershinken, M., Erdbrügger, T., Radecke, J.-O., Sprenger, A., Schneider, T., Lencer, R., Gross, J., and Wolters, C.H. . “Comparing the Performance of Beamformer Algorithms in Estimating Orientations of Neural Sources.” iScience 27 (3) 109150. doi: 10.1016/j.isci.2024.109150.
- Schijven, D, Postema, MC, Fukunaga, M, Matsumoto, J, Miura, K, de Zwarte, SMC, van Haren, NEM, Cahn, W, Hulshoff, Pol HE, Kahn, RS, Ayesa-Arriola, R, Ortiz-García, de la Foz V, Tordesillas-Gutierrez, D, Vázquez-Bourgon, J, Crespo-Facorro, B, Dahl, A, Alnæs, D, Agartz, I, Westlye, LT, Jönsson, EG, Andreassen, OA, Bruggemann, JM, Kochunov, P, Michie, PT, Catts, SV, Quidé, Y, Mowry, BJ, Schall, U, Rasser, PE, Carr, VJ, Scott, RJ, Loughland, CM, Pantelis, C, Green, MJ, Henskens, FA, de Haan, L, Brosch, K, Weickert, CS, Weickert, TW, Stein, F, Jansen, A, Pfarr, JK, Ringwald, KG, Krämer, B, Gruber, O, Kircher, TTJ, Nenadić, I, Preda, A, Mathalon, DH, Bustillo, J, Satterthwaite, TD, Chen, J, Potkin, SG, Ford, JM, Calhoun, VD, Fan, F, Xiang, H, Wang, Z, Tan, Y, Garcia-Leon, MA, Fuentes-Claramonte, P, Ehrlich, S, Bernardoni, F, Ciullo, V, Piras, F, Vecchio, D, Banaj, N, Guerrero-Pedraza, A, Salvador, R, Sarró, S, Pomarol-Clotet, E, Voineskos, AN, Sim, K, Ciufolini, S, Dazzan, P, Spalletta, G, Michielse, S, van Amelsvoort, T, Dickie, EW, Borgwardt, S, Schmidt, A, Whalley, HC, McIntosh, AM, Kim, WS, Murray, RM, Andreou, C, Chung, YC, Grotegerd, D, Emsley, R, Dannlowski, U, Lencer, R, du, Plessis S, Lawrie, SM, Scheffler, F, Luckhoff, HK, Pergola, G, Bertolino, A, Antonucci, LA, Fazio, L, Stephen, JM, Mayer, AR, Edmond, JT, Rootes-Murdy, K, Cervenka, S, Sellgren, CM, Tomyshev, AS, Lebedeva, I, Lois, NG, Arango, C, Díaz-Caneja, CM, Janssen, J, Kwak, YB, Kim, M, Spaniel, F, Skoch, A, Hajek, T, Kaiser, S, Kirschner, M, Georgiadis, F, Uhlmann, A, Oertel, V, Stäblein, M, Knöchel, C, Bakker, G, James, A, Kwon, JS, Oh, S, Homan, P, Surbeck, W, Franke, B, Fisher, SE, Gur, RC, Glahn, DC, Jahanshad, N, Hashimoto, R, Stein, DJ, Howells, FM, Diaz-Zuluaga, AM, Temmingh, HS, López-Jaramillo, C, Pineda-Zapata, JA, Ji, E, Homan, S, Luders, E, Medland, SE, Thompson, PM, Turner, JA, van Erp, TGM, and Francks, C. . “Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium.” Proceedings of the National Academy of Sciences of the United States of America 120 (14): e2213880120–e2213880120. doi: 10.1073/pnas.2213880120.
- Schijven, D, Postema, MC, Fukunaga, M, Matsumoto, J, Miura, K, de Zwarte, SMC, van Haren, NEM, Cahn, W, Hulshoff, Pol HE, Kahn, RS, Ayesa-Arriola, R, Ortiz-García, de la Foz V, Tordesillas-Gutierrez, D, Vázquez-Bourgon, J, Crespo-Facorro, B, Dahl, A, Alnæs, D, Agartz, I, Westlye, LT, Jönsson, EG, Andreassen, OA, Bruggemann, JM, Kochunov, P, Michie, PT, Catts, SV, Quidé, Y, Mowry, BJ, Schall, U, Rasser, PE, Carr, VJ, Scott, RJ, Loughland, CM, Pantelis, C, Green, MJ, Henskens, FA, de Haan, L, Brosch, K, Weickert, CS, Weickert, TW, Stein, F, Jansen, A, Pfarr, JK, Ringwald, KG, Krämer, B, Gruber, O, Kircher, TTJ, Nenadić, I, Preda, A, Mathalon, DH, Bustillo, J, Satterthwaite, TD, Chen, J, Potkin, SG, Ford, JM, Calhoun, VD, Fan, F, Xiang, H, Wang, Z, Tan, Y, Garcia-Leon, MA, Fuentes-Claramonte, P, Ehrlich, S, Bernardoni, F, Ciullo, V, Piras, F, Vecchio, D, Banaj, N, Guerrero-Pedraza, A, Salvador, R, Sarró, S, Pomarol-Clotet, E, Voineskos, AN, Sim, K, Ciufolini, S, Dazzan, P, Spalletta, G, Michielse, S, van Amelsvoort, T, Dickie, EW, Borgwardt, S, Schmidt, A, Whalley, HC, McIntosh, AM, Kim, WS, Murray, RM, Andreou, C, Chung, YC, Grotegerd, D, Emsley, R, Dannlowski, U, Lencer, R, du, Plessis S, Lawrie, SM, Scheffler, F, Luckhoff, HK, Pergola, G, Bertolino, A, Antonucci, LA, Fazio, L, Stephen, JM, Mayer, AR, Edmond, JT, Rootes-Murdy, K, Cervenka, S, Sellgren, CM, Tomyshev, AS, Lebedeva, I, Lois, NG, Arango, C, Díaz-Caneja, CM, Janssen, J, Kwak, YB, Kim, M, Spaniel, F, Skoch, A, Hajek, T, Kaiser, S, Kirschner, M, Georgiadis, F, Uhlmann, A, Oertel, V, Stäblein, M, Knöchel, C, Bakker, G, James, A, Kwon, JS, Oh, S, Homan, P, Surbeck, W, Franke, B, Fisher, SE, Gur, RC, Glahn, DC, Jahanshad, N, Hashimoto, R, Stein, DJ, Howells, FM, Diaz-Zuluaga, AM, Temmingh, HS, López-Jaramillo, C, Pineda-Zapata, JA, Ji, E, Homan, S, Luders, E, Medland, SE, Thompson, PM, Turner, JA, van Erp, TGM, and Francks, C. . “Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium.” Proceedings of the National Academy of Sciences of the United States of America 120 (14): e2213880120–e2213880120. doi: 10.1073/pnas.2213880120.
- Radecke, J.-O., Sprenger, A., Stöckler, H., Espeter, L., Reichhardt, M., Thomann, L.S., Erdbrügger, T., Buschermöhle, Y., Borgwardt, S., Schneider, T.R., Gross, J., Wolters, C.H., and Lencer, R. . “Normative tDCS over V5 and FEF reveals practice-induced modulation of extraretinal smooth pursuit mechanisms.” Scientific Reports 13 21380. doi: 10.1038/s41598-023-48313-z.
- Erdbrügger, T., Westhoff, A., Höltershinken, M., Radecke, J.-O., Buschermöhle, Y., Buyx, A., Wallois, F., Pursiainen, S., Gross, J., Lencer, R., Engwer, C., and Wolters, C.H. . “CutFEM forward modeling for EEG source analysis.” Frontiers in Human Neuroscience 17 1216758. doi: 10.3389/fnhum.2023.1216758.
- Schwarzer, JM, Meyhoefer, I, Antonucci, LA, Kambeitz-Ilankovic, L, Surmann, M, Bienek, O, Romer, G, Dannlowski, U, Hahn, T, Korda, A, Dwyer, DB, Ruef, A, Haas, SS, Rosen, M, Lichtenstein, T, Ruhrmann, S, Kambeitz, J, Salokangas, RKR, Pantelis, C, Schultze-Lutter, F, Meisenzahl, E, Brambilla, P, Bertolino, A, Borgwardt, S, Upthegrove, R, Koutsouleris, N, and Lencer, R. . “The impact of visual dysfunctions in recent-onset psychosis and clinical high-risk state for psychosis.” Neuropsychopharmacology 47 (12): 2051–2060. doi: 10.1038/s41386-022-01385-3.
- Trubetskoy, Vassily; Pardinas, Antonio F.; Qi, Ting; (..); Arolt, Volker; (..); Baune, Bernhard T.; (..); Indonesia Schizophrenia Consortium; PsychENCODE; Psychosis Endophenotypes Int Conso; SynGO Consortium; Psychiat Genomics Consortium. . “Mapping genomic loci implicates genes and synaptic biology in schizophrenia.” Nature 604: 502–508. doi: 10.1038/s41586-022-04434-5.
- Trempler, I., Binder, E., Reuter, M., Plieger, T., Standke, I., Mecklenbrauck, F., Kaltwasser, I., Meinert, S., Forstner, A.J., Noethen, M., Rietschel, M., Stürmer, S., Dannlowski, U., Tittgemeyer, M., Lencer, R., Fink, G.R., and Schubotz, R.I. . “Effects of DRD2/ANKK1 and COMT Val158Met polymorphisms on stabilization against and adaptation to unexpected vents.” Cerebral cortex 32 (24): 5698–5715. doi: 10.1093/cercor/bhac046.
- Xiao, Y, Liao, W, Long, Z, Tao, B, Zhao, Q, Luo, C, Tamminga, CA, Keshavan, MS, Pearlson, GD, Clementz, BA, Gershon, ES, Ivleva, EI, Keedy, SK, Biswal, BB, Mechelli, A, Lencer, R, Sweeney, JA, Lui, S, and Gong, Q. . “Subtyping Schizophrenia Patients Based on Patterns of Structural Brain Alteration.” Schizophrenia Bulletin 48. doi: 10.1093/schbul/sbab110.
- Dwyer, DB, Buciuman, MO, Ruef, A, Kambeitz, J, Sen Dong, M, Stinson, C, Kambeitz-Ilankovic, L, Degenhardt, F, Sanfelici, R, Antonucci, LA, Lalousis, PA, Wenzel, J, Urquijo-Castro, MF, Popovic, D, Oeztuerk, OF, Haas, SS, Weiske, J, Hauke, D, Neufang, S, Schmidt-Kraepelin, C, Ruhrmann, S, Penzel, N, Lichtenstein, T, Rosen, M, Chisholm, K, Riecher-Rössler, A, Egloff, L, Schmidt, A, Andreou, C, Hietala, J, Schirmer, T, Romer, G, Michel, C, Rössler, W, Maj, C, Borisov, O, Krawitz, PM, Falkai, P, Pantelis, C, Lencer, R, Bertolino, A, Borgwardt, S, Noethen, M, Brambilla, P, Schultze-Lutter, F, Meisenzahl, E, Wood, SJ, Davatzikos, C, Upthegrove, R, Salokangas, RKR, and N, Koutsouleris. . “Clinical, Brain, and Multilevel Clustering in Early Psychosis and Affective Stages.” JAMA Psychiatry 79: 677–689. doi: 10.1001/jamapsychiatry.2022.1163.
- Eskridge, CLM, Hochberger, WC, Kaseda, ET, Lencer, R, Reilly, JL, Keedy, SK, Keefe, RSE, Pearlson, GD, Keshavan, MS, Tamminga, CA, Sweeney, JA, and Hill, SK. . “Deficits in generalized cognitive ability, visual sensorimotor function, and inhibitory control represent discrete domains of neurobehavioral deficit in psychotic disorders.” Schizophrenia Research 236. doi: 10.1016/j.schres.2021.07.036.
- Standke, I, Trempler, I, Dannlowski, U, Schubotz, RI, and Lencer, R. . “Cerebral and behavioral signs of impaired cognitive flexibility and stability in schizophrenia spectrum disorders.” NeuroImage: Clinical 32 102855. doi: 10.1016/j.nicl.2021.102855.
- Wenzel J, Haas SS Dwyer DB Ruef A Oeztuerk OF Antonucci LA von Saldern S Bonivento C Garzitto M Ferro A Paolini M Blautzik J Borgwardt S Brambilla P Meisenzahl E Salokangas RKR Upthegrove R Wood SJ Kambeitz J Koutsouleris N Kambeitz-Ilankovic L, and U), PRONIAconsortium (Dannlowski. . “Cognitive subtypes in recent onset psychosis: distinct neurobiological fingerprints?” Neuropsychopharmacology 46: 1475–1483.. doi: 10.1038/s41386-021-00963-1.
- Koutsouleris, N, Dwyer, DB, Degenhardt, F, Maj, C, Urquijo-Castro, MF, Sanfelici, R, Popovic, D, Oezturk, O, Haas, SS, Weiske, J, Ruef, A, Kambeitz-Ilankovic, L, Antonucci, LA, Neufang, S, Schmidt-Kraepelin, C, Ruhrmann, S, Penzel, N, Kambeitz, J, and Haidl, TK … Meisenzahl E. . “Multimodal Machine Learning Workflows for Prediction of Psychosis in Patients With Clinical High-Risk Syndromes and Recent-Onset Depression.” JAMA Psychiatry 78. doi: 10.1001/jamapsychiatry.2020.3604.
- Popovic D, Ruef A Dwyer DB Antonucci LA Eder J Sanfelici R Kambeitz-Ilankovic L Oztuerk OF Dong MS Paul R Paolini M Hedderich D Haidl T Kambeitz J Ruhrmann S Chisholm K Schultze-Lutter F Falkai P Pergola G Blasi G Bertolino A Lencer R Dannlowski U Upthegrove R Salokangas RKR Pantelis C Meisenzahl E Wood SJ Brambilla P Borgwardt S Koutsouleris N, and Consortium, PRONIA. . “Traces of Trauma: A Multivariate Pattern Analysis of Childhood Trauma, Brain Structure, and Clinical Phenotypes.” Biological Psychiatry 88. doi: 10.1016/j.biopsych.2020.05.020.
- Rojnic, Kuzman M., Andlauer, O., Burmeister, K., Dvoracek, B., Lencer, R., Koelkebeck, K., Maric, N., Nawka, A., Pantovic-Stefanovic, M., Riese, F., Aukst, Margetic B., Bosnjak, D., Ruzic, M., Curkovic, M., Grubsin, J., Madzarac, Z., Makaric, P., Petric, D., Radic, K., and Savic, A. . “Effective assessment of psychotropic medication side effects using PsyLOG mobile application.” Schizophrenia Research null (null). doi: 10.1016/j.schres.2017.04.038.
- Lencer, R., Meermeier, A., Silling, K., Gremmler, S., and Lappe, M. . “Instability of visual error processing for sensorimotor adaptation in schizophrenia.” European Archives of Psychiatry and Clinical Neuroscience 2016.
- Kuzman, M., Andlauer, O., Burmeister, K., Dvoracek, B., Lencer, R., Koelkebeck, K., Nawka, A., and Riese, F. . “The psylog mobile application: Development of a tool for the assessment and monitoring of side effects of psychotropic medication.” Psychiatria Danubina 29 (2): 214–217.
- Gonzalez-Hernandez, J.A., Pita-Alcorta, C., Wolters, C.H., Padron, A., Finale, A., Galan-Garcia, L., Marot, M., and Lencer, R. . “Specificity and sensitivity of visual evoked potentials in the diagnosis of schizophrenia: Rethinking VEPs.” Schizophrenia Research 2015 (166): 231–234. doi: 10.1016/j.schres.2015.05.007.
- Lindner, C., Dannlowski, U., Walhöfer, K., Rödiger, M., Maisch, B., Bauer, J., Ohrmann, P., Lencer, R., Zwitserlood, P., Kersting, A., Heindel, W., Arolt, V., Kugel, H., and Suslow, T. . “Social alienation in schizophrenia patients: Association with insula responsiveness to facial expressions of disgust.” PloS one 9 (1). doi: 10.1371/journal.pone.0085014.
- Suslow, T., Lindner, C., Dannlowski, U., Walhöfer, K., Rödiger, M., Maisch, B., Bauer, J., Ohrmann, P., Lencer, R., Zwitserlood, P., Kersting, A., Heindel, W., Arolt, V., and Kugel, H. . “Automatic amygdala response to facial expression in schizophrenia: Initial hyperresponsivity followed by hyporesponsivity.” BMC Neuroscience 14. doi: 10.1186/1471-2202-14-140.
Supervised Doctoral Studies
- Surmann, Marian (): Wie kann die Behandlung von Betroffenen mit psychotischen Erkrankungen verbessert werden? Eine Verschiebung des Behandlungsfokus jenseits der Pharmakotherapie.
- Supervisors
- Zwitserlood, Pienie
- Lencer, Rebekka
- Reviewers
- Bölte, Jens
- Lencer, Rebekka
- Surmann, Marian (): Wie kann die Behandlung von Betroffenen mit psychotischen Erkrankungen verbessert werden? Eine Verschiebung des Behandlungsfokus jenseits Pharmakotherapie.
- Supervisors
- Bölte, Jens
- Zwitserlood, Pienie
- Lencer, Rebekka
- Zwitserlood, Pienie
- Reviewers
- Bölte, Jens
- Lencer, Rebekka
- Trempler, Ima Carolyn (): Neurocognitive Mechanisms of Flexibility and Stability of Prediction and their lmpairment in Parkinson's Disease
- Supervisors
- Schubotz, Ricarda I.
- Lencer, Rebekka
- Fink, Gereon
- Lencer, Rebekka
- Surmann, Marian (): Wie kann die Behandlung von Betroffenen mit psychotischen Erkrankungen verbessert werden? Eine Verschiebung des Behandlungsfokus jenseits der Pharmakotherapie.