Formulierung von anspruchsvollen pharmazeutischen Wirkstoffen (u.a. schwer wasserlösliche Wirkstoffe)

Herstellung von Wirkstoffnanopartikeln und nanopartikuläre Lipidträgersysteme mittels verschiedener Technologien

Einarbeitung von nanopartikulären Systemen in orodispersible und mukoadhäsive Formen

2D-Druck von wirkstoffhaltigen Tinten auf geeignete Trägersysteme

Academic Education

2018

Promotion zum Dr.-Ing. an der Technischen Universität Braunschweig

2011

Studienabschluss zum Dipl.-Ing. an der Technischen Universität Braunschweig

Positions

since 10.2023

Universitätsprofessur für Pharmazeutische Technologie, Universität Münster / Stiftungsprofessur der Rottendorf Stiftung

03.2022 – 09.2023

Juniorprofessur für Pharmazeutische Technologie, Universität Tübingen

03.2019 – 02.2022

Wissenschaftliche Mitarbeiterin (PostDoc) am Institut für Pharmazeutische Technologie und Biopharmazie, Technische Universität Braunschweig

08.2017 – 02.2019

Senior Formulation Scientist & Project Manager, NextPharma GmbH

02.2012 – 06.2017

Wissenschaftliche Mitarbeiterin am Institut für Partikeltechnik, Technische Universität Braunschweig

2026

• Scholten, Julia, Pein-Hackelbusch, Miriam, Sokolowsky, Martina, Park, Julien, and Steiner, Denise. 2026. “Formulation of poorly water-soluble drugs in lipid nanocarriers: a suitable approach for taste masking or bitter-taste enhancing?” International Journal of Pharmaceutics 699 126993. doi: 10.1016/j.ijpharm.2026.126993.

2025

• Sukhbat, Oyunbileg, Steiner, Denise, and Bunjes, Heike. 2025. “Autoclaving behavior of trimyristin nanoemulsions stabilized with different poloxamers.” International Journal of Pharmaceutics 673 125376. doi: 10.1016/j.ijpharm.2025.125376.
• Quodbach, J., Preis, E., Karkossa, F., Winck, J., Finke, J.H., and Steiner, D. 2025. “Novel Strategies for the Formulation of Poorly Water-Soluble Drug Substances by Different Physical Modification Strategies with a Focus on Peroral Applications.” Pharmaceuticals 18 (8) 1089. doi: 10.3390/ph18081089.
• Klein, Isabelle, and Steiner, Denise. 2025. “Development and application of a novel tracer system for the evaluation of temperature exposure of lipid nanoparticles in spray drying and dual centrifugation.” European journal of pharmaceutics and biopharmaceutics 217 114889. doi: 10.1016/j.ejpb.2025.114889.
• Herrmann, Fabian C., Hofmann, Nicole, Haslacher, Fiona, and Steiner, Denise. 2025. “Embedding lipid nanodispersions in matrices: preparation of solid dosage forms with high lipid content and structural investigations using atomic force microscopy.” European Journal of Pharmaceutical Sciences 215 107279. doi: 10.1016/j.ejps.2025.107279.
• Hellmund, Nico, Inguva, Venkatesh, and Steiner, Denise. 2025. “Evaluation of emulsification behavior of two dual centrifuge types aided by CFD simulation.” International Journal of Pharmaceutics 686 126366. doi: 10.1016/j.ijpharm.2025.126366.

2024

• Steiner, Denise, Meyer, Alexander, Immohr, Laura Isabell, and Pein-Hackelbusch, Miriam. 2024. “Critical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients.” Pharmaceutics 16: 658–658. doi: 10.3390/pharmaceutics16050658.

2023

• Koehler, Jonas K., Schmager, Stefanie, Bender, Valentin, Steiner, Denise, and Massing, Ulrich. 2023. “Preparation of Nanosized Pharmaceutical Formulations by Dual Centrifugation.” Pharmaceuticals 16: 1519. doi: 10.3390/ph16111519.
• Steiner, Denise., Tidau, Marius., and Finke, Jan Henrik. 2023. “Embedding of poorly water-soluble drugs in orodispersible films - Comparison of five formulation strategies.” Pharmaceutics 15 (17): 1–22. doi: 10.3390/pharmaceutics15010017.

2022

• Steiner, Denise, Schumann, Leonie V., and Bunjes, Heike. 2022. “Processing of lipid nanodispersions into solid powders by spray drying.” Pharmaceutics 14 (11): 1–17. doi: 10.3390/pharmaceutics14112464.

2021

• Steiner, Denise, Emmendörffer, Jakob F., and Bunjes, Heike. 2021. “Orodispersible films: A delivery platform for solid lipid nanoparticles?” Pharmaceutics 13 (12): 1–17. doi: 10.3390/pharmaceutics13122162.
• Steiner, Denise, and Bunjes, Heike. 2021. “Influence of process and formulation parameters on the preparation of solid lipid nanoparticles by dual centrifugation.” International Journal of Pharmaceutics: X 3: 1–11. doi: 10.1016/j.ijpx.2021.100085.

2019

• Steiner, Denise, Finke, Jan Henrik, and Kwade, Arno. 2019. “SOFTs – Structured orodispersible film templates.” European journal of pharmaceutics and biopharmaceutics 137: 209–217. doi: 10.1016/j.ejpb.2019.03.001.
• Steiner, Denise, Finke, Jan Henrik, and Kwade, Arno. 2019. “Model-based description of disintegration time and dissolution rate of nanoparticle-loaded orodispersible films.” European Journal of Pharmaceutical Sciences 132: 18–26. doi: 10.1016/j.ejps.2019.02.029.

2018

• Steiner, Denise, Finke, Jan Henrik, and Kwade, Arno. 2018. “Instant ODFs – Development of an intermediate, nanoparticle-based product platform for individualized medication.” European journal of pharmaceutics and biopharmaceutics 126: 149–158. doi: 10.1016/j.ejpb.2017.04.014.
• Speer, Isabell, Steiner, Denise, Thabet, Yasmin, Breitkreutz, Jörg, and Kwade, Arno. 2018. “Comparative study on disintegration methods for oral film preparations.” European journal of pharmaceutics and biopharmaceutics 132: 50–61. doi: 10.1016/j.ejpb.2018.09.005.

2017

• Göke, Katrina, Lorenz, Thomas, Repanas, Alexandros, Schneider, Frederic, Steiner, Denise, Baumann, Knut, Bunje, Heike, Dietzel, Andreas, Finke, Jan H., Glasmacher, Birgit, and Kwade, Arno. 2017. “Novel strategies for the formulation and processing of poorly watersoluble drugs.” European journal of pharmaceutics and biopharmaceutics 126: 40–56. doi: 10.1016/j.ejpb.2017.05.008.
• Steiner, Denise, Finke, Jan Henrik, and Kwade, Arno. 2017. “Redispersion of Nanoparticle-Loaded Orodispersible Films: Preservation of Particle Fineness.” Chemie Ingenieur Technik 89: 1034–1040. doi: 10.1002/cite.201600139.
• Erfinder: Steiner, Denise, and Kwade, Arno. 2017. Deutsche (DE102017103346 A1) und internationale Patentanmeldung (WO 2018/149983A1), Titel: "Structured orodispersible films"

2016

• Steiner, Denise, Finke, Jan Henrik, and Kwade, Arno. 2016. “Efficient production of nanoparticle-loaded orodispersible films by process integration in a stirred media mill.” International Journal of Pharmaceutics 511: 804–813. doi: 10.1016/j.ijpharm.2016.07.058.
• Steiner, Denise, Finke, Jan Henrik, Breitung-Faes, Sandra, and Kwade, Arno. 2016. “Breakage, temperature dependency and contamination of Lactose during ball milling in ethanol.” Advanced Powder Technology 27: 1700–1709. doi: 10.1016/j.apt.2016.05.034.

• Manuel Gottowik: 2D-Druck von lipidhaltigen Nanodispersionen auf wirkstofffreie Substrate
• Kotschate, Olivia: Herstellung proteinbasierter Nanopartikel mittels Mikrofluidik

  Further Supervisor

  Langer, Klaus

  Reviewers

  Langer, Klaus

  Steiner, Denise

• Scholten, Julia Marie: Einbettung von wirkstoffhaltigen Lipidanodispersionen in orodispersible Filme
• Klein, Isabelle: Sprühtrocknung und Weiterverarbeitung von wirkstoffhaltigen Lipidnanodispersionen zu orodispersiblen Tabletten
• Hellmund, Nico: Formulierung und Charakterisierung von lipidhaltigen, mucoadhäsiven Arzneiformen
• Mahlberg, Lena: 2D-Druck von Nanodispersionen auf strukturierte orodispersible Formen

• Steiner, Denise 2024: “Embedding of lipid nanodispersions in ODFs”. 7th APV Winter Conference: ODx and MBx - orodispersible and mucoadhesive buccal formulations: Novel technologies, new products, future opportunities, Innsbruck, Jan 25, 2024.
• Steiner, Denise 2023: “Evaluation of drying behaviour and temperature exposure of lipid nanodispersions during spray drying ”. International Congress on Particle Technology, Nürnberg, Sep 26, 2023.
• Steiner, Denise 2022: „Wirkstoff Meets Lipid - Nanopartikuläre Lipidträgersysteme eingebettet in feste Matrizes“. DPhG-Vortrag Regionalgruppe Südbaden, Freiburg, Jun 29, 2022.
• Steiner, Denise 2022: “Processing of lipid nanodispersions into solid formulations by spray drying”. 13. World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Rotterdam, Mar 29, 2022.
• Steiner, Denise 2021: “Embedding solid lipid nanoparticles in orodispersible films - A feasibility study”. 4. Braunschweig International Symposium on Pharmaceutical Engineering Research, Braunschweig, Sep 16, 2021.
• Steiner, Denise; Finke, Jan 2018: “Instant preparations for orodispersible films”. 3. APV Winterkonferenz zum Thema “Individualized Medicines for oral use – visions and challenges”, Innsbruck, Jan 25, 2018.
• Steiner, Denise 2017: “Individualized medication with poorly water-soluble APIs – Instant ODFs”. 2. Europeance Conference on Pharmaceutics, Krakau, Apr 3, 2017.
• Steiner, Denise 2016: “Loading nanoparticular suspensions on drug-free orodispersible films”. International Congress on Particle Technology, Nürnberg, Apr 20, 2016.
• Steiner, Denise 2015: “Efficient production of nanoparticle-loaded orodispersible films by process integration in a stirred media mill”. 1. Symposium on Pharmaceutical Engineering Research, Braunschweig, Oct 20, 2015.
• Steiner, Denise 2014: “Stirred media milling of an organic model compound in ethanol”. 6. International Congress on Pharmaceutical Engineering, Graz, Jun 16, 2014.