Institut für Pharmazeutische Biologie und Phytochemie	Tel. (0251) 83-33380 Fax: (0251) 83-38341 e-mail: pharmbio@uni-muenster.de www: www.uni-muenster.de/Chemie/pb
Hittorfstrasse 56 48149 Münster Geschäftsführender Direktor: Prof. Dr. Andreas Hensel
Forschungsschwerpunkte 2003 - 2004    zurück    weiter

Prof. Dr. A. Hensel Glycobiology (Oligo-, Polysaccharides, Glyoproteins): structural aspects and pharmacological activities   Untersuchung kohlenhydrathaltiger Naturstoffe (Oligo-/Polysaccharide, Glycoproteine, Glycopeptide) hinsichtlich ihrer Interaktion mit cellulären Oberflächenrezeptoren animaler Systeme. Schwerpunktarbeiten: Beeinflussung der Zellphysiologie epidermaler Zellen; antiadhäsive Substanzen gegenüber pathogenen Keimen (Helicobacter sp., Campylobacter sp., Candida sp.) Projektdauer: seit 1995 Drittmittelgeber: Diverse Unternehmen der Kosmetikbranche und Pharmaindustrie Beteiligte Wissenschaftler: Prof. Hensel, Dr. Deters Veröffentlichungen 2003: Deters A, Schnetz E, Schmitt M, Hensel A (2003) Effects of zink histidine and zink sulphate on normal human keratinocytes. Research in Complementary and Classical Natural Medicine. 10, 19-25. Lengsfeld C, Schmidgall J, R. Schwartz-Albiez, Hensel A. Functionality of oligo- and polysaccharides against gastrointestinal epithelial membranes: bioadhesive, epithel-protecting and mucin-stimulating properties. Journal Natural Products, submitted DauerA, Rimpler H, Hensel A (2003) Polymeric proanthocyanidins from the bark of Hamamelis virginiana L. Planta Medica. 69, 89-91. Schröder K, Holtkötter O, Schlotmann K, Deters A, Schnetz E, Hensel A (2003) Oligo- and polysaccahride-containing cosmetical and dermatological prepartions for treatment of epithelial barrier tissue. Deutsches Patent und Markenamt sowie Europäisches Patentamt 2004, 103 46 833.1, Date of Publishing: 06.04.2005. Hensel A, Cartellieri S: MEMOPHARM (2003) Deutscher Apotheker Verlag, MED-PHARM-Publisher, Stuttgart, 2. edition, 780 pages, in press (Ausbietungssdatum 28.März.2003). Veröffentlichungen 2004: Deters A, Brunold C, Hensel A (2004) Polysaccharides from Hibiscus sabdariffa flowers stimulate proliferation and early differentiation of human keratinocyte. Planta Medica, 70, 370-373. Lengsfeld C, Titgemeyer F, Faller G, Hensel A (2004) Glycosylated compounds from okra inhibit adhesion of Helicobacter pylori to human gastric mucosa.Journal of Agricultural Food Chemistry 52, 1495-1503. Lengsfeld C, Deters A, Hensel A (2004) High molecular weight polysaccharides from black currant seed inhibit adhesion of Helicobacter pylori to human gastric mucosa; Planta Medica, 70, 620-626. Sidler-Knoepfl F, Wermelinger T, Viviani A, Rist L, Scheer R, Hensel A. Human cancer cells inhibit individuell receptiveness towards different mistletoe extracts: feasibility study for an individualized mistletoe therapy. Die Pharmazie, in press Deters A, Schröder KR, Hensel A: Kiwi fruit (Actinidia chinensis L.) polysaccharides exert stimulating effects on cell proliferation via enhanced growth factor receptors, energy production and collagen synthesis of human keratinocytes, fibroblasts and skin equivalents, Journal of Cell Physiology, in press Deters A, Schröder KR, Hensel A: Polysaccharides from Black Currant (Ribes nigrum L.) seeds are proliferation inductors of human skin keratinocytes and fibroblasts by influencing growth factor receptors. Biomaterials, submitted Deters A, Hensel A: Polysaccharides from St John's worth (Hypericum perforatum) induce differentiation of human kerytinocytes. J. Ethnopharmacol, submitted Deters A, Schröder K, Hensel A: Ispaghula seed husk polysaccharides promote proliferation of human epithelial cells. Planta Medica, in press