Professor Dr. Hans-Ulrich Humpf

Professur für Lebensmittelchemie (Prof. Humpf)
Professor Dr. Hans-Ulrich Humpf

Corrensstr. 45
48149 Münster

  • Research Areas

    • Studies on the thermal stability, biosynthesis, toxicity and (intestinal) metabolism of mycotoxins.
    • Development of human biomonitoring methods (HBM) for exposure assessment of mycotoxins and detection of nutritional biomarkers.
    • Metabolomics- and proteomics-based approaches to characterise cellular responses upon exposure to mycotoxins and other food constituents
    • transfer of food constituents across the intestinal barrier (Caco-2 model) as well as the blood-brain-barrier.
    • Studies on the occurrence and significance of mycotoxins in indoor environments
  • CV


    Habilitation und Erlangung der Venia legendi im Fachgebiet "Lebensmittelchemie"
    Forschungsaufenthalt an der Emory University, Atlanta, USA, Department of Biochemistry bei Herrn Prof. Dr. A.H. Merrill
    2. Ausbildungsphase für Lebensmittelchemiker am Landesuntersuchungsamt in Erlangen, Staatsprüfung für Lebensmittelchemiker
    Dissertation am Lehrstuhl für Lebensmittelchemie der Universität Würzburg bei Prof. Dr. P. Schreier


    W3-Full-Professor for Food Chemistry and Director of the Institute of Food Chemistry at the University of Münster
    Dean of the Faculty for Chemistry and Pharmacy at the Westfälischen Wilhelms-Universität Münster
    Managing Direktor of the Institute of Food Chemistry
    C3-Professor of Food Chemistry at the University of Münster
    Wissenschaftlicher Assistent und seit 01.10.2000 Oberassistent am Lehrstuhl für Lebensmittelchemie der Universität Würzburg
    Post-doc an der Columbia University, New York, Department of Chemistry bei Prof. Dr. K. Nakanishi
    Wissenschaftlicher Mitarbeiter am Lehrstuhl für Lebensmittelchemie der Universität Würzburg


    Josef-Schormüller-Stipendium – Lebensmittelchemische Gesellschaft (LChG) - Fachgruppe in der Gesellschaft Deutscher
    Studienabschluss-Stipendium – Fonds der Chemischen Industrie (FCI)
    Stockmeyer Wissenschaftspreis 2002 – Heinrich-Stockmeyer-Stiftung
    Peter B. Czedik-Eysenberg-Preis – GÖCH - Gesellschaft Österreichischer Chemiker - Arbeitsgruppe Lebensmittel, Kosmetik und Gebrauchsgegenstände

    External Functions

    Federal Institute for Risk Assessment (BfR) (BfR Commission for Contaminants in the Food Chain)
    Mitglied in der der Senatskommission der Deutschen Forschungsgemeinschaft zur gesundheitlichen Bewertung von Lebensmitteln (SKLM)
    Mitglied der Gesellschaft für Mykotoxinforschung e.V.
    Member of the American Chemical Society
    Mitglied in der Gesellschaft Deutscher Chemiker GDCh
    Society for Mycotoxin Research
    Präsident der Gesellschaft für Mykotoxinforschung e.V.
    Federal Institute for Risk Assessment (BfR) (of the Expert Commission "Contaminants and other undesirable substances in the food chain")
    Associate Editor der Zeitschrift "Molecular Nutrition and Food-Research", Wiley-VCH


    University of Münster, Lebensmittelchemie (W3) – accepted
    Universität Hamburg, Lebensmittelchemie (C4) – rejected
    University of Halle-Wittenberg, Lebensmittelchemie (C4) – rejected
    University of Hohenheim, Lebensmittelchemie (C3) – rejected
    University of Münster, Lebensmittelchemie (C3) – accepted
  • Teaching

  • Publications

    • Andreeßen C., Wolf N., Cramer B., Humpf H., Steinbüchel A. . ‘In vitro biosynthesis of 3-mercaptolactate by lactate dehydrogenases.’ Enzyme and Microbial Technology 108, No. null: 1–10. doi: 10.1016/j.enzmictec.2017.08.005.
    • Viegas S., Osteresch B., Almeida A., Cramer B., Humpf H., Viegas C. . ‘Enniatin B and ochratoxin A in the blood serum of workers from the waste management setting.’ Mycotoxin Research 34, No. 2: 85–90. doi: 10.1007/s12550-017-0302-1.

    • Hickert S., Hermes L., Marques L., Focke C., Cramer B., Lopes N., Flett B., Humpf H. . ‘Alternaria toxins in South African sunflower seeds: cooperative study.’ Mycotoxin Research 33, No. 4: 309–321. doi: 10.1007/s12550-017-0290-1.
    • Cramer B., Hübner F., Humpf H. . ‘Applications of High-Performance Liquid Chromatography-Mass Spectrometry Techniques for the Analysis of Chemical Contaminants and Residues in Food.’ In Chemical Contaminants and Residues in Food: Second Edition, edited by Schrenk D, 51–66. Elsevier Inc. doi: 10.1016/B978-0-08-100674-0.00003-5.
    • Schmidt H., Becker S., Cramer B., Humpf H. . ‘Impact of Mechanical and Thermal Energies on the Degradation of T-2 and HT-2 Toxins during Extrusion Cooking of Oat Flour.’ Journal of Agricultural and Food Chemistry 65, No. 20: 4177–4183. doi: 10.1021/acs.jafc.7b01484.
    • Kalinina S., Jagels A., Cramer B., Geisen R., Humpf H. . ‘Influence of environmental factors on the production of penitrems A–F by Penicillium crustosum.’ Toxins 9, No. 7. doi: 10.3390/toxins9070210.
    • Osteresch B., Viegas S., Cramer B., Humpf H. . ‘Multi-mycotoxin analysis using dried blood spots and dried serum spots.’ Analytical and Bioanalytical Chemistry 409, No. 13: 3369–3382. doi: 10.1007/s00216-017-0279-9.
    • Arndt B., Janevska S., Schmid R., Hübner F., Tudzynski B., Humpf H. . ‘A Fungal N-Dimethylallyltryptophan Metabolite from Fusarium fujikuroi.’ Chembiochem 18, No. 10: 899–904. doi: 10.1002/cbic.201600691.
    • Legros N., Pohlentz G., Runde J., Dusny S., Humpf H., Karch H., Müthing J. . ‘Colocalization of receptors for Shiga toxins with lipid rafts in primary human renal glomerular endothelial cells and influence of D-PDMP on synthesis and distribution of glycosphingolipid receptors.’ Glycobiology 27, No. 10: 947–965. doi: 10.1093/glycob/cwx048.
    • Jarolim K., Del Favero G., Ellmer D., Stark T., Hofmann T., Sulyok M., Humpf H., Marko D. . ‘Dual effectiveness of Alternaria but not Fusarium mycotoxins against human topoisomerase II and bacterial gyrase.’ Archives of Toxicology 91, No. 4: 2007–2016. doi: 10.1007/s00204-016-1855-z.
    • Janevska S., Arndt B., Baumann L., Apken L., Marques L., Humpf H., Tudzynski B. . ‘Establishment of the inducible Tet-on system for the activation of the silent trichosetin gene cluster in Fusarium fujikuroi.’ Toxins 9, No. 4. doi: 10.3390/toxins9040126.
    • Studt L., Janevska S., Arndt B., Boedi S., Sulyok M., Humpf H., Tudzynski B., Strauss J. . ‘Lack of the COMPASS component Ccl1 reduces H3K4 trimethylation levels and affects transcription of secondary metabolite genes in two plant-pathogenic fusarium species.’ Frontiers in Microbiology 7, No. null. doi: 10.3389/fmicb.2016.02144.
    • Kouzel I., Pohlentz G., Schmitz J., Steil D., Humpf H., Karch H., Müthing J. . ‘Shiga toxin glycosphingolipid receptors in human Caco-2 and HCT-8 colon epithelial cell lines.’ Toxins 9, No. 11. doi: 10.3390/toxins9110338.
    • Humpf H., Schneider C., Stevens J. . ‘Hot Topics in 2017 – Gut Microbiota, Whole Grains and Health.’ Molecular Nutrition and Food Research 61, No. 1. doi: 10.1002/mnfr.201770014.

    • Brezina U., Rempe I., Kersten S., Valenta H., Humpf H., Dänicke S. . ‘Determination of zearalenone, deoxynivalenol and metabolites in bile of piglets fed diets with graded levels of Fusarium toxin contaminated maize.’ World Mycotoxin Journal 9, No. 2: 179–193. doi: 10.3920/WMJ2015.1902.
    • Yamashita S., Bergmann D., Sato A., Nomoto M., Tada Y., Humpf H., Itami K., Hagihara S. . ‘High-throughput assay for quantification of aminoglycoside-Ribosome interaction.’ Chemistry Letters 45, No. 9: 1048–1050. doi: 10.1246/cl.160508.
    • Goldbeck C., Fürst P., Humpf H., Schymanski D. . ‘Kunststoffpartikel sind überall – auch in Lebensmitteln?Nachrichten aus der Chemie 64, No. 9: 842–846. doi: 10.1002/nadc.20164052892.
    • Havermann S., Humpf H., Wätjen W. . ‘Baicalein modulates stress-resistance and life span in C. elegans via SKN-1 but not DAF-16.’ Fitoterapia 113, No. null: 123–127. doi: 10.1016/j.fitote.2016.06.018.
    • Bernhardt K., Valenta H., Kersten S., Humpf H., Dänicke S. . ‘Determination of T-2 toxin, HT-2 toxin, and three other type A trichothecenes in layer feed by high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS)—comparison of two sample preparation methods.’ Mycotoxin Research 32, No. 2: 89–97. doi: 10.1007/s12550-016-0244-z.
    • Rösler S., Sieber C., Humpf H., Tudzynski B. . ‘Interplay between pathway-specific and global regulation of the fumonisin gene cluster in the rice pathogen Fusarium fujikuroi.’ Applied Microbiology and Biotechnology 100, No. 13: 5869–5882. doi: 10.1007/s00253-016-7426-7.
    • Studt L., Rösler S., Burkhardt I., Arndt B., Freitag M., Humpf H., Dickschat J., Tudzynski B. . ‘Knock-down of the methyltransferase Kmt6 relieves H3K27me3 and results in induction of cryptic and otherwise silent secondary metabolite gene clusters in Fusarium fujikuroi.’ Environmental Microbiology 18, No. 11: 4037–4054. doi: 10.1111/1462-2920.13427.
    • Havermann S., Chovolou Y., Humpf H., Wätjen W. . ‘Modulation of the Nrf2 signalling pathway in Hct116 colon carcinoma cells by baicalein and its methylated derivative negletein.’ Pharmaceutical Biology 54, No. 9: 1491–1502. doi: 10.3109/13880209.2015.1104703.
    • Korte R., Monneuse J., Gemrot E., Metton I., Humpf H., Brockmeyer J. . ‘New High-Performance Liquid Chromatography Coupled Mass Spectrometry Method for the Detection of Lobster and Shrimp Allergens in Food Samples via Multiple Reaction Monitoring and Multiple Reaction Monitoring Cubed.’ Journal of Agricultural and Food Chemistry 64, No. 31: 6219–6227. doi: 10.1021/acs.jafc.6b02620.
    • Humpf H., Schneider C., Stevens F. . ‘Obesity, Cancer and Nutrition, Gut Microbiota - Special Issues 2016.’ Molecular Nutrition and Food Research 60, No. 1: 5–6. doi: 10.1002/mnfr.201670014.
    • Hickert S., Bergmann M., Ersen S., Cramer B., Humpf H. . ‘Survey of Alternaria toxin contamination in food from the German market, using a rapid HPLC-MS/MS approach.’ Mycotoxin Research 32, No. 1: 7–18. doi: 10.1007/s12550-015-0233-7.

    • Bittner Andrea ,Cramer Benedikt ,Harrer Henning, Humpf Hans-Ulrich. . ‘Structure elucidation and in vitro cytotoxicity of ochratoxin α amide, a new degradation product of ochratoxin A.’ Mycotoxin Research 31, No. 2: 83–90. doi: 10.1007/s12550-014-0218-y.
    • Steil D., Schepers C., Pohlentz G., Legros N., Runde J., Humpf H., Karch H., Müthing J. . ‘Shiga toxin glycosphingolipid receptors of Vero-B4 kidney epithelial cells and their membrane microdomain lipid environment.’ Journal of Lipid Research 56, No. 12: 2322–2336. doi: 10.1194/jlr.M063040.
    • Arndt B., Studt L., Wiemann P., Osmanov H., Kleigrewe K., Köhler J., Krug I., Tudzynski B., Humpf H. . ‘Genetic engineering, high resolution mass spectrometry and nuclear magnetic resonance spectroscopy elucidate the bikaverin biosynthetic pathway in Fusarium fujikuroi.’ Fungal Genetics and Biology 84, No. null: 26–36. doi: 10.1016/j.fgb.2015.09.006.
    • Hickert S., Krug I., Cramer B., Humpf H. . ‘Detection and Quantitative Analysis of the Non-cytotoxic allo-Tenuazonic Acid in Tomato Products by Stable Isotope Dilution HPLC-MS/MS.’ Journal of Agricultural and Food Chemistry 63, No. 50: 10879–10884. doi: 10.1021/acs.jafc.5b04812.
    • Hickert S., Gerding J., Ncube E., Hübner F., Flett B., Cramer B., Humpf H. . ‘A new approach using micro HPLC-MS/MS for multi-mycotoxin analysis in maize samples.’ Mycotoxin Research 31, No. 2: 109–115. doi: 10.1007/s12550-015-0221-y.
    • Gerding J., Ali N., Schwartzbord J., Cramer B., Brown D., Degen G., Humpf H. . ‘A comparative study of the human urinary mycotoxin excretion patterns in Bangladesh, Germany, and Haiti using a rapid and sensitive LC-MS/MS approach.’ Mycotoxin Research 31, No. 3: 127–136. doi: 10.1007/s12550-015-0223-9.
    • Bittner,Katharina M. K.M.,Kemme,Theresa T.,Peters,Katharina K.,Kersten,Susanne S.,Dänicke,Sven S.,Humpf,Hans Ulrich H.U.,. . ‘Systemic absorption and metabolism of dietary procyanidin B4 in pigs.’ Molecular Nutrition and Food Research 58, No. 12: 2273. doi: 10.1002/mnfr.201400435.
    • Humpf,Hans Ulrich H.U.,Schneider,Claus C.,Stevens,Jan Frederik J.F.,. . ‘Scoping dietary supplements versus botanical medicines.’ Molecular Nutrition and Food Research 59, No. 1: 6. doi: 10.1002/mnfr.201570004.
    • Habermeyer,Michael M.,Roth,Angelika A.,Guth,Sabine E. S.E.,Diel,Patrick P.,Engel,Karl Heinz K.H.,Epe,Bernd B.,Fürst,Peter P.,Heinz,Volker V.,Humpf,Hans Ulrich H.U.,Joost,Hans Georg H.G.,Knorr,Dietrich D.,De Kok,Theo Martinus C M T.M.C.M.,Kulling,Sabine E. S.E.,Lampen,Alfonso D. A.D.,Marko,Doris D.,Rechkemmer,Gerhard R. G.R.,Rietjens,Ivonne M C M I.M.C.M.,Stadler,Richard H. R.H.,Vieths,Stefan S.,Vogel,Rudi F. R.F.,Steinberg,Pablo P.,Eisenbrand,Gerhard G.,. . ‘Nitrate and nitrite in the diet: How to assess their benefit and risk for human health.’ Molecular Nutrition and Food Research 59, No. 1: 128. doi: 10.1002/mnfr.201400286.
    • Gerding,Johannes J.,Cramer,Benedikt B.,Humpf,Hans Ulrich H.U.,. . ‘Determination of mycotoxin exposure in Germany using an LC-MS/MS multibiomarker approach.’ Molecular Nutrition and Food Research 58, No. 12: 2368. doi: 10.1002/mnfr.201400406.

    • Hennemeier,Isabell I.,Humpf,Hans Ulrich H.U.,Gekle,Michael M.,Schwerdt,Gerald G.,. . ‘Role of microRNA-29b in the ochratoxin A-induced enhanced collagen formation in human kidney cells.’ Toxicology 324: 122. doi: 10.1016/j.tox.2014.07.012.
    • Von Bargen,Christoph C.,Brockmeyer,Jens J.,Humpf,Hans Ulrich H.U.,. . „Meat authentication: A new HPLC-MS/MS based method for the fast and sensitive detection of horse and pork in highly processed food.“ Journal of Agricultural and Food Chemistry 62, No. 39: 9435. doi: 10.1021/jf503468t.
    • Havermann,Susannah S.,Chovolou,Yvonni Y.,Humpf,Hans Ulrich H.U.,Wätjen,Wim W.,. . ‘Caffeic acid phenethylester increases stress resistance and enhances lifespan in Caenorhabditis elegans by modulation of the insulin-like DAF-16 signalling pathway.’ PloS one 9, No. 6. doi: 10.1371/journal.pone.0100256.
    • Humpf HU, Wüst M, Hayen H,. . „Too shortsighted? Planned reform of the practical year in North Rhine-Westphalia | Zu kurz gedacht?: Geplante reform des praktischen jahres in NRW.“ Deutsche Lebensmittel-Rundschau 110, No. 1: 12.
    • Rychlik,Michael M.,Humpf,Hans Ulrich H.U.,Marko,Doris D.,Dänicke,Sven S.,Mally,Angela A.,Berthiller,Franz F.,Klaffke,Horst St H.S.,Lorenz,Nicole N.,. . ‘Proposal of a comprehensive definition of modified and other forms of mycotoxins including “masked” mycotoxins.’ Mycotoxin Research 30, No. 4: 205. doi: 10.1007/s12550-014-0203-5.
    • Harrer,Henning H.,Humpf,Hans Ulrich H.U.,Voss,Kenneth A. K.A.,. . ‘In vivo formation of N-acyl-fumonisin B1.’ Mycotoxin Research 31, No. 1: 40. doi: 10.1007/s12550-014-0211-5.
    • Humpf,Hans Ulrich H.U.,Schneider,Claus C.,Stevens,Jan Frederik J.F.,. . ‘Functional Food - Where do we go?Molecular Nutrition and Food Research 58, No. 1: 6. doi: 10.1002/mnfr.201470004.
    • Brezina,Ulrike U.,Rempe,Inga I.,Kersten,Susanne S.,Valenta,Hana H.,Humpf,Hans Ulrich H.U.,Dänicke,Sven S.,. . ‘Diagnosis of intoxications of piglets fed with Fusarium toxin-contaminated maize by the analysis of mycotoxin residues in serum, liquor and urine with LC-MS/MS.’ Archives of Animal Nutrition 68, No. 6: 447. doi: 10.1080/1745039X.2014.973227.
    • Brezina,Ulrike U.,Valenta,Hana H.,Rempe,Inga I.,Kersten,Susanne S.,Humpf,Hans Ulrich H.U.,Dänicke,Sven S.,. . ‘Development of a liquid chromatography tandem mass spectrometry method for the simultaneous determination of zearalenone, deoxynivalenol and their metabolites in pig serum.’ Mycotoxin Research 30, No. 3: 186. doi: 10.1007/s12550-014-0200-8.
    • Leucht K., Fischbeck A., Caj M., Liebisch G., Hartlieb E., Benes P., Fried M., Humpf H.-U., Rogler G., Hausmann M. . ‘Sphingomyelin and phosphatidylcholine contrarily affect the induction of apoptosis in intestinal epithelial cells.’ Molecular Nutrition and Food Research 58, No. 4: 782–798. doi: 10.1002/mnfr.201300369.
    • Guaratini T., Silva D.B., Bizaro A.C., Sartori L.R., Humpf H.-U., Lopes N.P., Costa-Lotufo L.V., Lopes J.L.C. . ‘In vitro metabolism studies of erythraline, the major spiroalkaloid from Erythrina verna.’ BMC Complementary and Alternative Medicine 14, No. null. doi: 10.1186/1472-6882-14-61.
    • Lohrey L., Uehara T.N., Tani S., Yamaguchi J., Humpf H.-U., Itami K. . ‘2,4- and 2,5-disubstituted arylthiazoles: Rapid synthesis by c-h coupling and biological evaluation.’ European Journal of Organic Chemistry null, No. null. doi: 10.1002/ejoc.201402129. [online first]

    • Studt L, Humpf HU, Tudzynski B. . ‘Signaling governed by G proteins and cAMP is crucial for growth, secondary metabolism and sexual development in Fusarium fujikuroi.PloS one 8, No. 2: e58185. doi: 10.1371/journal.pone.0058185.
    • Weidner M, Hüwel S, Ebert F, Schwerdtle T, Galla HJ, Humpf HU. . ‘Influence of T-2 and HT-2 toxin on the blood-brain barrier in vitro: new experimental hints for neurotoxic effects.PloS one 8, No. 3: e60484. doi: 10.1371/journal.pone.0060484.
    • Silva,Denise Brentan D.B.,Guaratini,Thais T.,Vessecchi,Ricardo L. R.L.,Lopes,Norberto Peporine N.P.,Cramer,Benedikt B.,Humpf,Hans Ulrich H.U.,Callegari Lopes,JoÃo Luis J.L.,. . ‘H2 unimolecular elimination in electrospray ionization mass spectrometry from erythraline, a spirocyclic alkaloid.’ European Journal of Mass Spectrometry 19, No. 5: 350. doi: 10.1255/ejms.1243.
    • Humpf,Hans Ulrich H.U.,Cramer,Benedikt B.,. . ‘HPLC-MS/MS-analysis of Mycotoxins: Current applications and future perspectives.’ Journal of Plant Pathology 1, No. SUPPL: S1.39.
    • Blaas N, Humpf HU. . ‘Structural profiling and quantitation of glycosyl inositol phosphoceramides in plants with Fourier transform mass spectrometry.Journal of Agricultural and Food Chemistry 61, No. 18: 4257. doi: 10.1021/jf4001499.
    • Harrer H, Laviad EL, Humpf HU, Futerman AH. . ‘Identification of N-acyl-fumonisin B1 as new cytotoxic metabolites of fumonisin mycotoxins.Molecular Nutrition and Food Research 57, No. 3: 516. doi: 10.1002/mnfr.201200465.
    • Weidner M, Lenczyk M, Schwerdt G, Gekle M, Humpf HU. . ‘Neurotoxic potential and cellular uptake of T-2 toxin in human astrocytes in primary culture.Chemical Research in Toxicology 26, No. 3: 347. doi: 10.1021/tx3004664.
    • Havermann,Susannah S.,Rohrig,Ricarda R.,Chovolou,Yvonni Y.,Humpf,Hans Ulrich H.U.,Wätjen,Wim W.,. . ‘Molecular effects of baicalein in Hct116 cells and Caenorhabditis elegans: Activation of the Nrf2 signaling pathway and prolongation of lifespan.’ Journal of Agricultural and Food Chemistry 61, No. 9: 2164. doi: 10.1021/jf304553g.
    • Engemann A, Focke C, Humpf HU. . ‘Intestinal formation of N-nitroso compounds in the pig cecum model.Journal of Agricultural and Food Chemistry 61, No. 4: 998–1005. doi: 10.1021/jf305040e.
    • Mulac D, Lepski S, Ebert F, Schwerdtle T, Humpf HU. . ‘Cytotoxicity and fluorescence visualization of ergot alkaloids in human cell lines.Journal of Agricultural and Food Chemistry 61, No. 2: 462. doi: 10.1021/jf304569q.
    • Lohrey,Lilia L.,Marschik,Stefanie S.,Cramer,Benedikt B.,Humpf,Hans Ulrich H.U.,. . ‘Large-scale synthesis of isotopically labeled 13C 2-tenuazonic acid and development of a rapid HPLC-MS/MS method for the analysis of tenuazonic acid in tomato and pepper products.’ Journal of Agricultural and Food Chemistry 61, No. 1: 120. doi: 10.1021/jf305138k.
    • Lohrey L, Marschik S, Cramer B, Humpf HU. . ‘Large-scale synthesis of isotopically labeled 13C2-tenuazonic acid and development of a rapid HPLC-MS/MS method for the analysis of tenuazonic acid in tomato and pepper products.Journal of Agricultural and Food Chemistry 61, No. 1: 114. doi: 10.1021/jf305138k.

    • Wiemann P, Albermann S, Niehaus EM, Studt L, von Bargen KW, Brock NL, Humpf HU, Dickschat JS, Tudzynski B. . ‘The Sfp-type 4'-phosphopantetheinyl transferase Ppt1 of Fusarium fujikuroi controls development, secondary metabolism and pathogenicity.PloS one 7, No. 5: e37519. doi: 10.1371/journal.pone.0037519.
    • Ferse I, Langlitz M, Kleigrewe K, Rzeppa S, Lenczyk M, Harrer H, Cramer B, Humpf HU. . ‘Isolation and structure elucidation of two new cytotoxic metabolites from red yeast rice.Natural Product Research 26, No. 20: 1914. doi: 10.1080/14786419.2011.639074.
    • von Bargen C, Hübner F, Cramer B, Rzeppa S, Humpf HU. . ‘Systematic approach for structure elucidation of polyphenolic compounds using a bottom-up approach combining ion trap experiments and accurate mass measurements.Journal of Agricultural and Food Chemistry 60, No. 45: 11274. doi: 10.1021/jf3030369.
    • Kleigrewe K., Niehaus E.-M., Wiemann P., Tudzynski B., Humpf H.-U. . ‘New approach via gene knockout and single-step chemical reaction for the synthesis of isotopically labeled fusarin c as an internal standard for the analysis of this fusarium mycotoxin in food and feed samples.Journal of Agricultural and Food Chemistry 60, No. 34: 8350. doi: 10.1021/jf302534x.
    • Studt L, Troncoso C, Gong F, Hedden P, Toomajian C, Leslie JF, Humpf HU, Rojas MC, Tudzynski B. . ‘Segregation of secondary metabolite biosynthesis in hybrids of Fusarium fujikuroi and Fusarium proliferatum.Fungal Genetics and Biology 49, No. 7: 567. doi: 10.1016/j.fgb.2012.05.005.
    • Kleigrewe K, Aydin F, Hogrefe K, Piecuch P, Bergander K, Würthwein EU, Humpf HU. . ‘Structure elucidation of new fusarins revealing insights in the rearrangement mechanisms of the Fusarium mycotoxin fusarin C.Journal of Agricultural and Food Chemistry 60, No. 21: 5497. doi: 10.1021/jf3009469.
    • Rzeppa S, Bittner K, Döll S, Dänicke S, Humpf HU. . ‘Urinary excretion and metabolism of procyanidins in pigs.Molecular Nutrition and Food Research 56, No. 4: 653. doi: 10.1002/mnfr.201100471.
    • Hübner F, Harrer H, Fraske A, Kneifel S, Humpf HU. . ‘Large scale purification of B-type fumonisins using centrifugal partition chromatography (CPC).Mycotoxin Research 28, No. 1: 37–43. doi: 10.1007/s12550-011-0114-7.
    • Engemann A, Hübner F, Rzeppa S, Humpf HU. . ‘Intestinal metabolism of two A-type procyanidins using the pig cecum model: detailed structure elucidation of unknown catabolites with Fourier transform mass spectrometry (FTMS).Journal of Agricultural and Food Chemistry 60, No. 3: 749. doi: 10.1021/jf203927g.

    • Kleigrewe K, Söhnel AC, Humpf HU. . ‘A new high-performance liquid chromatography-tandem mass spectrometry method based on dispersive solid phase extraction for the determination of the mycotoxin fusarin C in corn ears and processed corn samples.Journal of Agricultural and Food Chemistry 59, No. 19: 10470. doi: 10.1021/jf2026814.
    • Rzeppa S, Von Bargen C, Bittner K, Humpf HU. . ‘Analysis of Flavan-3-ols and procyanidins in food samples by reversed phase high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry (RP-HPLC-ESI-MS/MS).Journal of Agricultural and Food Chemistry 59, No. 19: 10594. doi: 10.1021/jf202697j.
    • Mulac D, Grote AK, Kleigrewe K, Humpf HU. . ‘Investigation of the metabolism of ergot alkaloids in cell culture by fourier transformation mass spectrometry.Journal of Agricultural and Food Chemistry 59, No. 14: 7798. doi: 10.1021/jf2012024.
    • Mulac D, Humpf HU. . ‘Cytotoxicity and accumulation of ergot alkaloids in human primary cells.Toxicology 282, No. 3: 112. doi: 10.1016/j.tox.2011.01.019.
    • Wiese C, Grosse Maestrup E, Schepmann D, Grimme S, Humpf HU, Brust P, Wünsch B. . ‘Enantioselective σ1 receptor binding and biotransformation of the spirocyclic PET tracer 1'-benzyl-3-(3-fluoropropyl)-3H-spiro[[2]benzofuran-1,4'-piperidine].Chirality 23, No. 2: 148. doi: 10.1002/chir.20893.
    • Bauwens A, Bielaszewska M, Kemper B, Langehanenberg P, von Bally G, Reichelt R, Mulac D, Humpf HU, Friedrich AW, Kim KS, Karch H, Müthing J. . ‘Differential cytotoxic actions of Shiga toxin 1 and Shiga toxin 2 on microvascular and macrovascular endothelial cells.Thrombosis and Haemostasis 105, No. 3: 515. doi: 10.1160/TH10-02-0140.
    • Wiese C, Maestrup EG, Schepmann D, Grimme S, Humpf HU, Brust P, Wunsch B. . ‘Enantioselective sigma(1) Receptor Binding and Biotransformation of the Spirocyclic PET Tracer 1 '-Benzyl-3-(3-fluoropropyl)-3H-spiro[[2]benzofuran-1,4 '-piperidine].’ Chirality 23, No. 2: 148–154. doi: 10.1002/chir.20893.
    • Fischbeck A, Leucht K, Frey-Wagner I, Bentz S, Pesch T, Kellermeier S, Krebs M, Fried M, Rogler G, Hausmann M, Humpf HU. . ‘Sphingomyelin induces cathepsin D-mediated apoptosis in intestinal epithelial cells and increases inflammation in DSS colitis.’ Gut 60, No. 1: 55–65. doi: 10.1136/gut.2009.201988.
    • Franzmann C, Schröder J, Mϋnzing K, Wolf K, Lindhauer M, Humpf H. . ‘Distribution of ergot alkaloids and ricinoleic acid in different milling fractions.’ Mycotoxin Research 27: 13–21. doi: 10.1007/s12550-010-0070-7.

    • Danicke S, Beyer M, Breves G, Valenta H, Humpf HU. . ‘Effects of oral exposure of pigs to deoxynivalenol (DON) sulfonate (DONS) as the non-toxic derivative of DON on tissue residues of DON and de-epoxy-DON and on DONS blood levels.’ Food Additives and Contaminants: Part A: Chemistry, Analysis, Control, Exposure and Risk Assessment 27, No. 11: 1558–1565. doi: 10.1080/19440049.2010.501036.
    • Danicke S, Pahlow G, Beyer M, Goyarts T, Breves G, Valenta H, Humpf HU. . ‘Investigations on the kinetics of the concentration of deoxynivalenol (DON) and on spoilage by moulds and yeasts of wheat grain preserved with sodium metabisulfite (Na2S2O5, SBS) and propionic acid at various moisture contents.’ Archives of Animal Nutrition 64, No. 3: 190–203. doi: 10.1080/17450391003693159.
    • Beyer M, Dänicke S, Rohweder D, Humpf H-U. . ‘Determination of Deoxynivalenol-sulfonate (DONS) in cereals by hydrophilic interaction chromatography coupled to tandem mass spectrometry.’ Mycotoxin Research 26, No. 2: 109–117. doi: 10.1007/s12550-010-0046-7.
    • Hasslauer I, Oehme A, Locher S, Valotis A, van't Slot G, Humpf HU, Schreier P. . ‘Flavan-3-ol C-glycosides - Preparation and model experiments mimicking their human intestinal transit.’ Molecular Nutrition and Food Research 54, No. 11: 1546–1555. doi: 10.1002/mnfr.201000003.
    • Wiemann P, Brown DW, Kleigrewe K, Bok JW, Keller NP, Humpf HU, Tudzynski B. . ‘FfVel1 and FfLae1, components of a velvet-like complex in Fusarium fujikuroi, affect differentiation, secondary metabolism and virulence.’ Molecular Microbiology 77, No. 4: 972–994. doi: 10.1111/j.1365-2958.2010.07263.x.
    • van't Slot G, Mattern W, Rzeppa S, Grewe D, Humpf HU. . ‘Complex Flavonoids in Cocoa: Synthesis and Degradation by Intestinal Microbiota.’ Journal of Agricultural and Food Chemistry 58, No. 15: 8879–8886. doi: 10.1021/jf1012242.
    • Franzmann C, Wachter J, Dittmer N, Humpf HU. . ‘Ricinoleic Acid as a Marker for Ergot Impurities in Rye and Rye Products.’ Journal of Agricultural and Food Chemistry 58, No. 7: 4223–4229. doi: 10.1021/jf1006903.
    • Hasche A, Ferenz KB, Rose K, König S, Humpf HU, Klumpp S, Krieglstein J. . ‘Binding of ATP to nerve growth factor: characterization and relevance for bioactivity.Neurochemistry International 56, No. 2: 276–84. doi: 10.1016/j.neuint.2009.10.012.
    • Cramer B, Harrer H, Nakamura K, Uemura D, Humpf HU. . ‘Total synthesis and cytotoxicity evaluation of all ochratoxin A stereoisomers.’ Bioorganic and Medicinal Chemistry 18, No. 1: 343–357. doi: 10.1016/j.bmc.2009.10.050.

    • Holl R, Jung B, Schepmann D, Humpf HU, Grunert R, Bednarski PJ, Englberger W, Wünsch B. . ‘Synthesis and Pharmacological Evaluation of SNC80 Analogues with a Bridged Piperazine Ring.’ ChemMedChem 4, No. 12: 2111–2122. doi: 10.1002/cmdc.200900358.
    • Beyer M, Ferse I, Humpf H-U. . ‘Large-scale production of selected type A trichothecenes: The use of HT-2 toxin and T-2 triol as precursors for the synthesis of d 3-T-2 and d 3-HT-2 toxin.’ Mycotoxin Research 25, No. 1: 41–52. doi: 10.1007/s12550-009-0006-2.
    • Fischbeck A, Kruger M, Blaas N, Humpf HU. . ‘Analysis of Sphingomyelin in Meat Based on Hydrophilic Interaction Liquid Chromatography Coupled to Electrospray Ionization-Tandem Mass Spectrometry (HILIC-HPLC-ESI-MS/MS).’ Journal of Agricultural and Food Chemistry 57, No. 20: 9469–9474. doi: 10.1021/jf9025376.
    • Pfeiffer E, Hildebrand A, Damm G, Rapp A, Cramer B, Humpf HU, Metzler M. . ‘Aromatic hydroxylation is a major metabolic pathway of the mycotoxin zearalenone in vitro.’ Molecular Nutrition and Food Research 53, No. 9: 1123–1133. doi: 10.1002/mnfr.200800584.
    • van't Slot G, Humpf HU. . ‘Degradation and Metabolism of Catechin, Epigallocatechin-3-gallate (EGCG), and Related Compounds by the Intestinal Microbiota in the Pig Cecum Model.’ Journal of Agricultural and Food Chemistry 57, No. 17: 8041–8048. doi: 10.1021/jf900458e.
    • Wiemann P, Willmann A, Straeten M, Kleigrewe K, Beyer M, Humpf HU, Tudzynski B. . ‘Biosynthesis of the red pigment bikaverin in Fusarium fujikuroi: genes, their function and regulation.’ Molecular Microbiology 72, No. 4: 931–946. doi: 10.1111/j.1365-2958.2009.06695.x.
    • Konigs M, Mulac D, Schwerdt G, Gekle M, Humpf HU. . ‘Metabolism and cytotoxic effects of T-2 toxin and its metabolites on human cells in primary culture.’ Toxicology 258, No. 2-3: 106–115. doi: 10.1016/j.tox.2009.01.012.
    • Schwerdt G, Konigs M, Holzinger H, Humpf HU, Gekle M. . ‘Effects of the mycotoxin fumonisin B-1 on cell death in human kidney cells and human lung fibroblasts in primary culture.’ Journal of Applied Toxicology 29, No. 2: 174–182. doi: 10.1002/jat.1398.
    • Beyer M, Ferse I, Mulac D, Wurthwein EU, Humpf HU. . ‘Structural Elucidation of T-2 Toxin Thermal Degradation Products and Investigations toward Their Occurrence in Retail Food.’ Journal of Agricultural and Food Chemistry 57, No. 5: 1867–1875. doi: 10.1021/jf803516s.
    • Trebstein A, Marschik S, Lauber U, Humpf HU. . ‘Acetonitrile: the better extractant for the determination of T-2 and HT-2 toxin in cereals using an immunoaffinity-based cleanup?European Food Research and Technology 228, No. 4: 519–529. doi: 10.1007/s00217-008-0959-y.
    • Schwerdt G, Holzinger H, Konigs M, Humpf HU, Gekle M. . ‘Effect of ochratoxin A on cell survival and collagen homeostasis in human mesangial cells in primary culture.’ Food and Chemical Toxicology 47, No. 1: 209–213. doi: 10.1016/j.fct.2008.11.001.
    • Aldick T, Bielaszewska M, Uhlin BE, Humpf HU, Wai SN, Karch H. . ‘Vesicular stabilization and activity augmentation of enterohaemorrhagic Escherichia coli haemolysin.Molecular Microbiology 71, No. 6: 1496–1508. doi: 10.1111/j.1365-2958.2009.06618.x.
    • Fischbeck A, Krüger M, Blaas N, Humpf HU. . ‘Analysis of sphingomyelin in different meat and fish based on normal phase high-performance liquid chromatography (NP-HPLC).’ J. Agric. Food Chem. 57: 9469–9474.

    • Danicke S, Beineke A, Goyarts T, Valenta H, Beyer M, Humpf HU. . ‘Effects of a Fusarium toxin-contaminated triticale, either untreated or treated with sodium metabisulphite (Na2S2O5, SBS), on weaned piglets with a special focus on liver function as determined by the C-13-methacetin breath test.’ Archives of Animal Nutrition 62, No. 4: 263–286. doi: 10.1080/17450390802214167.
    • Aldick T, Bielaszewska M, Uhlin BE, Humpf HU, Wai SN, Karch H. . ‘Enterohemorrhagic Escherichia coli hemolysin delivery to target cells.’ International Journal of Medical Microbiology 298: 84.
    • Cramer B, Konigs M, Humpf HU. . ‘Identification and in vitro cytotoxicity of ochratoxin a degradation products formed during coffee roasting.’ Journal of Agricultural and Food Chemistry 56, No. 14: 5673–5681. doi: 10.1021/jf801296z.
    • Trebstein A, Seefelder W, Lauber U, Humpf HU. . ‘Determination of T-2 and HT-2 toxins in cereals including oats after immunoaffinity cleanup by liquid chromatography and fluorescence detection.’ Journal of Agricultural and Food Chemistry 56, No. 13: 4968–4975. doi: 10.1021/jf800316m.
    • Konigs M, Schwerdt G, Gekle M, Humpf HU. . ‘Effects of the mycotoxin deoxynivalenol on human primary hepatocytes.’ Molecular Nutrition and Food Research 52, No. 7: 830–839. doi: 10.1002/mnfr.200700439.
    • Gong YY, Torres-Sanchez L, Lopez-Carrillo L, Peng JH, Sutcliffe AE, White KL, Humpf HU, Turner PC, Wild CP. . ‘Association between tortilla consumption and human urinary fumonisin B1 levels in a Mexican population.’ Cancer Epidemiology, Biomarkers and Prevention 17, No. 3: 688–694. doi: 10.1158/1055-9965.EPI-07-2534.
    • Hein EM, Rose K, Van't Slot G, Friedrich AW, Humpf HU. . ‘Deconjugation and degradation of flavonol glycosides by pig cecal microbiota characterized by fluorescence in situ hybridization (FISH).’ Journal of Agricultural and Food Chemistry 56, No. 6: 2281–2290. doi: 10.1021/jf073444o.

    • Brockmeyer J, Bielaszewska M, Fruth A, Bonn ML, Mellmann A, Humpf HU, Karch H. . ‘Subtypes of the plasmid-encoded serine protease EspP in Shiga toxin-producing Escherichia coli: distribution, secretion, and proteolytic activity.’ Applied and Environmental Microbiology 73, No. 20: 6351–6359. doi: 10.1128/AEM.00920-07.
    • Koenigs M, Lenczyk M, Schwerdt G, Holzinger H, Gekle M, Humpf HU. . ‘Cytotoxicity, metabolism and cellular uptake of the mycotoxin deoxynivalenol in human proximal tubule cells and lung fibroblasts in primary culture.’ Toxicology 240, No. 1-2: 48–59. doi: 10.1016/j.tox.2007.07.016.
    • Cramer B, Bretz M, Humpf HU. . ‘Stable isotope dilution analysis of the Fusarium mycotoxin zearalenone.’ Journal of Agricultural and Food Chemistry 55, No. 21: 8353–8358. doi: 10.1021/jf0717283.
    • Seiferlein M, Humpf HU, Voss KA, Sullards MC, Allegood JC, Wang E, Merrill AH. . ‘Hydrolyzed fumonisins HFB1 and HFB2 are acylated in vitro and in vivo by ceramide synthase to form cytotoxic N-acyl-metabolites.’ Molecular Nutrition and Food Research 51, No. 9: 1120–1130. doi: 10.1002/mnfr.200700118.
    • Schwerdt G, Holzinger H, Sauvant C, Konigs M, Humpf HU, Gekle M. . ‘Long-term effects of ochratoxin A on fibrosis and cell death in human proximal tubule or fibroblast cells in primary culture.’ Toxicology 232, No. 1-2: 57–67. doi: 10.1016/j.tox.2006.12.008.

    • Bartke N, Fischbeck A, Humpf HU. . ‘Analysis of sphingolipids in potatoes (Solanum tuberosum L.) and sweet potatoes (Ipomoea batatas (L.) Lam.) by reversed phase high-performance liquid chromatography electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS).’ Molecular Nutrition and Food Research 50, No. 12: 1201–1211. doi: 10.1002/mnfr.200600140.
    • Keppler K, Hein EM, Humpf HU. . ‘Metabolism of quercetin and rutin by the pig caecal microflora prepared by freeze-preservation.’ Molecular Nutrition and Food Research 50, No. 8: 686–695. doi: 10.1002/mnfr.200600016.
    • Bretz M, Beyer M, Cramer B, Knecht A, Humpf HU. . ‘Thermal degradation of the Fusarium mycotoxin deoxynivalenol.’ Journal of Agricultural and Food Chemistry 54, No. 17: 6445–6451. doi: 10.1021/jf061008g.
    • Knecht A, Humpf HU. . ‘Cytotoxic and antimitotic effects of N-containing Monascus metabolites studied using immortalized human kidney epithelial cells.’ Molecular Nutrition and Food Research 50, No. 4-5: 406–412. doi: 10.1002/mnfr.200500238.
    • Klotzel M, Lauber U, Humpf HU. . ‘A new solid phase extraction clean-up method for the determination of 12 type A and B trichothecenes in cereals and cereal-based food by LC-MS/MS.’ Molecular Nutrition and Food Research 50, No. 3: 261–269. doi: 10.1002/mnfr.200500234.
    • Knecht A, Cramer B, Humpf HU. . ‘New Monascus metabolites: Structure elucidation and toxicological properties studied with immortalized human kidney epithelial cells.’ Molecular Nutrition and Food Research 50, No. 3: 314–321. doi: 10.1002/mnfr.200500229.
    • Bretz M, Beyer M, Cramer B, Humpf HU. . ‘Stable isotope dilution analysis of the Fusarium mycotoxins deoxynivalenol and 3-acetyldeoxynivalenol.’ Molecular Nutrition and Food Research 50, No. 3: 251–260. doi: 10.1002/mnfr.200500230.
    • Labib S, Hummel S, Richling E, Humpf HU, Schreier P. . ‘Use of the pig caecum model to mimic the human intestinal metabolism of hispidulin and related compounds.’ Molecular Nutrition and Food Research 50, No. 1: 78–86. doi: 10.1002/mnfr.200500144.

    • Bretz M, Beyer M, Cramer B, Humpf HU. . ‘Synthesis of stable isotope labeled 3-acetyldeoxynivalenol.’ Molecular Nutrition and Food Research 49, No. 12: 1151–1153. doi: 10.1002/mnfr.200500153.
    • Goßmann M, Kleta S, Humpf H-U, Büttner C. . ‘Investigation on contamination of asparagus spears (Asparagus officinalis L.) with Fusarium proliferatum (Matsushima) Nirenberg during main harvest | Untersuchungen zum endophytischen Befall von Fusarium proliferatum (Matsushima) Nirenberg in geernteten Stangen von Spargel (Asparagus officinalis L.).’ Gesunde Pflanzen 57, No. 2-3: 53–58. doi: 10.1007/s10343-005-0065-z.
    • Klotzel M, Gutsche B, Lauber U, Humpf HU. . ‘Determination of 12 type A and B trichothecenes in cereals by liquid chromatography-electrospray ionization tandem mass spectrometry.’ Journal of Agricultural and Food Chemistry 53, No. 23: 8904–8910. doi: 10.1021/jf051501c.
    • Keppler K, Humpf HU. . ‘Metabolism of anthocyanins and their phenolic degradation products by the intestinal microflora.’ Bioorganic and Medicinal Chemistry 13, No. 17: 5195–5205. doi: 10.1016/j.bmc.2005.05.003.
    • Klotzel M, Schmidt S, Lauber U, Thielert G, Humpf HU. . ‘Comparison of different clean-up procedures for the analysis of deoxynivalenol in cereal-based food and validation of a reliable HPLC method.’ Chromatographia 62, No. 1-2: 41–48. doi: 10.1365/s10337-005-0576-x.
    • Liu CL, Liu FM, Xu WN, Kofoet A, Humpf HU, Jiang SR. . ‘Occurrence of fumonisins B-1 and B-2 in asparagus from Shandong province, P.R. China.’ Food additives and contaminants 22, No. 7: 673–676. doi: 10.1080/02652030500133016.
    • Bretz M, Knecht A, Gockler S, Humpf HU. . ‘Structural elucidation and analysis of thermal degradation products of the Fusarium mycotoxin nivalenol.’ Molecular Nutrition and Food Research 49, No. 4: 309–316. doi: 10.1002/mnfr.200400092.
    • Fischbeck A, Bartke N, Humpf HU. . ‘New applications of the CD Exciton chirality method. Stereochemical assignment of organic compounds containing carboxylic acid groups.’ Chemical Monthly / Monatshefte für Chemie 136, No. 3: 397–410. doi: 10.1007/s00706-004-0277-4.
    • Bretz M, Göckler S, Humpf H. . ‘Isolation and structural elucidation of thermal degradation products of the Fusarium mycotoxin nivalenol.’ Mycotoxin Research 21: 15–17. doi: 10.1007/BF02954807.
    • Knecht A, Schwerdt G, Gekle M, Humpf H. . ‘Combinatory effects of citrinin and ochratoxin A in immortalized human proximal tubule cells.’ Mycotoxin Research 21: 176–181. doi: 10.1007/BF02959258.

    • Humpf HU, Voss KA. . ‘Effects of thermal food processing on the chemical structure and toxicity of fumonisin mycotoxins.’ Molecular Nutrition and Food Research 48, No. 4: 255–269. doi: 10.1002/mnfr.200400033.
    • Royer D, Humpf HU, Guy PA. . ‘Quantitative analysis of Fusarium mycotoxins in maize using accelerated solvent extraction before liquid chromatography atmospheric pressure chemical ionization tandem mass spectrometry.’ Food additives and contaminants 21, No. 7: 678–692. doi: 10.1080/02652030410001711304.

    • Seefelder W, Humpf HU, Schwerdt G, Freudinger R, Gekle M. . ‘Induction of apoptosis in cultured human proximal tubule cells by fumonisins and fumonisin metabolites.’ Toxicology and Applied Pharmacology 192, No. 2: 146–153. doi: 10.1016/S0041-008X(03)00262-X.
    • Seefelder W, Knecht A, Humpf HU. . ‘Bound fumonisin B-1: Analysis of fumonisin-B-1 glyco and amino acid conjugates by liquid chromatography-electrospray ionization-tandem mass spectrometry.’ Journal of Agricultural and Food Chemistry 51, No. 18: 5567–5573. doi: 10.1021/jf0344338.
    • Wild D, Toth G, Humpf HU. . ‘New Monascus metabolites with a pyridine structure in red fermented rice.’ Journal of Agricultural and Food Chemistry 51, No. 18: 5493–5496. doi: 10.1021/jf030213i.

    • Desai K, Sullards MC, Allegood J, Wang E, Schmelz EM, Hartl M, Humpf HU, Liotta DC, Peng Q, Merrill AH. . ‘Fumonisins and fumonisin analogs as inhibitors of ceramide synthase and inducers of apoptosis.’ Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 1585, No. 2-3: 188–192. doi: 10.1016/S1388-1981(02)00340-2.
    • Seefelder W, Schwerdt G, Freudinger R, Gekle M, Humpf HU. . ‘Liquid chromatography/electrospray ionisation-mass spectrometry method for the quantification of sphingosine and sphinganine in cell cultures exposed to fumonisins.’ Journal of Chromatography B 780, No. 1: 137–144. doi: 10.1016/S1570-0232(02)00440-3.
    • Wild D, Toth G, Humpf HU. . ‘New Monascus metabolite isolated from red yeast rice (angkak, red koji).’ Journal of Agricultural and Food Chemistry 50, No. 14: 3999–4002. doi: 10.1021/jf020023s.
    • Seefelder W, Gossmann M, Humpf HU. . ‘Analysis of fumonisin B-1 in Fusarium proliferatum-infected asparagus spears and garlic bulbs from Germany by liquid chromatography - Electrospray ionization mass spectrometry.’ Journal of Agricultural and Food Chemistry 50, No. 10: 2778–2781. doi: 10.1021/jf0115037.
    • Weil K, Humpf HU, Schwab W, Schreier P. . ‘Absolute configuration of 3-hydroxy acids formed by Stenotrophomonas maltophilia: Application of multidimensional gas chromatography and circular dichroism spectroscopy.’ Chirality 14, No. 1: 51–58. doi: 10.1002/chir.10029.
    • Merill AH, Sullards C, Allegood J, Wang E, Linn SC, Andras L, Liotta DC, Hartl M, Humpf HU. . ‘Insights into the Modulation of Ceramide Metabolism by Naturally Occurring and Synthetic Sphingolipid Analogs as Monitored by Electrospray Tandem Mass.’ In Ceramide Signaling, edited by Futerman AH, 1–8. New York: Springer International Publishing.

    • Weckerle B, Schreier P, Humpf HU. . ‘A new one-step strategy for the stereochemical assignment of acyclic 2-and 3-sulfanyl-1-alkanols using the CD exciton chirality method.’ Journal of Organic Chemistry 66, No. 24: 8160–8164. doi: 10.1021/jo010768h.
    • Broring M, Brandt CD, Lex J, Humpf HU, Bley-Escrich J, Gisselbrecht JP. . ‘Molecular and electronic structure of (2,2 '-bidipyrrinato)nickel(II) complexes.’ European Journal of Inorganic Chemistry , No. 10: 2549–2556. doi: 10.1002/1099-0682(200109)2001:102549::AID-EJIC2549>3.0.CO;2-7.
    • Adam W, Humpf HU, Roschmann KJ, Saha-Moller CR. . ‘Enantioselective epoxidation with chiral Mn-III(salen) catalysts: Kinetic resolution of aryl-substituted allylic alcohols.’ Journal of Organic Chemistry 66, No. 17: 5796–5800. doi: 10.1021/jo010350j.
    • Hartl M, Humpf HU. . ‘Combined synthetic/CD strategy for the stereochemical assignment of the tricarballylic acid side chains of fumonisin B-1.’ Journal of Organic Chemistry 66, No. 11: 3678–3681. doi: 10.1021/jo0000630.
    • Seefelder W, Hartl M, Humpf HU. . ‘Determination of N-(carboxymethyl)fumonisin B-1 in corn products by liquid chromatography/electrospray ionization-mass spectrometry.’ Journal of Agricultural and Food Chemistry 49, No. 5: 2146–2151. doi: 10.1021/jf001429c.
    • Seefelder W, Humpf H. . ‘Formation of Fumonisin artefacts in thermal treated food.’ Mycotoxin Research 17: 116–119. doi: 10.1007/BF03036725.
    • Seefelder W, Humpf HU, Schwerdt G, Freudinger R, Gekle M. . ‘Induction of Apoptosis in Cultured Human Proximal Tubule Cells by Fumonisins and Fumonisin Metabolites.’ Mycotoxin Research 17A: 107–111. doi: 10.1016/S0041-008X(03)00262-X.

    • Hartl M, Humpf HU. . ‘Toxicity assessment of fumonisins using the brine shrimp (Artemia salina) bioassay.’ Food and Chemical Toxicology 38, No. 12: 1097–1102. doi: 10.1016/S0278-6915(00)00112-5.
    • Adam W, Groer P, Humpf HU, Saha-Moller CR. . ‘Synthesis of optically active alpha-methylene beta-lactams through lipase-catalyzed kinetic resolution.’ Journal of Organic Chemistry 65, No. 16: 4919–4922. doi: 10.1021/jo0003089.
    • Hartl M, Humpf HU. . ‘2-Naphthol as a powerful chromophore for the configurational assignment of carboxylic acid groups via the CD exciton chirality method.’ Tetrahedron: Asymmetry 11, No. 8: 1741–1747. doi: 10.1016/S0957-4166(00)00116-6.
    • Adam W, Lukacs Z, Viebach K, Humpf HU, Saha-Moller CR, Schreier P. . ‘Microscale determination of the absolute configuration of alpha-aryl-substituted alcohols by the CD exciton chirality method.’ Journal of Organic Chemistry 65, No. 1: 186–190. doi: 10.1021/jo991424i.
    • Hartl M, Humpf H. . ‘The brine shrimp (Artemia salina) bioassay: A simple method to assess the toxicity of fumonisin mycotoxins.’ Mycotoxin Research 16: 83. doi: 10.1007/BF02942988.

    • Hartl M, Herderich M, Humpf HU. . ‘Rapid determination of fumonisin FB1 in corn products by high-performance liquid chromatography-electrospray mass spectrometry.’ European Food Research and Technology 209, No. 5: 348–351. doi: 10.1007/s002170050507.
    • Hartl M, Humpf HU. . ‘Simultaneous determination of fumonisin B-1 and hydrolyzed fumonisin B-1 in corn products by liquid chromatography/electrospray ionization mass spectrometry.’ Journal of Agricultural and Food Chemistry 47, No. 12: 5078–5083. doi: 10.1021/jf990046f.
    • Degelmann P, Becker M, Herderich M, Humpf H-U. . ‘Determination of ochratoxin A in beer by high-performance liquid chromatography.’ Chromatographia 49, No. 9-10: 543–546. doi: 10.1007/BF02467756.

    • Hör K, Gimple O, Schreier P, Humpf H-U. . ‘Absolute Configurational Assignment of Acyclic Hydroxy Carboxylic Acids: A New Strategy in Exciton-Coupled Circular Dichroism.’ Journal of Organic Chemistry 63, No. 2: 322–325.
    • Hartl M, Humpf H-U. . ‘Assigning the absolute configuration of fumonisins by the circular dichroism exciton chirality method.’ Tetrahedron: Asymmetry 9, No. 9: 1549–1556. doi: 10.1016/S0957-4166(98)00123-2.
    • Roth M, Gutsche B, Herderich M, Humpf H-U, Schreier P. . ‘Dioxygenation of Long-Chain Alkadien(trien)ylphenols by Soybean Lipoxygenase.’ Journal of Agricultural and Food Chemistry 46, No. 8: 2951–2956. doi: 10.1021/jf980196a.
    • Adam W, Lazarus M, Schmerder A, Humpf H-U, Saha-Möller CR, Schreier P. . ‘Synthesis of optically active α-hydroxy acids by kinetic resolution through lipase-catalyzed enantioselective acetylation.’ European Journal of Organic Chemistry , No. 9: 2013–2018. doi: 10.1002/(SICI)1099-0690(199809)1998:92013::AID-EJOC2013>3.0.CO;2-S.
    • Adam W, Boland W, Hartmann-Schreier J, Humpf H-U, Lazarus M, Saffert A, Saha-Möller CR, Schreier P. . ‘α hydroxylation of carboxylic acids with molecular oxygen catalyzed by the α oxidase of peas (Pisum sativum): A novel biocatalytic synthesis of enantiomerically pure (R)-2-hydroxy acids.’ Journal of the American Chemical Society 120, No. 43: 11044–11048. doi: 10.1021/ja981252r.
    • Humpf HU, Schmelz EM, Meredith FI, Vesper H, Vales TR, Wang E, Menaldino DS, Liotta DC, Merrill AH. . ‘Acylation of naturally occurring and synthetic 1-deoxysphinganines by ceramide synthase. Formation of N-palmitoyl-aminopentol produces a toxic metabolite of hydrolyzed fumonisin, AP1, and a new category of ceramide synthase inhibitor.Journal of Biological Chemistry 273, No. 30: 19060–19064. doi: 10.1074/jbc.273.30.19060.
    • Humpf H-U. . ‘Fumonisine in Lebensmitteln: Empfindlicher und selektiver Nachweis mittels HPLC-MS/MS.GIT 42, No. 2: 84–85.
    • Becker M, Degelmann P, Herderich M, Schreier P, Humpf HU. . ‘High-Performance Liquid Chromatography-Electrospray Ionisation-Tandem Mass Spectrometry (HPLC-ESI-MS/MS) for the Analysis of Ochratoxin.’ J. Chromatogr. 818, No. 2: 260–264.
    • Humpf HU, Schmelz EM, Meredith FI, Merrill AH. . ‘N-Palmitoyl-HFB1: A New Metabolite of Hydrolyzed Fumonisin (HFB1) in Rat Liver Microsomes.’ Rev. Méd. Vét 149, No. 6: 576.

    • Gimple O, Schreier P, Humpf H-U. . ‘A new exciton-coupled circular dichroism method for assigning the absolute configuration in acyclic α- and β-hydroxy carboxylic acids.’ Tetrahedron: Asymmetry 8, No. 1: 11–14. doi: 10.1016/S0957-4166(96)00490-9.
    • Herderich M, Richling E, Röscher R, Schneider C, Schwab W, Humpf H-U, Schreier P. . ‘Application of atmospheric pressure ionization HPLC-MS-MS for the analysis of natural products.’ Chromatographia 45: 127–132. doi: 10.1007/BF02505549.
    • Hoch U, Humpf H-U, Schreier P, Saha-Möller CR, Adam W. . ‘Configurational assignment of optically active hydroperoxy homoallylic alcohols and the corresponding diols by circular dichroism and multidimensional gas chromatography.’ Chirality 9, No. 1: 69–74. doi: 10.1002/(SICI)1520-636X(1997)9:169::AID-CHIR13>3.3.CO;2-W.
    • Adam W, Lazarus M, Boss B, Saha-Möller CR, Humpf H-U, Schreier P. . ‘Enzymatic Resolution of Chiral 2-Hydroxy Carboxylic Acids by Enantioselective Oxidation with Molecular Oxygen Catalyzed by the Glycolate Oxidase from Spinach (Spinacia oleracea).’ Journal of Organic Chemistry 62, No. 22: 7844–7849.
    • Schneider C, Schreier P, Humpf H-U. . ‘Exciton-coupled circular dichroism (ECCD) in acyclic hydroxylated dienes: A sensitive method for the direct stereochemical assignment of lipoxygenase products.’ Chirality 9, No. 5-6: 563–567. doi: 10.1002/(SICI)1520-636X(1997)9:5/6563::AID-CHIR25>3.3.CO;2-5.
    • Adam W, Humpf H-U, Korb MN, Schreier P. . ‘The configurational assignment of the optically active 5-(1-hydro- peroxyethyl)-3-ethoxycarbonyl-2-methylfuran and its alcohol by exciton- coupled circular dichroism (ECCD).’ Tetrahedron: Asymmetry 8, No. 21: 3555–3558. doi: 10.1016/S0957-4166(97)00515-6.

    • Schreder B, Lukacs Z, Schmitt M, Schreier P, Humpf H-U. . ‘1-Naphthoic acid: A new type of asymmetric chromophore for exciton-coupled circular dichroism (ECCD).’ Tetrahedron: Asymmetry 7, No. 6: 1543–1546. doi: 10.1016/0957-4166(96)00176-0.
    • Adam W, Hoch U, Humpf H-U, Saha-Möller CR, Schreier P. . ‘Horseradish peroxidase (HRP)-catalysed enantioselective reduction of racemic hydroperoxy homoallylic alcohols: A novel enzymatic method for the preparation of optically active, unsaturated diols and hydroperoxy alcohols.’ Chemical communications , No. 24: 2701–2702. doi: 10.1039/cc9960002701.
    • Lukacs Z, Schaper S, Herderich M, Schreier P, Humpf H-U. . ‘Identification and determination of fumonisin FB1 and FB2 in corn and corn products by high-performance liquid chromatography - Electrospray-ionization tandem mass spectrometry (HPLC-ESI-MS-MS).’ Chromatographia 43, No. 3-4: 124–128. doi: 10.1007/BF02292939.

    • Person RV, Monde K, Humpf HU, Berova N, Nakanishi K. . ‘A new approach in exciton-coupled circular dichroism (ECCD)--insertion of an auxiliary stereogenic center.Chirality 7, No. 3: 128. doi: 10.1002/chir.530070304.
    • Humpf H-U, Berova N, Nakanishi K, Jarstfer MB, Poulter CD. . ‘Allylic and homoallylic exciton coupled CD: A sensitive method for determining the absolute stereochemistry of natural products.’ Journal of Organic Chemistry 60, No. 11: 3539–3542. doi: 10.1021/jo00116a048.

    • Humpf HU, Zhao N, Berova N, Nakanishi K, Schreier P. . ‘Absolute stereochemistry of natural 3,4-dihydroxy-beta-ionone glycosides by the CD exciton chirality method.Journal of Natural Products 57, No. 12: 1762–1765. doi: 10.1021/np50114a027.

    • Humpf H-U, Wintoch H, Schreier P. . ‘3,4-dhydroxy-7,8-dihydro-β-ionol β-D-gucopyranoside: Natural precursor of isomeric vitispiranes from gooseberry (Ribes uva crispa L.) and whitebeam (Sorbus aria) leaves.’ Journal of Agricultural and Food Chemistry 40, No. 11: 2060–2062. doi: 10.1021/jf00023a006.
    • Humpf H-U, Schreier P. . ‘3-Hydroxy-5,6-epoxy-β-ionol β-D-Glucopyranoside and 3-hydroxy-7,8-dihydro-β-ionol β-d-glucopyranoside: New C13 norisoprenoid glucoconjugates from sloe tree (prunus spinosa l.) leaves.’ Journal of Agricultural and Food Chemistry 40, No. 10: 1898–1901. doi: 10.1021/jf00022a034.

    • Humpf H-U, Winterhalter P, Schreier P. . ‘3,4-Dihydroxy-7,8-dihydro-β-ionone β-d-glucopyranoside: natural precursor of 2,2,6,8-tetramethyl-7,l 1-dioxatricyclote.[]-ene (Riesling Acetal) and l,l,6-trimethyl-l,2-dihydronaphthalene in red currant (Ribes rubrum L.) leaves.’ Journal of Agricultural and Food Chemistry 39, No. 10: 1833–1835. doi: 10.1021/jf00010a029.
    • Humpf H-U, Schreier P. . ‘Bound aroma compounds from the fruit and the leaves of blackberry (Rubus laciniata, L.).’ Journal of Agricultural and Food Chemistry 39, No. 10: 1830–1832. doi: 10.1021/jf00010a028.
  • Promotion

    Franziska Michaela JürgensInvestigation of pharmacokinetic properties of antileishmanial Sesquiterpene lactones from Arnica montana L. (Thesis written in German)
    Wünsch, AngelikaImitation von Lipoproteinen als nanopartikuläre Arzneistoffträgersysteme
    Dr. Sueck, FranziskaVorkommen, Proteinaffinität, Metabolismus und biologische Halbwertszeit der Mykotoxine 2’R-Ochratoxin A und Ochratoxin A beim Menschen
    Dr. Krug, Isabel DorisIn vitro-Untersuchungen zu den Effekten ausgewählter Mykotoxine und mariner Biotoxine an der Blut-Hirn-Schranke
    Dr. Wagner (geb. Ferse), InesIsolierung und Strukturaufklärung neuer Monascus-Sekundärmetabolite in Rotschimmelreis sowie Synthese von Ochratoxin A-Derivaten zur Untersuchung der StrukturWirkungs-Beziehung
    Dr. Kuchenbuch (geb. Schmidt), Henning SörenInvestigations on the stability and degradation of T-2 toxin during thermal food processing
    Dr. Hickert, Sebastian RudolfInvestigation on Alternaria mycotoxins with focus on tenuazonic acid and studies oin the potential of micro-HPLC-MS/MS and MALDI-Imaging mass spectrometry for mycotoxin analysis
    Dr. Saenger (geb. Kemme), TheresaStudien zum Nachweis ernährungsbedingter Biomarker im Humanurin
    Kalinina SvetlanaPenicillium spp. as a Source of Secondary Metabolites: Structure Elucidation, Occurrence in Food, Cytotoxicity, and Biological Activity
    Dr. Bergmann, DominikStabilisotopenmarkierte Darstellung des Mykotoxins Citrinin und seines Hauptmetaboliten Dihydrocitrinon sowie Synthese von Aminoglykosid-Derivaten
    Dr. Uebel, ThomasImpact of aserone isomers on cellular redox status and the onset of DNA-integrity
    Dr. Rottkord, UlrikeStruktur-Wirkungs-Beziehungen zur Toxizität von Ochratoxin A und kombinatorische Effekte mit Citrinin
    Dr. Arndt, BirgitStudies on the secondary metabolism of Fusarium fujikuroi
    Haupenthal, SabrinaBeeinflussung der DNA-Integrität durch Metaboliten natürlicher kanzerogener Phenylpropanoide.
    Analysis and Characterization of Food Allergens: A Mass Spectrometric Approach
    Dr. Dopstadt, JulianDas Potential des Mutterkornpilzes Claviceps purpurea zur Produktion neuer Sekundärmetaboliten
    Dr. Rösler, Sarah M.Complex Regulation of Secondary Metabolism in the Phytopathogenic Fungus Fusarium fujikuroi
    Dr. Lichtenwald, MarinaMolecular and phenotypical analysis of biofilm formation of enterohaemorrhagiuc Eschericia coli
    Instrumentelle Analytik (LC/ICPMS/MS) und toxikologische Charakterisierung von Arsenolipiden
    Dr. Gerding, JohannesBiomarkerbasierte Abschätzung der humanen Mykotoxinexposition und Untersuchung des Metabolismus ausgewählter Mykotoxine
    Kunsmann, LisaCharakterisierung von Membranvesikeln enterohämorrhagischer Escherichia coli
    Investigation of natural products as MHC-II loading enhancers with the HLA-DR1 serotype as an example (Thesis written in German)
    Dr. Hummel, MarleneAllergene Proteine in Gewürzen: Massenspektro-metrische Identifizierung und Charakterisierung von 2S Albuminen aus Senf und Sesam
    Matrix-gebundene Ochratoxin A-Rückstände in thermisch behandelten Lebensmitteln: Strukturaufklärung, Analytik und Bioverfügbarkeit
    Studien zum Vorkommen, zur systemischen Absorption und zum Metabolismus von Polyphenolen
    Dr. von Bargen, Katharina WalburgaIdentifizierung und Strukturaufklärung neuer Sekundärmetaboliten aus Fusarium fujikuroi sowie Untersuchungen zur Biosynthese und Analytik
    Etablierung eines LC/FTMS basierten Testsystems zur Quantifizierung der epigenetische Effekte von Arsenverbindungen
    Authentifizierung und Strukturaufklärung von Lebensmittelinhaltsstoffen mittels massenspektrometrischer Methoden am Beispiel von Proteinen und Polyphenolen
    Intestinal absorption of flavonoids and metabolites in the Caco-2 model
    Organoquecksilberspezies und der zelluläre DNA-Schadensresponse
    Funktionale Charakterisierung der Serinprotease-Autotransporter EspPα und Espl aus enterohämorrhagischen Escherichia coli
    Charakterisierung und massenspektrometrische Nachweis von Nussallergenen
    Untersuchungen zur Toxizität und zum Metabolismus von Fusarium-Mykotoxinen in humanen Primärzellen
    Bioverfügbarkeit, Metabolismus und Toxizität von Arsenozuckern
    Effects of biotic and abiotic factors on the production of Fusarium-mycotoxins by phytophathogenic Fusarium-isolates
    Dr. Brezina, UlrikeDetermination of zearalenone, deoxynivalenol and their metabolites in physiological samples of pigs with LC-MS/MS: Development of multi-mycotoxin methods and verification through a dose-response feeding study
    Darstellung der stabilisotopenmarkierten Mykotoxine Moniliformin und Tenuazonsäure sowie Synthese von bioaktiven Arylthiazolen mittels direkter Fusarin-Analoga
    Dr. Havermann, SusannahAktivierung des ARE durch Flavonole und Hydroxyzimtsäurederivate: Untersuchungen in Zellkultursystemen und C. elegans
    Intestinaler Metabolismus von Lebensmittelinhaltsstoffen im Schweine-Caecum-Modell
    Vorkommen von Fusarin-C-Mykotoxinen in Lebensmitteln und Strukturaufklärung neuer Fusarin-Analoga
    Dr. Diederich, JohannesManganspeziation in biologischen Proben
    Dr. Ehlers, SusanAnalytik von Perfluoralkylsäuren in verschiedenen Matrices zur Klärung der Toxikokinetik in Tierarten die der Lebensmittelgewinnung dienen
    Studien zur systemischen Absorption und zum Metabolismus von Anthocyanen im Tiermodell Schwein
    Dr. Riedel, SylviaModulation of lipid metabolism as a possible tool to prevent carcinoigenoic effects of fumonisin B1
    Untersuchungen zur massenspektrometrischen Charakterisierung von Sphingophospholipiden in humaner Milch und pflanzlichen Lebensmitteln
    Isolierung, Strukturaufklärung und Analytik von Procyanidinen sowie Kinetikstudien im Tiermodell am Schwein
    Dr. Bevanda-Franjic, MarijaneIn vitro-Studien von Anthocyanen im Caco-2-Modellsystem
    Zellkulturstudien zur Cytotoxizität, zur Aufnahme und zum Transportmechanismus von Mutterkornalkaloiden
    Darstellung der stabilisotopen-markierten Mykotoxine Fumonisin B1 und Alternariol
    Dr. Betz, JosefineStruktur-Funktions-Analysen von Shiga Toxin-Rezeptoren mikro- und makrovaskulärer humaner Endothelzellen
    Dr. Neue, KristinaElucidation of N-glycosylation by unspecific proteolysis in combination with ZIC-HILIC SPE and de novo sequencing of IgG primary structures by use of direct nanoESI Q-Tof mass spectrometry
    Dr. Franzmann, CarolinUntersuchungen zum Vorkommen, zur Stabilität und zum thermischen Abbau von Mutterkornalkaloiden in Roggen und Roggenprodukten
    Dr. Harrer, Henning Uwe MichaelDie Bedeutung des Sphingolipidstoffwechsels für die toxikologische Wirkungsweise der Fumonisin-Mykotoxine
    Dr. Nollen, Maike CoraUntersuchungen zur indirekten Genotoxizität von Arsenit und seinem Metabolit monomethylarsonige Säure
    Regulation of secondary metabolism in phytophathogenic Fusarium spp.
    Dr. van 't Slot, GordonUntersuchungen zum intestinalen Metabolismus von pflanzlichen Lebensmittelinhaltsstoffen
    Dr. Fischbeck, AnneVorkommen von Sphingomyelin in der menschlichen Ernährung und seine Bedeutung bei entzündlichen Darmerkrankungen im Tiermodell
    Dr. Trebstein, AnkeAnalytik von Mykotoxinen der Gattung Fusarium mittels Hochleistungsflüssigchromatographie mit Fluoreszenzdetektion und Tandem-Massenspektrometrie
    Dr. Beyer, MaritaProduktion, Analytik und Abbau bedeutender Trichothecen-Mykotoxine
    Structure and function of the plasmid-encoded bacterial serine protease autotransporter EspP from Shiga toxin-producing Escherichia coli
    Dr. Aldick, ThomasStabilität und Aktivität von freiem und vesikulärem Hämolysin aus enterohämorrhagischen Escherichia coli
    Thermischer Abbau und Analytik der Mykotoxine Ochratoxin A und Zearalenon
    Dr. Königs, MaikaUntersuchungen zur Cytotoxizität und zum Metabolismus von Fusarientoxinen in humanen Primärzellen
    Dr. Rose, Ina KatrinMetabolismus von Flavonoiden durch die intestinale Mikroflora im Schweine-Caecum-Modell
    Dr. Klötzel, MariannaEntwicklung von Analyseverfahren zur empfindlichen Bestimmung von Fusarientoxinen in Lebensmitteln
    Dr. Bartke, NanaUntersuchungen zum Vorkommen von Sphingolipiden in pflanzlichen Lebensmitteln
    Dr. Knecht, AnjaMonascus-Sekundärmetabolite: Neue Verbindungen und Untersuchungen zur biologischen Aktivität
    Dr. Bretz, Michael EwaldProduktion, Analytik und Abbau ausgewählter Fusarientoxine