• Research Areas

    • Computational Chemistry
    • Theoretical Organic Chemistry
    • Organic Reaction Mechanisms
    • Non Covalent Interactions
    • Cooperativity in Chemistry
  • Latest Publications

    • Schifferer, L; Hoppmann, L; Groeters, R; Mück-Lichtenfeld, C; Daniliuc, CG; García Mancheño, O. . ‘Divergent access to fused N -heterocycle-thiazolines by solvent-dependent reaction of isoquinolinium thiolates with silylketene acetals.’ Chemical Communications (London) 59: 6032–6035. doi: 10.1039/D3CC00781B.
    • Zhang J; Mück-Lichtenfeld C; Studer A. . ‘Photocatalytic phosphine-mediated water activation for radical hydrogenation.’ Nature 619: 506–513. doi: 10.1038/s41586-023-06141-1.
    • Onneken, C.; Morack, T.; Soika, J.; Sokolova, O.; Niemeyer, N.; Mück-Lichtenfeld, C.; Daniliuc, C.G.; Neugebauer, J.; Gilmour, R. . ‘Light-enabled deracemization of cyclopropanes by Al-salen photocatalysis.’ Nature 621: 753–759. doi: 10.1038/s41586-023-06407-8.
    • Sun, Q.; Mück-Lichtenfeld, C.; Kehr, G.; Erker G. . ‘Molecular pyramids — from tetrahedranes to [6]pyramidanes.’ Nature Reviews Chemistry 7, No. 10: 732–746. doi: 10.1038/s41570-023-00525-7.
    • Wang, Z.; Livingstone, K.; Hümpel, C.; Daniliuc, C.G.; Mück-Lichtenfeld, C.; Gilmour, R. . ‘Regioselective, catalytic 1,1-difluorination of enynes.’ Nature Chemistry 15: 1515–1522. doi: 10.1038/s41557-023-01344-5.

    • Keuter J, Hepp A, Massolle A, Neugebauer J, Mück‐Lichtenfeld C, Lips F. . ‘Synthesis and Reactivity of a Neutral Homocyclic Silylene.’ Angewandte Chemie - International Edition 61, No. 5: e202114485. doi: 10.1002/anie.202114485.
    • Wilm LFB, Das M, Janssen‐Müller D, Mück‐Lichtenfeld C, Glorius F, Dielmann F. . ‘Photoswitchable Nitrogen Superbases: Using Light for Reversible Carbon Dioxide Capture.’ Angewandte Chemie - International Edition 61, No. 3: e202112344. doi: 10.1002/anie.202112344.
    • Sun, Q.; Daniliuc, C.G.; Yu, X.; Mück-Lichtenfeld, C.; Kehr, G.; Erker, G. . ‘Borole/Borapyramidane Relationship.’ Journal of the American Chemical Society 144: 7815–7821. doi: 10.1021/jacs.2c01727.
    • Logvinenko IG, Kondratov IS, Pridma SO, Tolmachova NA, Morev RN, Dolovanyuk VG, Boretskyi AL, Stepaniuk RO, Trofymchuk SA, Mück-Lichtenfeld C, Daniliuc CG, Haufe G. . ‘Synthesis and physical chemical properties of CF3O-containg secondary amines—Perspective building blocks for drug discovery.’ Journal of Fluorine Chemistry 257-258: 109990. doi: https://doi.org/10.1016/j.jfluchem.2022.109990.
    • Sun Q, Daniliuc CG, Mück‐Lichtenfeld C, Kehr G, Erker G. . ‘Formation of a Hybrid 1‐Bora‐3‐boratabenzene Heteroarene Anion Derivative.’ Angewandte Chemie - International Edition 61, No. 31: e202205565. doi: 10.1002/anie.202205565.
    • Möbius JHJ, Guddorf BJ, Hepp A, Bergander K, Daniliuc CG, Mück-Lichtenfeld C, Lips F. . ‘Direct Formation and Reactivity of a Bromo- and Amido-Substituted Cyclotrisilene.’ Organometallics 41: 2146–2153. doi: 10.1021/acs.organomet.2c00245.
    • Plöger S, Mück-Lichtenfeld C, Daniliuc CG, Studer A. . ‘Azodioxy compounds as precursors for C-radicals and their application in thermal styrene difunctionalization.’ Chemical science 13: 9749–9754. doi: 10.1039/D2SC03860A.
    • Schäfers F, Dutta S, Kleinmans R, Mück-Lichtenfeld C, Glorius F. . ‘Asymmetric Addition of Allylsilanes to Aldehydes: A Cr/Photoredox Dual Catalytic Approach Complementing the Hosomi–Sakurai Reaction.’ ACS Catalysis 12: 12281–12290. doi: 10.1021/acscatal.2c03960.
    • Rotering P, Mück-Lichtenfeld C, Dielmann F. . ‘Solvent-free photochemical decomposition of sulfur hexafluoride by phosphines: formation of difluorophosphoranes as versatile fluorination reagents.’ Green Chemistry 24: 8054–8061. doi: 10.1039/D2GC02172B.
    • Danelzik T, Joseph S, Mück-Lichtenfeld C, Daniliuc CG, García Mancheño O. . ‘Benzotriazolium Salts: Emergent Readily Accessible Bench-Stable Lewis Acid Catalysts.’ Organic letters 24: 6105–6110. doi: 10.1021/acs.orglett.2c01697.
    • Lenz P; Oshimizu R; Klabunde S; Daniliuc CG; Mück‐Lichtenfeld C; Tendyck JC; Mori T; Uhl W; Hansen MR; Eckert H; Yamaguchi S; Studer A. . ‘Oxy‐Borylenes as Photoreductants: Synthesis and Application in Dehalogenation and Detosylation Reactions.’ Angewandte Chemie - International Edition 61, No. 42: e202209391. doi: 10.1002/anie.202209391.

    • Sietmann J, Ong M, Mück‐Lichtenfeld C, Daniliuc CG, Wiest JM. . ‘Desymmetrization of Prochiral Cyclobutanones via Nitrogen Insertion: A Concise Route to Chiral γ‐Lactams.’ Angew. Chem. Int. Ed. 60: 9719–9723. doi: 10.1002/anie.202100642.
    • Schroeder C, Zones SI, Mück-Lichtenfeld C, Hansen MR, Koller H. . ‘High Aluminum Ordering in SSZ-59: Residual 1H-27Al Dipolar Coupling Effects in 1H MAS NMR Spectra of Brønsted Acid Sites in Zeolites.’ J. Phys. Chem. C 125: 4869–4877. doi: 10.1021/acs.jpcc.0c11379.
    • Lünne F, Köhler J, Stroh C, Müller L, Daniliuc CG, Mück-Lichtenfeld C, Würthwein E, Esselen M, Humpf H, Kalinina SA. . ‘Insights into Ergochromes of the Plant Pathogen Claviceps purpurea.’ J. Nat. Prod. 84: 2630–2643. doi: 10.1021/acs.jnatprod.1c00264.
    • Belina SP, Qing S, Dudziński P, Matsnev AV, Mück-Lichtenfeld C, Haufe G, Thrasher JS. . ‘Preparation and Characterization of Pentafluoro-λ6-sulfanyldifluoromethane and Pentafluoro-λ6-sulfanyl-1,1,2,2-tetrafluoroethane.’ Helvetica Chimica Acta 104, No. 10: e2100138. doi: 10.1002/hlca.202100138.
    • Jie X, Li J, Daniliuc CG, Wübker A, Hansen MR, Eckert H, Mück‐Lichtenfeld C, Kehr G, Erker G. . ‘The Bis(η 6 ‐benzene)lithium Cation: A Fundamental Main‐Group Organometallic Species.’ Angew. Chem. Int. Ed. 60: 22879–22884. doi: 10.1002/anie.202108376.
    • Morack T, Onneken C, Nakakohara H, Mück-Lichtenfeld C, Gilmour R. . ‘Enantiodivergent Prenylation via Deconjugative Isomerization.’ ACS Catal. 11: 11929–11937. doi: 10.1021/acscatal.1c03089.
    • Wedi P, Farizyan M, Bergander K, Mück‐Lichtenfeld C, Gemmeren M. . ‘Mechanism of the Arene‐Limited Nondirected C−H Activation of Arenes with Palladium**.’ Angew. Chem. Int. Ed. 60: 15641–15649. doi: 10.1002/anie.202105092.
    • Neufeld J, Stünkel T, Mück‐Lichtenfeld C, Daniliuc CG, Gilmour R. . ‘Trifluorinated Tetralins via I(I)/I(III)‐Catalysed Ring Expansion: Programming Conformation by [CH 2 CH 2 ] → [CF 2 CHF] Isosterism.’ Angew. Chem. Int. Ed. 60: 13647–13651. doi: 10.1002/anie.202102222.
    • Wang D, Mück-Lichtenfeld C, Daniliuc CG, Studer A. . ‘Radical Aryl Migration from Boron to Carbon.’ J. Am. Chem. Soc. 143: 9320–9326. doi: 10.1021/jacs.1c04217.
    • Kran E, Mück‐Lichtenfeld C, Daniliuc CG, Studer A. . ‘Synthesis of Stannylated Aryl Imines and Amines via Aryne Insertion Reactions into Sn−N Bonds.’ Chem. Eur. J. 27: 9281–9285. doi: 10.1002/chem.202101124.

    • Küpers V, Weintz D, Mück-Lichtenfeld C, Bieker P, Winter M, Kolek M. . ‘Approaching Electrochemical Limits of MgxClyz+ Complex-Based Electrolytes for Mg Batteries by Tailoring the Solution Structure.’ Journal of The Electrochemical Society 167, No. 16: 160505. doi: 10.1149/1945-7111/abc7e4.
    • Li W, Wagener T, Hellmann L, Daniliuc CG, Mück-Lichtenfeld C, Neugebauer J, Glorius F. . ‘Design of Ru(II)-NHC-Diamine Precatalysts Directed by Ligand Cooperation: Applications and Mechanistic Investigations for Asymmetric Hydrogenation.’ Journal of the American Chemical Society 142, No. 15: 7100–7107. doi: 10.1021/jacs.0c00985.
    • Kaldas SJ, Kran E, Mück-Lichtenfeld C, Yudin AK, Studer A. . ‘Reaction of Vinyl Aziridines with Arynes: Synthesis of Benzazepines and Branched Allyl Fluorides.’ Chemistry – A European Journal 26, No. 7: 1501–1505. doi: 10.1002/chem.201904727.
    • Schroeder C, Siozios V, Mück-Lichtenfeld C, Hunger M, Hansen MR, Koller H. . ‘Hydrogen Bond Formation of Brønsted Acid Sites in Zeolites.’ Chemistry of Materials 32: 1564–1574. doi: 10.1021/acs.chemmater.9b04714.
    • Weidlich F, Esumi N, Chen D, Mück‐Lichtenfeld C, Zysman‐Colman E, Studer A. . ‘Mild C−F Activation in Perfluorinated Arenes through Photosensitized Insertion of Isonitriles at 350 nm.’ Adv. Synth. Catal. 362: 376–383. doi: 10.1002/adsc.201901126.
    • Schroeder C, Mück‐Lichtenfeld C, Xu L, Grosso‐Giordano NA, Okrut A, Chen C, Zones SI, Katz A, Hansen MR, Koller H. . ‘A Stable Silanol Triad in the Zeolite Catalyst SSZ‐70.’ Angew. Chem. Int. Ed. 59: 10939–10943. doi: 10.1002/anie.202001364.
    • Li J, Mück-Lichtenfeld C, Daniliuc CG, Kehr G, Erker G. . ‘Using the Secondary PH/BH Functional Groups of an Active Geminal Frustrated Lewis Pair for Carbon Monoxide Reduction and Reactions with Nitriles and Isonitriles.’ Angewandte Chemie - International Edition 59, No. 30: 12477–12483. doi: 10.1002/anie.202000612.
    • Chen C, Daniliuc CG, Mück-Lichtenfeld C, Kehr G, Erker G. . ‘A rare olefin 1,1-carboboration reaction opens a synthetic pathway to an unusually structured frustrated Lewis pair.’ Chemical communications 56: 8806–8809. doi: 10.1039/D0CC01255F.
    • Tao X, Gruber MM, Daniliuc CG, Mück-Lichtenfeld C, Kehr G, Erker G. . ‘Cyclobutene Formation by Borane Catalyzed [2+2] Cycloaddition of a Vinylphosphane with Conjugated Ynones.’ European Journal of Inorganic Chemistry 2020, No. 23: 2270–2272. doi: 10.1002/ejic.202000293.
    • Wang D, Mück-Lichtenfeld C, Studer A. . ‘1,n-Bisborylalkanes via Radical Boron Migration.’ Journal of the American Chemical Society 142, No. 20: 9119–9123. doi: 10.1021/jacs.0c03058.
    • Keuter J, Schwermann C, Hepp A, Bergander K, Droste J, Hansen MR, Doltsinis NL, Mück-Lichtenfeld C, Lips F. . ‘A highly unsaturated six-vertex amido-substituted silicon cluster.’ Chemical science 11: 5895–5901. doi: 10.1039/D0SC01427C.
    • Chen C, Daniliuc CG, Mück-Lichtenfeld C, Kehr G, Erker G. . ‘A BH Borenium-Derived Thioxoborane, Its Persulfide, and Their Li + -Induced Reactions with Alkynes and with Carbon Dioxide.’ J. Am. Chem. Soc. 142: 19763–19771. doi: 10.1021/jacs.0c10078.
    • Becker MR, Morack T, Robertson J, Metternich JB, Mück-Lichtenfeld C, Daniliuc C, Burley GA, Gilmour R. . ‘Contra-thermodynamic E → Z isomerization of cinnamamides via selective energy transfer catalysis.’ Tetrahedron 76: 131198–. doi: 10.1016/j.tet.2020.131198.
    • Küpers V, Weintz D, Mück-Lichtenfeld C, Bieker P, Winter M, Kolek M. . ‘Approaching Electrochemical Limits of Mg x Cl y z + Complex-Based Electrolytes for Mg Batteries by Tailoring the Solution Structure.’ J. Electrochem. Soc. 167: 160505. doi: 10.1149/1945-7111/abc7e4.
    • Chen C, Li J, Daniliuc CG, Mück-Lichtenfeld C, Kehr G, Erker G. . ‘The [(NHC)B(H)C6F5]+ Cations and Their [B](H)−CO Borane Carbonyls.’ Angewandte Chemie - International Edition 59, No. 48: 21460–21464. doi: 10.1002/anie.202009353.
    • Sun Q, Daniliuc CG, Mück-Lichtenfeld C, Bergander K, Kehr G, Erker G. . ‘Reductive Cleavage of the CO Molecule by a Reactive Vicinal Frustrated PH/BH Lewis Pair.’ Journal of the American Chemical Society 142, No. 41: 17260–17264. doi: 10.1021/jacs.0c07161.
    • Erdeljac N, Mück‐Lichtenfeld C, Daniliuc CG, Gilmour R. . ‘Conformational Analysis of Acyclic α‐Fluoro Sulfur Motifs.’ Chemistry - A European Journal 26: 13704–13715. doi: 10.1002/chem.202003361.

    • Faßbender SI, Molloy JJ, Mück-Lichtenfeld C, Gilmour R. . ‘Geometric E → Z Isomerisation of Alkenyl Silanes by Selective Energy Transfer Catalysis: Stereodivergent Synthesis of Triarylethylenes via a Formal anti -Metallometallation.’ Angew. Chem. Int. Ed. 58: 18619–18626. doi: 10.1002/anie.201910169.
    • Wang D, Mück-Lichtenfeld C, Studer A. . ‘Hydrogen Atom Transfer Induced Boron Retaining Coupling of Organoboronic Esters and Organolithium Reagents.’ J. Am. Chem. Soc. 141: 14126–14130. doi: 10.1021/jacs.9b07960.
    • Wang L, Li J, Deng D, Daniliuc CG, Mück-Lichtenfeld C, Kehr G, Erker G. . ‘Carbon–carbon bond forming reactions of acetylenic esters and ketones within frustrated phosphane/borane Lewis pair frameworks.’ Dalton Trans. 48: 11921–11926. doi: 10.1039/C9DT02624J.
    • Guddorf BJ, Mück-Lichtenfeld C, Hepp A, Lips F. . ‘Formation of an NHC-stabilized heterocyclic housane and its isomerization into a cyclopentenyl anion analogue.’ Chemical communications 55: 12896–12899. doi: 10.1039/C9CC07109A.
    • Li J, Daniliuc CG, Mück-Lichtenfeld C, Kehr G, Erker G. . ‘Multi-Component Synthesis of Rare 1,3-Dihydro-1,3-azaborinine Derivatives: Application of a Bora-Nazarov Type Reaction.’ Angew. Chem. Int. Ed. 58: 15377–15380. doi: 10.1002/anie.201909530.
    • Bentler P, Bergander K, Daniliuc CG, Mück-Lichtenfeld C, Jumde RP, Hirsch AKH, Gilmour R. . ‘Inverting Small Molecule-Protein Recognition by the Fluorine Gauche Effect: Selectivity Regulated by Multiple H→F Bioisosterism.’ Angew. Chem. Int. Ed. 58: 10990–10994. doi: 10.1002/anie.201905452.
    • Scheipers I, Mück-Lichtenfeld C, Studer A. . ‘Palladium-Catalyzed Decarboxylative γ-Arylation for the Synthesis of Tetrasubstituted Chiral Allenes.’ Angew. Chem. Int. Ed. 58: 6545–6548. doi: 10.1002/anie.201901848.
    • Bock J, Daniliuc CG, Bergander K, Mück-Lichtenfeld C, Hennecke U. . ‘Synthesis, structural characterisation, and synthetic application of stable seleniranium ions.’ Org. Biomol. Chem. 17: 3181–3185. doi: 10.1039/C9OB00078J.
    • Keuter J, Hepp A, Mück-Lichtenfeld C, Lips F. . ‘Facile Access to an NHC-Coordinated Silicon Ring Compound with a Si=N Group and a Two-Coordinate Silicon Atom.’ Angew. Chem. Int. Ed. 58: 4395–4399. doi: 10.1002/anie.201813674.
    • Wilm, L.F.B., Eder, T., Mück-Lichtenfeld, C., Mehlmann, P., Wünsche, M., Buß, F., Dielmann, F. . ‘Reversible CO 2 fixation by N-heterocyclic imines forming water-stable zwitterionic nitrogen-base–CO 2 adducts.’ Green Chem. 21: 640–648. doi: 10.1039/C8GC02952K.
    • Morack T, Mück-Lichtenfeld C, Gilmour R. . ‘Bioinspired Radical Stetter Reaction: Radical Umpolung Enabled by Ion-Pair Photocatalysis.’ Angew. Chem. Int. Ed. 58: 1208–1212. doi: 10.1002/anie.201809601.

    • Cheng Y, Mück-Lichtenfeld C, Studer A. . ‘Transition Metal-Free 1,2-Carboboration of Unactivated Alkenes.’ J. Am. Chem. Soc. 140: 6221–6225. doi: 10.1021/jacs.8b03333.
    • Friese FW, Mück-Lichtenfeld C, Studer A. . ‘Remote C−H functionalization using radical translocating arylating groups.’ Nat Commun 9: 2808. doi: 10.1038/s41467-018-05193-6.
    • Buß F, Rotering P, Mück-Lichtenfeld C, Dielmann F. . ‘Crystalline, room-temperature stable phosphine–SO 2 adducts: generation of sulfur monoxide from sulfur dioxide.’ Dalton Trans. 47: 10420–10424. doi: 10.1039/C8DT01484A.
    • Buß F, Mück-Lichtenfeld C, Mehlmann P, Dielmann F. . ‘Nucleophilic Activation of Sulfur Hexafluoride: Metal-Free, Selective Degradation by Phosphines.’ Angew. Chem. Int. Ed. 57: 4951–4955. doi: 10.1002/anie.201713206.
    • Wang T, Daniliuc CG, Mück-Lichtenfeld C, Kehr G, Erker G. . ‘Formation of Reactive π-Conjugated Frustrated N/B Pairs by Borane-Induced Propargyl Amine Rearrangement.’ J. Am. Chem. Soc. 140: 3635–3643. doi: 10.1021/jacs.7b11958.
    • Sampedro A, Ramos-Torres Á, Schwöppe C, Mück-Lichtenfeld C, Helmers I, Bort A, Díaz-Laviada I, Fernández G. . ‘Hierarchical Self-Assembly of BODIPY Dyes as a Tool to Improve the Antitumor Activity of Capsaicin in Prostate Cancer.’ Angew. Chem. Int. Ed. 57: 17235–17239. doi: 10.1002/anie.201804783.