Research

Prof. Dr. Klaus Langer

Research group

Focus area of research:

Drug targeting - nanotechnology, e.g. albumin- or PLGA based
Drug targeting: surface modifications
Tumor targeting
Drug formulation

Projects
- W2-Stiftungsprofessur mit Tenure-Track auf eine W3-Professur (Stiftungslehrstuhl) "Pharmazeutische Technologie" (2023 – 2033)
  Individual Granted Project: Rottendorf Stiftung
- Regenerativer Einsatz nanopartikulärer Substanzen zur Auflösung von Kalzifikationen der Retina – REpAIR (2025 – 2028)
  Individual Granted Project: Bundesministerium für Forschung, Technologie und Raumfahrt | Project Number: 03VP13100
- PharMSchool (2019 – 2027)
  Individual Granted Project: Universitätsgesellschaft Münster e.V., Deutsche Pharmazeutische Gesellschaft e.V., Rottendorf Stiftung
- Self Immolative Drug Delivery Systems based on Polycarbonate Copolymers (2022 – 2025)
  Individual Granted Project: DFG - Sachbeihilfe/Einzelförderung | Project Number: LA 1165/5-3
- Entwicklung einer Arzneiform zur TG-1-Enzymsubstitution der lamallären Ichthyose (2021 – 2024)
  Individual Granted Project: United for Fighting Ichthyosis - Amici per la Pelle
- Stabilisierung von nanopartikulären pharmazeutischen Wirkstoffen durch humanes Serumalbumin (HSA) (2020 – 2023)
  Individual Granted Project: INVITE GmbH
- Self Immolative Drug Delivery Systems based on Polycarbonate Copolymers (2018 – 2022)
  Individual Granted Project: DFG - Sachbeihilfe/Einzelförderung | Project Number: LA 1165/5-1
- Transglutaminase 1-Liposomen - Forschungsarbeiten auf dem Gebiet der lamellären Ichthyose (2020 – 2021)
  Individual Granted Project: Leibniz-Forschungsinstitut für Molekulare Pharmakologie
- Patientenrelevanz generischer Substitution am Beispiel von L-Dopa (2018 – 2021)
  Individual Granted Project: Apothekerstiftung Westfalen-Lippe | Project Number: Wa/mie
- EXC 1003 B1 - Formation and Properties of Epithelial and Endothelial Barriers (2012 – 2019)
  Subproject in DFG-Joint Project Hosted at the University of Münster: DFG - Exzellenzcluster | Project Number: EXC1003/1
- Auftragsanalytik (REM, DSC, ...) für den Bereich der Arzneimittelherstellung (2013 – 2018)
  Individual Granted Project: Rottendorf Pharma GmbH
- Verbundprojekt: Zielgesteuerte BioTransporter oral applizierter Photosensibilisatoren zur photodynamischen Therapie gastrointestinaler Carcinome (GITCare) - Teilvorhaben: Nanostrukturierte Trägersysteme und deren biologische Bewertung (2015 – 2018)
  Participation in Federally Funded Joint Project: Bundesministerium für Forschung, Technologie und Raumfahrt | Project Number: 13N13423
- Rezepturfit - Validierung von Rezepturprozessen (2016 – 2017)
  Individual Granted Project: Apothekerstiftung Westfalen-Lippe
- PharMSchool-Symposium (2017)
  Scientific Event: Sonstige Mittelgeber
- Biokonjugate zur peroralen Anwendung für den Transport von Problemarzneistoffen zur Behandlung des Cholangiozellulären Karzinoms – BioTraP for CCC (2011 – 2015)
  Participation in Federally Funded Joint Project: Bundesministerium für Forschung, Technologie und Raumfahrt | Project Number: 13N11390
- Development for nanoparticles for Parkinson disease (2013 – 2014)
  Individual Granted Project: Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
- Stem cell generation and manipulation by nanoparticle mediated gene transfer for the safe clinical application of gene-modified cells – NanoGene (2011 – 2014)
  Participation in Federally Funded Joint Project: Bundesministerium für Forschung, Technologie und Raumfahrt | Project Number: 13N1I539
- ERA-NET Neuron NanoBrain – NanoBrain (2010 – 2013)
  Individual Granted Project: Sonstige Mittelgeber
- Schaltbare Nanopartikel als Wirkstoffträger (2010 – 2012)
  Own Resources Project
- Development of cell type specific drug carrier systems for cancer therapy – NanoCancer (2006 – 2010)
  Own Resources Project
- Nanoparticulate dosage forms for specific tumor therapy – NanoDrug (2004 – 2007)
  Own Resources Project
Analytics / Processes

Analytics
- Chromatography (HPLC, GPC, FFFF)
- Spektroscopic methods (UV, PCS; NMR, MS in cooperation with further institutes)
- Bioassay and analysis
- Microscopic investigations (REM, fluorescence microscopy)
- Dissolution testing
Processes
- Freeze-drying
- Spray-drying
Bioactivity
- in vitro screening
- Cell lines (CaCo-2, MCF-7, BT-474, SKBR-3, TFK-1, EGI-1, HepG-2, HT-29, HEK-293)
- Cytotoxicity
- Cell proliferation
- in vivo investigations in cooperation with the UKM (Muenster)

Prof. Dr. Denise Steiner

Research group

Focus area of research:

Nanoparticulate systems
Lipid-based, nanoparticular carrier systems
Processing of drug nanoparticles
Innovative dosage forms
Orodispersible and mucoadhesive forms
2D-printing of drug-containing inks

Analytics / Processes

Analytics
- Particle size measurements (laser diffraction, dynamic light scattering)
- Differential scanning calorimetry
- Microscopic examinations (SEM, fluorescence microscopy)
- Mechanical properties such as tensile and compressive strength
Processes
- Spray drying
- Fluidized bed granulation
- Tableting
- 2D-printing
- Grinding (e.g. by dual centrifugation)
- High-pressure homogenization

Dr. Sarah Hester

Research group

Focus area of research:

Nanoparticulate formulations of poorly soluble drugs
Reduction of immune response by surface modification of nanoparticulate systems
Scalable processes for nanoparticulate formulations

Analytics / Processes

Analytics
- HPLC
- Gel Permeation Chromatography (GPC)
- AF4
- Particle size measurements (PCS)
- Differential scanning calorimetry (DSC)
Methods
- Freeze-drying
- Sonication
- High pressure homogenization
- Tangential Flow Filtration
Statististics
- Design of Experiments

Research

Projects

Analytics / Processes

Analytics

Processes

Bioactivity

Analytics / Processes

Analytics

Processes

Analytics / Processes

Analytics

Methods

Statististics