Research Foci
- Studies on the thermal stability, biosynthesis, toxicity and (intestinal) metabolism of mycotoxins.
- Development of human biomonitoring methods (HBM) for exposure assessment of mycotoxins and detection of nutritional biomarkers.
- Metabolomics- and proteomics-based approaches to characterise cellular responses upon exposure to mycotoxins and other food constituents
- transfer of food constituents across the intestinal barrier (Caco-2 model) as well as the blood-brain-barrier.
- Studies on the occurrence and significance of mycotoxins in indoor environments
CV
Academic Education
- Habilitation und Erlangung der Venia legendi im Fachgebiet "Lebensmittelchemie"
- Forschungsaufenthalt an der Emory University, Atlanta, USA, Department of Biochemistry bei Herrn Prof. Dr. A.H. Merrill
- 2. Ausbildungsphase für Lebensmittelchemiker am Landesuntersuchungsamt in Erlangen, Staatsprüfung für Lebensmittelchemiker
- Dissertation am Lehrstuhl für Lebensmittelchemie der Universität Würzburg bei Prof. Dr. P. Schreier
Positions
- Dean of the Faculty for Chemistry and Pharmacy at the Westfälischen Wilhelms-Universität Münster
- W3-Full-Professor for Food Chemistry and Director of the Institute of Food Chemistry at the University of Münster
- Managing Direktor of the Institute of Food Chemistry
- C3-Professor of Food Chemistry at the University of Münster
- Wissenschaftlicher Assistent und seit 01.10.2000 Oberassistent am Lehrstuhl für Lebensmittelchemie der Universität Würzburg
- Post-doc an der Columbia University, New York, Department of Chemistry bei Prof. Dr. K. Nakanishi
- Wissenschaftlicher Mitarbeiter am Lehrstuhl für Lebensmittelchemie der Universität Würzburg
Honors
- Josef-Schormüller-Stipendium – Lebensmittelchemische Gesellschaft (LChG) - Fachgruppe in der Gesellschaft Deutscher
- Studienabschluss-Stipendium – Fonds der Chemischen Industrie (FCI)
- Stockmeyer Wissenschaftspreis 2002 – Heinrich-Stockmeyer-Stiftung
- Peter B. Czedik-Eysenberg-Preis – GÖCH - Gesellschaft Österreichischer Chemiker - Arbeitsgruppe Lebensmittel, Kosmetik und Gebrauchsgegenstände
External Functions
- German Research Foundation (DFG) (Member of the DFG Review Board "Biological Chemistry and Food Chemistry" for the subject Food Chemistry)
- Springer-Nature (Editor in Chief of the journal Mycotoxin Research)
- Federal Institute for Risk Assessment (BfR) (BfR Commission for Contaminants in the Food Chain, Member)
- Society for Mycotoxin Research (President)
- Wiley-VCH (Editor in Chief of the journal "Molecular Nutrition and Food-Research")
- Mitglied in der der Senatskommission der Deutschen Forschungsgemeinschaft zur gesundheitlichen Bewertung von Lebensmitteln (SKLM)
- Federal Institute for Risk Assessment (BfR) (of the Expert Commission "Contaminants and other undesirable substances in the food chain", Member)
- Präsident der Gesellschaft für Mykotoxinforschung e.V.
- Associate Editor der Zeitschrift "Molecular Nutrition and Food-Research", Wiley-VCH
- Mitglied der Gesellschaft für Mykotoxinforschung e.V.
- Member of the American Chemical Society
- Mitglied in der Gesellschaft Deutscher Chemiker GDCh
Appointments
- Ruf auf eine W3-Professur für Lebensmittelchemie an der Universität Münster
University of Münster, Lebensmittelchemie (W3) – accepted - Ruf auf eine C4-Professur für Lebensmittelchemie, Universität Hamburg
University of Hamburg, Lebensmittelchemie (C4) – rejected - Ruf auf eine C4-Professur für Lebensmittelchemie, Universität Halle-Wittenberg
Martin Luther University Halle-Wittenberg, Lebensmittelchemie (C4) – rejected - Ruf auf eine C3-Professur für Lebensmittelchemie, Universität Hohenheim
University of Hohenheim, Lebensmittelchemie (C3) – rejected - Ruf auf eine C3-Professur für Lebensmittelchemie an der Universität Münster
University of Münster, Lebensmittelchemie (C3) – accepted
Teaching
- Lecture: Spezielle Lebensmittelchemie [124220]
- [ – | Mon, – | | LC 1]
- [ – | Fri, – | | LC 1]
- Seminar: Institutsseminar [124233]
(in cooperation with Florian Hübner, Melanie Esselen, Matthias Behrens and Benedikt Cramer)- [Thu, – | ]
- Seminar: Aktuelle Forschung [124229]
(in cooperation with Florian Hübner, Melanie Esselen, Matthias Behrens and Benedikt Cramer)- [ – | Thu, – | | LC 1]
- Seminar/Tutorial: Literaturseminar für Doktoranden [124234]
(in cooperation with Melanie Esselen)- [Mon – Fri | ad hoc]
- Introduction to academic work: Anleitung zu selbständigen wissenschaftlichen Arbeiten - AK Humpf [124232]
- [Mon – Fri | ad hoc]
- Presentation: Vortrag zur Bachelorarbeit [124219]
(in cooperation with Michael Lange-Aperdannier, Florian Hübner, Melanie Esselen, Benedikt Cramer and Matthias Behrens)- [ – | Single Course]
- Lecture: Spezielle Lebensmittelchemie
- Lecture: Biochemie der Ernährung
(in cooperation with Melanie Esselen)- Seminar: Aktuelle Forschung
(in cooperation with Florian Hübner, Melanie Esselen, Matthias Behrens and Benedikt Cramer)- Seminar: Seminar Isotopen- und Enantiomerenanalytik
- Seminar: Institutsseminar
(in cooperation with Florian Hübner, Melanie Esselen, Matthias Behrens and Benedikt Cramer)- Seminar/Tutorial: Literaturseminar für Doktoranden
(in cooperation with Melanie Esselen)- Seminar/Tutorial: Literaturseminar für Doktoranden
(in cooperation with Melanie Esselen)- Introduction to academic work: Anleitung zu selbständigen wissenschaftlichen Arbeiten - AK Humpf
Publications
- Lipinski, S, Becker, M, Lindekamp, N, Humpf, H, and Cramer, B. . “Formation of Furan, Alkylfurans and Acrylamide during Breakfast Cereal Manufacturing: Comparison of Model Experiments with Industrial Processes.” Preprint. Food Control 179: 111598.. doi: 10.1016/j.foodcont.2025.111598.
- Bieß, N, Behrens, M, Humpf, H-U, and Gerdemann, A. . “Elucidation of Sulforaphane‐Mediated Effects on the Cellular Human Metabolome Using Metabolic Profiling.” Molecular Nutrition and Food Research 70 (1). doi: 10.1002/mnfr.70373.
- Phillips, E., Ngure, F.M., Kassim, N., Turner, P.C., Makule, E., Smith, L.E., Makori, N., Cramer, B., Humpf, H.-U., Nelson, R.J., and Stoltzfus, R.J. . “The effect of an intervention to reduce aflatoxin consumption from 6 to 18 mo of age on length-for-age z-scores in rural Tanzania: a cluster-randomized trial.” American Journal of Clinical Nutrition 121 (2): 333–342. doi: 10.1016/j.ajcnut.2024.11.022.
- Lipinski, Sarah, Becker, Marlen, Meyer, Jens Chr., Nowakowski, Christine, Humpf, Hans-Ulrich, and Cramer, Benedikt. . “Impact of Physicochemical Parameters on the Furan, Alkylfuran, and Acrylamide Formation during Extrusion Cooking of Breakfast Cereals.” ACS Food Science & Technology 2025. doi: 10.1021/acsfoodscitech.4c00727.
- Gerdemann, A, Behrens, M, Günther, G, Ghallab, A, Hengstler, JG., Humpf, H-U, and Esselen, M. . “A simplified LC–MS-based method for sensitive analysis of DNA adducts utilizing accessible in vitro metabolism models.” Archives of Toxicology 99: 4021–4034. doi: 10.1007/s00204-025-04125-w.
- Lins, A., Keuter, L., Mulac, D., Humpf, H.-U., and Langer, K. . “Are stabilizers, located on the surface of PLGA nanoparticles, able to modify the protein adsorption pattern?” International Journal of Pharmaceutics 674. doi: 10.1016/j.ijpharm.2025.125488.
- Brückner, L, Neuendorff, F, Hadenfeldt, K, Behrens, M, Cramer, B, and Humpf, H. . “Thermal Stability and Matrix Binding of Citrinin in the Thermal Processing of Starch-Rich Foods.” Toxins 17 (2): 86–86. doi: 10.3390/toxins17020086.
- Cramer, Benedikt, Visintin, Lia, Maris, Elias, Kuhn, Michael, Degen, Gisela H., Turner, Paul C., Humpf, Hans-Ulrich, and De Saeger, Sarah. . “Human biomonitoring of mycotoxins: key challenges and future directions.” Mycotoxin Research 42 (1) 13. doi: 10.1007/s12550-025-00612-2.
- Kuhn, Michael, Kyei, Nicholas N.A., Cramer, Benedikt, and Humpf, Hans-Ulrich. . “Online solid phase extraction-LC-MS/MS with two step peak focusing for sensitive multi-analyte analysis of mycotoxins in urine.” Microchemical Journal 219 115821. doi: 10.1016/j.microc.2025.115821.
- Witzel, K, Djalali, Farahani-Kofoet R, Döll, S, Lindemann, V, Cramer, B, Humpf, H, and Zrenner, R. . “Metabolomics and dual proteomics identify contrasting patterns of major pathways affected in asparagus shoot upon Fusarium infection.” Plant and Soil 2024. doi: 10.1007/s11104-024-07069-9.
- Modrzewska, M., Popowski, D., Błaszczyk, L., Stępień, Ł., Urbaniak, M., Bryła, M., Cramer, B., Humpf, H.-U., and Twarużek, M. . “Antagonistic properties against Fusarium sporotrichioides and glycosylation of HT-2 and T-2 toxins by selected Trichoderma strains.” Scientific Reports 14 (1). doi: 10.1038/s41598-024-55920-x.
- Hassan, R., Gerdemann, A., Cramer, B., Hobloss, Z., Myllys, M., González, D., Albrecht, W., Veerkamp, J., Friebel, A., Hoehme, S., Esselen, M., Degen, G., Humpf, H., Hengstler, J., and Ghallab, A. . “Integrated data from intravital imaging and HPLC–MS/MS analysis reveal large interspecies differences in AFB1 metabolism in mice and rats.” Archives of Toxicology 98 (4): 1081–1093. doi: 10.1007/s00204-024-03688-4.
- Pierzgalski, A., Bryła, M., Cramerm, B., Humpf, H.-U., and Twarużek, M. . “Co-occurrence of T-2 and HT-2 Mycotoxins and α and β Anomers of Their Glucosides in Wheat and Oat Grains.” Journal of Agricultural and Food Chemistry 72 (6): 3150–3159. doi: 10.1021/acs.jafc.3c07465.
- Eisenbrand, Gerhard, Buettner, Andrea, Diel, Patrick, Epe, Bernd, Foerst, Petra, Grune, Tillman, Haller, Dirk, Heinz, Volker, Hellwig, Michael, Humpf, Hans-Ulrich, Jaeger, Henry, Kulling, Sabine, Lampen, Alfonso, Leist, Marcel, Mally, Angela, Marko, Doris, Noethlings, Ute, Roehrdanz, Elke, Spranger, Joachim, Steinberg, Pablo, Vieths, Stefan, Waetjen, Wim, and Hengstler, Jan G. . “Commentary of the SKLM to the EFSA opinion on risk assessment of N-nitrosamines in food.” Archives of Toxicology 98 (6). doi: 10.1007/s00204-024-03726-1.
- Pierzgalski, Adam, Bryla, Marcin, Cramer, Benedikt, Humpf, Hans-Ulrich, and Twaruzek, Magdalena. . “Co-occurrence of T-2 and HT-2 Mycotoxins and α and <i>β</i> Anomers of Their Glucosides in Wheat and Oat Grains.” Journal of Agricultural and Food Chemistry 72 (6). doi: 10.1021/acs.jafc.3c07465.
- Frank, Amelie, Greve, Hanna, Huebner, Florian, and Humpf, Hans-Ulrich. . “Human Intervention Study: Alkylresorcinol Metabolites as Potential Biomarkers for Grain Intake and the Occurrence of Alkylresorcinols in Commonly Consumed Foods in the German Retail Sector.” ACS Omega 9 (22). doi: 10.1021/acsomega.4c00733.
- Atanasoff-Kardjalieff, Anna K., Berger, Harald, Steinert, Katharina, Janevska, Slavica, Ponts, Nadia, Humpf, Hans-Ulrich, Kalinina, Svetlana, and Studt-Reinhold, Lena. . “Incorporation of the histone variant H2A.Z counteracts gene silencing mediated by H3K27 trimethylation in <i>Fusarium fujikuroi</i>.” Epigenetics and Chromatin 17 (1). doi: 10.1186/s13072-024-00532-y.
- Hassan, Reham, Gerdemann, Andrea, Cramer, Benedikt, Hobloss, Zaynab, Myllys, Maiju, Gonzalez, Daniela, Albrecht, Wiebke, Veerkamp, Jannik, Friebel, Adrian, Hoehme, Stefan, Esselen, Melanie, Degen, Gisela H., Humpf, Hans-Ulrich, Hengstler, Jan G., and Ghallab, Ahmed. . “Integrated data from intravital imaging and HPLC-MS/MS analysis reveal large interspecies differences in AFB1 metabolism in mice and rats.” Archives of Toxicology 1. doi: 10.1007/s00204-024-03688-4.
- Kuhn, Michael, Hassan, Reham, Gonzalez, Daniela, Myllys, Maiju, Hobloss, Zaynab, Degen, Gisela H., Humpf, Hans-Ulrich, Hengstler, Jan G., Cramer, Benedikt, and Ghallab, Ahmed. . “Role of albumin in the metabolism and excretion of ochratoxin A.” Mycotoxin Research 1. doi: 10.1007/s12550-024-00538-1.
- Keuter, Lucas, Wolbeck, Alessa, Kasimir, Matthias, Schuermann, Lina, Behrens, Matthias, and Humpf, Hans-Ulrich. . “Structural Impact of Steroidal Glycoalkaloids: Barrier Integrity, Permeability, Metabolism, and Uptake in Intestinal Cells.” Molecular Nutrition and Food Research 68 (6). doi: 10.1002/mnfr.202300639.
- Gesing, Katrin, Lenz, Florian, Schreiber, Sebastian, Kasimir, Matthias, Humpf, Hans-Ulrich, and Jose, Joachim. . “Surface Display and Engineering of Laccase CotA for Increased Growth of <i>Pseudomonas putida</i> on Lignin.” ChemCatChem 16 (4). doi: 10.1002/cctc.202301055.
- Steinert, Katharina, Atanasoff-Kardjalieff, Anna K., Messner, Elias, Gorfer, Markus, Niehaus, Eva-Maria, Humpf, Hans-Ulrich, Studt-Reinhold, Lena, and Kalinina, Svetlana A. . “Tools to make Stachybotrys chartarum genetically amendable: Key to unlocking cryptic biosynthetic gene clusters.” Fungal Genetics and Biology 172. doi: 10.1016/j.fgb.2024.103892.
- Lins, A., Keuter, L., Mulac, D., Humpf, H.-U., and Langer, K. . “Are stabilizers, located at the surface of PLGA nanoparticles, able to modify the protein adsorption pattern?” contributed to the 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Wien.
- Lins, A., Keuter, L., Fortmann, M., Mulac, D., Humpf, H.-U., and Langer, K. . “Impact of the protein corona on nanoparticle uptake by macrophages.” contributed to the DPhG Annual Meeting (2024), Münster.
- Brückner, Lea, Cramer, Benedikt, and Humpf, Hans-Ulrich. . “Reactions of citrinin with amino compounds modelling thermal food processing.” Mycotoxin Research 40 (4): 709–720. doi: 10.1007/s12550-024-00557-y.
- Varga, Elisabeth, Marko, Doris, Meyer, Karsten, Cramer, Benedikt, Humpf, Hans-Ulrich, and Plötz, Madeleine. . “Vienna, the ‘City of Music’, meets mycotoxin research at the 45th Mycotoxin Workshop.” Mycotoxin Research 40 (3): 327–329. doi: 10.1007/s12550-024-00542-5.
- Gerdemann, A, Broenhorst, M, Behrens, M, Humpf, HU, and Esselen, M. . “Polyphenols Cause Structure Dependent Effects on the Metabolic Profile of Human Hepatocarcinogenic Cells.” Molecular Nutrition and Food Research 67 (21): e2300052–e2300052. doi: 10.1002/mnfr.202300052.
- Kleinehr, J, Schöfbänker, M, Daniel, K, Günl, F, Mohamed, FF, Janowski, J, Brunotte, L, Boergeling, Y, Liebmann, M, Behrens, M, Gerdemann, A, Klotz, L, Esselen, M, Humpf, HU, Ludwig, S, and Hrincius, ER. . “Glycolytic interference blocks influenza A virus propagation by impairing viral polymerase-driven synthesis of genomic vRNA.” PLoS Pathogens 19 (7): e1010986.. doi: 10.1371/journal.ppat.1010986.
- Patnana, P.K., Liu, L., Frank, D., Nimmagadda, S., Behrens, M., Ahmed, H., Xie, X., Liebmann, M., Wei, L., Gerdemann, A., Thivakaran, A., Humpf, H.U., Klotz, L., Dugas, M., Varghese, J., Trajkovic-Arsic, M., Siveke, J.T., Hanenberg, H., Opalka, B., Dührsen, U., Reinhardt, H.C., Guenther, U., von, Bubnoff N., and Khandanpour, C. . “Dose-dependent expression of GFI1 alters metabolism in the haematopoietic progenitors and MLL::AF9-induced leukaemic cells.” British Journal of Haematology 202 (5): 1033–1048. doi: 10.1111/bjh.18939.
- Lins, A., Keuter, L., Mulac, D., Humpf, H.-U., and Langer, K. . “Role of stabilizers in protein adsorption patterns of PLGA nanoparticles.” contribution to the DPhG Annual Meeting, Tübingen
- Gerdemann, A, Cramer, B, Degen, GH, Veerkamp, J, Günther, G, Albrecht, W, Behrens, M, Esselen, M, Ghallab, A, Hengstler, JG, and Humpf, H-U. . “Comparative metabolism of aflatoxin B1 in mouse, rat and human primary hepatocytes using HPLC–MS/MS.” Archives of Toxicology 97 (12): 3179–3196. doi: 10.1007/s00204-023-03607-z.
- Nikmaram, N., Brückner, L., Cramer, B., Humpf, H.-U., and Keener, K. . “Degradation products of aflatoxin M1 (AFM1) formed by high voltage atmospheric cold plasma (HVACP) treatment.” Toxicon 230. doi: 10.1016/j.toxicon.2023.107160.
- Lipinski, S., Lindekamp, N., Funck, N., Cramer, B., and Humpf, H.-U. . “Determination of furan and alkylfuran in breakfast cereals from the European market and their correlation with acrylamide levels.” European Food Research and Technology 2023. doi: 10.1007/s00217-023-04374-y.
- Kyei, N.N.A., Waid, J.L., Ali, N., Cramer, B., Humpf, H.-U., and Gabrysch, S. . “Maternal exposure to multiple mycotoxins and adverse pregnancy outcomes: a prospective cohort study in rural Bangladesh.” Archives of Toxicology 97 (6): 1795–1812. doi: 10.1007/s00204-023-03491-7.
- Hahn, M., Lindemann, V., Behrens, M., Mulac, D., Langer, K., Esselen, M., and Humpf, H.-U. . “Permeability of dopamine D2 receptor agonist hordenine across the intestinal and blood-brain barrier in vitro.” PloS one 17 (6): e0269486–e0269486. doi: 10.1371/journal.pone.0269486.
- Gerdemann, A, Behrens, M, Esselen, M, and Humpf, HU. . “Metabolic profiling as a powerful tool for the analysis of cellular alterations caused by 20 mycotoxins in HepG2 cells.” Archives of Toxicology 96 (11): 2983–2998. doi: 10.1007/s00204-022-03348-5.
- Kyei, N.N.A., Cramer, B.Humpf H.-U., Degen, G.H., Ali, N., and Gabrysch, S. . “Assessment of multiple mycotoxin exposure and its association with food consumption: a human biomonitoring study in a pregnant cohort in rural Bangladesh.” Archives of Toxicology 96 (7): 2123–2138. doi: 10.1007/s00204-022-03288-0.
- Eisenbrand, G, Baum, M, Cartus, AT, Diel, P, Engel, KH, Engeli, B, Epe, B, Grune, T, Guth, S, Haller, D, Heinz, V, Hellwig, M, Hengstler, JG, Henle, T, Humpf, HU, Joost, HG, Jäger, H, Lachenmeier, DW, Kulling, S, Leist, M, Lampen, A, Marko, D, Mally, A, Röhrdanz, E, Nöthlings, U, Spranger, J, Roth, A, Vieths, S, Stadler, R, Steinberg, P, and Wätjen, W. . “Salivary nitrate/nitrite and acetaldehyde in humans: potential combination effects in the upper gastrointestinal tract and possible consequences for the in vivo formation of N-nitroso compounds-a hypothesis.” Archives of Toxicology 96 (6): 1905–1914. doi: 10.1007/s00204-022-03296-0.
- Lindemann, V, Schleiner, T, Maier, U, Fels, H, Cramer, B, and Humpf, HU. . “Analysis of mold and mycotoxins in naturally infested indoor building materials.” Mycotoxin Research 2022. doi: 10.1007/s12550-022-00461-3.
- Puel, O, Cramer, B., Oswald, I.P., and Humpf, H.-U. . “From the laboratory bench to the lecture hall: latest findings from mycotoxin research presented at the 43rd Mycotoxin Workshop.” Mycotoxin Research 2022. doi: 10.1007/s12550-022-00462-2.
- Kasimir, M, Behrens, M, and Humpf, HU. . “C Lignin in the Pig Cecum Model.” Journal of Agricultural and Food Chemistry 70 (27): 8317–8325. doi: 10.1021/acs.jafc.2c02836.
- Lindemann, V, Jagels, A, Behrens, M, Hübner, F, and Humpf, HU. . “In Vitro Metabolism of Phenylspirodrimanes Derived from the Indoor Fungus Stachybotrys.” Toxins 14 (6): 395. doi: 10.3390/toxins14060395.
- Lindemann, V, Schmidt, J, Cramer, B, and Humpf, HU. . “Detection of Mycotoxins in Highly Matrix-Loaded House-Dust Samples by QTOF-HRMS, IM-QTOF-HRMS, and TQMS: Advantages and Disadvantages.” Analytical Chemistry 94 (10): 4209–4217. doi: 10.1021/acs.analchem.1c04254.
- Gerhard, MN, Schymanski, D, Ebner, I, Esselen, M, Stahl, T, and Humpf, HU. . “Can the presence of additives result in false positive errors for microplastics in infant feeding bottles?” Food Additives and Contaminants: Part A: Chemistry, Analysis, Control, Exposure and Risk Assessment 39 (1): 185–197. doi: 10.1080/19440049.2021.1989498.
- Müller, L, Keuter, L, Bücksteeg, D, Uebel, T, Wilken, M, Schürmann, L, Behrens, M, Humpf, H, and Esselen, M. . “Metabolic conjugation reduces in vitro toxicity of the flavonoid nevadensin.” Food and Chemical Toxicology 164: 113006. doi: 10.1016/j.fct.2022.113006.
- Penczynski, K, Cramer, B, Dietrich, S, Humpf, H, Abraham, K, and Weikert, C. . “Mycotoxins in Serum and 24-h Urine of Vegans and Omnivores from the Risks and Benefits of a Vegan Diet (RBVD) Study.” Molecular Nutrition and Food Research 66 (6). doi: 10.1002/mnfr.202100874.
- Lindemann, V, Schmidt, J, Cramer, B, and Humpf, H. . “Detection of Mycotoxins in Highly Matrix-Loaded House-Dust Samples by QTOF-HRMS, IM-QTOF-HRMS, and TQMS: Advantages and Disadvantages.” Analytical Chemistry 94 (10): 4209–4217. doi: 10.1021/acs.analchem.1c04254.
- Jürgens, FM, Behrens, M, Humpf, H-U, Robledo, SM, and Schmidt, TJ. . “In Vitro Metabolism of Helenalin Acetate and 11α,13-Dihydrohelenalin Acetate: Natural Sesquiterpene Lactones from Arnica.” Metabolites 12: 88.. doi: 10.3390/metabo12010088.
- Barth, C., Spreen, H., Mulac, D., Keuter, L., Behrens, M., Humpf, H.-U., and Langer, K. . “Spacer length and serum protein adsorption affect active targeting of trastuzumab-modified nanoparticles.” Biomaterials and Biosystems 5: 100032. doi: 10.1016/j.bbiosy.2021.100032.
- Hassan, R., Friebel, A., Brackhagen, L., Hobloss, Z., Myllys, M., González, D., Albrecht, W., Mohammed, E.S.I., Seddek, A.l., Marchan, R., Cadenas, C., Cramer, B., Humpf, H.U., Hartl, L., Simbrunner, B., Reiberger, T., Trauner, M., Hoehme, S., Degen, G.H., Hengstler, J.G., and Ghallab, A. . “Hypoalbuminemia affects the spatio-temporal tissue distribution of ochratoxin A in liver and kidneys: consequences for organ toxicity.” Archives of Toxicology 96 (11): 2967–2981. doi: 10.1007/s00204-022-03361-8.
- Hassan, R., González, D., Hobloss, Z., Brackhagen, L., Myllys, M., Friebel, A., Seddek, A.l., Marchan, R., Cramer, B., Humpf, H.U., Hoehme, S., Degen, G.H., Hengstler, J.G., and Ghallab, A. . “Inhibition of cytochrome P450 enhances the nephro- and hepatotoxicity of ochratoxin A.” Archives of Toxicology 96 (12): 3349–3361. doi: 10.1007/s00204-022-03395-y.
- Jürgens, Michaela Franziska, Behrens, Matthias, Humpf, Hans-Ulrich, Robledo, M.Sara, and Schmidt, J.Thomas. . “In Vitro Metabolism of Helenalin Acetate and 11α,13-Dihydrohelenalin Acetate: Natural Sesquiterpene Lactones from Arnica.” Metabolites 12 (1): 88. doi: 10.3390/metabo12010088.
- Lünne, F, Köhler, J, Stroh, C, Müller, L, Daniliuc, CG, Mück-Lichtenfeld, C, Würthwein, EU, Esselen, M, Humpf, HU, and Kalinina, SA. . “Insights into Ergochromes of the Plant Pathogen <i>Claviceps purpurea</i>.” Journal of Natural Products 84 (10): 2630–2643. doi: 10.1021/acs.jnatprod.1c00264.
- Detzner, J, Püttmann, C, Pohlentz, G, Humpf, HU, Mellmann, A, Karch, H, and Müthing, J. . “Primary Human Colon Epithelial Cells (pHCoEpiCs) Do Express the Shiga Toxin (Stx) Receptor Glycosphingolipids Gb3Cer and Gb4Cer and Are Largely Refractory but Not Resistant towards Stx.” International Journal of Molecular Sciences 22 (18): 10002. doi: 10.3390/ijms221810002.
- Detzner, J, Klein, AL, Pohlentz, G, Krojnewski, E, Humpf, HU, Mellmann, A, Karch, H, and Müthing, J. . “Primary Human Renal Proximal Tubular Epithelial Cells (pHRPTEpiCs): Shiga Toxin (Stx) Glycosphingolipid Receptors, Stx Susceptibility, and Interaction with Membrane Microdomains.” Toxins 13 (8): 529.
- Behrens, M, Hüwel, S, Galla, H-J, and Humpf, H-U. . “Efflux at the Blood-Brain Barrier Reduces the Cerebral Exposure to Ochratoxin A, Ochratoxin α, Citrinin and Dihydrocitrinone.” Toxins 13 (5): 327.. doi: 10.3390/toxins13050327.
- Detzner, J, Krojnewski, E, Pohlentz, G, Steil, D, Humpf, HU, Mellmann, A, Karch, H, and Müthing, J. . “Shiga Toxin (Stx)-Binding Glycosphingolipids of Primary Human Renal Cortical Epithelial Cells (pHRCEpiCs) and Stx-Mediated Cytotoxicity.” Toxins 13 (2): 139.. doi: 10.3390/toxins13020139.
- Kalinina, S, Cramer, B, and Humpf, H. . “Current and future perspectives of mycotoxin research — report from the 42nd Mycotoxin Workshop (Online conference).” Mycotoxin Research 37 (4): 275–278. doi: 10.1007/s12550-021-00439-7.
- Schmidt, J, Cramer, B, Turner, PC, Stoltzfus, RJ, Humphrey, JH, Smith, LE, and Humpf, H-. . “Determination of urinary mycotoxin biomarkers using a sensitive online solid phase extraction‐uhplc‐ms/ms method.” Toxins 13 (6). doi: 10.3390/toxins13060418.
- Spreen, H., Behrens, M., Mulac, D., Humpf, H., and Langer, K. . “Identification of main influencing factors on the protein corona composition of PLGA and PLA nanoparticles.” European journal of pharmaceutics and biopharmaceutics 163: 212–222.
- Schmidt, J, Lindemann, V, Olsen, M, Cramer, B, and Humpf, H-U. . “Dried urine spots as sampling technique for multi-mycotoxin analysis in human urine.” Mycotoxin Research 37 (2): 129–140. doi: 10.1007/s12550-021-00423-1.
- Ghallab, A, Hassan, R, Myllys, M, Albrecht, W, Friebel, A, Hoehme, S, Hofmann, U, Seddek, A-, Braeuning, A, Kuepfer, L, Cramer, B, Humpf, H-, Boor, P, Degen, GH, and Hengstler, JG. . “Subcellular spatio-temporal intravital kinetics of aflatoxin B1 and ochratoxin A in liver and kidney.” Archives of Toxicology 95 (6): 2163–2177. doi: 10.1007/s00204-021-03073-5.
- Kopp, N., Civenni, G., Marson, D., Laurini, E., Pricl, S., Catapano, C.V., Humpf, H.-U., Almansa, C., Nieto, F.R., Schepmann, D., and Wünsch, B. . “Chemoenzymatic synthesis of 2,6-disubsttuted tetrahydropyrans with high 1 receptor affinity, antitumor and analgesic activity.” European Journal of Medicinal Chemistry 219: 113443.. doi: 10.1016/j.ejmech.2021.113443.
- Haidar, Samer, Jürgens, Michaela Franziska, Aichele, Dagmar, Jagels, Annika, Humpf, Hans-Ulrich, and Jose, Joachim. . “Natural Compounds Isolated from <i>Stachybotrys chartarum</i> Are Potent Inhibitors of Human Protein Kinase CK2.” Molecules 26 (15): 4453. doi: 10.3390/molecules26154453.
- Jagels, A, Stephan, F, Ernst, S, Lindemann, V, Cramer, B, Hübner, F, and Humpf, H-U. . “Artificial vs natural Stachybotrys infestation—Comparison of mycotoxin production on various building materials.” Indoor Air 30 (6): 1268–1282. doi: 10.1111/ina.12705.
- Schulz, M, Gaitanoglou, V, Mantel, O, Hoevelmann, Y, Huebner, F, Dobrindt, U, and Humpf, HU. . “Metabolomics Study on Pathogenic and Non-pathogenic E. coli with Closely Related Genomes with a Focus on Yersiniabactin and Its Known and Novel Derivatives.” Metabolites 10 (6): 221.. doi: 10.3390/metabo10060221.
- Kasimir, Matthias Behrens Matthias, Schulz, Mareike Kuchenbuch Henning, and Focke, Christine Humpf Hans-Ulrich. . “Intestinal Metabolism of α- and β‑Glucosylated Modified Mycotoxins T‑2 and HT‑2 Toxin in the Pig Cecum Model.” Journal of Agricultural and Food Chemistry 68 (19). doi: 10.1021/acs.jafc.0c00576.
- Hövelmann, Y, Lewin, L, Steinert, K, Hübner, F, and Humpf, HU. . “Mass Spectrometry–Based Analysis of Urinary Biomarkers for Dietary Tomato Intake.” Molecular Nutrition & Food Research 64.
- Hövelmann, Y, Steinert, K, Hübner, F, and Humpf, HU. . “Identification of a novel N-caprylhistamine-β-glucoside from tomato fruits and LC-MS/MS-based food screening for imidazole alkaloids.” Food Chemistry 312.
- Warensjö, Lemming E, Montano, Montes A, Schmidt, J, Cramer, B, Humpf, H-, Moraeus, L, and Olsen, M. . “Mycotoxins in blood and urine of Swedish adolescents—possible associations to food intake and other background characteristics.” Mycotoxin Research 36 (2): 193–206. doi: 10.1007/s12550-019-00381-9.
- Korff, M, Imberg, L, Will, JM, Buckreis, N, Kalinina, SA, Wenzel, BM, Kastner, GA, Daniliuc, CG, Barth, M, Ovsepyan, RA, Butov, KR, Humpf, HU, Lehr, M, Panteleev, MA, Poso, A, Karst, U, Stenmetzer, T, Bendas, G, and Kalinin, DV. . “Acylated 1H-1,2,4-Triazol-5-amines Targeting Human Coagulation Factor XIIa and Thrombin: Conventional and Microscale Synthesis, Anticoagulant Properties, and Mechanism of Action.” Journal of Medicinal Chemistry 63 (21): 13159–13186. doi: 10.1021/acs.jmedchem.0c01635.
- Marques, LMM, Behrens, M, Kalinina, S, Rottkord, U, Adhikari, A, (S), Shrestha RL, Humpf, H, and Lopes, NP. . “Govaniadine Evaluation of Cytotoxicity and Permeability in Cell Culture.” Revista Brasileira de Farmacognosia 30 (3): 374–380. doi: 10.1007/s43450-020-00066-w.
- Detzner, J, Steil, D, Pohlentz, G, Legros, N, Humpf, HU, Mellmann, A, Karch, H, and Muthing, J. . “Real-time interaction analysis of Shiga toxins and membrane microdomains of primary human brain microvascular endothelial cells.” Glycobiology 30 (3): 174–185. doi: 10.1093/glycob/cwz091.
- Detzner, J, Gloerfeld, C, Pohlentz, G, Legros, N, Humpf, HU, Mellmann, A, Karch, H, and Muthing, J. . “Structural Insights into Escherichia coli Shiga Toxin (Stx) Glycosphingolipid Receptors of Porcine Renal Epithelial Cells and Inhibition of Stx-Mediated Cellular Injury Using Neoglycolipid-Spiked Glycovesicles.” Microorganisms 7 (11): 582.. doi: 10.3390/microorganisms7110582.
- Partikel, K., Korte, R., Stein, N.C., Mulac, D., Herrmann, F.C., Humpf, H.-U., and Langer, K. . “Effect of nanoparticle size and PEGylation on the protein corona of PLGA nanoparticles.” European journal of pharmaceutics and biopharmaceutics 2019: 70–80.
- Partikel, K., Korte, R., Mulac, D., Humpf, H.-U., and Langer, K. . “Serum type and concentration both affecting the protein corona composition of PLGA nanoparticles.” Beilstein Journal of Nanotechnology 10: 1002–1015.
- Sueck, F, Hemp, V, Specht, J, Torres, O, Cramer, B, and Humpf, H-U. . “Occurrence of the ochratoxin A degradation product 2′R-ochratoxin a in coffee and other food: An update.” Toxins 11 (6): 329.. doi: 10.3390/toxins11060329.
- Kuchenbuch, HS, Cramer, B, and Humpf, H-U. . “Matrix binding of T-2 toxin: structure elucidation of reaction products and indications on the fate of a relevant food-borne toxin during heating.” Mycotoxin Research 35 (3): 261–270. doi: 10.1007/s12550-019-00350-2.
- Sueck, F, Cramer, B, Czeschinski, P, and Humpf, H-. . “Human Study on the Kinetics of 2′R-Ochratoxin A in the Blood of Coffee Drinkers.” Molecular Nutrition and Food Research 63 (4): 1801026.. doi: 10.1002/mnfr.201801026.
- Kuchenbuch, HS, Schulz, M, Becker, S, Cramer, B, and Humpf, H-. . ACS Symposium Series, Vol. 1306, Thermal reactions and the formation of degradation products of T-2 and HT-2 toxin during processing of oats American Chemical Society. doi: 10.1021/bk-2019-1306.ch007.
- Sueck, F, Specht, J, Cramer, B, and Humpf, H-. . “Identification of ochratoxin-N-acetyl-L-cysteine as a new ochratoxin A metabolite and potential biomarker in human urine.” Mycotoxin Research 2020 (36): 1–10. doi: 10.1007/s12550-019-00360-0.
- Jagels, A, Lindemann, V, Ulrich, S, Gottschalk, C, Cramer, B, Hübner, F, Gareis, M, and Humpf, H-U. . “Exploring secondary metabolite profiles of stachybotrys spp. By LC-MS/MS.” Toxins 11 (3): 133.. doi: 10.3390/toxins11030133.
- Hövelmann, Y, Lewin, L, Hübner, F, and Humpf, HU. . “Large-Scale Screening of Foods for Glucose-Derived β-Carboline Alkaloids by Stable Isotope Dilution LC–MS/MS.” Journal of Agricultural and Food Chemistry 67: 3890–3899.
- Hövelmann, Y, Hahn, M, Hübner, F, and Humpf, HU. . “Detection of Novel Cytotoxic Imidazole Alkaloids in Tomato Products by LC-MS/MS.” Journal of Agricultural and Food Chemistry 67: 3670–3678.
- Hövelmann, Y, Jagels, A, Schmid, R, Hübner, F, and Humpf, HU. . “Identification of potential human urinary biomarkers for tomato juice intake by mass spectrometry-based metabolomics.” European Journal of Nutrition 59: 685–697.
- Faisal, Zelma, Kunsági-Máté, Sándor, Lemli, Beáta, Szente, Lajos, Bergmann, Dominik, Humpf, Hans-Ulrich, and Poór, Miklós. . “Interaction of Dihydrocitrinone with Native and Chemically Modified Cyclodextrins.” Molecules 24 (7): 1328. doi: 10.3390/molecules24071328.
- Kuchenbuch, Henning S., Becker, Stefanie, Schulz, Mareike, Cramer, Benedikt, and Humpf, Hans-Ulrich. . “Thermal stability of T-2 and HT-2 toxins during biscuit- and crunchy muesli-making and roasting.” Food Additives and Contaminants: Part A: Chemistry, Analysis, Control, Exposure and Risk Assessment 35: 2158–2167. doi: 10.1080/19440049.2018.1530456.
- Jagels, A, Hövelmann, Y, Zielinski, A, Esselen, M, Köhler, J, Hübner, F, and Humpf, HU. . “Stachybotrychromenes A-C: novel cytotoxic meroterpenoids from Stachybotrys sp.” Mycotoxin Res. 34: 179–185.
- Krug, I, Behrens, M, Esselen, M, and Humpf, HU. . “Transport of enniatin B and enniatin B1 across the blood-brain barrier and hints for neurotoxic effects in cerebral cells.” PloS one 13(5). doi: 10.1371/journal.pone.0197406.
- Sueck, F, Poór, M, Faisal, Z, Gertzen, C, Cramer, B, Lemli, B, Kunsági-Máté, S, Gohlke, H, and Humpf, H-U. . “Interaction of ochratoxin A and its thermal degradation product 2'R-ochratoxin A with human serum albumin.” Toxins 10 (7). doi: 10.3390/toxins10070256.
- Schmidt, HS, Schulz, M, Focke, C, Becker, S, Cramer, B, and Humpf, H-U. . “Glucosylation of T-2 and HT-2 toxins using biotransformation and chemical synthesis: Preparation, stereochemistry, and stability.” Mycotoxin Research 34 (3): 159–172. doi: 10.1007/s12550-018-0310-9.
- Kalinina, SA, Jagels, A, Hickert, S, Mauriz, Marques LM, Cramer, B, and Humpf, H. . “Detection of the Cytotoxic Penitrems A-F in Cheese from the European Single Market by HPLC-MS/MS.” Journal of Agricultural and Food Chemistry 66 (5): 1264–1269. doi: 10.1021/acs.jafc.7b06001.
- Faisal, Z, Derdák, D, Lemli, B, Kunsági-Máté, S, Bálint, M, Hetényi, C, Csepregi, R, Kőszegi, T, Sueck, F, Cramer, B, Humpf, H, and Poór, M. . “Interaction of 2'R-ochratoxin A with serum albumins: Binding site, effects of site markers, thermodynamics, species differences of albumin-binding, and influence of albumin on its toxicity in MDCK cells.” Toxins 10 (9). doi: 10.3390/toxins10090353.
- Bauer, JI, Gross, M, Cramer, B, Humpf, H, Hamscher, G, and Usleber, E. . “Immunochemical Analysis of Paxilline and Ergot Alkaloid Mycotoxins in Grass Seeds and Plants.” Journal of Agricultural and Food Chemistry 66 (1): 315–322. doi: 10.1021/acs.jafc.7b05580.
- Faisal, Zelma, Derdák, Diána, Lemli, Beáta, Kunsági-Máté, Sándor, Bálint, Mónika, Hetényi, Csaba, Csepregi, Rita, Koszegi, Tamas, Sueck, Franziska, Cramer, Benedikt, Humpf, Hans-Ulrich, and Poór, Miklós. . “Interaction of 2′R-ochratoxin A with Serum Albumins: Binding Site, Effects of Site Markers, Thermodynamics, Species Differences of Albumin-binding, and Influence of Albumin on Its Toxicity in MDCK Cells.” Toxins 10 (9): 353. doi: 10.3390/toxins10090353.
- Sueck, F., Poór, M., Faisal, Z., Gertzen, C.G.W., Cramer, B., Lemli, B., Kunsági-Máté, S., Gohlke, H., and Humpf, H.-U. . “Interaction of Ochratoxin A and Its Thermal Degradation Product 2′<i>R</i>-Ochratoxin A with Human Serum Albumin.” Toxins 10 (7): 256. doi: 10.3390/toxins10070256.
- Andreeßen, C., Wolf, N., Cramer, B., Humpf, H., and Steinbüchel, A. . “In vitro biosynthesis of 3-mercaptolactate by lactate dehydrogenases.” Enzyme and Microbial Technology 108 (null): 1–10. doi: 10.1016/j.enzmictec.2017.08.005.
- Viegas, S., Osteresch, B., Almeida, A., Cramer, B., Humpf, H., and Viegas, C. . “Enniatin B and ochratoxin A in the blood serum of workers from the waste management setting.” Mycotoxin Research 34 (2): 85–90. doi: 10.1007/s12550-017-0302-1.
- Rottkord, U., Röhl, C., Ferse, I., Schulz, M., Rückschloss, U., Gekle, M., Schwerdt, G., and Humpf, H. . “Structure–activity relationship of ochratoxin A and synthesized derivatives: importance of amino acid and halogen moiety for cytotoxicity.” Archives of Toxicology 91 (3): 1461–1471. doi: 10.1007/s00204-016-1799-3.
- Saenger, T., Hübner, F., and Humpf, H. . “Short-term biomarkers of apple consumption.” Molecular Nutrition and Food Research 61 (3). doi: 10.1002/mnfr.201600629.
- Legros, N., Dusny, S., Humpf, H., Pohlentz, G., Karch, H., and Müthing, J. . “Shiga toxin glycosphingolipid receptors and their lipid membrane ensemble in primary human blood-brain barrier endothelial cells.” Glycobiology 27 (1): 99–109. doi: 10.1093/glycob/cww090.
- Wu, Q., Kuča, K., Humpf, H., Klímová, B., and Cramer, B. . “Fate of deoxynivalenol and deoxynivalenol-3-glucoside during cereal-based thermal food processing: a review study.” Mycotoxin Research 33 (1): 79–91. doi: 10.1007/s12550-016-0263-9.
- Muñoz, K., Cramer, B., Dopstadt, J., Humpf, H., and Degen, G. . “Evidence of ochratoxin A conjugates in urine samples from infants and adults.” Mycotoxin Research 33 (1): 39–47. doi: 10.1007/s12550-016-0261-y.
- Dopstadt, J., Vens-Cappell, S., Neubauer, L., Tudzynski, P., Cramer, B., Dreisewerd, K., and Humpf, H. . “Localization of ergot alkaloids in sclerotia of Claviceps purpurea by matrix-assisted laser desorption/ionization mass spectrometry imaging.” Analytical and Bioanalytical Chemistry 409 (5): 1221–1230. doi: 10.1007/s00216-016-0047-2.
- Hickert, S., Hermes, L., Marques, L., Focke, C., Cramer, B., Lopes, N., Flett, B., and Humpf, H. . “Alternaria toxins in South African sunflower seeds: cooperative study.” Mycotoxin Research 33 (4): 309–321. doi: 10.1007/s12550-017-0290-1.
- Cramer, B., Hübner, F., and Humpf, H. . “Applications of High-Performance Liquid Chromatography-Mass Spectrometry Techniques for the Analysis of Chemical Contaminants and Residues in Food.” in Chemical Contaminants and Residues in Food: Second Edition, Vol. null , edited by D Schrenk. Elsevier. doi: 10.1016/B978-0-08-100674-0.00003-5.
- Schmidt, H., Becker, S., Cramer, B., and Humpf, H. . “Impact of Mechanical and Thermal Energies on the Degradation of T-2 and HT-2 Toxins during Extrusion Cooking of Oat Flour.” Journal of Agricultural and Food Chemistry 65 (20): 4177–4183. doi: 10.1021/acs.jafc.7b01484.
- Kalinina, S., Jagels, A., Cramer, B., Geisen, R., and Humpf, H. . “Influence of environmental factors on the production of penitrems A–F by Penicillium crustosum.” Toxins 9 (7). doi: 10.3390/toxins9070210.
- Osteresch, B., Viegas, S., Cramer, B., and Humpf, H. . “Multi-mycotoxin analysis using dried blood spots and dried serum spots.” Analytical and Bioanalytical Chemistry 409 (13): 3369–3382. doi: 10.1007/s00216-017-0279-9.
- Arndt, B., Janevska, S., Schmid, R., Hübner, F., Tudzynski, B., and Humpf, H. . “A Fungal N-Dimethylallyltryptophan Metabolite from Fusarium fujikuroi.” ChemBioChem 18 (10): 899–904. doi: 10.1002/cbic.201600691.
- Legros, N., Pohlentz, G., Runde, J., Dusny, S., Humpf, H., Karch, H., and Müthing, J. . “Colocalization of receptors for Shiga toxins with lipid rafts in primary human renal glomerular endothelial cells and influence of D-PDMP on synthesis and distribution of glycosphingolipid receptors.” Glycobiology 27 (10): 947–965. doi: 10.1093/glycob/cwx048.
- Jarolim, K., Del, Favero G., Ellmer, D., Stark, T., Hofmann, T., Sulyok, M., Humpf, H., and Marko, D. . “Dual effectiveness of Alternaria but not Fusarium mycotoxins against human topoisomerase II and bacterial gyrase.” Archives of Toxicology 91 (4): 2007–2016. doi: 10.1007/s00204-016-1855-z.
- Janevska, S., Arndt, B., Baumann, L., Apken, L., Marques, L., Humpf, H., and Tudzynski, B. . “Establishment of the inducible Tet-on system for the activation of the silent trichosetin gene cluster in Fusarium fujikuroi.” Toxins 9 (4). doi: 10.3390/toxins9040126.
- Studt, L., Janevska, S., Arndt, B., Boedi, S., Sulyok, M., Humpf, H., Tudzynski, B., and Strauss, J. . “Lack of the COMPASS component Ccl1 reduces H3K4 trimethylation levels and affects transcription of secondary metabolite genes in two plant-pathogenic fusarium species.” Frontiers in Microbiology 7 (null). doi: 10.3389/fmicb.2016.02144.
- Kouzel, I., Pohlentz, G., Schmitz, J., Steil, D., Humpf, H., Karch, H., and Müthing, J. . “Shiga toxin glycosphingolipid receptors in human Caco-2 and HCT-8 colon epithelial cell lines.” Toxins 9 (11). doi: 10.3390/toxins9110338.
- Humpf, H., Schneider, C., and Stevens, J. . “Hot Topics in 2017 – Gut Microbiota, Whole Grains and Health.” Molecular Nutrition and Food Research 61 (1). doi: 10.1002/mnfr.201770014.
- Rösler, S., Kramer, K., Finkemeier, I., Humpf, H., and Tudzynski, B. . “The SAGA complex in the rice pathogen Fusarium fujikuroi: structure and functional characterization.” Molecular Microbiology 102 (6): 951–974. doi: 10.1111/mmi.13528.
- Dopstadt, J., Neubauer, L., Tudzynski, P., and Humpf, H. . “The epipolythiodiketopiperazine gene cluster in Claviceps purpurea: Dysfunctional cytochrome P450 enzyme prevents formation of the previously unknown clapurines.” PloS one 11 (7). doi: 10.1371/journal.pone.0158945.
- Hickert, S., Cramer, B., Letzel, M., and Humpf, H.-U. . “Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry imaging of ochratoxin A and fumonisins in mold-infected food.” Rapid Communications in Mass Spectrometry 30 (23): 2508–2516. doi: 10.1002/rcm.7733.
- Hövelmann, Y., Hickert, S., Cramer, B., and Humpf, H. . “Determination of exposure to the alternaria mycotoxin tenuazonic acid and its isomer allo-tenuazonic acid in a German population by stable isotope dilution HPLC-MS3.” Journal of Agricultural and Food Chemistry 64 (34): 6641–6647. doi: 10.1021/acs.jafc.6b02735.
- Osteresch, B., Cramer, B., and Humpf, H. . “Analysis of ochratoxin A in dried blood spots - Correlation between venous and finger-prick blood, the influence of hematocrit and spotted volume.” Journal of Chromatography B 1020 (null): 158–164. doi: 10.1016/j.jchromb.2016.03.026.
- Simon, H, Hoffmann, G, Hubner, F, Humpf, HU, and Karst, U. . “Electrochemical simulation of metabolic reactions of the secondary fungal metabolites alternariol and alternariol methyl ether.” Analytical and Bioanalytical Chemistry 408 (10): 2471–2483.
- Simon, H., Hoffmann, G., Hübner, F., Humpf, H., and Karst, U. . “Electrochemical simulation of metabolic reactions of the secondary fungal metabolites alternariol and alternariol methyl ether.” Analytical and Bioanalytical Chemistry null (null): 1–13. doi: 10.1007/s00216-016-9344-z.
- Wang, M, Carver, J, Phelan, V, Sanchez, L, Garg, N, Peng, Y, Nguyen, D, Watrous, J, Kapono, C, Luzzatto-Knaan, T, Porto, C, Bouslimani, A, Melnik, A, Meehan, M, Liu, W, Crüsemann, M, Boudreau, P, Esquenazi, E, Sandoval-Calderón, M, Kersten, R, Pace, L, Quinn, R, Duncan, K, Hsu, C, Floros, D, Gavilan, R, Kleigrewe, K, Northen, T, Dutton, R, Parrot, D, Carlson, E, Aigle, B, Michelsen, C, Jelsbak, L, Sohlenkamp, C, Pevzner, P, Edlund, A, McLean, J, Piel, J, Murphy, B, Gerwick, L, Liaw, C, Yang, Y, Humpf, H, Maansson, M, Keyzers, R, Sims, A, Johnson, A, Sidebottom, A, Sedio, B, Klitgaard, A, Larson, C, Boya, C, Torres-Mendoza, D, Gonzalez, D, Silva, D, Marques, L, Demarque, D, Pociute, E, O{'}Neill, E, Briand, E, Helfrich, E, Granatosky, E, Glukhov, E, Ryffel, F, Houson, H, Mohimani, H, Kharbush, J, Zeng, Y, Vorholt, J, Kurita, K, Charusanti, P, McPhail, K, Nielsen, K, Vuong, L, Elfeki, M, Traxler, M, Engene, N, Koyama, N, Vining, O, Baric, R, Silva, R, Mascuch, S, Tomasi, S, Jenkins, S, Macherla, V, Hoffman, T, Agarwal, V, Williams, P, Dai, J, Neupane, R, Gurr, J, Rodríguez, A, Lamsa, A, Zhang, C, Dorrestein, K, Duggan, B, Almaliti, J, Allard, P, Phapale, P, Nothias, L, Alexandrov, T, Litaudon, M, Wolfender, J, Kyle, J, Metz, T, Peryea, T, Nguyen, D, VanLeer, D, Shinn, P, Jadhav, A, Müller, R, Waters, K, Shi, W, Liu, X, Zhang, L, Knight, R, Jensen, P, Palsson, B, Pogliano, K, Linington, R, Gutiérrez, M, Lopes, N, Gerwick, W, Moore, B, Dorrestein, P, and Bandeira, N. . “Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking.” Nature Biotechnology 34: 828–837. doi: 10.1038/nbt.3597.
- Brezina, U., Rempe, I., Kersten, S., Valenta, H., Humpf, H., and Dänicke, S. . “Determination of zearalenone, deoxynivalenol and metabolites in bile of piglets fed diets with graded levels of Fusarium toxin contaminated maize.” World Mycotoxin Journal 9 (2): 179–193. doi: 10.3920/WMJ2015.1902.
- Yamashita, S., Bergmann, D., Sato, A., Nomoto, M., Tada, Y., Humpf, H., Itami, K., and Hagihara, S. . “High-throughput assay for quantification of aminoglycoside-Ribosome interaction.” Chemistry Letters 45 (9): 1048–1050. doi: 10.1246/cl.160508.
- Goldbeck, C., Fürst, P., Humpf, H., and Schymanski, D. . “Kunststoffpartikel sind überall – auch in Lebensmitteln?” Nachrichten aus der Chemie 64 (9): 842–846. doi: 10.1002/nadc.20164052892.
- Havermann, S., Humpf, H., and Wätjen, W. . “Baicalein modulates stress-resistance and life span in C. elegans via SKN-1 but not DAF-16.” Fitoterapia 113 (null): 123–127. doi: 10.1016/j.fitote.2016.06.018.
- Bernhardt, K., Valenta, H., Kersten, S., Humpf, H., and Dänicke, S. . “Determination of T-2 toxin, HT-2 toxin, and three other type A trichothecenes in layer feed by high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS)—comparison of two sample preparation methods.” Mycotoxin Research 32 (2): 89–97. doi: 10.1007/s12550-016-0244-z.
- Rösler, S., Sieber, C., Humpf, H., and Tudzynski, B. . “Interplay between pathway-specific and global regulation of the fumonisin gene cluster in the rice pathogen Fusarium fujikuroi.” Applied Microbiology and Biotechnology 100 (13): 5869–5882. doi: 10.1007/s00253-016-7426-7.
- Studt, L., Rösler, S., Burkhardt, I., Arndt, B., Freitag, M., Humpf, H., Dickschat, J., and Tudzynski, B. . “Knock-down of the methyltransferase Kmt6 relieves H3K27me3 and results in induction of cryptic and otherwise silent secondary metabolite gene clusters in Fusarium fujikuroi.” Environmental Microbiology 18 (11): 4037–4054. doi: 10.1111/1462-2920.13427.
- Havermann, S., Chovolou, Y., Humpf, H., and Wätjen, W. . “Modulation of the Nrf2 signalling pathway in Hct116 colon carcinoma cells by baicalein and its methylated derivative negletein.” Pharmaceutical Biology 54 (9): 1491–1502. doi: 10.3109/13880209.2015.1104703.
- Korte, R., Monneuse, J., Gemrot, E., Metton, I., Humpf, H., and Brockmeyer, J. . “New High-Performance Liquid Chromatography Coupled Mass Spectrometry Method for the Detection of Lobster and Shrimp Allergens in Food Samples via Multiple Reaction Monitoring and Multiple Reaction Monitoring Cubed.” Journal of Agricultural and Food Chemistry 64 (31): 6219–6227. doi: 10.1021/acs.jafc.6b02620.
- Humpf, H., Schneider, C., and Stevens, F. . “Obesity, Cancer and Nutrition, Gut Microbiota - Special Issues 2016.” Molecular Nutrition and Food Research 60 (1): 5–6. doi: 10.1002/mnfr.201670014.
- Hickert, S., Bergmann, M., Ersen, S., Cramer, B., and Humpf, H. . “Survey of Alternaria toxin contamination in food from the German market, using a rapid HPLC-MS/MS approach.” Mycotoxin Research 32 (1): 7–18. doi: 10.1007/s12550-015-0233-7.
- Bittner, Andrea Cramer Benedikt, and Harrer, Henning Humpf Hans-Ulrich. . “Structure elucidation and in vitro cytotoxicity of ochratoxin α amide, a new degradation product of ochratoxin A.” Mycotoxin Research 31 (2): 83–90. doi: 10.1007/s12550-014-0218-y.
- Behrens, M, Hüwel, S, Galla, H, and Humpf, H. . “Blood-Brain Barrier Effects of the Fusarium Mycotoxins Deoxynivalenol, 3 Acetyldeoxynivalenol, and Moniliformin and Their Transfer to the Brain.” PloS one 10 (11): 1–20. doi: 10.1371/journal.pone.0143640.
- Michielse, C, Studt, L, Janevska, S, Sieber, C, Arndt, B, Espino, J, Humpf, H, Güldener, U, and Tudzynski, B. . “The global regulator FfSge1 is required for expression of secondary metabolite gene clusters but not for pathogenicity in Fusarium fujikuroi.” Environmental Microbiology 17: 2690–2708. doi: 10.1111/1462-2920.12592.
- Steil, D., Schepers, C., Pohlentz, G., Legros, N., Runde, J., Humpf, H., Karch, H., and Müthing, J. . “Shiga toxin glycosphingolipid receptors of Vero-B4 kidney epithelial cells and their membrane microdomain lipid environment.” Journal of Lipid Research 56 (12): 2322–2336. doi: 10.1194/jlr.M063040.
- Arndt, B., Studt, L., Wiemann, P., Osmanov, H., Kleigrewe, K., Köhler, J., Krug, I., Tudzynski, B., and Humpf, H. . “Genetic engineering, high resolution mass spectrometry and nuclear magnetic resonance spectroscopy elucidate the bikaverin biosynthetic pathway in Fusarium fujikuroi.” Fungal Genetics and Biology 84 (null): 26–36. doi: 10.1016/j.fgb.2015.09.006.
- Hickert, S., Krug, I., Cramer, B., and Humpf, H. . “Detection and Quantitative Analysis of the Non-cytotoxic allo-Tenuazonic Acid in Tomato Products by Stable Isotope Dilution HPLC-MS/MS.” Journal of Agricultural and Food Chemistry 63 (50): 10879–10884. doi: 10.1021/acs.jafc.5b04812.
- Hickert, S., Gerding, J., Ncube, E., Hübner, F., Flett, B., Cramer, B., and Humpf, H. . “A new approach using micro HPLC-MS/MS for multi-mycotoxin analysis in maize samples.” Mycotoxin Research 31 (2): 109–115. doi: 10.1007/s12550-015-0221-y.
- Gerding, J., Ali, N., Schwartzbord, J., Cramer, B., Brown, D., Degen, G., and Humpf, H. . “A comparative study of the human urinary mycotoxin excretion patterns in Bangladesh, Germany, and Haiti using a rapid and sensitive LC-MS/MS approach.” Mycotoxin Research 31 (3): 127–136. doi: 10.1007/s12550-015-0223-9.
- Bittner, Katharina M. K.M., Kemme, Theresa T., Peters, Katharina K., Kersten, Susanne S., Dänicke, Sven S., and Humpf, Hans Ulrich H.U. . “Systemic absorption and metabolism of dietary procyanidin B4 in pigs.” Molecular Nutrition and Food Research 58 (12): 2273. doi: 10.1002/mnfr.201400435.
- Humpf, Hans Ulrich H.U., Schneider, Claus C., and Stevens, Jan Frederik J.F. . “Scoping dietary supplements versus botanical medicines.” Molecular Nutrition and Food Research 59 (1): 6. doi: 10.1002/mnfr.201570004.
- Habermeyer, Michael M., Roth, Angelika A., Guth, Sabine E. S.E., Diel, Patrick P., Engel, Karl Heinz K.H., Epe, Bernd B., Fürst, Peter P., Heinz, Volker V., Humpf, Hans Ulrich H.U., Joost, Hans Georg H.G., Knorr, Dietrich D., De Kok, Theo Martinus C M T.M.C.M., Kulling, Sabine E. S.E., Lampen, Alfonso D. A.D., Marko, Doris D., Rechkemmer, Gerhard R. G.R., Rietjens, Ivonne M C M I.M.C.M., Stadler, Richard H. R.H., Vieths, Stefan S., Vogel, Rudi F. R.F., Steinberg, Pablo P., and Eisenbrand, Gerhard G. . “Nitrate and nitrite in the diet: How to assess their benefit and risk for human health.” Molecular Nutrition and Food Research 59 (1): 128. doi: 10.1002/mnfr.201400286.
- Gerding, Johannes J., Cramer, Benedikt B., and Humpf, Hans Ulrich H.U. . “Determination of mycotoxin exposure in Germany using an LC-MS/MS multibiomarker approach.” Molecular Nutrition and Food Research 58 (12): 2368. doi: 10.1002/mnfr.201400406.
- Hennemeier, Isabell I., Humpf, Hans Ulrich H.U., Gekle, Michael M., and Schwerdt, Gerald G. . “Role of microRNA-29b in the ochratoxin A-induced enhanced collagen formation in human kidney cells.” Toxicology 324: 122. doi: 10.1016/j.tox.2014.07.012.
- Von Bargen, Christoph C., Brockmeyer, Jens J., and Humpf, Hans Ulrich H.U. . “Meat authentication: A new HPLC-MS/MS based method for the fast and sensitive detection of horse and pork in highly processed food.” Journal of Agricultural and Food Chemistry 62 (39): 9435. doi: 10.1021/jf503468t.
- Havermann, Susannah S., Chovolou, Yvonni Y., Humpf, Hans Ulrich H.U., and Wätjen, Wim W. . “Caffeic acid phenethylester increases stress resistance and enhances lifespan in Caenorhabditis elegans by modulation of the insulin-like DAF-16 signalling pathway.” PloS one 9 (6). doi: 10.1371/journal.pone.0100256.
- Sartori, LR, Vessecchi, R, Humpf, HU, Da, Costa FB, and Lopes, NP. . “A systematic investigation of the fragmentation pattern of two furanoheliangolide C-8 stereoisomers using electrospray ionization mass spectrometry.” Rapid Communications in Mass Spectrometry 28 (7): 723–30. doi: 10.1002/rcm.6839.
- Niehaus, E.-M., von, Bargen K.W., Espino, J.J., Pfannmüller, A., Humpf, H.-U., and Tudzynski, B. . “Characterization of the fusaric acid gene cluster in Fusarium fujikuroi.” Applied Microbiology and Biotechnology 98 (4): 1749–62. doi: 10.1007/s00253-013-5453-1.
- Unterberg, M, Leffers, L, Hübner, F, Humpf, H, Lepikhov, K, Walter, J, Ebert, F, and Schwerdtle, T. . “Toxicity of arsenite and thio-DMAV after long-term (21 days) incubation of human urothelial cells: Cytotoxicity, genotoxicity and epigenetics.” Toxicology Research 3: 456–464. doi: 10.1039/c4tx00036f.
- Leucht, K., Fischbeck, A., Caj, M., Liebisch, G., Hartlieb, E., Benes, P., Fried, M., Humpf, H.-U., Rogler, G., and Hausmann, M. . “Sphingomyelin and phosphatidylcholine contrarily affect the induction of apoptosis in intestinal epithelial cells.” Molecular Nutrition and Food Research 58 (4): 782–798. doi: 10.1002/mnfr.201300369.
- Guaratini, T., Silva, D.B., Bizaro, A.C., Sartori, L.R., Humpf, H.-U., Lopes, N.P., Costa-Lotufo, L.V., and Lopes, J.L.C. . “In vitro metabolism studies of erythraline, the major spiroalkaloid from Erythrina verna.” BMC Complementary and Alternative Medicine 14 (null). doi: 10.1186/1472-6882-14-61.
- Lohrey, L., Uehara, T.N., Tani, S., Yamaguchi, J., Humpf, H.-U., and Itami, K. . “2,4- and 2,5-disubstituted arylthiazoles: Rapid synthesis by c-h coupling and biological evaluation.” European Journal of Organic Chemistry null (null). doi: 10.1002/ejoc.201402129.
- Humpf, HU, Wüst, M, and Hayen, H. . “Too shortsighted? Planned reform of the practical year in North Rhine-Westphalia | Zu kurz gedacht?: Geplante reform des praktischen jahres in NRW.” Deutsche Lebensmittel-Rundschau 110 (1): 12.
- Rychlik, Michael M., Humpf, Hans Ulrich H.U., Marko, Doris D., Dänicke, Sven S., Mally, Angela A., Berthiller, Franz F., Klaffke, Horst St H.S., and Lorenz, Nicole N. . “Proposal of a comprehensive definition of modified and other forms of mycotoxins including ‘masked’ mycotoxins.” Mycotoxin Research 30 (4): 205. doi: 10.1007/s12550-014-0203-5.
- Harrer, Henning H., Humpf, Hans Ulrich H.U., and Voss, Kenneth A. K.A. . “In vivo formation of N-acyl-fumonisin B1.” Mycotoxin Research 31 (1): 40. doi: 10.1007/s12550-014-0211-5.
- Humpf, Hans Ulrich H.U., Schneider, Claus C., and Stevens, Jan Frederik J.F. . “Functional Food - Where do we go?” Molecular Nutrition and Food Research 58 (1): 6. doi: 10.1002/mnfr.201470004.
- Brezina, Ulrike U., Rempe, Inga I., Kersten, Susanne S., Valenta, Hana H., Humpf, Hans Ulrich H.U., and Dänicke, Sven S. . “Diagnosis of intoxications of piglets fed with Fusarium toxin-contaminated maize by the analysis of mycotoxin residues in serum, liquor and urine with LC-MS/MS.” Archives of Animal Nutrition 68 (6): 447. doi: 10.1080/1745039X.2014.973227.
- Brezina, Ulrike U., Valenta, Hana H., Rempe, Inga I., Kersten, Susanne S., Humpf, Hans Ulrich H.U., and Dänicke, Sven S. . “Development of a liquid chromatography tandem mass spectrometry method for the simultaneous determination of zearalenone, deoxynivalenol and their metabolites in pig serum.” Mycotoxin Research 30 (3): 186. doi: 10.1007/s12550-014-0200-8.
- Studt, L, Humpf, HU, and Tudzynski, B. . “Signaling governed by G proteins and cAMP is crucial for growth, secondary metabolism and sexual development in Fusarium fujikuroi.” PloS one 8 (2): e58185.. doi: 10.1371/journal.pone.0058185.
- Weidner, M, Hüwel, S, Ebert, F, Schwerdtle, T, Galla, HJ, and Humpf, HU. . “Influence of T-2 and HT-2 toxin on the blood-brain barrier in vitro: new experimental hints for neurotoxic effects.” PloS one 8 (3): e60484.. doi: 10.1371/journal.pone.0060484.
- Studt, L., Schmidt, F.J., Jahn, L., Sieber, C.M.K., Connolly, L.R., Niehaus, E.-M., Freitag, M., Humpf, H.-U., and Tudzynski, B. . “Two histone deacetylases, FfHda1 and FfHda2, are important for Fusarium fujikuroi secondary metabolism and virulence.” Applied and Environmental Microbiology 79 (24): 7719–34. doi: 10.1128/AEM.01557-13.
- Bittner, A, Cramer, B, and Humpf, HU. . “Matrix binding of ochratoxin A during roasting.” Journal of Agricultural and Food Chemistry 61 (51): 12737–43. doi: 10.1021/jf403984x.
- von, Bargen C, Dojahn, J, Waidelich, D, Humpf, HU, and Brockmeyer, J. . “New sensitive high-performance liquid chromatography-tandem mass spectrometry method for the detection of horse and pork in halal beef.” Journal of Agricultural and Food Chemistry 61 (49): 11986–94. doi: 10.1021/jf404121b.
- Silva, Denise Brentan D.B., Guaratini, Thais T., Vessecchi, Ricardo L. R.L., Lopes, Norberto Peporine N.P., Cramer, Benedikt B., Humpf, Hans Ulrich H.U., and Callegari Lopes, JoÃoLuis J.L. . “H2 unimolecular elimination in electrospray ionization mass spectrometry from erythraline, a spirocyclic alkaloid.” European Journal of Mass Spectrometry 19 (5): 350. doi: 10.1255/ejms.1243.
- von, Bargen K.W., Niehaus, E.-M., Bergander, K., Brun, R., Tudzynski, B., and Humpf, H.-U. . “Structure elucidation and antimalarial activity of apicidin F: an apicidin-like compound produced by Fusarium fujikuroi.” Journal of Natural Products 76 (11): 2136–40. doi: 10.1021/np4006053.
- Holl, K, Falck, E, Köhler, J, Schepmann, D, Humpf, HU, Brust, P, and Wünsch, B. . “Synthesis, Characterization, and Metabolism Studies of Fluspidine Enantiomers.” ChemMedChem 2013. doi: 10.1002/cmdc.201300322.
- Bittner, K, Rzeppa, S, and Humpf, HU. . “Distribution and quantification of flavan-3-ols and procyanidins with low degree of polymerization in nuts, cereals, and legumes.” Journal of Agricultural and Food Chemistry 61 (38): 9148–54. doi: 10.1021/jf4024728.
- Humpf, Hans Ulrich H.U., and Cramer, Benedikt B. . “HPLC-MS/MS-analysis of Mycotoxins: Current applications and future perspectives.” Journal of Plant Pathology 1 (SUPPL): S1.39..
- Niehaus, E.-M., Kleigrewe, K., Wiemann, P., Studt, L., Sieber, C.M.K., Connolly, L.R., Freitag, M., Güldener, U., Tudzynski, B., and Humpf, H.-U. . “Genetic manipulation of the Fusarium fujikuroi fusarin gene cluster yields insight into the complex regulation and fusarin biosynthetic pathway.” Chemistry and Biology 20 (8): 1055–66. doi: 10.1016/j.chembiol.2013.07.004.
- Bergmann, D, Hübner, F, and Humpf, HU. . “Stable isotope dilution analysis of small molecules with carboxylic acid functions using 18O labeling for HPLC-ESI-MS/MS: analysis of fumonisin B1.” Journal of Agricultural and Food Chemistry 61 (33): 7904–8. doi: 10.1021/jf4022702.
- Wiemann, P., Sieber, C.M.K., von, Bargen K.W., Studt, L., Niehaus, E.-M., Espino, J.J., Huß, K., Michielse, C.B., Albermann, S., Wagner, D., Bergner, S.V., Connolly, L.R., Fischer, A., Reuter, G., Kleigrewe, K., Bald, T., Wingfield, B.D., Ophir, R., Freeman, S., Hippler, M., Smith, K.M., Brown, D.W., Proctor, R.H., Münsterkötter, M., Freitag, M., Humpf, H.-U., Güldener, U., and Tudzynski, B. . “Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites.” PLoS Pathogens 9 (6): e1003475.. doi: 10.1371/journal.ppat.1003475.
- Blaas, N, and Humpf, HU. . “Structural profiling and quantitation of glycosyl inositol phosphoceramides in plants with Fourier transform mass spectrometry.” Journal of Agricultural and Food Chemistry 61 (18): 4257–69. doi: 10.1021/jf4001499.
- Harrer, H, Laviad, EL, Humpf, HU, and Futerman, AH. . “Identification of N-acyl-fumonisin B1 as new cytotoxic metabolites of fumonisin mycotoxins.” Molecular Nutrition and Food Research 57 (3): 516–22. doi: 10.1002/mnfr.201200465.
- Weidner, M, Lenczyk, M, Schwerdt, G, Gekle, M, and Humpf, HU. . “Neurotoxic potential and cellular uptake of T-2 toxin in human astrocytes in primary culture.” Chemical Research in Toxicology 26 (3): 347–55. doi: 10.1021/tx3004664.
- Havermann, Susannah S., Rohrig, Ricarda R., Chovolou, Yvonni Y., Humpf, Hans Ulrich H.U., and Wätjen, Wim W. . “Molecular effects of baicalein in Hct116 cells and Caenorhabditis elegans: Activation of the Nrf2 signaling pathway and prolongation of lifespan.” Journal of Agricultural and Food Chemistry 61 (9): 2164. doi: 10.1021/jf304553g.
- Engemann, A, Focke, C, and Humpf, HU. . “Intestinal formation of N-nitroso compounds in the pig cecum model.” Journal of Agricultural and Food Chemistry 61 (4): 998–1005. doi: 10.1021/jf305040e.
- Mulac, D, Lepski, S, Ebert, F, Schwerdtle, T, and Humpf, HU. . “Cytotoxicity and fluorescence visualization of ergot alkaloids in human cell lines.” Journal of Agricultural and Food Chemistry 61 (2): 462–71. doi: 10.1021/jf304569q.
- Lohrey, Lilia L., Marschik, Stefanie S., Cramer, Benedikt B., and Humpf, Hans Ulrich H.U. . “Large-scale synthesis of isotopically labeled 13C 2-tenuazonic acid and development of a rapid HPLC-MS/MS method for the analysis of tenuazonic acid in tomato and pepper products.” Journal of Agricultural and Food Chemistry 61 (1): 120. doi: 10.1021/jf305138k.
- Lohrey, L, Marschik, S, Cramer, B, and Humpf, HU. . “Large-scale synthesis of isotopically labeled 13C2-tenuazonic acid and development of a rapid HPLC-MS/MS method for the analysis of tenuazonic acid in tomato and pepper products.” Journal of Agricultural and Food Chemistry 61 (1): 114–20. doi: 10.1021/jf305138k.
- Biedermann, L, Mwinyi, J, Scharl, M, Frei, P, Zeitz, J, Kullak-Ublick, G, Vavricka, S, Fried, M, Weber, A, Humpf, H, Peschke, S, Jetter, A, Krammer, G, and Rogler, G. . “Bilberry ingestion improves disease activity in mild to moderate ulcerative colitis - An open pilot study.” Journal of Crohn's & Colitis 7: 271–279. doi: 10.1016/j.crohns.2012.07.010.
- Silva, D, Guaratini, T, Vessecchi, R, Lopes, N, Cramer, B, Humpf, H, and Callegari, Lopes J. . “H2 unimolecular elimination in electrospray ionization mass spectrometry from erythraline, a spirocyclic alkaloid.” European Journal of Mass Spectrometry 19: 345–350. doi: 10.1255/ejms.1243.
- Leffers, L, Unterberg, M, Bartel, M, Hoppe, C, Pieper, I, Stertmann, J, Ebert, F, Humpf, H, and Schwerdtle, T. . “In vitro toxicological characterisation of the S-containing arsenic metabolites thio-dimethylarsinic acid and dimethylarsinic glutathione.” Toxicology 305: 109–119. doi: 10.1016/j.tox.2013.01.007.
- Lohrey, L, Marschik, S, Cramer, B, and Humpf, H. . “Large-scale synthesis of isotopically labeled 13C 2-tenuazonic acid and development of a rapid HPLC-MS/MS method for the analysis of tenuazonic acid in tomato and pepper products.” Journal of Agricultural and Food Chemistry 61: 114–120. doi: 10.1021/jf305138k.
- Wiemann, P, Albermann, S, Niehaus, EM, Studt, L, von, Bargen KW, Brock, NL, Humpf, HU, Dickschat, JS, and Tudzynski, B. . “The Sfp-type 4'-phosphopantetheinyl transferase Ppt1 of Fusarium fujikuroi controls development, secondary metabolism and pathogenicity.” PloS one 7 (5): e37519.. doi: 10.1371/journal.pone.0037519.
- Ferse, I, Langlitz, M, Kleigrewe, K, Rzeppa, S, Lenczyk, M, Harrer, H, Cramer, B, and Humpf, HU. . “Isolation and structure elucidation of two new cytotoxic metabolites from red yeast rice.” Natural Product Research 26 (20): 1914–21. doi: 10.1080/14786419.2011.639074.
- von, Bargen C, Hübner, F, Cramer, B, Rzeppa, S, and Humpf, HU. . “Systematic approach for structure elucidation of polyphenolic compounds using a bottom-up approach combining ion trap experiments and accurate mass measurements.” Journal of Agricultural and Food Chemistry 60 (45): 11274–82. doi: 10.1021/jf3030369.
- Welsch, T, and Humpf, HU. . “HT-2 toxin 4-glucuronide as new T-2 toxin metabolite: enzymatic synthesis, analysis, and species specific formation of T-2 and HT-2 toxin glucuronides by rat, mouse, pig, and human liver microsomes.” Journal of Agricultural and Food Chemistry 60 (40): 10170–8. doi: 10.1021/jf302571y.
- Kleigrewe, K., Niehaus, E.-M., Wiemann, P., Tudzynski, B., and Humpf, H.-U. . “New approach via gene knockout and single-step chemical reaction for the synthesis of isotopically labeled fusarin c as an internal standard for the analysis of this fusarium mycotoxin in food and feed samples.” Journal of Agricultural and Food Chemistry 60 (34): 8350–5. doi: 10.1021/jf302534x.
- Studt, L, Troncoso, C, Gong, F, Hedden, P, Toomajian, C, Leslie, JF, Humpf, HU, Rojas, MC, and Tudzynski, B. . “Segregation of secondary metabolite biosynthesis in hybrids of Fusarium fujikuroi and Fusarium proliferatum.” Fungal Genetics and Biology 49 (7): 567–77. doi: 10.1016/j.fgb.2012.05.005.
- Studt, L, Wiemann, P, Kleigrewe, K, Humpf, HU, and Tudzynski, B. . “Biosynthesis of fusarubins accounts for pigmentation of Fusarium fujikuroi perithecia.” Applied and Environmental Microbiology 78 (12): 4468–80. doi: 10.1128/AEM.00823-12.
- Weidner, M, Welsch, T, Hübner, F, Schwerdt, G, Gekle, M, and Humpf, HU. . “Identification and apoptotic potential of T-2 toxin metabolites in human cells.” Journal of Agricultural and Food Chemistry 60 (22): 5676–84. doi: 10.1021/jf300634k.
- Kleigrewe, K, Aydin, F, Hogrefe, K, Piecuch, P, Bergander, K, Würthwein, EU, and Humpf, HU. . “Structure elucidation of new fusarins revealing insights in the rearrangement mechanisms of the Fusarium mycotoxin fusarin C.” Journal of Agricultural and Food Chemistry 60 (21): 5497–505. doi: 10.1021/jf3009469.
- Rzeppa, S, Bittner, K, Döll, S, Dänicke, S, and Humpf, HU. . “Urinary excretion and metabolism of procyanidins in pigs.” Molecular Nutrition and Food Research 56 (4): 653–65. doi: 10.1002/mnfr.201100471.
- von, Bargen KW, Lohrey, L, Cramer, B, and Humpf, HU. . “Analysis of the Fusarium mycotoxin moniliformin in cereal samples using 13C2-moniliformin and high-resolution mass spectrometry.” Journal of Agricultural and Food Chemistry 60 (14): 3586–91. doi: 10.1021/jf300323d.
- Mulac, D, Hüwel, S, Galla, HJ, and Humpf, HU. . “Permeability of ergot alkaloids across the blood-brain barrier in vitro and influence on the barrier integrity.” Molecular Nutrition and Food Research 56 (3): 475–85. doi: 10.1002/mnfr.201100431.
- Hübner, F, Harrer, H, Fraske, A, Kneifel, S, and Humpf, HU. . “Large scale purification of B-type fumonisins using centrifugal partition chromatography (CPC).” Mycotoxin Research 28 (1): 37–43. doi: 10.1007/s12550-011-0114-7.
- Engemann, A, Hübner, F, Rzeppa, S, and Humpf, HU. . “Intestinal metabolism of two A-type procyanidins using the pig cecum model: detailed structure elucidation of unknown catabolites with Fourier transform mass spectrometry (FTMS).” Journal of Agricultural and Food Chemistry 60 (3): 749–57. doi: 10.1021/jf203927g.
- Von, Bargen K, Lohrey, L, Cramer, B, and Humpf, H. . “Analysis of the Fusarium mycotoxin moniliformin in cereal samples using 13C 2-moniliformin and high-resolution mass spectrometry.” Journal of Agricultural and Food Chemistry 60: 3586–3591. doi: 10.1021/jf300323d.
- Hennemeier, I, Humpf, H, Gekle, M, and Schwerdt, G. . “The food contaminant and nephrotoxin ochratoxin A enhances Wnt1 inducible signaling protein 1 and tumor necrosis factor-α expression in human primary proximal tubule cells.” Molecular Nutrition and Food Research 56: 1375–1384. doi: 10.1002/mnfr.201200164.
- Slot, G, Rose, K, Engemann, A, and Humpf, H. . ACS Symposium Series, Vol. 1093, The pig cecum model - A powerful tool for studying the intestinal metabolism of flavonoids 2012: American Chemical Society. doi: 10.1021/bk-2012-1093.ch027.
- van, Valen F, Harrer, H, Hotfilder, M, Dirksen, U, Pap, T, Gosheger, G, Humpf, HU, and Jürgens, H. . “A Novel Role of IGF1 in Apo2L/TRAIL-Mediated Apoptosis of Ewing Tumor Cells.” Sarcoma 2012: 782970..
- Kuczius, T, Hummel, M, Böhler, O, and Humpf, HU. . “Development and applications of simultaneous immunochemical staining and serial detection of overlapping proteins in blotting procedures.” Journal of Immunological Methods 386 (1-2): 70–77.
- Storck, W, Meisen, I, Gianmoena, K, Pläger, I, Kouzel, IU, Bielaszewska, M, Haier, J, Mormann, M, Humpf, HU, Karch, H, and Müthing, J. . “Shiga toxin glycosphingolipid receptor expression and toxin susceptibility of human pancreatic ductal adenocarcinomas of differing origin and differentiation.” Biological Chemistry 393 (8): 785–799. doi: 10.1515/hsz-2012-0165.
- Betz, J, Bauwens, A, Kunsmann, L, Bielaszewska, M, Mormann, M, Humpf, HU, Karch, H, Friedrich, AW, and Müthing, J. . “Uncommon membrane distribution of Shiga toxin glycosphingolipid receptors in toxin-sensitive human glomerular microvascular endothelial cells.” Biological Chemistry 393 (3): 133–147.
- Kleigrewe, K, Söhnel, AC, and Humpf, HU. . “A new high-performance liquid chromatography-tandem mass spectrometry method based on dispersive solid phase extraction for the determination of the mycotoxin fusarin C in corn ears and processed corn samples.” Journal of Agricultural and Food Chemistry 59 (19): 10470–6. doi: 10.1021/jf2026814.
- Rzeppa, S, Von, Bargen C, Bittner, K, and Humpf, HU. . “Analysis of Flavan-3-ols and procyanidins in food samples by reversed phase high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry (RP-HPLC-ESI-MS/MS).” Journal of Agricultural and Food Chemistry 59 (19): 10594–603. doi: 10.1021/jf202697j.
- Mulac, D, Grote, AK, Kleigrewe, K, and Humpf, HU. . “Investigation of the metabolism of ergot alkaloids in cell culture by fourier transformation mass spectrometry.” Journal of Agricultural and Food Chemistry 59 (14): 7798–807. doi: 10.1021/jf2012024.
- Mulac, D, and Humpf, HU. . “Cytotoxicity and accumulation of ergot alkaloids in human primary cells.” Toxicology 282 (3): 112–21. doi: 10.1016/j.tox.2011.01.019.
- Wiese, C, Grosse, Maestrup E, Schepmann, D, Grimme, S, Humpf, HU, Brust, P, and Wünsch, B. . “Enantioselective σ1 receptor binding and biotransformation of the spirocyclic PET tracer 1'-benzyl-3-(3-fluoropropyl)-3H-spiro[[2]benzofuran-1,4'-piperidine].” Chirality 23 (2): 148–54. doi: 10.1002/chir.20893.
- Bauwens, A, Bielaszewska, M, Kemper, B, Langehanenberg, P, von, Bally G, Reichelt, R, Mulac, D, Humpf, HU, Friedrich, AW, Kim, KS, Karch, H, and Müthing, J. . “Differential cytotoxic actions of Shiga toxin 1 and Shiga toxin 2 on microvascular and macrovascular endothelial cells.” Thrombosis and Haemostasis 105 (3): 515–28. doi: 10.1160/TH10-02-0140.
- Wiese, C, Maestrup, EG, Schepmann, D, Grimme, S, Humpf, HU, Brust, P, and Wunsch, B. . “Enantioselective sigma(1) Receptor Binding and Biotransformation of the Spirocyclic PET Tracer 1 '-Benzyl-3-(3-fluoropropyl)-3H-spiro[[2]benzofuran-1,4 '-piperidine].” Chirality 23 (2): 148–154. doi: 10.1002/chir.20893.
- Fischbeck, A, Leucht, K, Frey-Wagner, I, Bentz, S, Pesch, T, Kellermeier, S, Krebs, M, Fried, M, Rogler, G, Hausmann, M, and Humpf, HU. . “Sphingomyelin induces cathepsin D-mediated apoptosis in intestinal epithelial cells and increases inflammation in DSS colitis.” Gut 60 (1): 55–65. doi: 10.1136/gut.2009.201988.
- Betz, J, Bielaszewska, M, Thies, A, Humpf, HU, Dreisewerd, K, Karch, H, Kim, KS, Friedrich, AW, and Müthing, J. . “Shiga toxin glycosphingolipid receptors in microvascular and macrovascular endothelial cells: differential association with membrane lipid raft microdomains.” Journal of Lipid Research 52 (4): 618–634. doi: 10.1194/jlr.M010819.
- Wiese, C, Maestrup, E, Schepmann, D, Grimme, S, Humpf, H, Brust, P, and Wünsch, B. . “Enantioselective σ1 receptor binding and biotransformation of the spirocyclic PET tracer 1′-benzyl-3-(3-fluoropropyl)-3H-spiro[[2] benzofuran-1,4′-piperidine].” Chirality 23: 148–154. doi: 10.1002/chir.20893.
- Blaas, N, Schüürmann, C, Bartke, N, Stahl, B, and Humpf, H. . “Structural profiling and quantification of sphingomyelin in human breast milk by HPLC-MS/MS.” Journal of Agricultural and Food Chemistry 59: 6018–6024. doi: 10.1021/jf200943n.
- Lohrey, L, Murata, T, Uemura, D, and Humpf, H. . “Synthesis of isotopically labeled fusarium mycotoxin 13C 2-moniliformin [1-hydroxycyclobut-1-ene-3,4-dione].” SYNLETT 2011: 2242–2244. doi: 10.1055/s-0030-1261189.
- Franzmann, C, Schröder, J, Mϋnzing, K, Wolf, K, Lindhauer, M, and Humpf, H. . “Distribution of ergot alkaloids and ricinoleic acid in different milling fractions.” Mycotoxin Research 27: 13–21. doi: 10.1007/s12550-010-0070-7.
- Danicke, S, Beyer, M, Breves, G, Valenta, H, and Humpf, HU. . “Effects of oral exposure of pigs to deoxynivalenol (DON) sulfonate (DONS) as the non-toxic derivative of DON on tissue residues of DON and de-epoxy-DON and on DONS blood levels.” Food Additives and Contaminants: Part A: Chemistry, Analysis, Control, Exposure and Risk Assessment 27 (11): 1558–1565. doi: 10.1080/19440049.2010.501036.
- Danicke, S, Pahlow, G, Beyer, M, Goyarts, T, Breves, G, Valenta, H, and Humpf, HU. . “Investigations on the kinetics of the concentration of deoxynivalenol (DON) and on spoilage by moulds and yeasts of wheat grain preserved with sodium metabisulfite (Na2S2O5, SBS) and propionic acid at various moisture contents.” Archives of Animal Nutrition 64 (3): 190–203. doi: 10.1080/17450391003693159.
- Beyer, M, Dänicke, S, Rohweder, D, and Humpf, H-U. . “Determination of Deoxynivalenol-sulfonate (DONS) in cereals by hydrophilic interaction chromatography coupled to tandem mass spectrometry.” Mycotoxin Research 26 (2): 109–117. doi: 10.1007/s12550-010-0046-7.
- Hasslauer, I, Oehme, A, Locher, S, Valotis, A, van't, Slot G, Humpf, HU, and Schreier, P. . “Flavan-3-ol C-glycosides - Preparation and model experiments mimicking their human intestinal transit.” Molecular Nutrition and Food Research 54 (11): 1546–1555. doi: 10.1002/mnfr.201000003.
- Wiemann, P, Brown, DW, Kleigrewe, K, Bok, JW, Keller, NP, Humpf, HU, and Tudzynski, B. . “FfVel1 and FfLae1, components of a velvet-like complex in Fusarium fujikuroi, affect differentiation, secondary metabolism and virulence.” Molecular Microbiology 77 (4): 972–994. doi: 10.1111/j.1365-2958.2010.07263.x.
- van't, Slot G, Mattern, W, Rzeppa, S, Grewe, D, and Humpf, HU. . “Complex Flavonoids in Cocoa: Synthesis and Degradation by Intestinal Microbiota.” Journal of Agricultural and Food Chemistry 58 (15): 8879–8886. doi: 10.1021/jf1012242.
- Franzmann, C, Wachter, J, Dittmer, N, and Humpf, HU. . “Ricinoleic Acid as a Marker for Ergot Impurities in Rye and Rye Products.” Journal of Agricultural and Food Chemistry 58 (7): 4223–4229. doi: 10.1021/jf1006903.
- Hasche, A, Ferenz, KB, Rose, K, König, S, Humpf, HU, Klumpp, S, and Krieglstein, J. . “Binding of ATP to nerve growth factor: characterization and relevance for bioactivity.” Neurochemistry International 56 (2): 276–284. doi: 10.1016/j.neuint.2009.10.012.
- Cramer, B, Harrer, H, Nakamura, K, Uemura, D, and Humpf, HU. . “Total synthesis and cytotoxicity evaluation of all ochratoxin A stereoisomers.” Bioorganic & Medicinal Chemistry 18 (1): 343–357. doi: 10.1016/j.bmc.2009.10.050.
- Holl, R, Jung, B, Schepmann, D, Humpf, HU, Grunert, R, Bednarski, PJ, Englberger, W, and Wünsch, B. . “Synthesis and Pharmacological Evaluation of SNC80 Analogues with a Bridged Piperazine Ring.” ChemMedChem 4 (12): 2111–2122. doi: 10.1002/cmdc.200900358.
- Beyer, M, Ferse, I, and Humpf, H-U. . “Large-scale production of selected type A trichothecenes: The use of HT-2 toxin and T-2 triol as precursors for the synthesis of d 3-T-2 and d 3-HT-2 toxin.” Mycotoxin Research 25 (1): 41–52. doi: 10.1007/s12550-009-0006-2.
- Fischbeck, A, Kruger, M, Blaas, N, and Humpf, HU. . “Analysis of Sphingomyelin in Meat Based on Hydrophilic Interaction Liquid Chromatography Coupled to Electrospray Ionization-Tandem Mass Spectrometry (HILIC-HPLC-ESI-MS/MS).” Journal of Agricultural and Food Chemistry 57 (20): 9469–9474. doi: 10.1021/jf9025376.
- Pfeiffer, E, Hildebrand, A, Damm, G, Rapp, A, Cramer, B, Humpf, HU, and Metzler, M. . “Aromatic hydroxylation is a major metabolic pathway of the mycotoxin zearalenone in vitro.” Molecular Nutrition and Food Research 53 (9): 1123–1133. doi: 10.1002/mnfr.200800584.
- van't, Slot G, and Humpf, HU. . “Degradation and Metabolism of Catechin, Epigallocatechin-3-gallate (EGCG), and Related Compounds by the Intestinal Microbiota in the Pig Cecum Model.” Journal of Agricultural and Food Chemistry 57 (17): 8041–8048. doi: 10.1021/jf900458e.
- Wiemann, P, Willmann, A, Straeten, M, Kleigrewe, K, Beyer, M, Humpf, HU, and Tudzynski, B. . “Biosynthesis of the red pigment bikaverin in Fusarium fujikuroi: genes, their function and regulation.” Molecular Microbiology 72 (4): 931–946. doi: 10.1111/j.1365-2958.2009.06695.x.
- Konigs, M, Mulac, D, Schwerdt, G, Gekle, M, and Humpf, HU. . “Metabolism and cytotoxic effects of T-2 toxin and its metabolites on human cells in primary culture.” Toxicology 258 (2-3): 106–115. doi: 10.1016/j.tox.2009.01.012.
- Schwerdt, G, Konigs, M, Holzinger, H, Humpf, HU, and Gekle, M. . “Effects of the mycotoxin fumonisin B-1 on cell death in human kidney cells and human lung fibroblasts in primary culture.” Journal of Applied Toxicology 29 (2): 174–182. doi: 10.1002/jat.1398.
- Beyer, M, Ferse, I, Mulac, D, Wurthwein, EU, and Humpf, HU. . “Structural Elucidation of T-2 Toxin Thermal Degradation Products and Investigations toward Their Occurrence in Retail Food.” Journal of Agricultural and Food Chemistry 57 (5): 1867–1875. doi: 10.1021/jf803516s.
- Trebstein, A, Marschik, S, Lauber, U, and Humpf, HU. . “Acetonitrile: the better extractant for the determination of T-2 and HT-2 toxin in cereals using an immunoaffinity-based cleanup?” European Food Research and Technology 228 (4): 519–529. doi: 10.1007/s00217-008-0959-y.
- Schwerdt, G, Holzinger, H, Konigs, M, Humpf, HU, and Gekle, M. . “Effect of ochratoxin A on cell survival and collagen homeostasis in human mesangial cells in primary culture.” Food and Chemical Toxicology 47 (1): 209–213. doi: 10.1016/j.fct.2008.11.001.
- Trebstein, A, Lauber, U, and Humpf, H. . “Analysis of fusarium toxins via HPLC-MS/MS multimethods: Matrix effects and strategies for compensation.” Mycotoxin Research 25: 201–213. doi: 10.1007/s12550-009-0029-8.
- Fischbeck, A, Krüger, M, Blaas, N, and Humpf, H. . “Analysis of sphingomyelin in meat based on hydrophilic interaction liquid chromatography coupled to electrospray lonization-tandem mass spectrometry (HILIC-HPLC-ESI-MS/MS).” Journal of Agricultural and Food Chemistry 57: 9469–9474. doi: 10.1021/jf9025376.
- Schwerdt, G, Königs, M, Holzinger, H, Humpf, H, and Gekle, M. . “Effects of the mycotoxin fumonisin B1 on cell death in human kidney cells and human lung fibroblasts in primary culture.” Journal of Applied Toxicology 29: 174–182. doi: 10.1002/jat.1398.
- Cramer, B, Beyer, M, and Humpf, H. . ACS Symposium SeriesVol., Vol. 1031, Stable isotope labeled mycotoxins as standards for HPLC-MS/MS analysis: Review and evaluation of published procedures for the introduction of stable isotopes into mycotoxins Washington: American Chemical Society. doi: 10.1021/bk-2009-1031.ch018.
- Fischbeck, A, Krüger, M, Blaas, N, and Humpf, HU. . “Analysis of sphingomyelin in different meat and fish based on normal phase high-performance liquid chromatography (NP-HPLC).” J. Agric. Food Chem. 57: 9469–9474.
- Aldick, T, Bielaszewska, M, Uhlin, BE, Humpf, HU, Wai, SN, and Karch, H. . “Vesicular stabilization and activity augmentation of enterohaemorrhagic Escherichia coli haemolysin.” Molecular Microbiology 71 (6): 1496–1508. doi: 10.1111/j.1365-2958.2009.06618.x.
- Danicke, S, Beineke, A, Goyarts, T, Valenta, H, Beyer, M, and Humpf, HU. . “Effects of a Fusarium toxin-contaminated triticale, either untreated or treated with sodium metabisulphite (Na2S2O5, SBS), on weaned piglets with a special focus on liver function as determined by the C-13-methacetin breath test.” Archives of Animal Nutrition 62 (4): 263–286. doi: 10.1080/17450390802214167.
- Aldick, T, Bielaszewska, M, Uhlin, BE, Humpf, HU, Wai, SN, and Karch, H. . “Enterohemorrhagic Escherichia coli hemolysin delivery to target cells.” International Journal of Medical Microbiology 298: 84–84.
- Cramer, B, Konigs, M, and Humpf, HU. . “Identification and in vitro cytotoxicity of ochratoxin a degradation products formed during coffee roasting.” Journal of Agricultural and Food Chemistry 56 (14): 5673–5681. doi: 10.1021/jf801296z.
- Trebstein, A, Seefelder, W, Lauber, U, and Humpf, HU. . “Determination of T-2 and HT-2 toxins in cereals including oats after immunoaffinity cleanup by liquid chromatography and fluorescence detection.” Journal of Agricultural and Food Chemistry 56 (13): 4968–4975. doi: 10.1021/jf800316m.
- Konigs, M, Schwerdt, G, Gekle, M, and Humpf, HU. . “Effects of the mycotoxin deoxynivalenol on human primary hepatocytes.” Molecular Nutrition and Food Research 52 (7): 830–839. doi: 10.1002/mnfr.200700439.
- Gong, YY, Torres-Sanchez, L, Lopez-Carrillo, L, Peng, JH, Sutcliffe, AE, White, KL, Humpf, HU, Turner, PC, and Wild, CP. . “Association between tortilla consumption and human urinary fumonisin B1 levels in a Mexican population.” Cancer Epidemiology, Biomarkers and Prevention 17 (3): 688–694. doi: 10.1158/1055-9965.EPI-07-2534.
- Hein, EM, Rose, K, Van't, Slot G, Friedrich, AW, and Humpf, HU. . “Deconjugation and degradation of flavonol glycosides by pig cecal microbiota characterized by fluorescence in situ hybridization (FISH).” Journal of Agricultural and Food Chemistry 56 (6): 2281–2290. doi: 10.1021/jf073444o.
- Goßmann, M, Beran, F, Bedlan, G, Plenk, A, Hamedinger, S, Öhlinger, R, Humpf, H, and Büttner, C. . “Investigation on asparagus spears during the main harvest byFusarium spp.- infections and contamination by Fumonisin B1 | Spargelstangenuntersuchungen zur Haupterntezeit auf Infektionen mitFusarium spp. und Kontaminationen mit Fumonisin B1.” Mycotoxin Research 24: 88–97. doi: 10.1007/BF02985286.
- Brockmeyer, J, Bielaszewska, M, Fruth, A, Bonn, ML, Mellmann, A, Humpf, HU, and Karch, H. . “Subtypes of the plasmid-encoded serine protease EspP in Shiga toxin-producing Escherichia coli: distribution, secretion, and proteolytic activity.” Applied and Environmental Microbiology 73 (20): 6351–6359. doi: 10.1128/AEM.00920-07.
- Koenigs, M, Lenczyk, M, Schwerdt, G, Holzinger, H, Gekle, M, and Humpf, HU. . “Cytotoxicity, metabolism and cellular uptake of the mycotoxin deoxynivalenol in human proximal tubule cells and lung fibroblasts in primary culture.” Toxicology 240 (1-2): 48–59. doi: 10.1016/j.tox.2007.07.016.
- Cramer, B, Bretz, M, and Humpf, HU. . “Stable isotope dilution analysis of the Fusarium mycotoxin zearalenone.” Journal of Agricultural and Food Chemistry 55 (21): 8353–8358. doi: 10.1021/jf0717283.
- Seiferlein, M, Humpf, HU, Voss, KA, Sullards, MC, Allegood, JC, Wang, E, and Merrill, AH. . “Hydrolyzed fumonisins HFB1 and HFB2 are acylated in vitro and in vivo by ceramide synthase to form cytotoxic N-acyl-metabolites.” Molecular Nutrition and Food Research 51 (9): 1120–1130. doi: 10.1002/mnfr.200700118.
- Schwerdt, G, Holzinger, H, Sauvant, C, Konigs, M, Humpf, HU, and Gekle, M. . “Long-term effects of ochratoxin A on fibrosis and cell death in human proximal tubule or fibroblast cells in primary culture.” Toxicology 232 (1-2): 57–67. doi: 10.1016/j.tox.2006.12.008.
- Seiferlein, M, Humpf, H, Voss, K, Sullards, M, Allegood, J, Wang, E, and Merrill, Jr.A. . “Hydrolyzed fumonisins HFB1 and HFB2 are acylated in vitro and in vivo by ceramide synthase to form cytotoxic N-acyl-metabolites.” Molecular Nutrition and Food Research 51: 1120–1130. doi: 10.1002/mnfr.200700118.
- Bartke, N, Fischbeck, A, and Humpf, HU. . “Analysis of sphingolipids in potatoes (Solanum tuberosum L.) and sweet potatoes (Ipomoea batatas (L.) Lam.) by reversed phase high-performance liquid chromatography electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS).” Molecular Nutrition and Food Research 50 (12): 1201–1211. doi: 10.1002/mnfr.200600140.
- Keppler, K, Hein, EM, and Humpf, HU. . “Metabolism of quercetin and rutin by the pig caecal microflora prepared by freeze-preservation.” Molecular Nutrition and Food Research 50 (8): 686–695. doi: 10.1002/mnfr.200600016.
- Bretz, M, Beyer, M, Cramer, B, Knecht, A, and Humpf, HU. . “Thermal degradation of the Fusarium mycotoxin deoxynivalenol.” Journal of Agricultural and Food Chemistry 54 (17): 6445–6451. doi: 10.1021/jf061008g.
- Knecht, A, and Humpf, HU. . “Cytotoxic and antimitotic effects of N-containing Monascus metabolites studied using immortalized human kidney epithelial cells.” Molecular Nutrition and Food Research 50 (4-5): 406–412. doi: 10.1002/mnfr.200500238.
- Klotzel, M, Lauber, U, and Humpf, HU. . “A new solid phase extraction clean-up method for the determination of 12 type A and B trichothecenes in cereals and cereal-based food by LC-MS/MS.” Molecular Nutrition and Food Research 50 (3): 261–269. doi: 10.1002/mnfr.200500234.
- Knecht, A, Cramer, B, and Humpf, HU. . “New Monascus metabolites: Structure elucidation and toxicological properties studied with immortalized human kidney epithelial cells.” Molecular Nutrition and Food Research 50 (3): 314–321. doi: 10.1002/mnfr.200500229.
- Bretz, M, Beyer, M, Cramer, B, and Humpf, HU. . “Stable isotope dilution analysis of the Fusarium mycotoxins deoxynivalenol and 3-acetyldeoxynivalenol.” Molecular Nutrition and Food Research 50 (3): 251–260. doi: 10.1002/mnfr.200500230.
- Labib, S, Hummel, S, Richling, E, Humpf, HU, and Schreier, P. . “Use of the pig caecum model to mimic the human intestinal metabolism of hispidulin and related compounds.” Molecular Nutrition and Food Research 50 (1): 78–86. doi: 10.1002/mnfr.200500144.
- Bartke, N, Fischbeck, A, and Humpf, H. . “Analysis of sphingolipids in potatoes (Solanum tuberosum L.) and sweet potatoes (Ipomoea batatas (L.) Lam.) by reversed phase high-performance liquid chromatography electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS).” Molecular Nutrition and Food Research 50: 1201–1211. doi: 10.1002/mnfr.200600140.
- Bretz, M, Beyer, M, Cramer, B, and Humpf, HU. . “Synthesis of stable isotope labeled 3-acetyldeoxynivalenol.” Molecular Nutrition and Food Research 49 (12): 1151–1153. doi: 10.1002/mnfr.200500153.
- Goßmann, M, Kleta, S, Humpf, H-U, and Büttner, C. . “Investigation on contamination of asparagus spears (Asparagus officinalis L.) with Fusarium proliferatum (Matsushima) Nirenberg during main harvest | Untersuchungen zum endophytischen Befall von Fusarium proliferatum (Matsushima) Nirenberg in geernteten Stangen von Spargel (Asparagus officinalis L.).” Gesunde Pflanzen 57 (2-3): 53–58. doi: 10.1007/s10343-005-0065-z.
- Klotzel, M, Gutsche, B, Lauber, U, and Humpf, HU. . “Determination of 12 type A and B trichothecenes in cereals by liquid chromatography-electrospray ionization tandem mass spectrometry.” Journal of Agricultural and Food Chemistry 53 (23): 8904–8910. doi: 10.1021/jf051501c.
- Keppler, K, and Humpf, HU. . “Metabolism of anthocyanins and their phenolic degradation products by the intestinal microflora.” Bioorganic & Medicinal Chemistry 13 (17): 5195–5205. doi: 10.1016/j.bmc.2005.05.003.
- Klotzel, M, Schmidt, S, Lauber, U, Thielert, G, and Humpf, HU. . “Comparison of different clean-up procedures for the analysis of deoxynivalenol in cereal-based food and validation of a reliable HPLC method.” Chromatographia 62 (1-2): 41–48. doi: 10.1365/s10337-005-0576-x.
- Liu, CL, Liu, FM, Xu, WN, Kofoet, A, Humpf, HU, and Jiang, SR. . “Occurrence of fumonisins B-1 and B-2 in asparagus from Shandong province, P.R. China.” Food additives and contaminants 22 (7): 673–676. doi: 10.1080/02652030500133016.
- Bretz, M, Knecht, A, Gockler, S, and Humpf, HU. . “Structural elucidation and analysis of thermal degradation products of the Fusarium mycotoxin nivalenol.” Molecular Nutrition and Food Research 49 (4): 309–316. doi: 10.1002/mnfr.200400092.
- Fischbeck, A, Bartke, N, and Humpf, HU. . “New applications of the CD Exciton chirality method. Stereochemical assignment of organic compounds containing carboxylic acid groups.” Chemical Monthly / Monatshefte für Chemie 136 (3): 397–410. doi: 10.1007/s00706-004-0277-4.
- Goßmann, M, Kleta, S, Humpf, H, and Büttner, C. . “Investigation on contamination of asparagus spears (Asparagus officinalis L.) with Fusarium proliferatum (Matsushima) Nirenberg during main harvest | Untersuchungen zum endophytischen Befall von Fusarium proliferatum (Matsushima) Nirenberg in geernteten Stangen von Spargel (Asparagus officinalis L.).” Gesunde Pflanzen 57: 53–58. doi: 10.1007/s10343-005-0065-z.
- Bretz, M, Göckler, S, and Humpf, H. . “Isolation and structural elucidation of thermal degradation products of the Fusarium mycotoxin nivalenol | Isolierung und Strukturaufklärung von thermischen Abbauprodukten des Mykotoxins Nivalenol.” Mycotoxin Research 21: 15–17. doi: 10.1007/BF02954807.
- Bretz, M, Göckler, S, and Humpf, H. . “Isolation and structural elucidation of thermal degradation products of the Fusarium mycotoxin nivalenol.” Mycotoxin Research 21: 15–17. doi: 10.1007/BF02954807.
- Knecht, A, Schwerdt, G, Gekle, M, and Humpf, H. . “Combinatory effects of citrinin and ochratoxin A in immortalized human proximal tubule cells.” Mycotoxin Research 21: 176–181. doi: 10.1007/BF02959258.
- Humpf, HU, and Voss, KA. . “Effects of thermal food processing on the chemical structure and toxicity of fumonisin mycotoxins.” Molecular Nutrition and Food Research 48 (4): 255–269. doi: 10.1002/mnfr.200400033.
- Royer, D, Humpf, HU, and Guy, PA. . “Quantitative analysis of Fusarium mycotoxins in maize using accelerated solvent extraction before liquid chromatography atmospheric pressure chemical ionization tandem mass spectrometry.” Food additives and contaminants 21 (7): 678–692. doi: 10.1080/02652030410001711304.
- Royer, D, Humpf, H, and Guy, P. . “Quantitative analysis of Fusarium mycotoxins in maize using accelerated solvent extraction before liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry.” Food additives and contaminants 21: 678–692. doi: 10.1080/02652030410001711304.
- Seefelder, W, Humpf, HU, Schwerdt, G, Freudinger, R, and Gekle, M. . “Induction of apoptosis in cultured human proximal tubule cells by fumonisins and fumonisin metabolites.” Toxicology and Applied Pharmacology 192 (2): 146–153. doi: 10.1016/S0041-008X(03)00262-X.
- Seefelder, W, Knecht, A, and Humpf, HU. . “Bound fumonisin B-1: Analysis of fumonisin-B-1 glyco and amino acid conjugates by liquid chromatography-electrospray ionization-tandem mass spectrometry.” Journal of Agricultural and Food Chemistry 51 (18): 5567–5573. doi: 10.1021/jf0344338.
- Wild, D, Toth, G, and Humpf, HU. . “New Monascus metabolites with a pyridine structure in red fermented rice.” Journal of Agricultural and Food Chemistry 51 (18): 5493–5496. doi: 10.1021/jf030213i.
- Seefelder, W, Knecht, A, and Humpf, H. . “Bound fumonisin B1: Analysis of fumonisin-B1 glyco and amino acid conjugates by liquid chromatography-electrospray ionization-tandem mass spectrometry.” Journal of Agricultural and Food Chemistry 51: 5567–5573. doi: 10.1021/jf0344338.
- Desai, K, Sullards, MC, Allegood, J, Wang, E, Schmelz, EM, Hartl, M, Humpf, HU, Liotta, DC, Peng, Q, and Merrill, AH. . “Fumonisins and fumonisin analogs as inhibitors of ceramide synthase and inducers of apoptosis.” BBA - Molecular and Cell Biology of Lipids 1585 (2-3): 188–192. doi: 10.1016/S1388-1981(02)00340-2.
- Seefelder, W, Schwerdt, G, Freudinger, R, Gekle, M, and Humpf, HU. . “Liquid chromatography/electrospray ionisation-mass spectrometry method for the quantification of sphingosine and sphinganine in cell cultures exposed to fumonisins.” Journal of Chromatography B 780 (1): 137–144. doi: 10.1016/S1570-0232(02)00440-3.
- Wild, D, Toth, G, and Humpf, HU. . “New Monascus metabolite isolated from red yeast rice (angkak, red koji).” Journal of Agricultural and Food Chemistry 50 (14): 3999–4002. doi: 10.1021/jf020023s.
- Seefelder, W, Gossmann, M, and Humpf, HU. . “Analysis of fumonisin B-1 in Fusarium proliferatum-infected asparagus spears and garlic bulbs from Germany by liquid chromatography - Electrospray ionization mass spectrometry.” Journal of Agricultural and Food Chemistry 50 (10): 2778–2781. doi: 10.1021/jf0115037.
- Weil, K, Humpf, HU, Schwab, W, and Schreier, P. . “Absolute configuration of 3-hydroxy acids formed by Stenotrophomonas maltophilia: Application of multidimensional gas chromatography and circular dichroism spectroscopy.” Chirality 14 (1): 51–58. doi: 10.1002/chir.10029.
- Wild, D, Gareis, M, and Humpf, H. . “Analyses of red fermented rice (angkak) and report of a new Monascus metabolite.” Mycotoxin Research 18: 212–216. doi: 10.1007/BF02946098.
- Seefelder, W, Gossmann, M, and Humpf, H. . “Analysis of Fumonisin B1 in Fusarium proliferatum-infected asparagus spears and garlic bulbs from Germany by liquid chromatography-electrospray ionization mass spectrometry.” Journal of Agricultural and Food Chemistry 50: 2778–2781. doi: 10.1021/jf0115037.
- Merill, AH, Sullards, C, Allegood, J, Wang, E, Linn, SC, Andras, L, Liotta, DC, Hartl, M, and Humpf, HU. . “Insights into the Modulation of Ceramide Metabolism by Naturally Occurring and Synthetic Sphingolipid Analogs as Monitored by Electrospray Tandem Mass.” in Ceramide Signaling, edited by AH Futerman. New York: Springer International Publishing.
- Weckerle, B, Schreier, P, and Humpf, HU. . “A new one-step strategy for the stereochemical assignment of acyclic 2-and 3-sulfanyl-1-alkanols using the CD exciton chirality method.” Journal of Organic Chemistry 66 (24): 8160–8164. doi: 10.1021/jo010768h.
- Broring, M, Brandt, CD, Lex, J, Humpf, HU, Bley-Escrich, J, and Gisselbrecht, JP. . “Molecular and electronic structure of (2,2 '-bidipyrrinato)nickel(II) complexes.” European Journal of Inorganic Chemistry, № 10: 2549–2556. doi: 10.1002/1099-0682(200109)2001:102549::AID-EJIC2549>3.0.CO;2-7.
- Adam, W, Humpf, HU, Roschmann, KJ, and Saha-Moller, CR. . “Enantioselective epoxidation with chiral Mn-III(salen) catalysts: Kinetic resolution of aryl-substituted allylic alcohols.” Journal of Organic Chemistry 66 (17): 5796–5800. doi: 10.1021/jo010350j.
- Hartl, M, and Humpf, HU. . “Combined synthetic/CD strategy for the stereochemical assignment of the tricarballylic acid side chains of fumonisin B-1.” Journal of Organic Chemistry 66 (11): 3678–3681. doi: 10.1021/jo0000630.
- Seefelder, W, Hartl, M, and Humpf, HU. . “Determination of N-(carboxymethyl)fumonisin B-1 in corn products by liquid chromatography/electrospray ionization-mass spectrometry.” Journal of Agricultural and Food Chemistry 49 (5): 2146–2151. doi: 10.1021/jf001429c.
- Seefelder, W, Hartl, M, and Humpf, H. . “Determination of N-(carboxymethyl)fumonisin B1 in corn products by liquid chromatography/electrospray ionization-mass spectrometry.” Journal of Agricultural and Food Chemistry 49: 2146–2151. doi: 10.1021/jf001429c.
- Adam, W, Humpf, H, Roschmann, K, and Saha-Möller, C. . “Enantioselective epoxidation with chiral MnIII(salen) catalysts: Kinetic resolution of aryl-substituted allylic alcohols.” Journal of Organic Chemistry 66: 5796–5800. doi: 10.1021/jo010350j.
- Bröring, M, Brandt, C, Lex, J, Humpf, H, Bley-Escrich, J, and Gisselbrecht, J. . “Molecular and electronic structure of (2,2′-bidipyrrinato)nickel(II) complexes.” European Journal of Inorganic Chemistry 10: 2549–2556. doi: 10.1002/1099-0682(200109)2001:10<2549::AID-EJIC2549>3.0.CO;2-7.
- Seefelder, W, and Humpf, H. . “Formation of Fumonisin artefacts in thermal treated food.” Mycotoxin Research 17: 116–119. doi: 10.1007/BF03036725.
- Seefelder, W, Humpf, HU, Schwerdt, G, Freudinger, R, and Gekle, M. . “Induction of Apoptosis in Cultured Human Proximal Tubule Cells by Fumonisins and Fumonisin Metabolites.” Mycotoxin Research 17A: 107–111. doi: 10.1016/S0041-008X(03)00262-X.
- Hartl, M, and Humpf, HU. . “Toxicity assessment of fumonisins using the brine shrimp (Artemia salina) bioassay.” Food and Chemical Toxicology 38 (12): 1097–1102. doi: 10.1016/S0278-6915(00)00112-5.
- Adam, W, Groer, P, Humpf, HU, and Saha-Moller, CR. . “Synthesis of optically active alpha-methylene beta-lactams through lipase-catalyzed kinetic resolution.” Journal of Organic Chemistry 65 (16): 4919–4922. doi: 10.1021/jo0003089.
- Hartl, M, and Humpf, HU. . “2-Naphthol as a powerful chromophore for the configurational assignment of carboxylic acid groups via the CD exciton chirality method.” Tetrahedron: Asymmetry 11 (8): 1741–1747. doi: 10.1016/S0957-4166(00)00116-6.
- Adam, W, Lukacs, Z, Viebach, K, Humpf, HU, Saha-Moller, CR, and Schreier, P. . “Microscale determination of the absolute configuration of alpha-aryl-substituted alcohols by the CD exciton chirality method.” Journal of Organic Chemistry 65 (1): 186–190. doi: 10.1021/jo991424i.
- Adam, W, Lukacs, Z, Viebach, K, Humpf, H, Saha-Möller, C, and Schreier, P. . “Microscale determination of the absolute configuration of α-aryl- substituted alcohols by the CD exciton chirality method.” Journal of Organic Chemistry 65: 186–190. doi: 10.1021/jo991424i.
- Adam, W, Groer, P, Humpf, H, and Saha-Möller, C. . “Synthesis of optically active α-methylene β-lactams through lipase-catalyzed kinetic resolution.” Journal of Organic Chemistry 65: 4919–4922. doi: 10.1021/jo0003089.
- Hartl, M, and Humpf, H. . “The brine shrimp (Artemia salina) bioassay: A simple method to assess the toxicity of fumonisin mycotoxins.” Mycotoxin Research 16: 83. doi: 10.1007/BF02942988.
- Hartl, M, Herderich, M, and Humpf, HU. . “Rapid determination of fumonisin FB1 in corn products by high-performance liquid chromatography-electrospray mass spectrometry.” European Food Research and Technology 209 (5): 348–351. doi: 10.1007/s002170050507.
- Hartl, M, and Humpf, HU. . “Simultaneous determination of fumonisin B-1 and hydrolyzed fumonisin B-1 in corn products by liquid chromatography/electrospray ionization mass spectrometry.” Journal of Agricultural and Food Chemistry 47 (12): 5078–5083. doi: 10.1021/jf990046f.
- Degelmann, P, Becker, M, Herderich, M, and Humpf, H-U. . “Determination of ochratoxin A in beer by high-performance liquid chromatography.” Chromatographia 49 (9-10): 543–546. doi: 10.1007/BF02467756.
- Hartl, M, Herderich, M, and Humpf, H. . “Rapid determination of fumonisin FB1 in corn products by high-performance liquid chromatography-electrospray mass spectrometry.” European Food Research and Technology 209: 348–351. doi: 10.1007/s002170050507.
- Hartl, M, and Humpf, H. . “Simultaneous determination of fumonisin B1 and hydrolyzed fumonisin B1 in corn products by liquid chromatography/electrospray ionization mass spectrometry.” Journal of Agricultural and Food Chemistry 47: 5078–5083. doi: 10.1021/jf990046f.
- Hör, K, Gimple, O, Schreier, P, and Humpf, H-U. . “Absolute Configurational Assignment of Acyclic Hydroxy Carboxylic Acids: A New Strategy in Exciton-Coupled Circular Dichroism.” Journal of Organic Chemistry 63 (2): 322–325.
- Hartl, M, and Humpf, H-U. . “Assigning the absolute configuration of fumonisins by the circular dichroism exciton chirality method.” Tetrahedron: Asymmetry 9 (9): 1549–1556. doi: 10.1016/S0957-4166(98)00123-2.
- Roth, M, Gutsche, B, Herderich, M, Humpf, H-U, and Schreier, P. . “Dioxygenation of Long-Chain Alkadien(trien)ylphenols by Soybean Lipoxygenase.” Journal of Agricultural and Food Chemistry 46 (8): 2951–2956. doi: 10.1021/jf980196a.
- Adam, W, Lazarus, M, Schmerder, A, Humpf, H-U, Saha-Möller, CR, and Schreier, P. . “Synthesis of optically active α-hydroxy acids by kinetic resolution through lipase-catalyzed enantioselective acetylation.” European Journal of Organic Chemistry, № 9: 2013–2018. doi: 10.1002/(SICI)1099-0690(199809)1998:92013::AID-EJOC2013>3.0.CO;2-S.
- Adam, W, Boland, W, Hartmann-Schreier, J, Humpf, H-U, Lazarus, M, Saffert, A, Saha-Möller, CR, and Schreier, P. . “α hydroxylation of carboxylic acids with molecular oxygen catalyzed by the α oxidase of peas (Pisum sativum): A novel biocatalytic synthesis of enantiomerically pure (R)-2-hydroxy acids.” Journal of the American Chemical Society 120 (43): 11044–11048. doi: 10.1021/ja981252r.
- Humpf, HU, Schmelz, EM, Meredith, FI, Vesper, H, Vales, TR, Wang, E, Menaldino, DS, Liotta, DC, and Merrill, AH. . “Acylation of naturally occurring and synthetic 1-deoxysphinganines by ceramide synthase. Formation of N-palmitoyl-aminopentol produces a toxic metabolite of hydrolyzed fumonisin, AP1, and a new category of ceramide synthase inhibitor.” Journal of Biological Chemistry 273 (30): 19060–19064. doi: 10.1074/jbc.273.30.19060.
- Humpf, H, Schmelz, E, Meredith, F, Vesper, H, Vales, T, Wang, E, Menaldino, D, Liotta, D, and Merrill, Jr.A. . “Acylation of naturally occurring and synthetic 1-deoxysphinganines by ceramide synthase: Formation of N-palmitoyl-aminopentol produces a toxic metabolite of hydrolyzed fumonisin, AP1, and a new category of ceramide synthase inhibitor.” Journal of Biological Chemistry 273: 19060–19064. doi: 10.1074/jbc.273.30.19060.
- Becker, M, Degelmann, P, Herderich, M, Schreier, P, and Humpf, H. . “Column liquid chromatography-electrospray ionisation-tandem mass spectrometry for the analysis of ochratoxin.” Journal of Chromatography A 818: 260–264. doi: 10.1016/S0021-9673(98)00594-9.
- Humpf, H-U. . “Fumonisine in Lebensmitteln: Empfindlicher und selektiver Nachweis mittels HPLC-MS/MS.” GIT 42 (2): 84–85.
- Becker, M, Degelmann, P, Herderich, M, Schreier, P, and Humpf, HU. . “High-Performance Liquid Chromatography-Electrospray Ionisation-Tandem Mass Spectrometry (HPLC-ESI-MS/MS) for the Analysis of Ochratoxin.” J. Chromatogr. 818 (2): 260–264.
- Humpf, HU, Schmelz, EM, Meredith, FI, and Merrill, AH. . “N-Palmitoyl-HFB1: A New Metabolite of Hydrolyzed Fumonisin (HFB1) in Rat Liver Microsomes.” Rev. Méd. Vét 149 (6): 576–576.
- Gimple, O, Schreier, P, and Humpf, H-U. . “A new exciton-coupled circular dichroism method for assigning the absolute configuration in acyclic α- and β-hydroxy carboxylic acids.” Tetrahedron: Asymmetry 8 (1): 11–14. doi: 10.1016/S0957-4166(96)00490-9.
- Herderich, M, Richling, E, Röscher, R, Schneider, C, Schwab, W, Humpf, H-U, and Schreier, P. . “Application of atmospheric pressure ionization HPLC-MS-MS for the analysis of natural products.” Chromatographia 45: 127–132. doi: 10.1007/BF02505549.
- Hoch, U, Humpf, H-U, Schreier, P, Saha-Möller, CR, and Adam, W. . “Configurational assignment of optically active hydroperoxy homoallylic alcohols and the corresponding diols by circular dichroism and multidimensional gas chromatography.” Chirality 9 (1): 69–74. doi: 10.1002/(SICI)1520-636X(1997)9:169::AID-CHIR13>3.3.CO;2-W.
- Adam, W, Lazarus, M, Boss, B, Saha-Möller, CR, Humpf, H-U, and Schreier, P. . “Enzymatic Resolution of Chiral 2-Hydroxy Carboxylic Acids by Enantioselective Oxidation with Molecular Oxygen Catalyzed by the Glycolate Oxidase from Spinach (Spinacia oleracea).” Journal of Organic Chemistry 62 (22): 7844–7849.
- Schneider, C, Schreier, P, and Humpf, H-U. . “Exciton-coupled circular dichroism (ECCD) in acyclic hydroxylated dienes: A sensitive method for the direct stereochemical assignment of lipoxygenase products.” Chirality 9 (5-6): 563–567. doi: 10.1002/(SICI)1520-636X(1997)9:5/6563::AID-CHIR25>3.3.CO;2-5.
- Adam, W, Humpf, H-U, Korb, MN, and Schreier, P. . “The configurational assignment of the optically active 5-(1-hydro- peroxyethyl)-3-ethoxycarbonyl-2-methylfuran and its alcohol by exciton- coupled circular dichroism (ECCD).” Tetrahedron: Asymmetry 8 (21): 3555–3558. doi: 10.1016/S0957-4166(97)00515-6.
- Schreder, B, Lukacs, Z, Schmitt, M, Schreier, P, and Humpf, H-U. . “1-Naphthoic acid: A new type of asymmetric chromophore for exciton-coupled circular dichroism (ECCD).” Tetrahedron: Asymmetry 7 (6): 1543–1546. doi: 10.1016/0957-4166(96)00176-0.
- Adam, W, Hoch, U, Humpf, H-U, Saha-Möller, CR, and Schreier, P. . “Horseradish peroxidase (HRP)-catalysed enantioselective reduction of racemic hydroperoxy homoallylic alcohols: A novel enzymatic method for the preparation of optically active, unsaturated diols and hydroperoxy alcohols.” Chemical communications, № 24: 2701–2702. doi: 10.1039/cc9960002701.
- Lukacs, Z, Schaper, S, Herderich, M, Schreier, P, and Humpf, H-U. . “Identification and determination of fumonisin FB1 and FB2 in corn and corn products by high-performance liquid chromatography - Electrospray-ionization tandem mass spectrometry (HPLC-ESI-MS-MS).” Chromatographia 43 (3-4): 124–128. doi: 10.1007/BF02292939.
- Lukacs, Z, Schaper, S, Herderich, M, Schreier, P, and Humpf, H. . “Identification and determination of fumonisin FB1 and FB2 in corn and corn products by high-performance liquid chromatography - Electrospray-ionization tandem mass spectrometry (HPLC-ESI-MS-MS).” Chromatographia 43: 124–128. doi: 10.1007/BF02292939.
- Person, RV, Monde, K, Humpf, HU, Berova, N, and Nakanishi, K. . “A new approach in exciton-coupled circular dichroism (ECCD)--insertion of an auxiliary stereogenic center.” Chirality 7 (3): 128–35. doi: 10.1002/chir.530070304.
- Humpf, H-U, Berova, N, Nakanishi, K, Jarstfer, MB, and Poulter, CD. . “Allylic and homoallylic exciton coupled CD: A sensitive method for determining the absolute stereochemistry of natural products.” Journal of Organic Chemistry 60 (11): 3539–3542. doi: 10.1021/jo00116a048.
- Person, R, Monde, K, Humpf, H, Berova, N, and Nakanishi, K. . “A new approach in exciton‐coupled circular dichroism (ECCD)—insertion of an auxiliary stereogenic center.” Chirality 7: 128–135. doi: 10.1002/chir.530070304.
- Humpf, HU, Zhao, N, Berova, N, Nakanishi, K, and Schreier, P. . “Absolute stereochemistry of natural 3,4-dihydroxy-beta-ionone glycosides by the CD exciton chirality method.” Journal of Natural Products 57 (12): 1762–1765. doi: 10.1021/np50114a027.
- Humpf, H, Zhao, N, Berova, N, Nakanishi, K, and Schreier, P. . “Absolute stereochemistry of natural 3,4-Dihydroxy-β-ionone glycosides by the cd exciton chirality method.” Journal of Natural Products 57: 1762–1765. doi: 10.1021/np50114a027.
- Wintoch, H, Humpf, HU, and Schreier, P. . “Natural Precursor of Isomeric Vitispiranes from Plant Tissues: 3,4-Dihydroxy-7,8-dihydro-β-ionol β-D-glucoside.” in Progress in Flavour Precursor Studies, edited by P Schreier and P Winterhalter. Wheaton: Allured Publ..
- Humpf, H-U, Wintoch, H, and Schreier, P. . “3,4-dhydroxy-7,8-dihydro-β-ionol β-D-gucopyranoside: Natural precursor of isomeric vitispiranes from gooseberry (Ribes uva crispa L.) and whitebeam (Sorbus aria) leaves.” Journal of Agricultural and Food Chemistry 40 (11): 2060–2062. doi: 10.1021/jf00023a006.
- Humpf, H-U, and Schreier, P. . “3-Hydroxy-5,6-epoxy-β-ionol β-D-Glucopyranoside and 3-hydroxy-7,8-dihydro-β-ionol β-d-glucopyranoside: New C13 norisoprenoid glucoconjugates from sloe tree (prunus spinosa l.) leaves.” Journal of Agricultural and Food Chemistry 40 (10): 1898–1901. doi: 10.1021/jf00022a034.
- Humpf, H, and Schreier, P. . “3-Hydroxy-5,6-epoxy-β-ionol β-D-Glucopyranoside and 3-Hydroxy-7,8-dihydro-β-ionol β-D-Glucopyranoside: New C13 Norisoprenoid Glucoconjugates from Sloe Tree (Prunus spinosa L.) Leaves.” Journal of Agricultural and Food Chemistry 40: 1898–1901. doi: 10.1021/jf00022a034.
- Humpf, H-U, Winterhalter, P, and Schreier, P. . “3,4-Dihydroxy-7,8-dihydro-β-ionone β-d-glucopyranoside: natural precursor of 2,2,6,8-tetramethyl-7,l 1-dioxatricyclote.[6.2.1.0]-ene (Riesling Acetal) and l,l,6-trimethyl-l,2-dihydronaphthalene in red currant (Ribes rubrum L.) leaves.” Journal of Agricultural and Food Chemistry 39 (10): 1833–1835. doi: 10.1021/jf00010a029.
- Humpf, H-U, and Schreier, P. . “Bound aroma compounds from the fruit and the leaves of blackberry (Rubus laciniata, L.).” Journal of Agricultural and Food Chemistry 39 (10): 1830–1832. doi: 10.1021/jf00010a028.
- Humpf, H, Winterhalter, P, and Schreier, P. . “3,4- Dihydroxy-7,8-dihydro-β-ionone β-D-Glucopyranoside: Natural Precursor of 2,2,6,8-Tetramethyl-7,11-dioxatricyclo[6.2.1.01,6]undec-4-ene (Riesling Acetal) and 1,1,6-Trimethyl-1,2-dihydronaphthalene in Red Currant (Ribes rubrum L.) Leaves.” Journal of Agricultural and Food Chemistry 39: 1833–1835. doi: 10.1021/jf00010a029.
Supervised Doctoral Studies
- Laabs, Moritz (): Lipoprotein-imitierende, nanopartikuläre Arzneistoffträgersysteme zur Überwindung der Blut-Hirn-Schranke
- Further Supervisor
- Langer, Klaus
- Reviewers
- Langer, Klaus
- Steiner, Denise
- Lins, Anika (): Untersuchungen zur Proteincorona an kolloidalen Arzneistoffträgern.
- Further Supervisor
- Langer, Klaus
- Reviewers
- Langer, Klaus
- Humpf, Hans-Ulrich
- Franziska Michaela Jürgens (): Investigation of pharmacokinetic properties of antileishmanial Sesquiterpene lactones from Arnica montana L.
(Thesis written in German)
- Further Supervisor
- Schmidt, Thomas
- Reviewer
- Schmidt, Thomas J. (Professur für Pharmazeutische Biologie und Phytochemie (Prof. Schmidt)) Humpf, Hans-Ulrich – Professur für Lebensmittelchemie (Prof. Humpf)
- Wünsch, Angelika (): Imitation von Lipoproteinen als nanopartikuläre Arzneistoffträgersysteme
- Further Supervisor
- Langer, Klaus
- Dr. Krug, Isabel Doris (): In vitro-Untersuchungen zu den Effekten ausgewählter Mykotoxine und mariner Biotoxine an der Blut-Hirn-Schranke
- Dr. Sueck, Franziska (): Vorkommen, Proteinaffinität, Metabolismus und biologische Halbwertszeit der Mykotoxine 2’R-Ochratoxin A und Ochratoxin A beim Menschen
- Dr. Wagner (geb. Ferse), Ines (): Isolierung und Strukturaufklärung neuer Monascus-Sekundärmetabolite in Rotschimmelreis sowie Synthese von Ochratoxin A-Derivaten zur Untersuchung der StrukturWirkungs-Beziehung
- Dr. Kuchenbuch (geb. Schmidt), Henning Sören (): Investigations on the stability and degradation of T-2 toxin during thermal food processing
- Dr. Hickert, Sebastian Rudolf (): Investigation on Alternaria mycotoxins with focus on tenuazonic acid and studies oin the potential of micro-HPLC-MS/MS and MALDI-Imaging mass spectrometry for mycotoxin analysis
- Dr. Saenger (geb. Kemme), Theresa (): Studien zum Nachweis ernährungsbedingter Biomarker im Humanurin
- Kalinina Svetlana (): Penicillium spp. as a Source of Secondary Metabolites: Structure Elucidation, Occurrence in Food, Cytotoxicity, and Biological Activity
- Further Supervisors
- Wünsch, Bernhard
- Esselen, Melanie
- Dr. Bergmann, Dominik (): Stabilisotopenmarkierte Darstellung des Mykotoxins Citrinin und seines Hauptmetaboliten Dihydrocitrinon sowie Synthese von Aminoglykosid-Derivaten
- Dr. Uebel, Thomas (): Impact of aserone isomers on cellular redox status and the onset of DNA-integrity
- Supervisors
- Esselen, Melanie
- Humpf, Hans-Ulrich
- Dr. Rottkord, Ulrike (): Struktur-Wirkungs-Beziehungen zur Toxizität von Ochratoxin A und kombinatorische Effekte mit Citrinin
- Dr. Arndt, Birgit (): Studies on the secondary metabolism of Fusarium fujikuroi
- Further Supervisor
- Tudzynski, Bettina
- Korte, Robin (): Analysis and Characterization of Food Allergens: A Mass Spectrometric Approach
- Supervisors
- Prof. Dr. Humpf, Hans-Ulrich
- Prof. Dr. Brockmeyer, Jens
- Haupenthal, Sabrina (): Beeinflussung der DNA-Integrität durch Metaboliten natürlicher kanzerogener Phenylpropanoide.
- Further Supervisor
- Esselen, Melanie
- Dr. Dopstadt, Julian (): Das Potential des Mutterkornpilzes Claviceps purpurea zur Produktion neuer Sekundärmetaboliten
- Further Supervisor
- Tudzynski, Paul
- Dr. Rösler, Sarah M. (): Complex Regulation of Secondary Metabolism in the Phytopathogenic Fungus Fusarium fujikuroi
- Further Supervisors
- Klempnauer, Karl-Heinz
- Tudzynski, Bettina
- Dr. Lichtenwald, Marina (): Molecular and phenotypical analysis of biofilm formation of enterohaemorrhagiuc Eschericia coli
- Further Supervisor
- Karch, Helge
- Meyer, Sören (): Instrumentelle Analytik (LC/ICPMS/MS) und toxikologische Charakterisierung von Arsenolipiden
- Further Supervisors
- Schwerdtle, Tanja
- Karst, Uwe
- Dr. Gerding, Johannes (): Biomarkerbasierte Abschätzung der humanen Mykotoxinexposition und Untersuchung des Metabolismus ausgewählter Mykotoxine
- Schnieders, Annika (): Investigation of natural products as MHC-II loading enhancers with the HLA-DR1 serotype as an example
(Thesis written in German)
- Further Supervisor
- Schmidt, Thomas
- Reviewer
- Schmidt, Thomas Humpf, Hans-Ulrich
- Kunsmann, Lisa (): Charakterisierung von Membranvesikeln enterohämorrhagischer Escherichia coli
- Further Supervisors
- Karch, Helge
- Esselen, Melanie
- Dr. Hummel, Marlene (): Allergene Proteine in Gewürzen: Massenspektro-metrische Identifizierung und Charakterisierung von 2S Albuminen aus Senf und Sesam
- Bittner, Andrea (): Matrix-gebundene Ochratoxin A-Rückstände in thermisch behandelten Lebensmitteln: Strukturaufklärung, Analytik und Bioverfügbarkeit
- Bittner, Katharina (): Studien zum Vorkommen, zur systemischen Absorption und zum Metabolismus von Polyphenolen
- Dr. von Bargen, Katharina Walburga (): Identifizierung und Strukturaufklärung neuer Sekundärmetaboliten aus Fusarium fujikuroi sowie Untersuchungen zur Biosynthese und Analytik
- Bargen, Christoph (): Authentifizierung und Strukturaufklärung von Lebensmittelinhaltsstoffen mittels massenspektrometrischer Methoden am Beispiel von Proteinen und Polyphenolen
- Unterberg, Marlies (): Etablierung eines LC/FTMS basierten Testsystems zur Quantifizierung der epigenetische Effekte von Arsenverbindungen
- Further Supervisors
- Schwerdtle, Tanja
- Karst, Uwe
- Hemmersbach, Sarah (): Intestinal absorption of flavonoids and metabolites in the Caco-2 model
- Pieper, Imke (): Organoquecksilberspezies und der zelluläre DNA-Schadensresponse
- Further Supervisors
- Schwerdtle, Tanja
- Karst, Uwe
- Lepski, Silke (): Charakterisierung und massenspektrometrische Nachweis von Nussallergenen
- Weiss, André (): Funktionale Charakterisierung der Serinprotease-Autotransporter EspPα und Espl aus enterohämorrhagischen Escherichia coli
- Weidner, Maria (): Untersuchungen zur Toxizität und zum Metabolismus von Fusarium-Mykotoxinen in humanen Primärzellen
- Studt, Lena (): Effects of biotic and abiotic factors on the production of Fusarium-mycotoxins by phytophathogenic Fusarium-isolates
- Leffers, Larissa (): Bioverfügbarkeit, Metabolismus und Toxizität von Arsenozuckern
- Further Supervisors
- Schwerdtle, Tanja
- Karst, Uwe
- Dr. Brezina, Ulrike (): Determination of zearalenone, deoxynivalenol and their metabolites in physiological samples of pigs with LC-MS/MS: Development of multi-mycotoxin methods and verification through a dose-response feeding study
- Lohrey, Lilia (): Darstellung der stabilisotopenmarkierten Mykotoxine Moniliformin und Tenuazonsäure sowie Synthese von bioaktiven Arylthiazolen mittels direkter Fusarin-Analoga
- Engemann, Anna (): Intestinaler Metabolismus von Lebensmittelinhaltsstoffen im Schweine-Caecum-Modell
- Dr. Havermann, Susannah (): Aktivierung des ARE durch Flavonole und Hydroxyzimtsäurederivate: Untersuchungen in Zellkultursystemen und C. elegans
- Kleigrewe, Karin (): Vorkommen von Fusarin-C-Mykotoxinen in Lebensmitteln und Strukturaufklärung neuer Fusarin-Analoga
- Dr. Diederich, Johannes (): Manganspeziation in biologischen Proben
- Supervisors
- Schwerdtle, Tanja
- Michalke, B.
- Humpf, Hans-Ulrich.
- Michalke, B.
- Fraske, Andrea (): Studien zur systemischen Absorption und zum Metabolismus von Anthocyanen im Tiermodell Schwein
- Dr. Riedel, Sylvia (): Modulation of lipid metabolism as a possible tool to prevent carcinoigenoic effects of fumonisin B1
- Dr. Ehlers, Susan (): Analytik von Perfluoralkylsäuren in verschiedenen Matrices zur Klärung der Toxikokinetik in Tierarten die der Lebensmittelgewinnung dienen
- Dr. Bevanda-Franjic, Marijane (): In vitro-Studien von Anthocyanen im Caco-2-Modellsystem
- Rzeppa, Sebastian (): Isolierung, Strukturaufklärung und Analytik von Procyanidinen sowie Kinetikstudien im Tiermodell am Schwein
- Blaas, Nina (): Untersuchungen zur massenspektrometrischen Charakterisierung von Sphingophospholipiden in humaner Milch und pflanzlichen Lebensmitteln
- Mulac-Hahnen, Dennis (): Zellkulturstudien zur Cytotoxizität, zur Aufnahme und zum Transportmechanismus von Mutterkornalkaloiden
- Hübner, Florian (): Darstellung der stabilisotopen-markierten Mykotoxine Fumonisin B1 und Alternariol
- Dr. Betz, Josefine (): Struktur-Funktions-Analysen von Shiga Toxin-Rezeptoren mikro- und makrovaskulärer humaner Endothelzellen
- Dr. Neue, Kristina (): Elucidation of N-glycosylation by unspecific proteolysis in combination with ZIC-HILIC SPE and de novo sequencing of IgG primary structures by use of direct nanoESI Q-Tof mass spectrometry
- Dr. Harrer, Henning Uwe Michael (): Die Bedeutung des Sphingolipidstoffwechsels für die toxikologische Wirkungsweise der Fumonisin-Mykotoxine
- Dr. Franzmann, Carolin (): Untersuchungen zum Vorkommen, zur Stabilität und zum thermischen Abbau von Mutterkornalkaloiden in Roggen und Roggenprodukten
- Dr. Nollen, Maike Cora (): Untersuchungen zur indirekten Genotoxizität von Arsenit und seinem Metabolit monomethylarsonige Säure
- Further Supervisor
- Schwerdtle, Tanja
- Wiemann, Philipp (): Regulation of secondary metabolism in phytophathogenic Fusarium spp.
- Further Supervisor
- Tudzynski, Bettina
- Dr. van 't Slot, Gordon (): Untersuchungen zum intestinalen Metabolismus von pflanzlichen Lebensmittelinhaltsstoffen
- Dr. Fischbeck, Anne (): Vorkommen von Sphingomyelin in der menschlichen Ernährung und seine Bedeutung bei entzündlichen Darmerkrankungen im Tiermodell
- Dr. Trebstein, Anke (): Analytik von Mykotoxinen der Gattung Fusarium mittels Hochleistungsflüssigchromatographie mit Fluoreszenzdetektion und Tandem-Massenspektrometrie
- Dr. Beyer, Marita (): Produktion, Analytik und Abbau bedeutender Trichothecen-Mykotoxine
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