Publications
2024
Lyu XY, et al. Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity. Aging 2024 Oct 16;16(20):12955-12976. doi: 10.18632/aging.206135. [Epub 2024 Oct 16]
Büttner S. Membrankontaktstellen: wie Organellen miteinander reden. Biospektrum 2024.October 11; 30,621–624. doi: 10.1007/s12268-024-2300-0.
Prokisch S, Büttner S*. Partitioning into ER membrane microdomains impacts autophagic protein turnover during cellular aging. Scientific Reports 2024 Jun 13;14(1):13653. doi: 10.1038/s41598-024-64493-8.
Álvarez-Guerra I, Block E, Broeskamp F, Gabrijelčič S, Infant T, de Ory A, Habernig L, Andréasson C, Levine TP, Höög JL, Büttner S*. LDO proteins and Vac8 form a vacuole-lipid droplet contact site required for lipophagy in response to starvation. Developmental Cell 2024 Mar 25;59(6):759-775.e5. doi: 10.1016/j.devcel.2024.01.014. [Epub 2024 Feb 13]
Kohler V, Kohler A, Berglund LL, Hao X, Gersing S, Imhof A, Nyström T, Höög JL, Ott M, Andréasson C, Büttner S*. Nuclear Hsp104 safeguards the dormant translation machinery during quiescence. Nat Commun. 2024 Jan 15(1):315. doi: 10.1038/s41467-023-44538-8.
2023
Keuenhof KS, Kohler V, Broeskamp F, Panagaki D, Speese SD, Büttner S, Höög JL. Nuclear envelope budding and its cellular functions. Nucleus 2023 Dec 14(1):2178184. doi: 10.1080/19491034.2023.2178184.
Vázquez-Calvo C, Kohler V, Höög JL, Büttner S*, Ott M* (2023) Newly imported proteins in mitochondria are particularly sensitive to aggregation. Acta Physiologica 2023 Jul;238(3):e13985. doi: 10.1111/apha.13985. [Epub 2023 Jun 1]
2022
Diessl J, Berndtsson J, Broeskamp F, Habernig L, Kohler V, Vazquez-Calvo C, Nandy A, Peselj C, Drobysheva S, Pelosi L, Vögtle FN, Pierrel F, Ott M, Büttner S*. Manganese-driven CoQ deficiency. Nat Commun. 2022 Oct 13;13(1):6061. doi: 10.1038/s41467-022-33641-x.
Peselj C, Ebrahimi M, Broeskamp F, Prokisch S, Habernig L, Alvarez-Guerra I, Kohler V, Vögtle FN, Büttner S*. Sterol Metabolism Differentially Contributes to Maintenance and Exit of Quiescence. Front. Cell Dev. Biol. 2022 Feb 14:10:788472. doi: 10.3389/fcell.2022.788472.
2021
Habernig L, Broeskamp F, Aufschnaiter A, Diessl J, Peselj C, Urbauer E, Eisenberg T, de Ory A, Büttner S*. Ca2+ administration prevents α-synuclein proteotoxicity by stimulating calcineurin-dependent lysosomal proteolysis. PLoS Genetics 2021 Nov 15;17(11):e1009911. doi: 10.1371/journal.pgen.1009911.
Ebrahimi M, Habernig L, Broeskamp F, Aufschnaiter A, Diessl J, Atienza I, Matz S, Ruiz FA, Büttner S*. Phosphate Restriction Promotes Longevity via Activation of Autophagy and the Multivesicular Body Pathway. Cells 2021 Nov 13;10(11):3161. doi: 10.3390/cells10113161.
Panagaki D, Croft JT, Keuenhof K, Larsson Berglund L, Andersson S, Kohler V, Büttner S, Tamás MJ, Nyström T, Neutze R, Höög JL. Nuclear envelope budding is a response to cellular stress. PNAS 2021 Jul 27;118(30):e2020997118. doi: 10.1073/pnas.2020997118.
Poveda-Huertes D, Taskin AA, Dhaouadi I, Myketin L, Marada A, Habernig L, Büttner S, Vögtle FN. Increased mitochondrial protein import and cardiolipin remodelling upon early mtUPR. PLoS Genetics 2021 Jul 2;17(7):e1009664. doi: 10.1371/journal.pgen.1009664.
Kohler V, Büttner S*. Remodelling of nucleus-vacuole junctions during metabolic and proteostatic stress. Contact 2021 May 27:4:25152564211016608. doi: 10.1177/25152564211016608.
Braun RJ, Büttner S. Editorial: Modeling Neurodegeneration in Yeast. Front Mol Neurosci. 2021 Mar 1;14:645190. doi: 10.3389/fnmol.2021.645190.
Tosal-Castano S, Peselj C, Kohler V, Habernig L, Berglund LL, Ebrahimi M, Vögtle FN, Höög J, Andréasson C, Büttner S*. Snd3 controls nucleus-vacuole junctions in response to glucose signaling. Cell Reports 2021 Jan 19;34(3):108637. doi: 10.1016/j.celrep.2020.108637.
Klionsky DJ, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280. [Epub 2021 Feb 8]
2020
Berndtsson J, Aufschnaiter A, Rathore S, Marin-Buera L, Dawitz H, Diessl J, Kohler V, Barrientos A, Büttner S*, Fontanesi F*, Ott M*. Respiratory supercomplexes enhance electron transport by decreasing cytochrome c diffusion distance. EMBO Rep. 2020 Dec 3;21(12):e51015. doi: 10.15252/embr.202051015. [Epub 2020 Oct 5]
Cavinato M, Madreiter-Sokolowski CT, Büttner S, Schosserer M, Zwerschke W, Wedel S, Grillari J, Graier WF, Jansen-Dürr P. Targeting cellular senescence based on inter-organelle communication, multi-level proteostasis and metabolic control. FEBS J. 2021 Jun;288(12):3834-3854. doi: 10.1111/febs.15631. [Epub 2020 Dec 8]
Duan J, Zhao Y, Li H, Habernig L, Gordon MD, Miao X, Engström Y, and Büttner S*. Bab2 functions as an ecdysone-responsive transcriptional repressor during Drosophila development. Cell Reports 2020 Jul 28;32(4):107972. doi: 10.1016/j.celrep.2020.107972.
Toth A, Aufschnaiter A, Fedotovskaya O, Dawitz H, Ädelroth P, Büttner S*, Ott M*. Membrane-tethering of cytochrome c accelerates regulated cell death in yeast. Cell Death & Disease 2020 Sep 5;11(9):722. doi: 10.1038/s41419-020-02920-0.
Kohler V, Aufschnaiter A, and Büttner S*. Closing the Gap: Membrane Contact Sites in the Regulation of Autophagy. Cells 2020 May 9;9(5). doi: 10.3390/cells9051184.
Diessl J, Nandy A, Schug C, Habernig L, and Büttner S*. Stable and destabilized GFP reporters to monitor calcineurin activity in Saccharomyces cerevisiae. Microbial Cell 2020 Feb 5;7(4):106-114. doi: 10.15698/mic2020.04.713.
Poveda-Huertes D, Matic S, Marada A, Haberni L, Licheva M, Myketin L, Gilsbach R, Tosal-Castano S, Papinski D, Mulica P, Kretz O, Kücükköse C, Taskin AA, Hein L, Kraft C, Büttner S, Meisinger C, and Vögtle FN. An Early mtUPR: Redistribution of the Nuclear Transcription Factor Rox1 to Mitochondria Protects against Intramitochondrial Proteotoxic Aggregates. Molecular Cell 2020 Jan 2;77(1):180-188.e9. doi: 10.1016/j.molcel.2019.09.026. [Epub 2019 Oct 17]
Charmpilas N, Ruckenstuhl C, Sica V, Büttner S, Habernig L, Dichtinger S, Madeo F, Tavernarakis N, Bravo-San Pedro JM, and Kroemer G. Acyl-CoA-binding protein (ACBP): a phylogenetically conserved appetite stimulator. Cell Death Dis. 2020 Jan 6;11(1):7. doi: 10.1038/s41419-019-2205-x.
Aufschnaiter A, Kohler V, Büttner S. Chapter 8 – The mitochondrial network in Parkinon’s disease. Genetics, Neurology, Behaviour and Diet in Parkinson’s disease. Academic Press 2020.
Aufschnaiter A, Kohler V, Khalifa S, Abd El-Wahed A, Du M, El-Seedi H*, Büttner S*. Apitoxin and Its Components against Cancer, Neurodegeneration and Rheumatoid Arthritis: Limitations and Possibilities. Toxins 2020 Jan 21;12(2):66. doi: 10.3390/toxins12020066.
Vazquez-Calvo C, Suhm T, Büttner S*, Ott M*. The basic machineries for mitochondrial protein quality control. Mitochondrion 2020 Jan:50:121-131. doi: 10.1016/j.mito.2019.10.003. [Epub 2019 Oct 26]
2019
Andréasson C*, Ott M*, Büttner S*. Mitochondria orchestrate proteostatic and metabolic stress responses. EMBO Reports 2019 Oct 4;20(10):e47865. doi: 10.15252/embr.201947865. [Epub 2019 Sep 18]
Aufschnaiter A, Büttner S*. The vacuolar shapes of ageing: From function to morphology. BBA - Mol Cell Res. 2019 May;1866(5):957-970. doi: 10.1016/j.bbamcr.2019.02.011. [Epub 2019 Feb 21]
Gross AS, Zimmermann A, Pendl T, Schroeder S, Schoenlechner H, Knittelfelder O, Lamplmayr L, Santiso A, Aufschnaiter A, Waltenstorfer D, Ortonobes Lara S, Stryeck S, Kast C, Ruckenstuhl C, Hofer SJ, Michelitsch B, Woelflingseder M, Müller R, Carmona-Gutierrez D, Madl T, Büttner S, Fröhlich KU, Shevchenko A, Eisenberg T. Acetyl-CoA carboxylase 1-dependent lipogenesis promotes autophagy downstream of AMPK. J Biol Chem. 2019 Aug 9;294(32):12020-12039. doi: 10.1074/jbc.RA118.007020. [Epub 2019 Jun 17]
2018
Kohler V, Goessweiner-Mohr N, Aufschnaiter A, Fercher C, Probst I, Pavkov-Keller T, Hunger K, Wolinski H, Büttner S, Grohmann E, Keller W. TraN: A novel repressor of an Enterococcus conjugative type IV secretion system. Nucleic Acids Res. 2018 Sep 28;46(17):9201-9219. doi: 10.1093/nar/gky671.
Büttner S, Ludovico P, Thevissen K. From Regulated Cell Death to Adaptive Stress Strategies: Convergence and Divergence in Eukaryotic Cells. Oxid Med Cell Longev. 2018 Jun 24:2018:2480462. doi: 10.1155/2018/2480462.
Aufschnaiter A., Kohler V, Walter C, Tosal-Castano S, Habernig L, Wolinski H, Keller W, Vögtle FN, Büttner S*. The enzymatic core of the Parkinson’s Disease-associated protein LRRK2 impairs mitochondrial biogenesis in aging yeast. Front. Mol. Neurosci. 2018 Jun 21:11:205. doi: 10.3389/fnmol.2018.00205.
Yeaman MR, Büttner S, Thevissen K. Regulated Cell Death as a Therapeutic Target for Novel Antifungal Peptides and Biologics. Oxid Med Cell Longev. 2018 Apr 26:2018:5473817. doi: 10.1155/2018/5473817.
Suhm T, Kaimal JM, Dawitz H, Peselj C, Masser AE, Hanzén S, Ambrozic M, Smialowska A, Björck ML, Brzezinski P, Nyström T, Büttner S, Andréasson C, Ott M. Mitochondrial translation efficiency controls cytoplasmic protein homeostasis. Cell Metabolism 2018 Jun 5;27(6):1309-1322.e6. doi: 10.1016/j.cmet.2018.04.011. [Epub 2018 May 10]
Leibiger C, Deisel J, Aufschnaiter A, Ambros S, Tereshchenko M, Verheijen BM, Büttner S, Braun RJ. Endolysosomal pathway activity protects cells from neurotoxic TDP-43. Microbial Cell 2018 Mar 21;5(4):212-214. doi: 10.15698/mic2018.04.627.
Suhm T, Habernig L, Rzepka M, Kaimal JM, Andréasson C, Büttner S, Ott M. A novel system to monitor mitochondrial translation in yeast. Microbial Cell 2018 Jan 13;5(3):158-164. doi: 10.15698/mic2018.03.621.
Leibiger C, Deisel J, Aufschnaiter A, Ambros S, Tereshchenko M, Verheijen BM, Büttner S, Braun RJ. TDP-43 controls lysosomal pathways thereby determining its own clearance and cytotoxicity. Hum Mol Genet. 2018 May 1;27(9):1593-1607. doi: 10.1093/hmg/ddy066.
Carmona-Gutierrez D, et al. Guidelines and recommendations on yeast cell death nomenclature. Microbial Cell 2018 Jan 1;5(1):4-31. doi: 10.15698/mic2018.01.607.
Rockenfeller P, Smolnig M, Diessl J, Bashir M, Schmiedhofer V, Knittelfelder O, Ring J, Franz J, Foessl I, Khan MJ, Rost R, Graier WF, Kroemer G, Zimmermann A, Carmona-Gutierrez D, Eisenberg T, Büttner S, Sigrist SJ, Kühnlein RP, Kohlwein SD, Gourlay CW, Madeo F. Diacylglycerol triggers Rim101 pathway-dependent necrosis in yeast: a model for lipotoxicity. Cell Death Differ. 2018 Mar;25(4):767-783. doi: 10.1038/s41418-017-0014-2. [Epub 2017 Dec 11]
2017
Aufschnaiter A, Kohler V, Büttner S*. Taking out the garbage: cathepsin D and calcineurin in neurodegeneration. Neural Regen Res. 2017 Nov;12(11):1776-1779. doi: 10.4103/1673-5374.219031.
Ring J, Rockenfeller P, Abraham C, Tadic J, Poglitsch M, Schimmel K, Westermayer J, Schauer S, Achleitner B, Schimpel C, Moitzi B, Rechberger GN, Sigrist SJ, Carmona-Gutierrez D, Kroemer G, Büttner S, Eisenberg T, Madeo F. Mitochondrial energy metabolism is required for lifespan extension by the spastic paraplegia-associated protein spartin. Microbial Cell 2017 Nov 30;4(12):411-422. doi: 10.15698/mic2017.12.603.
Aufschnaiter A, Habernig L, Kohler V, Diessl J, Carmona-Gutierrez D, Eisenberg T, Keller W and Büttner S*. The coordinated action of calcineurin and cathepsin D protects against α-synuclein toxicity.Front. Mol. Neurosci. 2017 Jun 30:10:207. doi: 10.3389/fnmol.2017.00207.
Kohler V, Probst I, Aufschnaiter A, Büttner S, Schaden L, Rechberger GN, Koraimann G, Grohmann E, Keller W. Conjugative type IV secretion in Gram-positive pathogens: TraG, a lytic transglycosylase and endopeptidase, interacts with translocation channel protein TraM. Plasmid 2017 May:91:9-18. doi: 10.1016/j.plasmid.2017.02.002. [Epub 2017 Feb 17]
2016
Eisenberg T, Abdellatif M, Schroeder S, Primessnig U, Stekovic S, Pendl T, Harger A, Schipke J, Zimmermann A, Schmidt A, Tong M, Ruckenstuhl C, Dammbrueck C, Gross AS, Herbst V, Magnes C, Trausinger G, Narath S, Meinitzer A, Hu Z, Kirsch A, Eller K, Carmona-Gutierrez D, Büttner S, Pietrocola F, Knittelfelder O, Schrepfer E, Rockenfeller P, Simonini C, Rahn A, Horsch M, Moreth K, Beckers J, Fuchs H, Gailus-Durner V, Neff F, Janik D, Rathkolb B, Rozman J, de Angelis MH, Moustafa T, Haemmerle G, Mayr M, Willeit P, von Frieling-Salewsky M, Pieske B, Scorrano L, Pieber T, Pechlaner R, Willeit J, Sigrist SJ, Linke WA, Mühlfeld C, Sadoshima J, Dengjel J, Kiechl S, Kroemer G, Sedej S, Madeo F. Cardioprotection and lifespan extension by the natural polyamine spermidine. Nature Medicine 2016 Dec;22(12):1428-1438. doi: 10.1038/nm.4222. [Epub 2016 Nov 14]
Aufschnaiter A, Kohler V, Diessl J, Peselj C, Carmona-Gutierrez D, Keller W, Büttner S*. Mitochondrial lipids in neurodegeneration. Cell Tissue Res. 2017 Jan;367(1):125-140. doi: 10.1007/s00441-016-2463-1. [Epub 2016 Jul 23]
2015
Aufschnaiter A, and Büttner S*. Peroxisomal fission controls yeast life span. Cell Cycle 2015 Aug 3;14(15):2389-90. doi: 10.1080/15384101.2015.1063303.
2014
Büttner S, Broeskamp F, Sommer C, Markaki M, Habernig L, Alavian-Ghavanini A, Carmona-Gutierrez D, Eisenberg T, Michael E, Kroemer G, Tavernarakis N, Sigrist S, Madeo F. Spermidine protects against α-synuclein neurotoxicity. Cell Cycle 2014 Dec 15; 13(24) :3903-8. doi: 10.4161/15384101.2014.973309.
Eisenberg T, Schroeder S, Büttner S, Carmona-Gutierrez D, Pendl T, Andryushkova A, Mariño G, Pietrocola F, Harger A, Zimmermann A, Magnes C, Sinner F, Sedej S, Pieber TR, Dengjel J, Sigrist S, Kroemer G, Madeo F. A histone point mutation that switches on autophagy. Autophagy 2014 Jun;10(6):1143-5. doi: 10.4161/auto.28767.
Carmona-Gutierrez D and Büttner S*. The many ways to age for a single yeast cell. Yeast 2014 Aug;31(8):289-98. doi: 10.1002/yea.3020. [Epub 2014 Jun 13]
Ruckenstuhl C, Netzberger C, Entfellner I, Carmona-Gutierrez D, Kickenweiz T, Stekovic S, Gleixner C, Schmid C, Klug L, Hajnal I, Sorgo AG, Eisenberg T, Büttner S, Mariño G, Koziel R, Magnes C, Sinner F, Pieber TR, Jansen-Dürr P, Fröhlich K-U, Kroemer G, Madeo F. Autophagy extends lifespan via vacuolar acidification. Microbial Cell 2014 May 5;1(5):160-162. doi: 10.15698/mic2014.05.147.
Ruckenstuhl C, Netzberger C, Entfellner I, Carmona-Gutierrez D, Kickenweiz T, Stekovic S, Gleixner C, Schmid C, Klug L, Sorgo AG, Eisenberg T, Büttner S, Mariño G, Koziel R, Jansen-Dürr P, Fröhlich KU, Kroemer G, Madeo F. Lifespan extension by methionine restriction requires autophagy-dependent vacuolar acidification. PLoS Genetics 2014 May 1;10(5):e1004347. doi: 10.1371/journal.pgen.1004347.
Eisenberg T, Schroeder S, Andryushkova A, Pendl T, Küttner V, Bhukel A, Mariño G, Pietrocola F, Harger A, Zimmermann A, Moustafa T, Sprenger A, Jany E, Büttner S, Carmona-Gutierrez D, Ruckenstuhl C, Ring J, Reichelt W, Schimmel K, Leeb T, Moser C, Schatz S, Kamolz LP, Magnes C, Sinner F, Sedej S, Fröhlich KU, Juhasz G, Pieber TR, Dengjel J, Sigrist SJ, Kroemer G, Madeo F. Nucleo-cytosolic depletion of the energy metabolite acetyl-coenzyme a stimulates autophagy and prolongs lifespan. Cell Metabolism 2014 Mar 4;19(3):431-44. doi: 10.1016/j.cmet.2014.02.010.
2013
Büttner S, Habernig L, Broeskamp F, Ruli D, Vögtle FN, Vlachos M, Macchi F, Küttner V, Carmona-Gutierrez D, Eisenberg T, Ring J, Markaki M, Aras Taskin A, Benke S, Ruckenstuhl C, Braun R, Van den Haute C, Bammens T, van der Perren A, Fröhlich KU, Winderickx J, Kroemer G, Baekelandt V, Tavernarakis N, Kovacs GG, Dengjel J, Meisinger C, Sigrist SJ and Madeo F. Endonuclease G mediates α-synuclein cytotoxicity during Parkinson's disease. EMBO Journal 2013 Nov 27;32(23):3041-54. doi: 10.1038/emboj.2013.228. [Epub 2013 Oct 15]
Eisenberg T and Büttner S*. Lipids and cell death in yeast. FEMS Yeast Res. 2014 Feb;14(1):179-97. doi: 10.1111/1567-1364.12105. [Epub 2013 Oct 30]
Carmona-Gutierrez D, Alavian-Ghavanini A, Habernig L, Bauer MA, Hammer A, Rossmann C, Zimmermann AS, Ruckenstuhl C, Büttner S, Eisenberg T, Sattler W, Malle E, Madeo F. The cell death protease Kex1p is essential for hypochlorite-induced apoptosis in yeast. Cell Cycle 2013 Jun 1;12(11):1704-12. doi: 10.4161/cc.24801. [Epub 2013 May 1]
2012
Büttner S, Faes L, Reichelt NR, Broeskamp F, Habernig L, Benke S, Kourtis N, Ruli D, D’hooge P, Ghillebert R, Eisenberg T, Carmona Gutierrez D, Franssens V, Harger A, Pieber T, Freudenberger P, Kroemer G, Sigrist SJ, Winderickx J, Callewaert G, Tavernarakis N, Madeo F. The Ca2+/Mn2+ ion-pump PMR1 links elevation of cytosolic Ca2+ levels to α-synuclein toxicity in Parkinson’s disease models. Cell Death Differ. 2013 Mar;20(3):465-77. [Epub 2012 Nov 16]
Rinnerthaler M, Büttner S, Laun P, Heeren G, Felder TK, Klinger H, Weinberger M, Stolze K, Grousl T, Hasek J, Benada O, Frydlova I, Klocker A, Simon-Nobbe B, Jansko B, Breitenbach-Koller H, Eisenberg T, Gourlay CW, Madeo F, Burhans WC, Breitenbach M. Yno1p/Aim14p, a NADPH-oxidase ortholog, controls extramitochondrial reactive oxygen species generation, apoptosis, and actin cable formation in yeast. PNAS 2012 May 29;109 (22):8658–8663. [Epub 2012 May 14]
Laun P, Büttner S, Rinnerthaler M, Burhans WC, Breitenbach M. Yeast aging and apoptosis. Subcell Biochem. 2012; 57:207-32.
Breitenbach M, Laun P, Dickinson JR, Klocker A, Rinnerthaler M, Dawes IW, Aung-Htut MT, Breitenbach-Koller L, Caballero A, Nyström T, Büttner S, Eisenberg T, Madeo F, Ralser M. The role of mitochondria in the aging processes of yeast. Subcell Biochem. 2012; 57:55-78.
2011
Carmona-Gutierrez D, Reisenbichler A, Heimbucher P, Bauer MA, Braun RJ, Ruckenstuhl C, Büttner S, Eisenberg T, Rockenfeller P, Fröhlich KU, Kroemer G, Madeo F. Ceramide triggers metacaspase-independent mitochondrial cell death in yeast. Cell Cycle 2011 Nov 15;10(22):3973-8.
Swinnen E, Büttner S, Outeiro TF, Galas MC, Madeo F, Winderickx J, Franssens V. Aggresome formation and segregation of inclusions influence toxicity of α-synuclein and synphilin-1 in yeast. Biochem Soc Trans. 2011 Oct;39(5):1476-81.
Haemmerle G, Moustafa T, Woelkart G, Büttner S, Schmidt A, van de Weijer T, Hesselink M, Jaeger D, Kienesberger PC, Zierler K, Schreiber R, Eichmann T, Kolb D, Kotzbeck P, Schweiger M, Kumari M, Eder S, Schoiswohl G, Wongsiriroj N, Pollak NM, Radner FP, Preiss-Landl K, Kolbe T, Rülicke T, Pieske B, Trauner M, Lass A, Zimmermann R, Hoefler G, Cinti S, Kershaw EE, Schrauwen P, Madeo F, Mayer B, Zechner R. ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1. Nature Medicine 2011 Aug 21;17(9):1076-85.
Galluzzi L, Vanden Berghe T, Vanlangenakker N, Buettner S, Eisenberg T, Vandenabeele P, Madeo F, Kroemer G. Programmed necrosis from molecules to health and disease. Int Rev Cell Mol Biol. 2011; 289:1-35.
Braun RJ, Sommer C, Carmona-Gutierrez D, Khoury CM, Ring J, Büttner S, Madeo F. Neurotoxic 43-kDa TAR DNA-binding protein (TDP-43) triggers mitochondrion-dependent programmed cell death in yeast. J Biol Chem. 2011 Jun 3;286(22):19958-72.
Büttner S, Ruli D, Vögtle FN, Galluzzi L, Moitzi B, Eisenberg T, Kepp O, Habernig L, Carmona-Gutierrez D, Rockenfeller P, Laun P, Breitenbach M, Khoury C, Fröhlich KU, Rechberger G, Meisinger C, Kroemer G, Madeo F. A yeast BH3-only protein mediates the mitochondrial pathway of apoptosis. EMBO Journal 2011 Jun 14;30(14):2779-92.
Carmona-Gutiérrez D, Bauer MA, Ring J, Knauer H, Eisenberg T, Büttner S, Ruckenstuhl C, Reisenbichler A, Magnes C, Rechberger GN, Birner-Gruenberger R, Jungwirth H, Fröhlich KU, Sinner F, Kroemer G, Madeo F. The propeptide of yeast cathepsin D inhibits programmed necrosis. Cell Death Dis. 2011 May 19; 2:e161.
2010
Büttner S, Delay C, Franssens V, Bammens T, Ruli D, Zaunschirm S, de Oliveira RM, Outeiro TF, Madeo F, Buée L, Galas MC, Winderickx J. Synphilin-1 enhances α-synuclein aggregation in yeast and contributes to cellular stress and cell death in a Sir2-dependent manner. PLoS One 2010 Oct 27;5(10):e13700.
Rockenfeller P, Ring J, Muschett V, Beranek A, Buettner S, Carmona-Gutierrez D, Eisenberg T, Khoury C, Rechberger G, Kohlwein SD, Kroemer G, Madeo F. Fatty acids trigger mitochondrion-dependent necrosis. Cell Cycle 2010 Jul 15;9(14):2836-42.
Carmona-Gutierrez D, Ruckenstuhl C, Bauer MA, Eisenberg T, Büttner S, Madeo F. Cell death in yeast: growing applications of a dying buddy. Cell Death Differ. 2010 May;17(5):733-4.
Eisenberg T, Carmona-Gutierrez D, Büttner S, Tavernarakis N, Madeo F. Necrosis in yeast. Apoptosis 2010 Mar;15(3):257-68.
Madeo F, Eisenberg T, Büttner S, Ruckenstuhl C, Kroemer G. Spermidine: a novel autophagy inducer and longevity elixir. Autophagy 2010 Jan;6(1):160-2.
Carmona-Gutierrez D, Eisenberg T, Büttner S, Meisinger C, Kroemer G, Madeo F. Apoptosis in yeast: triggers, pathways, subroutines. Cell Death Differ. 2010 May;17(5):763-73.
Franssens V, Boelen E, Anandhakumar J, Vanhelmont T, Büttner S, Winderickx J. Yeast unfolds the road map toward alpha-synuclein-induced cell death. Cell Death Differ. 2010 May;17(5):746-53
Braun RJ, Büttner S, Ring J, Kroemer G, Madeo F. Nervous yeast: modeling neurotoxic cell death. Trends Biochem Sci. 2010 Mar;35(3):135-44.
2009
Eisenberg T, Knauer H, Schauer A, Büttner S, Ruckenstuhl C, Carmona-Gutierrez D, Ring J, Schroeder S, Magnes C, Antonacci L, Fussi H, Deszcz L, Hartl R, Schraml E, Criollo A, Megalou E, Weiskopf D, Laun P, Heeren G, Breitenbach M, Grubeck-Loebenstein B, Herker E, Fahrenkrog B, Fröhlich KU, Sinner F, Tavernarakis N, Minois N, Kroemer G, Madeo F. Induction of autophagy by spermidine promotes longevity. Nature Cell Biology 2009 Nov;11(11):1305-14.
Madeo F, Carmona-Gutierrez D, Ring J, Büttner S, Eisenberg T, Kroemer G. Caspase-dependent and caspase-independent cell death pathways in yeast. Biochem Biophys Res Commun. 2009 May 1;382(2):227-31.
Ruckenstuhl C, Büttner S, Carmona-Gutierrez D, Eisenberg T, Kroemer G, Sigrist SJ, Fröhlich KU, Madeo F. The Warburg effect suppresses oxidative stress induced apoptosis in a yeast model for cancer. PLoS One. 2009;4(2):e45
2008
Jungwirth H, Ring J, Mayer T, Schauer A, Büttner S, Eisenberg T, Carmona-Gutierrez D, Kuchler K, Madeo F. Loss of peroxisome function triggers necrosis. FEBS Lett. 2008 Aug 20;582(19):2882-6
Low CP, Shui G, Liew LP, Büttner S, Madeo F, Dawes IW, Wenk MR, Yang H. Caspase-dependent and -independent lipotoxic cell-death pathways in fission. J Cell Sci. 2008 Aug 15; 121:2671-84.
Büttner S, Bitto A, Ring J, Augsten M, Zabrocki P, Eisenberg T, Jungwirth H, Hutter S, Carmona-Gutierrez D, Kroemer G, Winderickx J, Madeo F. Functional mitochondria are required for alpha-synuclein toxicity in aging yeast. J Biol Chem. 2008 Mar 21; 283(12):7554-60.
2007
Almeida B, Büttner S, Ohlmeier S, Silva A, Mesquita A, Sampaio-Marques B, Osório NS, Kollau A, Mayer B, Leão C, Laranjinha J, Rodrigues F, Madeo F, Ludovico P. NO-mediated apoptosis in yeast. J Cell Sci. 2007 Sep 15; 120(Pt 18):3279-88.
Büttner S, Carmona-Gutierrez D, Vitale I, Castedo M, Ruli D, Eisenberg T, Kroemer G, Madeo F. Depletion of endonuclease G selectively kills polyploid cells. Cell Cycle 2007 May 2;6(9):1072-6.
Eisenberg T, Büttner S, Kroemer G, Madeo F. The mitochondrial pathway in yeast apoptosis. Apoptosis 2007 May;12(5):1011-23.
Büttner S, Carmona-Gutierrez D, Eisenberg T, Ruli D, Madeo F. Conspiracy of yeast killers: the fifth international meeting on yeast apoptosis. FEMS Yeast Res. 2007 Mar;7(2):351-4.
Büttner S, Eisenberg T, Carmona-Gutierrez D, Ruli D, Knauer H, Ruckenstuhl C, Sigrist C, Wissing S, Kollroser M, Fröhlich KU, Sigrist S, Madeo F. Endonuclease G regulates budding yeast life and death. Molecular Cell 2007 Jan 26; 25(2):233-46.
2006
Büttner S, Eisenberg T, Herker E, Carmona-Gutierrez D, Kroemer G, Madeo F. Why yeast cells can undergo apoptosis: death in times of peace, love, and war. J Cell Biol. 2006 Nov 20;175(4):521-5.
Braun RJ, Zischka H, Madeo F, Eisenberg T, Wissing S, Büttner S, Engelhardt SM, Büringer D, Ueffing M. Crucial mitochondrial impairment upon CDC48 mutation in apoptotic yeast. J Biol Chem. 2006 Sep 1;281(35):25757-67.
Allen C, Büttner S, Aragon AD, Thomas JA, Meirelles O, Jaetao JE, Benn D, Ruby SW, Veenhuis M, Madeo F, Werner-Washburne M. Isolation of quiescent and nonquiescent cells from yeast stationary-phase cultures. J Cell Biol. 2006 Jul 3;174(1):89-100.
2004
Wissing S, Ludovico P, Herker E, Büttner S, Engelhardt SM, Decker T, Link A, Proksch A, Rodrigues F, Corte-Real M, Fröhlich KU, Manns J, Candé C, Sigrist SJ, Kroemer G, Madeo F. An AIF orthologue regulates apoptosis in yeast. J Cell Biol. 2004 Sep 27;166(7):969-74.
Herker E, Jungwirth H, Lehmann KA, Maldener C, Fröhlich KU, Wissing S, Büttner S, Fehr M, Sigrist S, Madeo F. Chronological aging leads to apoptosis in yeast. J Cell Biol. 2004 Feb 16;164(4):501-7.