Topics of Research

The professorship, which was newly established at the University of Münster in winter semester 22/23, conducts research in the field of "Clinical Pharmacy" with a focus on "Individualized Pharmacotherapy".

For this purpose, the research group deals with the mass spectrometric investigation of central, pathophysiologically relevant peptide cascades in humans.

One focus is on the kallikrein-kinin system, which is closely linked to the renin-angiotensin-aldosterone system, the complement system and neurokinins (e.g. substance P), but whose complex interplay has so far been insufficiently described. The kallikrein-kinin system plays a significant role in major common diseases such as hypertension, diabetes mellitus and cancer, rare diseases such as hereditary angioedema, and also in inflammatory diseases such as sepsis, or malaria, etc. The group's work is contributing to the development of a new approach to the treatment of these diseases. The group's approaches not only contribute to a better basic understanding of physiological and pathophysiological regulation in the organism, but also have the potential to identify new promising drug targets for different diseases.

Based on this, preclinical and clinical studies are carried out in cooperation, in which the working group comprehensively illuminates new lead structures for identified drug targets pharmacokinetically, pharmacodynamically and also (pharmaco)metabolomically. For this bioanalytical research, the group's mass spectrometric analyses are based on biological fluids and insights into cascade processes in biological tissue. The research group's perspective is to advance individualized pharmacotherapy.