The German Research Foundation has approved the continuation of the Chembion Research Training Group at the University of Münster. The program for research into ion channels will receive around 4.5 million euros.

© B. Wünsch

The German Research Foundation (DFG) will fund the Research Training Group „Chemical Biology of Ion Channels (Chembion), located at the University of Münster, for a further 4.5 years. The participating doctoral students are researching small organic molecules with which the opening state of so-called ion channels can be specifically controlled. Ion channels are proteins that form pores in cell membranes and thus allow charged particles to pass through the cell membrane. This process plays an important role in the transmission of stimuli in nerve cells or the release of insulin, for example. The English-language doctoral program "Chemical biology of ion channels (Chembion)" will run in the second funding period from 1 April 2024 to 30 September 2028 and is funded by the DFG with around 4.5 million euros.

13 scientists from the Departments of Chemistry, Pharmacy and Medicine support the Research Training Group at the University of Münster. Prof. Dr. Bernard Wünsch from the Institute of Pharmaceutical and Medicinal Chemistry is the spokesperson for the program and explains the background to the research interest: "We are combining molecular expertise from pharmacy with cell physiological expertise from medicine in order to learn more about ion channels as important chemical control instruments in cells, tissues and organs. The targeted opening and closing of ion channels could lead to a wide range of applications, for example in cancer therapy or in the treatment of neuronal diseases."

The interdisciplinary collaboration between pharmacy/chemistry and medicine is also reflected in the graduate program, emphasizes the spokesperson: "All doctoral students are accompanied by two mentors from both disciplines. The element of "lab rotation", i.e. switching between the labs, allows the doctoral students to get to know new working methods." The independent organization of meetings and conferences also strengthens the young researchers' initiative and independence. A six-month stay abroad enables doctoral students in the Research Training Group to exchange ideas with international colleagues.

Structured doctorate at the University of Münster

Research Training Groups are university institutions for the promotion of young academics. They are funded by the DFG for a maximum of nine years. The focus is on the qualification of doctoral students within the framework of a thematically focused research program and a structured qualification concept. There are three DFG-funded Research Training Groups (RTGs) at the University of Münster.

Links:

Press release no. 45 of the DFG from 08.11.2023:

Link - Pressemitteilung

Stefan Groß receives a poster award at the DPhG Annual Meeting 2023 in Tübingen

© DPhG

On the occasion of the DPhG Annual Meeting 2023 in Tübingen, Stefan Groß, member of the research group of Prof. Wünsch and member of Chembion, received a poster award from Dovepress. He received the award for his presented poster entitled " A Chimeric Subtype-Selective Fluorescent Probe for GluN2A-containing NMDA Receptors”.

https://www.dphg.de/artikel/posterpreise-2023

Dr. Janosch Menke Receives CIC Award for Computational Chemistry

© GDCh - CIC

On the occasion of the annual meeting of the division "Computers in Chemistry" of the Gesellschaft Deutscher Chemiker (GDCh), Dr. Janosch Menke (AG Koch and Member of Chembion) received the CIC Award for Computational Chemistry. The award was given for his outstanding dissertation, in which Dr. Menke dealt with the application of artificial intelligence methods within computational drug discovery. The research focused on utilizing neuronal networks to enable faster identification of bioactive molecules.

Doctoral Ceremony

© L. Frye

Doctoral Ceremony July 2023

After the successful defense of their dissertation, Chembion members Kathrin Riske, Thorsten Loeck, Alexander Dombovski, Laura Vinnenberg, Héctor Noguera Hurtado, Tobias Schierling & Janosch Menke were formally announced at the doctoral ceremony on July 7.

Doctoral ceremony July 7

| Lecture and Poster Award
Lecture and Poster Award
Ms. Joana Massa and Prof. Dr. Tim Clark
© MMWS2023

Lecture and poster award for Joana Massa

On the occasion of the 35th Molecular Modeling Workshop in Erlangen , Ms. Joana Massa from the research group of Prof. Koch at the Institute of Pharmaceutical and Medicinal Chemistry, has received a poster and a presentation award.

Ms. Massa is a member of the Chembion graduate program.

She received the 3rd winner lecture award for a presentation on the research results of her Master's thesis entitled "Metadynamics Simulations of FPR2: Using an Enhanced Sampling Method to Elucidate The Mode of Action of a Diverse Set of Ligands". She received the poster award for her dissertation work entitled "KCa3.1 channel: Computational analysis of three known toxin inhibitors towards new extracellular inhibitors".

 

| Chembion Forschung bei der Tagesschau
Chembion Forschung bei der Tagesschau

Die Tagesschau berichtete am Freitag, den 27.01.2023 auf ihrer Seite über die Forschung des Chembion Mitglieds Prof. Dr. Timo Strünker (Reproduktionsmediziner und Androloge am Universitätsklinikum Münster).

Neue Studie: Bald Verhütungsmittel für den Mann?

Verlässliche Verhütung ist häufig noch immer Frauensache. Eine neue Studie zeigt jetzt, wie Spermien unfruchtbar gemacht werden können - ein zukünftiges Verhütungsmittel für den Mann? weiterlesen

| Horst-Böhme Award
Horst-Böhme Award
© Uni MS/P.Grewer

Dr. Anna Junker recieves Horst-Böhme Award

The young scientist Dr. Anna Junker from the European Institute for Molecular Imaging (EIMI) and member of the Research Training Group Chembion has been awarded the Horst Böhme Prize 2022 by the Foundation of the German Pharmaceutical Society (DPhG) for her outstanding achievements. The prize is awarded by the DPhG to people who have demonstrated special academic qualifications and who want to pursue an academic career.

| "Best Presentation by a PhD Student"
"Best Presentation by a PhD Student"

Photos

© GP2A Conference
  • Chembion Opening Ceremony
    © © Hauss/UKM
  • Chembion Retreat
    © F Begrow
  • © Uni MS
  • © J. Stepper
  • © J Stepper
  • © J. Stepper
  • 3rd Chembion Symposium
    © Stepper
  • Female Leadership Workshop
    © Vinnenberg
  • © J. Stepper
  • © junker
  • © Junker
  • Members of the RTG Chembion
    © J Stepper
  • Chembion retreat Schloss Raesfeld
    © J Stepper, M Wojciechowski
  • Ms Joana Massa and Prof. Dr. Tim Clark
    © MMWS2023
  • © Uni MS/P.Grewer
  • Nadine Ritter
    © Nadine Ritter
  • © Vinnenberg
  • © Rüters
  • © J Stepper
  • © Judith Stepper
  • © Judith Stepper
  • © Sr. Josit
  • Publications
    © Judith Stepper
  • Chembion Retreat
    © J Stepper
  • © J. Stepper
  • © J. Stepper
  • © J. Stepper
  • © J. Stepper
  • © J. Stepper
  • © wwu
  • © wwu
  • © Peralta
  • Program 2nd Chembion Symposium
    © J Stepper
  • Program 2nd Chembion Symposium
    © J Stepper
  • © J Stepper
  • © Uni MS
  • © Uni MS
  • © Uni MS
  • © Heike Blum
  • Prof. Dr. Kümmel
    © J Stepper
  • Prof. Dr. Gouaux
    © J Stepper
  • Prof. Dr. Kuhlmann
    © J Stepper
  • Dr. Seifert
    © J Stepper
  • © Judith Stepper
  • WWU Logo
    © Uni MS

Magdalena Wojciechowski receives the award "Best Presentation by a PhD Student"

On the occasion of the GP2A Annual Conference 2022 in Dublin, Magdalena Wojciechowski, PhD student in Prof. Jose's group at the Institute for Pharmaceutical and Medicinal Chemistry and member of the Research Training Group Chembion, received the "Best Presentation by a PhD Student" award. The title of her lecture was "Mutational analysis of the surface displayed HCN4-C-Linker-CNBD: a flow cytometry based ligand binding approach" and uses autodisplay to investigate the influence of different amino acids within the HCN4- cyclic nucleotide binding domain (CNBD) on the binding of 8-fluo-cAMP.

Phoenix-Pharmazie-Wissenschaftspreis
Phoenix-Pharmazie-Wissenschaftspreis

Herausragende interdisziplinäre Forschung zwischen Medizinischer Chemie und Elektrophysiologie: Bernhard Wünsch mit „Phoenix-Pharmazie-Wissenschaftspreis“ ausgezeichnet

Prof. Dr. Bernhard Wünsch vom Institut für Pharmazeutische und Medizinische Chemie der WWU erhielt Anfang Dezember den „Phoenix-Pharmazie-Wissenschaftspreis 2020“. Er wurde zusammen mit seinen Kollegen für seine interdisziplinäre Arbeit zwischen Medizinischer Chemie, Molekulardynamik und Elektrophysiologie geehrt.

Der Pharmazeutische Chemiker Prof. Dr. Bernhard Wünsch vom Institut für Pharmazeutische und Medizinische Chemie der Westfälischen Wilhelms-Universität Münster (WWU) erhielt gemeinsam mit Prof. Dr. Guiscard Seebohm und Dr. Julian Schreiber aus dem Institut für Genetik von Herzerkrankungen den „Phoenix-Pharmazie-Wissenschaftspreis 2020“. Der alle zwei Jahre vergebene Preis wird für hervorragende Forschungsarbeiten auf dem Gebiet der Pharmazeutischen und Medizinischen Chemie vergeben.
In der Preisträgerarbeit haben Bernhard Wünsch und seine Kollegen den Wirkungsmechanismus von neuartigen Wirkstoffen auf molekularer Ebene aufgeklärt. Im Mittelpunkt steht hierbei ein besonderer Subtyp des N-Methyl-D-aspartat- (NMDA) Rezeptors, der einen Liganden-gesteuerten Ionenkanal darstellt. Im Ruhezustand stehen der geöffnete und geschlossene Zustand des Ionenkanal-Rezeptors miteinander im Gleichgewicht. Wie durch einen „Fuß-in-der-Tür“ (Foot-in-the-door-Mechanismus) können unsere Wirkstoffe die Bewegung des Phenylalanins-176 – eine besondere Aminosäure weit außen am Rezeptor – blockieren und auf diese Weise den Ionenkanal inhibieren und die Passage von Ionen hemmen. Da der NMDA-Rezeptor eine besondere Rolle bei der Entwicklung neurodegenerativer Erkrankungen, wie beispielsweise Morbus Alzheimer, Morbus Parkinson oder Morbus Huntington spielt, ist die Aufklärung des molekularen Mechanismus‘ bedeutsam für die Entwicklung innovativer Therapiemöglichkeiten.

Link zu UKM Pressemitteilung

Link zu Originalpublikation in "Nature"
Link zu DAZ Artikel "Den Fuß in die Tür stellen"

Teamwork against forgetfulness: WWU researchers decipher mechanism of action of possible Alzheimer's drugs

The team led by Prof. Bernhard Wünsch and Prof. Guiscard Seebohm succeeded in deciphering a common mechanism of action of ifenprodil and other inhibitors. "Communications Biology" publishes the important discovery in the current issue.

Link - Pressemitteilung

PubMed - Link

 

Four million euros for research into ion channels: DFG approves joint Research Training Group of Chemistry and Pharmacy as well as Medicine

Press release from 15.05.2019

Link to press release