Research Areas
Prof. Bernhard Baune (PhD, MD, MPH, FRANZCP) is the Director of the University Hospital of Psychiatry and Psychotherapy, University of Münster, Germany. Prof. Baune is a Fellow of the Royal Australian and New Zealand College of Psychiatrist (FRANZCP), Australia. He is a professorial Fellow of the Department of Psychiatry, University of Melbourne and a Professorial Fellow of the Florey Mental Health Theme at the Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Australia.
He leads an extensive research program into personalised psychiatry, molecular psychiatry, prediction and biomarker research in psychiatry and treatment response prediction and in neuroimmunology. Key research achievements include an in-depth understanding of the interaction between the immune and nervous system, the development of a systems biology approach for response prediction and the establishment of innovative personalised clinical trials in major psychiatric disorders. He has a particular interest in cognitive function and psychosocial function in psychiatric disorders and in the severe course of mental illness, treatment response and recovery. Prof. Baune designs and conducts personalized randomized clinical trials that take clinical and biological information into account to inform treatments. He is developing novel pharmacological and psychological treatments for improving emotion processing, cognitive function and functional outcomes in mood disorders.
Prof. Baune’s translational work aims to make real-world differences to the lives of people with mental illness by integrating neurobiological and clinical information, by personalising treatments and by targeting the mechanisms of functional recovery.
Prof. Baune currently leads an international study on the genomics of cognitive function in depression; in addition, he founded and directs an international consortium on the genomics of severe depression and response to ECT in affective disorders (GenECT-ic) and leads an international research network on transnosological pharmacogenomics and transcriptomics of treatment response. His research is nationally and internationally funded and he has published more than 470 peer-reviewed articles, reviews and book chapters, edited several text books in Psychiatry, and most recently the books “Personalised Psychiatry” and “Inflammation and Immunity of Depression”.
Keywords: Genomics and transcriptomics of treatment response; Personalised Psychiatry; Immune-Neurobiology; Neurobiology of Functional Outcomes; biomarker research for mechanistic and prediction research
Selected Publications
Amare AT, KO Schubert, ConLiGen Consortium, Baune BT (2018) A polygenic score for schizophrenia and HLA and inflammation genes predict response to lithium in Bipolar Affective Disorder. JAMA Psychiatry, Jan 1;75(1):65-74. IF15.307
Pardiñas AF, Holmans P, Pocklington AJ, Escott-Price V, Ripke S, Carrera N, Legge S, Bishop S, Cameron D, Hamshere ML, Han J, HubbardL, Lynham A, Mantripragada K, Rees E, MacCabe JH, McCarroll SA, Baune BT, Breen G, Byrne EM, Dannlowski U, Eley TC, Hayward C, Martin NG, McIntosh AM, Plomin R, Porteous DJ, Wray NR, Caballero A, Geschwind DH, Huckins LM, Ruderfer DM, Santiago E, Sklar P, Stahl EA, Won H, Agerbo E, Andreassen OE, Bækvad-Hansen M, MortensenPB, Bøcker Pedersen C, Børglum AD, Bybjerg-Grauholm J, Als TD, Djurovic S, Durmishi N, Giørtz Pedersen M, Golimbet V, Grove J, Hougaard DM, Mattheisen M, Molden E, Mors O, Nordentoft M, Pejovic-Milovancevic M, Sigurdsson E, Silagadze T, Søholm Hansen C, Stefansson K, Stefansson H, Steinberg S, Tosato S, Werge T, GERAD1 Consortium, Collier DA, Rujescu D, Kirov G, Owen MJ, O’Donovan MC, Walters MTR (2018) Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection. Nat Genetics, 50(3):381-389 IF 27.959
Wray NR, Ripke S, Mattheisen M, Trzaskowski M, Byrne EM, Abdellaoui A, Adams MJ, Agerbo E, Air TM, Andlauer TMF, Bacanu SA, Bækvad-Hansen M, Beekman AFT, Bigdeli TB, Binder EB, Blackwood DRH, Bryois J, Buttenschøn HN, Bybjerg-Grauholm J, Cai N, Castelao E, Christensen JH, Clarke TK, Coleman JIR, Colodro-Conde L, Couvy-Duchesne B, Craddock N, Crawford GE, Crowley CA, Dashti HS, Davies G, Deary IJ, Degenhardt F, Derks EM, Direk N, Dolan CV, Dunn EC, Eley TC, Eriksson N, Escott-Price V, Kiadeh FHF, Finucane HK, Forstner AJ, Frank J, Gaspar HA, Gill M, Giusti-Rodríguez P, Goes FS, Gordon SD, Grove J, Hall LS, Hannon E, Hansen CS, Hansen TF, Herms S, Hickie IB, Hoffmann P, Homuth G, Horn C, Hottenga JJ, Hougaard DM, Hu M, Hyde CL, Ising M, Jansen R, Jin F, Jorgenson E, Knowles JA, Kohane IS, Kraft J, Kretzschmar WW, Krogh J, Kutalik Z, Lane JM, Li Y, Li Y, Lind PA, Liu X, Lu L, MacIntyre DJ, MacKinnon DF, Maier RM, Maier W, Marchini J, Mbarek H, McGrath P, McGuffin P, Medland SE, Mehta D, Middeldorp CM, Mihailov E, Milaneschi Y, Milani L, Mill J, Mondimore FM, Montgomery GW, Mostafavi S, Mullins N, Nauck M, Ng B, Nivard MG, Nyholt DR, O'Reilly PF, Oskarsson H, Owen MJ, Painter JN, Pedersen CB, Pedersen MG, Peterson RE, Pettersson E, Peyrot WJ, Pistis G, Posthuma D, Purcell SM, Quiroz JA, Qvist P, Rice JP, Riley BP, Rivera M, Saeed Mirza S, Saxena R, Schoevers R, Schulte EC, Shen L, Shi J, Shyn SI, Sigurdsson E, Sinnamon GBC, Smit JH, Smith DJ, Stefansson H, Steinberg S, Stockmeier CA, Streit F, Strohmaier J, Tansey KE, Teismann H, Teumer A, Thompson W, Thomson PA, Thorgeirsson TE, Tian C, Traylor M, Treutlein J, Trubetskoy V, Uitterlinden AG, Umbricht D, Van der Auwera S, van Hemert AM, Viktorin A, Visscher PM, Wang Y, Webb BT, Weinsheimer SM, Wellmann J, Willemsen G, Witt SH, Wu Y, Xi HS, Yang J, Zhang F; eQTLGen; 23andMe, Arolt V, Baune BT, Berger K, Boomsma DI, Cichon S, Dannlowski U, de Geus ECJ, DePaulo JR, Domenici E, Domschke K, Esko T, Grabe HJ, Hamilton SP, Hayward C, Heath AC, Hinds DA, Kendler KS, Kloiber S, Lewis G, Li QS, Lucae S, Madden PFA, Magnusson PK, Martin NG, McIntosh AM, Metspalu A, Mors O, Mortensen PB, Müller-Myhsok B, Nordentoft M, Nöthen MM, O'Donovan MC, Paciga SA, Pedersen NL, Penninx BWJH, Perlis RH, Porteous DJ, Potash JB, Preisig M, Rietschel M, Schaefer C, Schulze TG, Smoller JW, Stefansson K, Tiemeier H, Uher R, Völzke H, Weissman MM, Werge T, Winslow AR, Lewis CM, Levinson DF, Breen G, Børglum AD, Sullivan PF; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. (2018) Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nat Genetics, May;50(5):668-681.
Milaneschi Y, Lamers F, Peyrot WJ, Baune BT, Breen G, Dehghan A, Forstner AJ, Grabe HJ, Homuth G, Kan C, Lewis C, Mullins N, Nauck M, Pistis G, Preisig M, Rivera M, Rietschel M, Streit F, Strohmaier J, Teumer A, Van der Auwera S, Wray NR, Boomsma DI, Penninx BWJH; CHARGE Inflammation Working Group and the Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (2017) The “weight” of depression: genetic overlap between major depression with atypical features and obesity immune-metabolic dysregulations. JAMA Psychiatry, Dec 1;74(12):1214-1225
Ciobanu LG, Sachdev PS, Trollor JN, Reppermund S, Thalamuthu A, Mather KA, Cohen-Woods S, Baune BT (2016) Differential gene expression in brain and peripheral tissues in depression across the life span: A review of replicated findings. Neurosci Biobehav Rev. 71:281-293
Hou L….Baune BT…Schulze TG (2016) Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study. The Lancet, 12;387(10023):1085-93
Clark S, Baune BT, Schubert KO, Lavoi S, Rice S, Schäfer M, Benninger F, Feucht M, Klier C, McGorry P, Amminger GP (2016) Prediction of transition from ultra-high risk to first episode psychosis using a probabilistic model combining history, clinical assessment and fatty acid biomarkers. Transl Psychiatry, 20;6(9):e897
Dannlowski U, Kugel H, Grotegerd D, Redlich R, Opel N, Dohm K, Zaremba D, Grögler A, Schwieren J, Suslow T, Ohrmann P, Bauer J, Krug A, Kircher T, Jansen A, Domschke K, Hohoff C, Zwitserlood P, Heinrichs M, Arolt V, Heindel W, Baune BT (2016) Disadvantage of social sensitivity: Interaction of oxytocin receptor genotype and child maltreatment on brain structure. Biol Psychiatry, 80(5):398-405
Dannlowski U … Baune BT (2015) Multimodal imaging of a tescalcin (TESC)-regulating polymorphism (rs7294919) - specific effects on hippocampal gray matter structure. Mol Psychiatry; 20(3):398-404
Baune BT, Dannlowski U, Domschke K, Janssen DGA, Jordan MA, Ohrmann P, Bauer J, Biros E, Arolt V, Kugel H, Baxter AG, Suslow T (2010) The interleukin 1 beta (IL1B) gene is associated with failure to achieve remission and impaired emotion processing in major depression. Biol Psychiatry 67(6):543-9
Beste C, Kolev V, Yordanova J, Domschke K, Falkenstein M, Baune BT, Konrad C (2010) The role of BDNF val66met polymorphism for the synchronization of error-specific neural networks. J Neuroscience 30(32):10727-33
McAfoose J & Baune BT (2009) Evidence for a cytokine model of cognitive function. Neurosci Biobehav Rev 33(3):355-66
Academic CV
| 1989-1996 | Medicine, University of Münster, Germany |
| 1999-2001 | Master of Public Health (MPH), University of Bielefeld, Germany |
| 2017-2019 | Master of Business Administration (MBA – Health), University of Wismar, Germany |
| 02/2002 | Specialist certification in Psychiatry and Psychotherapy, Germany |
| 08/2002 | Specialist certification in addiction medicine, Germany |
| 09/2002 | Specialist certification in Psychiatry, United Kingdom |
| 01/2006 | Specialist certification in Psychiatry, Australian Medical Council |
| 09/2009 | Fellow of the Royal Australian and New Zealand College of Psychiatrists (RANZCP) (Eminence category) |
| 1996 | Doctorate in medicine (Dr.med.), Summa cum laude (University of Münster, Germany) |
| 2009 | Post-doctoral degree in Psychiatry: Venia Legendi (Habilitation) Psychiatry and Psychotherapy (2009) (University of Münster, Germany) |
Positions, Awards and Fellowships
Positions
Current
| since 03/19 |
Director, University of Hospital of Psychiatry and Psychotherapy, University of Münster (03/19 onwards |
| since 03/19 |
Honorary Professorial Fellow a) Department of Psychiatry, Melbourne Medical School The University of Melbourne |
Previous
| 08/18-02-19 | Cato Chair and Head of Department of Psychiatry, The University Melbourne, Melbourne, Australia |
| 01/11-07/18 | Chair and Head of Department of Psychiatry, University of Adelaide, Adelaide, Australia |
| 01/08-12/10 | Professor and Head of the Department of Psychiatry, James Cook University, Queensland, Australia |
| 01/06-12/07 | Associate Professor of Psychiatry and Psychiatric Neuroscience; School of Medicine, James Cook University, Queensland, Australia |
| 01/04-12/05 | Senior Psychiatrist and Head of Mood Disorders; Department of Psychiatry and Psychotherapy, University of Münster, Münster |
| 09/02-12/03 | Clinical Director and Senior Lecturer; Springfield University Hospital, University of London, London, UK |
| 1997-2002 | Completion of a structured training program in Psychiatry and Psychotherapy at the Universities of Jena and Witten-Herdecke and at the Centre for Psychiatry and Psychotherapy Bielefeld Bethel, Bielefeld, Germany, Teaching Hospital of the University of Münster, Germany |
Editorial Boards
| since 2007 | Section editor of “Neuroscience and Psychiatry”: “Public Library of Science (PLoS ONE)” |
| since 2009 | Member of the Editorial Board “STROKE” |
| since 2011 | Member of the Editorial Board “Translational Psychiatry” (NPG) |
| since 2011 | ad-hoc field Editor International Journal of Neuropsychopharmacology |
| since 2015 | Member of the Editorial Board “Australian and New Zealand Journal of Psychiatry” (ANZJP) |
| since 2016 | Member of the Editorial Board of “Pharmacopsychiatry” |
| since 2016 | Member of the Editorial Board of “International Journal of Methods in Psychiatric Research” |
| since 2018 | Associate Editor, Frontiers Psychiatry |
Publication record
1. Metrics (March 2019)
>480 career peer-review publications: 360 originals, 75 reviews; 47 books/chapters
Ratio of first/last to co-authored publications: 243:239
Cumulative impact factor: >2800
H-index: 60; i10-index: 155 (Number of publications with at least 10 citations)
Total: >13,000 citations
2. Quality of publications
Science (1x); N Eng J Medicine (1x); The Lancet (12x); Nature Genetics (3x); Mol Psychiatry (10x); Jama Psychiatry (3x); Biol Psychiatry (8x)
Honors and Awards
| 1997 | Best medical dissertation award (Dr.med.) (Germany) |
| 2003 | Innovation of health award (BKK, Germany) |
| 2006 | Premier of Queensland’s Export Award for Education, School of Medicine, James Cook University, Queensland, Australia |
| 2009 | International eminence membership with the Royal Australian and New Zealand College of Psychiatrists (RANZCP) |
| since 2014 | Professorial Fellow, University of New South Wales, Sydney, Australia |
| since 2019 | Professorial Fellow, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Australia |
| since 2019 |
Professorial Fellow, Department of Psychiatry, The University of Melbourne, Australia |