Klinik und Poliklinik für Kinder- und Jugendmedizin - Pädiatrische Hämatologie und Onkologie -	Tel. (0251) 83-47742 Fax: (0251) 83-47828 e-mail: paedonc@uni-muenster.de www: klinikum.uni-muenster.de/institute/paedonc
Albert-Schweitzer-Str. 33 48149 Münster Direktor: Prof. Dr. Med. Heribert Jürgens
Forschungsschwerpunkte 2003 - 2004    zurück    weiter

Klinische Studien Hämostaseologie: Blutungsneigung   Die Arbeitsgruppe Hämostaseologie mit dem Schwerpunkt Diagnostik und Betreuung von Blutungsleiden beschäftigt sich interdisziplinär und multizentrisch mit den ursächlichen Zusammenhängen der angeborenen und erworbenen Blutungsneigung. Zu diesen Themen werden neben der intensiven Patientenbetreuung multizentrische Studien zum Schlaganfall im Kindesalter, Sinusvenenthrombosen im Kindesalter, Thrombosen im Kindesalter sowie zur Hämophilie und Thrombophilie durchgeführt. Drittmittelgeber: Karl Bröcker Stiftung; Deutsche Schlaganfall-Stiftung; ZLB-Behring; Bayer Vital Beteiligte Wissenschaftler: Prof. Dr. med. Ulrike Nowak-Göttl; Prof. Dr. med. Heribert Jürgens; Dr. Andrea Kosch Veröffentlichungen: Friese,S., Muller-Hansen,I., Schoning,M., Nowak-Gottl,U., and Kuker,W. Isolated Internal Cerebral Venous Thrombosis in a Neonate with Increased Lipoprotein (a) Level: Diagnostic and Therapeutic Considerations. Neuropediatrics 34:36-39, 2003 Frohlich,B., Thedieck,S., Kosch,A., and Nowak-Gottl,U. Elevated protein Z is an independent risk factor in white children with venous thrombosis or stroke - A case-control study. Blood 102:552A-552A, 2003 Heidenreich,S., Junker,R., Wolters,H., Lang,D., Hessing,S., Nitsche,G., and Nowak-Gottl,U. Outcome of kidney transplantation in patients with inherited thrombophilia: data of a prospective study. J Am.Soc.Nephrol. 14:234-239, 2003 Heller,C., Heinecke,A., Junker,R., Knofler,R., Kosch,A., Kurnik,K., Schobess,R., von Eckardstein,A., Strater,R., Zieger,B., and Nowak-Gottl,U. Cerebral venous thrombosis in children: a multifactorial origin. Circulation 108:1362-1367, 2003 Heller,C. and Nowak-Gottl,U. Maternal thrombophilia and neonatal thrombosis. Best.Pract.Res.Clin Haematol. 16:333-345, 2003 Kurnik,K., Kosch,A., Strater,R., Schobess,R., Heller,C., and Nowak-Gottl,U. Recurrent thromboembolism in infants and children suffering from symptomatic neonatal arterial stroke: a prospective follow-up study. Stroke 34:2887-2892, 2003 Nowak-Gottl,U., Ahlke,E., Fleischhack,G., Schwabe,D., Schobess,R., Schumann,C., and Junker,R. Thromboembolic events in children with acute lymphoblastic leukemia (BFM protocols): prednisone versus dexamethasone administration. Blood 101:2529-2533, 2003 Nowak-Gottl,U., Escuriola,C., Kurnik,K., Schobess,R., Horneff,S., Kosch,A., Kreuz,W., and Pollmann,H. Haemophilia and thrombophilia. What do we learn about combined inheritance of both genetic variations? Hamostaseologie. 23:36-40, 2003 Nowak-Gottl,U., Gunther,G., Kurnik,K., Strater,R., and Kirkham,F. Arterial ischemic stroke in neonates, infants, and children: an overview of underlying conditions, imaging methods, and treatment modalities. Semin.Thromb.Hemost. 29:405-414, 2003 Nowak-Gottl,U., Kosch,A., and Schlegel,N. Neonatal thromboembolism. Semin.Thromb Hemost. 29:227-234, 2003 Nowak-Gottl,U., Kosch,A., Frohlich,B., and Langer,C. Tissue Factor Pathway Inhibitor (TFPI) concentrations in children with venous thrombosis and stroke and its association to elevated lipoprotein (a). Blood 102:551A-551A, 2003 Nowak-Gottl,U., Schobess,R., Kurnik,K., Kosch,A., and Kreuz,W. Elevated factor VIIIC:Ag in children with venous thrombosis and stroke - A case-control study. Blood 102:553A-553A, 2003 Nowak-Gottl,U., Schulte,T., and Kosch,A. Elevated fibrinogen beyond the acute thrombotic onset is a risk factor in children with thromboembolisin. Blood 102:118B-118B, 2003 Nowak-Gottl,U., Straeter,R., Sebire,G., and Kirkham,F. Antithrombotic drug treatment of pediatric patients with ischemic stroke. Paediatr.Drugs 5:167-175, 2003 Berner,R., Bialek,R., Forster,J., Giani,G., Hahn,A., Handwerker,G., von Kries,R., Nowak-Gottl,U., Reinalter,S., Schmitt,H.J., Thyen,U., and Vester,U. Survey unit for rare pediatric diseases in Germany (ESPED). Annual report 2002. Monatsschrift Kinderheilkunde 152:77-79, 2004 Brenner,B., Grabowski,E.F., Hellgren,M., Kenet,G., Massicotte,P., Manco-Johnson,M., Mathew,P., Muntean,W., Schlegel,N., and Nowak-Gottl,U. Thrombophilia and pregnancy complications. Thrombosis and Haemostasis 92:678-681, 2004 Debus,O.M., Kosch,A., Strater,R., Rossi,R., and Nowak-Gottl,U. The factor V G1691A mutation is a risk for porencephaly: A case-control study. Annals of Neurology 56:287-290, 2004 Duering,C., Kosch,A., Langer,C., Thedieck,S., and Nowak-Gottl,U. Total tissue factor pathway inhibitor is an independent risk factor for symptomatic paediatric venous thromboembolism and stroke. Thrombosis and Haemostasis 92:707-712, 2004 Kosch,A., Koch,H.G., Heinecke,A., Kurnik,K., Heller,C., and Nowak-Gottl,U. Increased fasting total homocysteine plasma levels as a risk factor for thromboembolism in children. Thrombosis and Haemostasis 91:308-314, 2004 Kosch,A., Kuwertz-Broking,E., Heller,C., Kurnik,K., Schobess,R., and Nowak-Gottl,U. Renal venous thrombosis in neonates: prothrombotic risk factors and long-term follow-up. Blood 104:1356-1360, 2004 Nowak-Gottl,U. and Kosch,A. Factor VIII, D-dimer, and thromboembolism in children. New England Journal of Medicine 351:1051-1053, 2004 Nowak-Gottl,U., Schlegel,N., and Brenner,B. New insights into paediatric hemostasis: thrombosis and bleeding issues. Thrombosis and Haemostasis 92:676-677, 2004