Analysis of Complex Disease Association Studies: A Practical Guide
Edited by: Eleftheria Zeggini and Andrew Morris
ISBN: 978-0-12-375142-3
Elsevier 2012
According to the National Institute of Health, a genome-wide association study is defined as any study of genetic variation across the entire human genome that is designed to identify genetic associations with observable traits (such as blood pressure or weight), or the presence or absence of a disease or condition. Whole genome information, when combined with clinical and other phenotype data, offers the potential for increased understanding of basic biological processes affecting human health, improvement in the prediction of disease and patient care, and ultimately the realization of the promise of personalized medicine. In addition, rapid advances in understanding the patterns of human genetic variation and maturing high-throughput, cost-effective methods for genotyping are providing powerful research tools for identifying genetic variants that contribute to health and disease. (good paragraph)
This burgeoning science merges the principles of statistics and genetics studies to make sense of the vast amounts of information available with the mapping of genomes. In order to make the most of the information available, statistical tools must be tailored and translated for the analytical issues which are original to large-scale association studies. This book will provide researchers with advanced biological knowledge who are entering the field of genome-wide association studies with the groundwork to apply statistical analysis tools appropriately and effectively. With the use of consistent examples throughout the work, chapters will provide readers with best practice for getting started (design), analyzing, and interpreting data according to their research interests. Frequently used tests will be highlighted and a critical analysis of the advantages and disadvantage complimented by case studies for each will provide readers with the information they need to make the right choice for their research. Additional tools including links to analysis tools, tutorials, and references will be available electronically to ensure the latest information is available.
—
Neu im Uninetz: eBooks von Elsevier
Von „ABC Proteins“ bis „Zinc Oxide Bulk, Thin Films and Nanostructures“ stehen mehrere Tausend Titel aus dem Programm der niederländischen Verlagsgruppe und den dazugehörigen Verlagen zur Verfügung. Es handelt sich um naturwissenschaftliche, ingenieurswissenschaftliche und betriebswirtschaftliche Werke, die zunächst für ein Jahr nutzbar sind. Die eBooks können online gelesen und durchsucht, aber auch ausgedruckt oder für eigene wissenschaftliche Zwecke abgespeichert werden.
Die Daten zu den Büchern werden in den kommenden Wochen voraussichtlich in disco eingetragen. Sie können aber bereits jetzt über diese Liste in den verfügbaren Titeln stöbern
Im OPAC, dem Buchkatalog der Universitätsbibliothek, kann man gezielt nach Online-Büchern suchen. Die Bibliothek hat die Lehrbücher unter den obigen Titeln der Liste aller Online-Lehrbücher hinzugefügt. Zugänglich sind diese Bücher nur im Hochschulnetz der Universität.und auf die eBooks zugreifen.