Dr. Fabian Herrmann

Institute of Pharmaceutical Biology and Phytochemistry

Corrensstraße 48, 

48149 Münster

Room C 090.050

Phone: +49 251 83 34672

Mail

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Publikations

RESEARCH PORTAL (University of Münster)

AFM.Lab

Current projects

• Ultrastructural evaluation of the anthelmintic effect of quassinoid derivatives
• Ultrastructural evaluation of the antitrypanosomal activity of various tubulin inhibitors of natural origin
• In silico-based identification and characterisation of inhibitors of leishmanial and trypanosomal folate metabolism
• Ultramicrotomy-based method development for the ultrastructural characterisation of cells, tissues and whole organisms by AFM

Research focus

Atomic force microscopy (AFM)

• AFM-based ultrastructural investigations of human pathogenic organisms to identify the mechanisms of action of bioactive natural products
• Ultrastructural characterisation of drug forms (e.g. nanoparticles) by AFM

Ultramicrotomy

• PEG-based ultramicrotomy of cells, tissues and whole organisms (section thickness around 100 nm) and subsequent microscopic characterisation (light microscopy and AFM (resolution down to approx. 10 nm))

Light microscopy

• Morphological studies on human pathogenic organisms (brightfield, darkfield, phase contrast, interference contrast, polarisation and fluorescence)

In silico-based drug design

• Pharmacophore-based virtual screening of natural product databases - Molecular docking methods

Enzymatic methods