Dr. rer. nat. Jandirk Sendker

  • Research Areas

    • Plant secondary metabolites in response to senescence processes
    • Medicinal Plants, Natural Products Chemistry
    • Natural products with activity against neglected tropical diseases
  • Doctoral Thesis

    Zur Entstehung primärer Amidglykoside aus cyanogenen Glykosiden

    Supervisor
  • CV

    Education

    -
    PhD in Pharmaceutical Biology (Westfälische Wilhelms-Universität, Prof. A. Nahrstedt)
    -
    Pharmacy Practice
    -
    Pharmacy studies (Westfälische Wilhelms-Universität)

    Positions

    since
    Senior lecturer (Institute of Pharmaceutical Biology and Phytochemistry)
    -
    Postdoc (Heinrich-Heine-Universität, Prof. P. Proksch)

    Honors

    Posterpreis der Gesellschaft für Phytotherapie 2015 - Gesellschaft für Phytotherapie e.V.

    External functions

    since
    Good Practice in Traditional Chinese Medicine Research Association (original member)
    since
    Society for Medicinal Plant and Natural Product Research
  • Teaching

  • Projects

    • Research Network Natural Products against Neglected Diseases (since )
      Own funding
    • ResNet NPND - Research Network Natural Products against Neglected Diseases (ResNet NPND) (since )
      Own funding
    • GP-TCM - Good Practice in Traditional Chinese Medicine GP-TCM ( - )
      Own funding | Project Number: HEALTH‐F4‐2009‐223154
  • Publications

    • Sendker J, Sheridan H. . ‘History and Current Status of Herbal Medicines.’ In Toxicology of Herbal Products, edited by Pelkonen O, Duez P, Vuorela PM, Vuorela H (Eds.): , 11-27. 1st Ed. Switzerland: Springer International Publishing. doi: 10.1007/978-3-319-43806-1_2.
    • Sendker J, Sheridan H. . ‘Composition and Quality Control of Herbal Medicines.’ In Toxicology of Herbal Products, edited by Pelkonen O, Duez P, Vuorela PM, Vuorela H (Eds.): , 29-65. 1st Ed. Switzerland: Springer International Publishing. doi: 10.1007/978-3-319-43806-1_3.
    • Sendker J, Böker I, Lengers I, Brandt S, Jose J, Stark T, Hofmann T, Fink C, Abdel-Aziz H, Hensel A. . ‘Phytochemical Characterization of Low Molecular Constituents from Marshmallow Roots (Althaea officinalis) and Inhibiting Effects of the Aqueous Extract on Human Hyaluronidase-1.’ Journal of Natural Products 80, No. 2: 290-297.
    • Sendker J, Böker I, Lengers I, Brandt S, Jose J, Abdel-Aziz H, Hensel A. . „Neuartige sulfatierte Flavonglucuronide und Scopoletinglycosid aus den Wurzeln von Althaea officinalis und anti-Hyaluronidase-1-Aktivität wässrigen Eibischextraktes.“Beitrag präsentiert auf der Phytotherapie 2016 "Extraktentwicklung - Klinik - Versorgungsforschung" Dreiländertagung mit Symposium Tiermedizin, Bonn, Germany. doi: DOI: 10.1055/s-0036-1584438.
    • Sendker J, Ellendorff T, Hölzenbein A. . ‘Occurrence of Benzoic Acid Esters as Putative Catabolites of Prunasin in Senescent Leaves of Prunus laurocerasus.’ Journal of Natural Products 79. doi: 10.1021/acs.jnatprod.5b0109.
    • Hielscher J, Lemmes AS, von Holtum B, Hasse A, Sendker J, Petereit F, Hensel A, Lechtenberg M. . „Nachweis und quantitative Bestimmung von Piperin in Cayennepfeffer, Chillipulver und Rosenpaprika – Sind Verunreinigungen mit echtem Pfeffer technisch unvermeidbar?Lebensmittelchemie 70: 81-112. doi: 10.1002/lemi.201690028.
    • Sendker J, Böker I, Lengers I, Brandt S, Jose J, Fink C, Abdel-Aziz H, Hensel A.New flavon glucuronides and Scopoletin glycosides from the roots of Althaea officinalis L.’Poster contributed to the 9th Joint Natural Products Conference, Copenhagen, Denmark, . doi: 10.1055/s-0036-1596320.
    • Hensel A, Sendker J. . „Eibischwurzel - Inhaltsstoffe der Droge und ihre molekularen Targets.“ Deutsche Apotheker Zeitung 156: 4280-4282.
    • Derksen A, Kühn J, Hafezi W, Sendker J, Ehrhardt C, Ludwig S, Hensel A. . ‘Antiviral activity of hydroalcoholic extract from Eupatorium perfoliatum L. against the attachment of influenza A virus.’ Journal of Ethnopharmacology 188: 144-152. doi: doi:10.1016/j.jep.2016.05.016.
    • Kisseih E, Agyare C, Lechtenberg M, Petereit F, Sendker J, Brandt S, Hensel A. . „Von der Ethnopharmakologie zur rationalen Phytotherapie: Phytochemische Charakterisierung und präklinische Untersuchungen zur potentiellen Wundheilungsaktivität von Extrakten aus Combretum mucronatum Schum. & Thonn.Zeitschrift für Phytotherapie 37: 59-65.
    • Beydokthi SS, Sendker J, Brandt S, Hensel A. . „Traditionally used medicinal plants against uncomplicated urinary tract infections: Hexadecyl coumaric acid ester from the rhizomes of Agropyron repens (L.) P. Beauv. with antiadhesive activity against uropathogenic E. coli.“ Fitoterapia ?. doi: 10.1016/j.fitote.2016.12.010. [Accepted]
    • Rafsanjany N, Sendker J, Lechtenberg M, Petereit F, Scharf B, Hensel A. . „Unkomplizierte Harnwegsinfektionen: Extrakte aus Maisgriffeln (Zea mays L.) wirken gegen uropathogene E. coli.“ Zeitschrift für Phytotherapie 37: 9-12.
    • Rafsanjany N, Sendker J, Lechtenberg M, Petereit F, Scharf B, Hensel A. . ‘Traditionally used medicinal plants against uncomplicated urinary tract infections: Are unusual, flavan-4-ol- and derhamnosylmaysin derivatives responsible for the antiadhesive activity of extracts obtained from stigmata of Zea mays L. against uropathogenic E. coli and Benzethonium chloride as frequent contaminant faking potential antibacterial activities?Fitoterapia 105, No. null: 246-253. doi: 10.1016/j.fitote.2015.07.014.
    • Ellendorff T, Brun R, Kaiser M, Schmidt TJ, Sendker J. . ‘PLS-Prediction and Confirmation of Hydrojuglone Glucoside as the Antitrypanosomal Constituent of Juglans Spp.Molecules 20: 10082-10094. doi: doi:10.3390/molecules200610082.
    • Hellenbrand N, Lechtenberg M, Petereit F, Sendker J, Hensel A. . ‘Isolation and Quantification of Oligomeric and Polymeric Procyanidins in the Aerial Parts of St. Johnʼs Wort (Hypericum perforatum)*.’ Planta Medica 81, No. 12-13: 1175-1189. doi: 10.1055/s-0035-1545916.
    • Sendker J, Böker I, Fink C, Kelber O, Hensel A. . „Phytochemische Untersuchung von Eibischwurzel aus Althaea officinalis L.: Alte Arzneidroge mit neuen Inhaltsstoffen.“Beitrag präsentiert auf der Phytokongress 2015, Rostock-Warnemünde. doi: DOI: 10.1055/s-00000101.
    • Lautenschläger M, Sendker J, Hüwel S, Galla HJ, Brandt S, Düfer M, Riehemann K, Hensel A. . ‘Intestinal formation of trans-crocetin from saffron extract (Crocus sativus L.) and in vitro permeation through intestinal and blood brain barrier.’ Phytomedicine 2015, No. 1: 36-44. doi: doi:10.1016/j.phymed.2014.10.009.
    • Sheridan H, Kopp B, Krenn L, Guo D, Sendker J. . ‘Traditional Chinese herbal preparation: Invoking the butterfly effect.’ Science 350, No. 6262 Suppl: S64-S66. doi: 10.1126/science.350.6262.871-c.
    • Rafsanjany N, Sendker J, Brandt S, Dobrindt U, Hensel A. . ‘In Vivo Consumption of Cranberry Exerts ex Vivo Antiadhesive Activity against FimH-Dominated Uropathogenic Escherischia coli: A Combined in Vivo, ex Vivo, and in Vitro Study of an Extract from Vaccinium macrocarpon.’ Journal of Agricultural and Food Chemistry 63: 8804-8818. doi: 10.1021/acs.jafc.5b03030.
    • Okoye FB, Richard SW, Sendker J, Aly AH, Quandt B, Wray V, Hensel A, Esimone CO, Debbab A, Diedrich M, Proksch P. . ‘Flavonoid glycosides from Olax mannii: Structure elucidation and effect on the nuclear factor kappa B pathway.’ Journal of Ethnopharmacology 175: 27-34. doi: 10.1016/j.jep.2015.10.019.
    • Kisseih E, Lechtenberg M, Petereit F, Sendker J, Zacharski D, Brandt S, Agyare C, Hensel A. . ‘Phytochemical characterization and in vitro wound healing activity of leaf extracts from Combretum mucronatum Schum. & Thonn.: Oligomeric procyanidins as strong inductors of cellular differentiation.’ Journal of Ethnopharmacology 174: 628-636. doi: 10.1016/j.jep.2015.06.008.
    • Spiegler V, Sendker J, Petereit F, Liebau E, Hensel A. . ‘Bioassay-Guided Fractionation of a Leaf Extract from Combretum mucronatum with Anthelmintic Activity: Oligomeric Procyanidins as the Active Principle.’ Molecules 20, No. 8: 14810-14832. doi: 10.3390/molecules200814810.
    • Rafsanjany N, Petereit F, Sendker J, Lechtenberg M, Hensel A.Beteiligung von Benzethoniumchlorid als Verunreinigung von Maydis stigma an der antiadhäsiven Wirkung gegenüber uropathogenen E. coli.’Poster präsentiert auf der Jahrestagung der Gesellschaft für Phytotherapie Phytokongress 2015, Rostock, .
    • Plöger M, Sendker J, Langer K, Schmidt TJ. . ‘Covalent modification of human serum albumin by the natural sesquiterpene lactone parthenolide.Molecules 20.
    • Hellenbrand N, Sendker J, Lechtenberg M, Petereit F, Hensel A. . ‘Isolation and quantification of oligomeric and polymeric procyanidins in leaves and flowers of Hawthorn (Crataegus spp.).’ Fitoterapia 104, No. null: 14-22. doi: 10.1016/j.fitote.2015.04.010.
    • Lautenschläger M, Lechtenberg M, Sendker J, Hensel A. . ‘Effective isolation protocol for secondary metabolites from Saffron: Semi-preparative scale preparation of crocin-1 and trans-crocetin.’ Fitoterapia 92: 290-295.
    • Marical G, Sendker J, Brandt S, de Lampasona MP, Catalán CAN, de Valdez GF, Hensel A. . ‘Gastroprotection as an example:Antiadhesion against Helicobacter pylori, anti-inflammatory and antioxidant activities of aqueous extracts from the aerial parts of Lippia integrifolia Hieron.’ Journal of Ethnopharmacology 155: 1125-1133. doi: 10.1016/j.jep.2014.06.039.
    • Lechtenberg M, Dierks F, Sendker J, Louis A, Schepker H, Hensel A. . ‘Extracts from Rhododendron ferrugineum Do Not Exhibit Grayanotoxin I: An Analytical Survey on Grayanotoxin I within the Genus Rhododendron.’ Planta Medica 80: 1321-1328. doi: http://dx.doi.org/ 10.1055/s-0034-1383039.
    • Ellendorff T, Sendker J, Schmidt TJ.Discovery of senescence associated metabolites in Juglans regia leaves by the use of Principal Component Analysis.’Poster contributed to the Phytokongress 2013, Leipzig, Germany, .
    • Ellendorff T, Sendker J, Klempnauer KH, Schmidt TJ.Application of multivariate statistical analysis for the discovery of compounds with c-Myb-inhibitory activity in extracts of Juglans species.’Poster contributed to the 61st International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, Münster, Germany, . doi: 10.1055/s-0033-1352082.
    • Hensel A, Heimink M, Lechtenberg M, Sendker J, Petereit F, Derksen A, Schmidt TJ, Kühn J, Nauert C. . „Eupatorium perfoliatum L. - Neue Befunde zu einer alten Arzneipflanze.“ Zeitschrift für Phytotherapie 34, No. 02: 90-98. doi: 10.1055/s-0032-1331485.
    • Sendker J, Petereit F, Lautenschläger M, Hellenbrand N, Hensel A. . ‘Phenylpropanoid-substituted Procyanidins and Tentatively Identified Procyanidin Glycosides from Hawthorn (Crataegus spp.).’ Planta Medica 79, No. 1: 45-51. doi: 10.1055/s-0032-1327926.
    • Wang R, Lechtenberg M, Sendker J, Petereit F, Deters A, Hensel A. . ‘Wound-healing plants from TCM: in vitro investigations on selected TCM plants and their influence on human dermal fibroblasts and keratinocytes.Fitoterapia 84: 308-317. doi: 10.1016/j.fitote.2012.12.020.
    • Schmidt TJ, Klaes M, Sendker J. . ‘Lignans in seeds of Linum species.Phytochemistry 82: 89-99. doi: 10.1016/j.phytochem.2012.07.004.
    • Sheridan H, Krenn L, Jiang R, Sutherland I, Ignatova S, Marmann A, Liang X, Sendker J. . ‘The potential of metabolic fingerprinting as a tool for the modernisation of TCM preparations.Journal of ethnopharmacology 140, No. 3: 482-91. doi: 10.1016/j.jep.2012.01.050.
    • Böker I, Sendker J, Stark T, Kelber O, Fink C, Hensel A.Cytoprotective effects of aqueous extracts from marshmallow roots (Althaea officialis).’Poster contributed to the Phytotherapeutika 2012, Wien, .
    • Böker I, Sendker J, Stark T, Kelber O, Fink C, Hensel A.Cytoprotective effects of aqueous extracts from Marshmallow roots (Althaea officinalis L.).’Poster contributed to the 3. Young Researcher Meeting, Münster, Germany, .
    • Derksen A, Sendker J, Hafezi W, Nauert C, Kühn J, Hensel A.Bioassay-guided fractionation of Eupatorium Perfoliatum L. towards anti-Influenza A-activity leads to dicaffeoyl quinic acids.’Poster contributed to the 8th Joint Meeting of AFERP, ASP, GA, PSE and SIF, New York, .
    • Lautenschläger M, Hellenbrand N, Sendker J, Zumdick S, Hensel A.Isolation and characterisation of cinchonains from Crataegi folium cum flore.’Poster contributed to the 3. Young Researcher Meeting, Münster, Germany, .
    • Sendker J. . D2.11 Workshop reviewing the correlation of methodology used in the analysis of priority list with best practice standards recommended in this study. , .
    • Sendker J. . D2.15 Review papers published in scientific journals , .
    • Sendker J. . D2.14 – Final report including complete database of experts and distribution of skills , .
    • Sendker J. . D2.13 Presentation of findings at the conference planned in work package , .
    • Hensel A, Maas M, Sendker J, Lechtenberg M, Petereit F, Deters A, Schmidt T, Stark T. . ‘Eupatorium perfoliatum L.: phytochemistry, traditional use and current applications.Journal of Ethnopharmacology 138, No. 3: 641-51. doi: 10.1016/j.jep.2011.10.002.
    • Sendker J, Marmann A, Krenn L, Sheridan H, Sutherland I, Ignatova S, Proksch P, Simmonds M, Verpoorte R, Diaz A, Bunel V, Zhu Y. . D2.10 Comprehensive report on the methodology used in the analysis of ‘priority list preparations , .
    • Sutherland I, Sendker J, Simmonds M, Ignatova S.Good Practice in TCMs (GPTCM).’Poster contributed to the 10th CGCM Meeting, Shanghai, .
    • Marmann A, Sendker J. . D2.8 Report on Workshop targeting metabolomics and quality control , .
    • Sendker J, Sheridan H, Marmann A. . D2.9 Report on workshop and recommendations for best practice in information analysis for fingerprinting and component analysis in CHM , .
    • Krenn L, Kopp B, Sheridan H, Marmann A, Ignatova S, Sutherland I, Proksch P, Simmonds M, Sendker J. . D2.12 Report on workshop and recommendations highlighting the status of the information and identifying non-standard areas. Recommendations for research agenda going forward. , .
    • Sendker J, Nahrstedt A. . ‘Synthesis and characterisation of α-Glycosyloxyamides derived from cyanogenic glycosides.Phytochemical analysis : PCA 21, No. 6: 575-81. doi: 10.1002/pca.1237.
    • Moghaddam FM, Farimani MM, Seirafi M, Taheri S, Khavasi HR, Sendker J, Proksch P, Wray V, Edrada R. . ‘Sesterterpenoids and Other Constituents of Salvia sahendica.’ JOURNAL OF NATURAL PRODUCTS 73, No. 9: 1601-1605. doi: 10.1021/np1002516.
    • Haarmann-Stemmann T, Sendker J, Gotz C, Krug N, Bothe H, Fritsche E, Proksch P, Abel J. . ‘Regulation of dioxin receptor function by different beta-carboline alkaloids.’ ARCHIVES OF TOXICOLOGY 84, No. 8: 619-629. doi: 10.1007/s00204-010-0548-2.
    • Hensel A, Schmidt TJ, Engelshowe R, Lechtenberg M, Petereit F, Sendker J, Krüger L. . Arzneipflanzen entdecken. (2. erweiterte Auflage). 2nd Ed. Münster: Eigenverlag.
    • Dias A, Kopp B, Fisher D, Stolte F, König G, Sheridan H, Sutherland I, Sendker J, Knapp K, Krenn L, Bayer M, Simmonds M, Proksch P, Duez P, Verpoorte R, Knöss W, Qiao Y, Zhu Y, Dong, Li H. . D2.7 Report on findings from workshop including minimum acceptable standards for extract preparation, purification and component analysis , .
    • Sendker J, Duez P. . D2.6 Workshop targeting selection of minimum acceptable standards for extract preparation, purification and component analysis , .
    • Xu J, Kjer J, Sendker J, Wray V, Guan HS, Edrada R, Muller WEG, Bayer M, Lin WH, Wu J, Proksch P. . ‘Cytosporones, coumarins, and an alkaloid from the endophytic fungus Pestalotiopsis sp isolated from the Chinese mangrove plant Rhizophora mucronata.’ BIOORGANIC & MEDICINAL CHEMISTRY 17, No. 20: 7362-7367. doi: 10.1016/j.bmc.2009.08.031.
    • Xu J, Kjer J, Sendker J, Wray V, Guan H, Lin W, Wu J, Proksch P.New polyketides from the endophytic fungus Pestalotiopsis sp isolated from the Chinese mangrove plant Rhizophora mucronata.’Poster contributed to the 57th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, Genever, . doi: 10.1055/s-0029-1234982.
    • Xu J, Kjer J, Sendker J, Wray V, Guan HS, Edrada R, Lin WH, Wu J, Proksch P. . ‘Chromones from the Endophytic Fungus Pestalotiopsis sp Isolated from the Chinese Mangrove Plant Rhizophora mucronata.’ JOURNAL OF NATURAL PRODUCTS 72, No. 4: 662-665. doi: 10.1021/np800748u.
    • Wang Y, Edrada-Ebel R, Tsevegsuren N, Sendker J, Braun M, Wray V, Lin WH, Proksch P. . ‘Dihydrostilbene Derivatives from the Mongolian Medicinal Plant Scorzonera radiata.’ JOURNAL OF NATURAL PRODUCTS 72, No. 4: 671-675. doi: 10.1021/np800782f.
    • Sendker J, Nahrstedt A. . ‘Generation of primary amide glucosides from cyanogenic glucosides.’ Phytochemistry 70, No. 3: 388-393. doi: 10.1016/j.phytochem.2008.11.008.
    • Sheridan H, Sendker J, Krenn L, Knöss W, König G, Bayer M, Knapp K, Diaz A. . D2.4 Report summarizing techniques and standards for the analysis of simple and complex extracts currently in use in reference laboratories , .
    • Bayer M, Knapp K, Sendker J, Proksch P. . D2.3 Establishment of an interactive website containing evolving information produced during the project and open to the Consortium , .
    • Sendker J. . D2.1 Report on Kick-Off Meeting , .
    • Sendker J, Bayer M, Proksch P. . D2.2 Report on findings including priority list of CHM , .
    • Kravets E, Steffen Y, Schewe T, Sendker J, Proksch P, Sies H.Membrane-bound catechol-O-methyltransferase is involved in the metabolism of (-)-epicatechinin human umbilical vein endothelial cells.’Poster contributed to the Society for Free Radical Research 2008, Berlin, .
    • Schulze-Dieckhoff J, Lechtenberg M, Sendker J, Luftmann H, Hensel A.Fractionation of a Hydroalcoholic Extract from Valerian Root using Flash Chromatography and Fast Centrifugal Partition Chromatography.’Poster contributed to the ISC 2008, Münster, .
    • Sendker J. . Zur Entstehung primärer Amidglykoside aus cyanogenen Glykosiden Doctoral Thesis, University of Muenster, Faculty of Mathematics and Natural Sciences.
    • Sendker J; Nahrstedt A.Occurrence of amides derived from corresponding cyanogenic glycosides.’Poster contributed to the 53rd Annual Meeting of the Society for Medicinal Plant Research (GA), 2005, Florence, .
  • Dissertations

    Ellendorff, TheresePlant senescense processes as source of new bioactive compounds against tumours and protozoal diseases
Jd 280px

Best WWU PhD thesises in 2007

Friday, 7th Dec 2007: 87 summa-cum-laude doctoral thesises were acknowleged by university rector, Prof. Dr. Ursula Nelles.