Prof. Steiner: Research and teaching
Research Foci
Formulierung von anspruchsvollen pharmazeutischen Wirkstoffen (u.a. schwer wasserlösliche Wirkstoffe)
Herstellung von Wirkstoffnanopartikeln und nanopartikuläre Lipidträgersysteme mittels verschiedener Technologien
Einarbeitung von nanopartikulären Systemen in orodispersible und mukoadhäsive Formen
2D-Druck von wirkstoffhaltigen Tinten auf geeignete Trägersysteme
CV
Academic Education
- Promotion zum Dr.-Ing. an der Technischen Universität Braunschweig
- Studienabschluss zum Dipl.-Ing. an der Technischen Universität Braunschweig
Positions
- Universitätsprofessur für Pharmazeutische Technologie, Universität Münster / Stiftungsprofessur der Rottendorf Stiftung
- Juniorprofessur für Pharmazeutische Technologie, Universität Tübingen
- Wissenschaftliche Mitarbeiterin (PostDoc) am Institut für Pharmazeutische Technologie und Biopharmazie, Technische Universität Braunschweig
- Senior Formulation Scientist & Project Manager, NextPharma GmbH
- Wissenschaftliche Mitarbeiterin am Institut für Partikeltechnik, Technische Universität Braunschweig
Publications
- Sukhbat, Oyunbileg, Steiner, Denise, and Bunjes, Heike. . “Autoclaving behavior of trimyristin nanoemulsions stabilized with different poloxamers.” International Journal of Pharmaceutics, № 673 125376. doi: 10.1016/j.ijpharm.2025.125376.
- Quodbach, J., Preis, E., Karkossa, F., Winck, J., Finke, J.H., and Steiner, D. . “Novel Strategies for the Formulation of Poorly Water-Soluble Drug Substances by Different Physical Modification Strategies with a Focus on Peroral Applications.” Pharmaceuticals, № 18 (8) 1089. doi: 10.3390/ph18081089.
- Steiner, Denise, Meyer, Alexander, Immohr, Laura Isabell, and Pein-Hackelbusch, Miriam. . “Critical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients.” Pharmaceutics, № 16: 658–658. doi: 10.3390/pharmaceutics16050658.
- Koehler, Jonas K., Schmager, Stefanie, Bender, Valentin, Steiner, Denise, and Ulrich, Massing. . “Preparation of Nanosized Pharmaceutical Formulations by Dual Centrifugation.” Pharmaceuticals, № 16: 1519. doi: 10.3390/ph16111519.
- Steiner, Denise., Tidau, Marius., and Finke, Jan Henrik. . “Embedding of poorly water-soluble drugs in orodispersible films - Comparison of five formulation strategies.” Pharmaceutics, № 15 (17): 1–22. doi: 10.3390/pharmaceutics15010017.
- Steiner, Denise, Schumann, Leonie V., and Bunjes, Heike. . “Processing of lipid nanodispersions into solid powders by spray drying.” Pharmaceutics, № 14 (11): 1–17. doi: 10.3390/pharmaceutics14112464.
- Steiner, Denise, Emmendörffer, Jakob F., and Bunjes, Heike. . “Orodispersible films: A delivery platform for solid lipid nanoparticles?” Pharmaceutics, № 13 (12): 1–17. doi: 10.3390/pharmaceutics13122162.
- Steiner, Denise, and Bunjes, Heike. . “Influence of process and formulation parameters on the preparation of solid lipid nanoparticles by dual centrifugation.” International Journal of Pharmaceutics: X, № 3: 1–11. doi: 10.1016/j.ijpx.2021.100085.
- Steiner, Denise, Finke, Jan Henrik, and Kwade, Arno. . “SOFTs – Structured orodispersible film templates.” European journal of pharmaceutics and biopharmaceutics, № 137: 209–217. doi: 10.1016/j.ejpb.2019.03.001.
- Steiner, Denise, Finke, Jan Henrik, and Kwade, Arno. . “Model-based description of disintegration time and dissolution rate of nanoparticle-loaded orodispersible films.” European Journal of Pharmaceutical Sciences, № 132: 18–26. doi: 10.1016/j.ejps.2019.02.029.
- Steiner, Denise, Finke, Jan Henrik, and Kwade, Arno. . “Instant ODFs – Development of an intermediate, nanoparticle-based product platform for individualized medication.” European journal of pharmaceutics and biopharmaceutics, № 126: 149–158. doi: 10.1016/j.ejpb.2017.04.014.
- Speer, Isabell, Steiner, Denise, Thabet, Yasmin, Breitkreutz, Jörg, and Kwade, Arno. . “Comparative study on disintegration methods for oral film preparations.” European journal of pharmaceutics and biopharmaceutics, № 132: 50–61. doi: 10.1016/j.ejpb.2018.09.005.
- Göke, Katrina, Lorenz, Thomas, Repanas, Alexandros, Schneider, Frederic, Steiner, Denise, Knut, Baumann, Bunje, Heike, Dietzel, Andreas, Finke, Jan H., Glasmacher, Birgit, and Kwade, Arno. . “Novel strategies for the formulation and processing of poorly watersoluble drugs.” European journal of pharmaceutics and biopharmaceutics, № 126: 40–56. doi: 10.1016/j.ejpb.2017.05.008.
- Steiner, Denise, Finke, Jan Henrik, and Kwade, Arno. . “Redispersion of Nanoparticle-Loaded Orodispersible Films: Preservation of Particle Fineness.” Chemie Ingenieur Technik, № 89: 1034–1040. doi: 10.1002/cite.201600139.
- Erfinder: Steiner, Denise, and Kwade, Arno. . Deutsche (DE102017103346 A1) und internationale Patentanmeldung (WO 2018/149983A1), Titel: "Structured orodispersible films"
- Steiner, Denise, Finke, Jan Henrik, and Kwade, Arno. . “Efficient production of nanoparticle-loaded orodispersible films by process integration in a stirred media mill.” International Journal of Pharmaceutics, № 511: 804–813. doi: 10.1016/j.ijpharm.2016.07.058.
- Steiner, Denise, Finke, Jan Henrik, Breitung-Faes, Sandra, and Kwade, Arno. . “Breakage, temperature dependency and contamination of Lactose during ball milling in ethanol.” Advanced Powder Technology, № 27: 1700–1709. doi: 10.1016/j.apt.2016.05.034.
Supervised Doctoral Studies
Scholten, Julia Marie Einbettung von wirkstoffhaltigen Lipidanodispersionen in orodispersible Filme Klein, Isabelle Sprühtrocknung und Weiterverarbeitung von wirkstoffhaltigen Lipidnanodispersionen zu orodispersiblen Tabletten Hellmund, Nico Formulierung und Charakterisierung von lipidhaltigen, mucoadhäsiven Arzneiformen Mahlberg, Lena 2D-Druck von Nanodispersionen auf strukturierte orodispersible Formen Scientific Talks
- Steiner, Denise : “Embedding of lipid nanodispersions in ODFs”. 7th APV Winter Conference: ODx and MBx - orodispersible and mucoadhesive buccal formulations: Novel technologies, new products, future opportunities, Innsbruck, .
- Steiner, Denise : “Evaluation of drying behaviour and temperature exposure of lipid nanodispersions during spray drying ”. International Congress on Particle Technology, Nürnberg, .
- Steiner, Denise : „Wirkstoff Meets Lipid - Nanopartikuläre Lipidträgersysteme eingebettet in feste Matrizes“. DPhG-Vortrag Regionalgruppe Südbaden, Freiburg, .
- Steiner, Denise : “Processing of lipid nanodispersions into solid formulations by spray drying”. 13. World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Rotterdam, .
- Steiner, Denise : “Embedding solid lipid nanoparticles in orodispersible films - A feasibility study”. 4. Braunschweig International Symposium on Pharmaceutical Engineering Research, Braunschweig, .
- Steiner, Denise; Finke, Jan : “Instant preparations for orodispersible films”. 3. APV Winterkonferenz zum Thema “Individualized Medicines for oral use – visions and challenges”, Innsbruck, .
- Steiner, Denise : “Individualized medication with poorly water-soluble APIs – Instant ODFs”. 2. Europeance Conference on Pharmaceutics, Krakau, .
- Steiner, Denise : “Loading nanoparticular suspensions on drug-free orodispersible films”. International Congress on Particle Technology, Nürnberg, .
- Steiner, Denise : “Efficient production of nanoparticle-loaded orodispersible films by process integration in a stirred media mill”. 1. Symposium on Pharmaceutical Engineering Research, Braunschweig, .
- Steiner, Denise : “Stirred media milling of an organic model compound in ethanol”. 6. International Congress on Pharmaceutical Engineering, Graz, .
Teaching
Lecture:
"Pharmazeutische Technologie einschließlich Medizinprodukte" (5th, 6th and 7th semester)
Seminar:
"Qualitätssicherung bei Herstellung und Prüfung von Arzneimitteln"
Staff
Postdocs, Dissertation, MSc
Dr. Venkatesh Inguva
Nico Hellmund
Isabelle Klein
Lena Mahlberg
Julia Scholten
Adrian Gierszewski