Publications
2022
Biyanee, A. Yusenko, M.V., Klempnauer, K.-H. (2022)
Src-family protein kinase inhibitors suppress MYB activity in a p300-dependent manner.
Cells, 11, 1162. (doi.org/10.3390/cells11071162).Abdel Ghani, L., Yusenko, M.V., Frank, D., Moorthy, R., Widen, J.C., Dörner, W., Khandanpour, C., Harki, D.A., Klempnauer, K.-H. (2022)
A synthetic covalent ligand of the C/EBPβ transactivation domain inhibits acute myeloid leukemia cells.
Cancer letters, 530, 170-180. (doi.org/10.1016/j.canlet.2022.01.024)Schmidt, T.J., Klempnauer, K.-H. (2022)
Natural Products with Antitumor Potential Targeting the MYB-C/EBPβ-p300 Transcription Module.
Molecules, 27, 2077. (doi.org/10.3390/molecules27072077)Yusenko, M.V., Klempnauer, K.-H. (2022)
Characterization of the MYB-inhibitory potential of the Pan-HDAC inhibitor LAQ824.
BBA Advances 2, 100034. (doi.org/10.1016/j.bbadva.2021.100034.)Yusenko, M.V., Biyanee, A., Frank, D., Köhler, L.H.F., Andersson, M.K., Khandanpour, C., Schobert, R., Stenman, G., Biersack, B., Klempnauer, K.-H. (2022)
Bcr-TMP, a Novel Nanomolar-Active Compound That Exhibits Both MYB- and Microtubule-Inhibitory Activity.
Cancers (Basel) 14, 43. (doi: 10.3390/cancers14010043.)Klempnauer, K.-H. (2022)
C/EBPβ sustains the oncogenic program of AML cells by cooperating with MYB and co-activator p300 in a transcriptional module.
Expt. Hematol., online ahead of print. (doi: 10.1016/j.exphem.2022.01.003.)2021
Yusenko, M.V., Biyanee ,A., Andersson, M.K., Radetzki, S., von Kries, J.P., Stenman, G., Karl-Heinz Klempnauer, K.-H. (2021)
Proteasome inhibitors suppress MYB oncogenic activity in a p300-dependent manner.
Cancer Letters. 520, 132-142. doi: 10.1016/j.canlet.2021.07.010M.V. Yusenko, A. Trentmann, D.A. Casolari , L. Abdel Ghani, M. Lenz , M. Horn, W. Dörner, S. Klempnauer, H.D. Mootz, M.F. Arteaga, J-H. Mikesch, R.J. D'Andrea, T.J. Gonda, C. Müller-Tidow, T.J. Schmidt, K.-H. Klempnauer (2021).
C/EBPβ is a MYB- and p300-cooperating pro-leukemogenic factor and promising drug target in acute myeloid leukemia.
Oncogene. 2021, doi: 10.1038/s41388-021-01800-x.J. P. Müller, S. Scholl, C. Kunick, K.-H. Klempnauer (2021)
Expression of protein kinase HIPK2 is subject to a quality control mechanism that acts during translation and requires its kinase activity to prevent degradation of nascent HIPK2.
Biochim Biophys Acta Mol Cell Res., 1868: 118894. doi: 10.1016/j.bbamcr.2020.118894.J. P. Müller, K.-H. Klempnauer (2021)
A novel function of CDC37 in co-translational degradation of nascent protein kinase HIPK2.
FEBS Lett., 2021, doi: 10.1002/1873-3468.14080.2020
H. Cibis, A. Biyanee, W. Dörner, H. D. Mootz, K.-H.Klempnauer (2020).
Characterization of the zinc finger proteins ZMYM2 and ZMYM4 as novel B-MYB binding proteins.
Sci. Rep., 10: 8390. doi: 10.1038/s41598-020-65443-w.M.V. Yusenko, A. Trentmann, M. K. Andersson, L. Abdel Ghani, A. Jakobs, M. F. Arteaga Paz, J. H. Mikesch, J. P. von Kries, G. Stenman, K.-H. Klempnauer (2020)
Monensin, a novel potent MYB inhibitor, suppresses proliferation of acute myeloid leukemia and adenoid cystic carcinoma cells.
Cancer Lett., 479: 61-70. doi: 10.1016/j.canlet.2020.01.039.A. Haas, B. S. Nilges, S. A. Leidel, K.-H. Klempnauer (2020)
PDCD4 controls the G1/S-phase transition in a telomerase-immortalized epithelial cell line and affects the expression level and translation of multiple mRNAs.
Sci Rep. 10: 2758. doi: 10.1038/s41598-020-59678-w.E. Werwein, A. Biyanee, K.-H. Klempnauer (2020)
Intramolecular interaction of B-MYB is regulated through Ser-577 phosphorylation.
FEBS Lett., 594: 4266-4279. doi: 10.1002/1873-3468.13940.2019
E. Werwein, H. Cibis, D. Hess, K.-H. Klempnauer (2019)
Activation of the oncogenic transcription factor B-Myb via multisite phosphorylation and prolyl Cis/trans isomerization.
Nucleic Acids Res., 47: 103-121, doi: 10.1093/nar/gky935.P. Brown; RELISH Consortium, Y. Zhou(2019)
Large expert-curated database for benchmarking document similarity detection in biomedical literature search.
Database (Oxford). 2019 Jan 1;2019:baz085. doi: 10.1093/database/baz085.2018
A. Coulibaly, A.Haas, S. Steinmann, A.Jakobs, T.J.Schmidt, K.-H. Klempnauer (2018)
The natural anti-tumor compound Celastrol targets a Myb-C/EBPß-p300 transcriptional module implicated in myeloid gene expression.
PLoS One. 13, e0190934. doi: 10.1371/journal.pone.0190934.M.Yusenko, A.Jakobs, K.-H. Klempnauer (2018)
A novel cell-based screening assay for small-molecule MYB inhibitors identifies podophyllotoxins teniposide and etoposide as inhibitors of MYB activity.
Sci Rep. 8, 13159. doi: 10.1038/s41598-018-31620-1.2017
K.D.Falkenberg, A. Jakobs, J.C.Matern, W.Dörner, S.Uttarkar, A.Trentmann, S.Steinmann, A.Coulibaly, C.Schomburg, H.D.Mootz, T.J.Schmidt, K.-H.Klempnauer (2017)
Withhaferin A, a natural compound with anti-tumor activity, is a potent inhibitor of transcription factor C/EBPß
Biochim. Biophys. Acta Mol. Cell Res. 1864, 1349-1358. doi: 10.1016/j.bbamcr.2017.05.003.S. Uttarkar, J. Frampton, K.-H. Klempnauer (2017)
Targeting the transcriptionfactor Myb by small molecular inhibitors
Exp. Hematol. 47, 31-35. DOI: 10.1016/j.exphem.2016.12.003.S.M. Henrich, C. Usadel, E. Werwein, K. Burdova, P. Janscak, S. Ferrari, D. Hess, K.-H. Klempnauer (2017)
Interplay with the Mre11-Rad50-Nbs1 complex and phosphorylation by GSK3β implicate human B-Myb in DNA-damage signaling
Sci Rep. 2017 Jan 27;7:41663.2016
S. Uttarkar, E. Dasse, A. Coulibaly, S. Steinmann, A. Jakobs, C. Schomburg, A. Trentmann, J. Jose, P. Schlenke, W.E. Berdel, T.J. Schmidt, C. Müller-Tidow, J. Frampton, K.-H. Klempnauer (2016)
Targeting acute myeloid leukemia with a small molecule inhibitor of the Myb/p300 interaction.
Blood, 127, 1173-1182.A. Jakobs, S. Uttarkar, C. Schomburg, S. Steinmann, A. Coulibaly, P. Schlenke, W.E. Berdel, C. Müller-Tidow, T.J. Schmidt, K.-H. Klempnauer. (2016)
An isoform-specific C/EBPβ inhibitor targets acute myeloid leukemia cells.
Leukemia, 30, 1612-1615.S. Dukare, K.-H. Klempnauer (2016)
A conserved patch of hydrophobic amino acids modulates Myb activity by mediating protein-protein interactions.
Biochim Biophys Acta. 1859, 914-921.S. Uttarkar, T. Piontek, S. Dukare, C. Schomburg, P. Schlenke, W.E. Berdel, C. Müller-Tidow, T.J. Schmidt., K.-H. Klempnauer (2016)
Small-molecule disruption of the Myb/p300 cooperation targets acute myeloid leukemia cells.
Mol Cancer Ther. 15, 2905-2915. DOI:10.1158/1535-7163.MCT-16-0185.A.Jakobs, S.Steinmann, S.M. Henrich, T.J. Schmidt, K.-H. Klempnauer (2016).
Helenalin acetate, a natural sesquiterpene lactone with anti-inflammatory and anti-cancer activity, disrupts the cooperation of CCAAT-box/enhancer-binding protein beta (C/EBPβ) and co-activator p300.
J. Biol. Chem. 291, 26098-26108. DOI:10.1074/jbc.M116.7481292015
S. Uttarkar, S. Dukare, M. Goblirsch, J. Jose, K.-H Klempnauer (2015)
Naphthol AS-E phosphate inhibits the activity of the transcription factor Myb by blocking the interaction with the KIX domain of the coactivator p300.
Mol Cancer Ther. 14, 1276-1285.J. Ohnheiser, E. Ferlemann, A. Haas, J.P. Müller, E. Werwein, O. Fehler, A. Biyanee, K.-H Klempnauer (2015)
Programmed cell death 4 protein (Pdcd4) and homeodomain-interacting protein kinase 2 (Hipk2) antagonistically control translation of Hipk2 mRNA.
Biochim Biophys Acta, 1853, 1564-1573.A. Biyanee, P. Singh, K.-H. Klempnauer (2015)
Translation, Pdcd4 and eIF4A.
Oncoscience, 2, 731-732.2014
O. Fehler, P. Singh, A. Haas, D. Ulrich, J.P. Müller, J. Ohnheiser, and K.-H. Klempnauer (2014)
An evolutionarily conserved interaction of tumor suppressor protein Pdcd4 with the poly(A)-binding protein contributes to translation suppression by Pdcd4.
Nucleic Acids Res. 2014;42:11107-11118.
https://www.ncbi.nlm.nih.gov/pubmed/25190455S. Brune, D. Schepmann, K.-H. Klempnauer, D. Marson, V. Dal Col, E. Laurini, M. Fermeglia, B. Wünsch, and S. Pricl (2014)
The sigma enigma: in vitro/in silico site-directed mutagenesis studies unveil ?1 receptor ligand binding.
Biochemistry. 2014;53:2993-3003.
https://www.ncbi.nlm.nih.gov/pubmed/24766040A. Biyanee, J. Ohnheiser, P. Singh, and K.-H. Klempnauer (2014)
A novel mechanism for the control of translation of specific mRNAs by tumor suppressor protein Pdcd4: inhibition of translation elongation.
Oncogene. 2014; doi: 10.1038/onc.2014.83. [Epub ahead of print]
https://www.ncbi.nlm.nih.gov/pubmed/246819502013
S. Steinmann, A, Coulibaly, J. Ohnheiser, A. Jakobs, K.-H. Klempnauer (2013)
Interaction and cooperation of the CCAAT-box enhancer binding protein beta (C/EBPβ) with the homeo-domain interacting protein kinase 2 (Hipk2).
J. Biol. Chem., in press.E. Werwein, M. Dzuganova, C. Usadel, K.-H. Klempnauer (2013)
B-Myb switches from Cyclin/Cdk-dependent to Jnk- and p38 kinase-dependent phosphorylation and associates with SC35 bodies after UV stress.
Cell Death Disease, 4, e511.G. Streubel, C. Bouchard, H. Berberich, M.S. Zeller, S. Teichmann, J. Adamkiewicz, R. Müller, K.-H. Klempnauer, U.-M. Bauer (2013)
PRMT4 is a novel coactivator of c-Myb- dependent transcription in haematopoietic cell lines.
Plos Genetics, 9, e1003343.C. Schomburg, W. Schuehly, F.B. Da Costa, K.-H. Klempnauer, T.J. Schmidt (2013)
Natural sesquiterpene lactones as inhibitors of Myb-dependent gene expression: Structure-activity relationships.
Eur. J Med. Chem., 63, 313-320.2012
E. Werwein, T. Schmedt, H. Hoffmann, C. Usadel, N. Obermann, J.D. Singer, K.-H. Klempnauer (2012)
B-Myb promotes S-phase independently of its sequence-specific DNA binding activity and interacts with polymerase delta-interacting protein 1 (Pdip1).
Cell Cycle 11, 4047-4058.O. Oka, L.C. Waters, S.L. Strong, N.S. Dosanjh, V. Veverka, F.W. Muskett, P.S. Renshaw, K.-H. Klempnauer, M.D. Carr (2012)
Interaction of the transactivation domain of B-Myb with the TAZ2 domain of the coactivator p300: Molecular features and properties of the complex.
Plos One, 7:e52906.N. Kumar, N. Wethkamp, L.C. Waters, M.D. Carr, K.-H. Klempnauer (2012)
Tumor suppressor protein Pdcd4 interacts with Daxx and modulates the stability of Daxx and the Hipk2-dependent phosphorylation of p53 at serine 46.
Oncogenesis, 2, e37.T. Bujnicki, C. Wilczek, C. Schomburg, F. Feldmann, P. Schlenke, C. Müller-Tidow, T.J. Schmidt, K.-H. Klempnauer. (2012)
Inhibition of Myb-dependent gene expression by the sesquiterpene lactone mexicanin-I.
Leukemia 26, 615-6222011
L.C. Waters, S.L. Strong, E. Ferlemann, O. Oka, F.W. Muskett, V. Veverka, S. Banerjee, T. Schmedt, A.J. Henry, K.-H. Klempnauer, M.D. Carr (2011)
Structure of the tandem MA-3 region of Pdcd4 and characterization of its interactions with eIF4A and eIF4G: molecular mechanisms of a tumour suppressor.
J. Biol. Chem. 286, 17270-17280.P. Singh, L. Wedeken, L.C. Waters, M.D. Carr, K.-H. Klempnauer (2011)
Pdcd4 directly binds the coding region of c-myb mRNA and suppresses its translation.
Oncogene 30, 4864-4873.L. Wedeken, P. Singh, K.-H. Klempnauer (2011)
The tumor suppressor protein Pdcd4 inhibits the translation of p53 mRNA.
J. Biol. Chem. 286, 42855-42862.2010
L.C. Waters, O. Oka, F.W. Muskett, S.L. Strong, T. Schmedt, K.-H. Klempnauer and M.D. Carr (2010)
Resonance assignment and secondary structure of the middle MA-3 domain and complete tandem MA-3 region of the tumour suppressor protein Pdcd4.
Biomol. NMR Assign. 1, 49-53.L. Wedeken, J. Ohnheiser, B. Hirschi, N. Wethkamp, K.-H. Klempnauer (2010)
Association of tumor suppressor protein Pdcd4 with ribosomes is mediated by protein-protein and protein-RNA interactions.
Genes Cancer 1, 293-301.2009
C. Wilczek, O. Chayka, A. Plachetka and K.-H. Klempnauer (2009)
Myb-induced chromatin remodelling at a dual enhancer/promoter element involves non-coding RNA transcription and is disrupted by oncogenic mutations of v-myb.
J. Biol. Chem. 284, 35314-35324.N. Wethkamp and K.-H. Klempnauer (2009)
Daxx is a transcriptional repressor of CCAAT/enhancer-binding proteins beta.
J. Biol. Chem. 284, 28783-28794.P. Singh, R. Marrikkannu, N. Bitomsky and K.-H. Klempnauer (2009)
Disruption of the Pdcd4 tumor suppressor gene in chicken DT40 cells reveals its role in the DNA-damage response.
Oncogene 28, 3758-3764.S.Steinmann, K.Schulte, K.Beck, T.Bujnicki, S.Chachra and K.-H. Klempnauer (2009)
v-Myc inhibits C/EBPβ activity by preventing C/EBPβ-induced phosphorylation of the co-activator p300.
Oncogene, 28, 2446-2455
online2008
A. Plachetka, O. Chayka, C. Wilczek, S. Melnik, C. Bonifer and K.-H. Klempnauer (2008)
C/EBPβ induces chromatin opening at a cell-type-specific enhancer.
Mol. Cell. Biol 28, 2102-2112.
onlineE. Pani, M. Menigatti, S. Schubert, D. Hess, B. Gerrits, K.-H. Klempnauer and S. Ferrari. (2008)
Pin1 interacts with c-Myb in a phosphorylation-dependent manner and regulates its transactviation activity.
Biochim. Biophys. Acta 1783, 4820-4829
onlineV. Yamkamon, O. Ivanova, D. Braas, O.Chayka, P. Patmasiriwat, and K.-H. Klempnauer (2008)
A dual activation mechanism for Myb-responsive genes in myelomonocytic cells.
Mol. Dis., 40, 219-226
online2007
H. Gundelach, D. Braas and K.-H. Klempnauer (2007)
The promoter regions of the Myb-regulated Adora2B and Mcm4 genes co-localize with origins of DNA replication.
BMC Molecular Biology 8: 75
onlineO. Ivanova, Daniel Braas, and Karl-Heinz Klempnauer (2007)
Oncogenic point mutations in the Myb DNA-binding domain alter the DNA-binding properties of myb at a physiological target gene.
Nucleic Acids Res., 35, 7237-7247
onlineL.C. Waters, V. Veverka, M. Böhm, T. Schmedt, P.T. Choong, F.W. Muskett, K.-H. Klempnauer, M.D. Carr (2007)
Structure of the C-terminal MA-3 domain of the tumour suppressor protein Pdcd4 and characterization of its interaction with eIF4a
Oncogene, 26, 4941-4950
online2006
Waters, L.C., Boehm, M., Veverka, F.W., Muskett, T.A., Frenkiel, T.A., Kelly, G.P., Prescott, A., Dosanjh, N.S., Klempnauer, K.-H. and Carr, M. (2006)
NMR assignment and secondary structure determination of the C-terminal MA-3 domain of the tumour suppressor protein Pdcd4
J. Biomol. NMR 36, Suppl 5:18K.-H. Klempnauer, L. Fischer, K. M. Otto
Einführung in die Biochemie
In: Bioprozesstechnik. Hrsg.: H. Chmiel. 2. Auflage Heidelberg: Spektrum Akademischer Verlag, 2006, S. 23-652005
D. Ahlbory, H. Appl, D. Lang and K.-H. Klempnauer (2005)
Disruption of B-myb in DT40 cells reveals novel function for B-Myb in the response to DNA-damage.
Oncogene, 24, 7127-7134T. Bartusel, S. Schubert and K.-H. Klempnauer (2005)
Regulation of the cyclin D1 and cyclin A1 promoters by B- Myb is mediated by Sp1 binding sites.
Gene, 351, 171-180O. Chayka, J. Kintscher, D. Braas and K.-H. Klempnauer (2005)
v-Myb mediates cooperation of a cell-specific enhancer with the mim-1 promoter.
Mol. Cell. Biol. 25, 499-511.2004
N. Bitomsky, M. Böhm and K.-H. Klempnauer (2004)
The transformation suppressor protein Pdcd4 interferes with JNK-mediated phosphorylation of c-Jun and recruitment of the coactivator p300 by c-Jun
Oncogene, 23, 7484-7493D. Braas, H. Gundelach and K.-H. Klempnauer (2004)
The glioma amplified sequence 41 gene (GAS41) is a direct Myb target gene.
Nucleic Acids Res., 32, 4750-4757J. Kintscher, V. Yamkamon, D. Braas and K.-H. Klempnauer (2004)
Identification of a Myb-responsive enhancer of the chicken C/EBPβ gene.
Oncogene, 23, 5807-5814S. Schubert, S. Horstmann, T. Bartusel and K.-H. Klempnauer (2004)
The cooperation of B-myb with the coactivator p300 is orchestrated by cyclins A and D1.
Oncogene 23, 1392-14042003
M. Böhm, K. Sawicka, J. P. Siebrasse, A. Brehmer-Fastnacht, R. Peters and K.-H. Klempnauer (2003)
The transformation suppressor protein Pdcd4 shuttles between nucleus and cytoplasm and binds RNA.
Oncogene, 22, 4905-4910D. Braas, D. Kattmann, J. Miethe and K.-H. Klempnauer (2003)
Analysis of Dnase I-hypersensitive sites in the chromatin of the chicken adenosine receptor 2B gene reveals multiple cell-type specific cis-regulatory elements
Gene, 303, 157-164C. Schwartz, K. Beck, S. Mink, M. Schmolke and K.-H. Klempnauer (2003)
Recruitment of p300 by C/EBPβ triggers phosphorylation of p300 and modulates coactivator activity
EMBO J., 22, 882-892J. Kintscher, J. Miethe and K.-H. Klempnauer (2003)
Analysis of DNase I-hypersensitive sites in the chromatin of the chicken C/EBPβ gene reveals multiple cis-regulatory elements
DNA Cell Biol., 22, 201-208T. Bartusel and K.-H. Klempnauer (2003)
Transactivation mediated by B-Myb is dependent on TAFII250
Oncogene, 22, 2932-29412002
D. Kattmann and K.-H. Klempnauer (2002)
Identification and characterization of the Myb-inducible promoter of the chicken adenosine receptor 2B gene.
Oncogene, 21, 4663-4672H. Appl and K.-H. Klempnauer (2002)
Targeted disruption of c-myb in the chicken pre B-cell line DT40.
Oncogene, 21, 3076-30812001
J. Miethe, Cl. Schwartz, K. Wottrich, D. Wenning and K.-H. Klempnauer (2001)
Crosstalk between Myc and activating transcription factor 2 (ATF2): Myc prolongs the half-life and induces phosphorylation of ATF2.
Oncogene, 20, 8116-8124.U. Schlichter, D. Kattmann, H. Appl, J. Miethe, A. Brehmer-Fastnacht and K.-H. Klempnauer (2001)
Identification of the myb-inducible promoter of the chicken Pdcd4 gene.
Biochim Biophys Acta., 1520, 99-104.U. Schlichter, O. Burk, S. Worpenberg and K.-H. Klempnauer (2001)
The chicken Pdcd4 gene is regulated by v-Myb.
Oncogene, 20, 231-239.2000
S. Horstmann, S. Ferrari and K.-H. Klempnauer (2000)
An alternatively spliced isoform of B-Myb is a transcriptional inhibitor.
Oncogene, 19, 5428-5434S. Charrassee, I. Carena, K.-H. Klempnauer and S. Ferrari (2000)
Degradation of B-Myb by ubiquitin-mediated proteolysis: involvement of the CDC34-SCFp45skp2 pathway.
Oncogene, 19, 2986-2995S. Horstmann, S. Ferrari and K.-H. Klempnauer (2000)
Regulation of B-Myb activity by cyclin D1.
Oncogene, 19, 298-3061999
O. Bartsch, S. Horstmann, K. Toprak, K.-H. Klempnauer and S. Ferrari (1999)
Identification of cyclin A/Cdk2 phosphorylation sites in B-Myb.
Eur. J. Biochem., 260, 384-391.O. Burk, and K.-H. Klempnauer (1999)
Myb and Ets transcription factors cooperate at the myb-inducible promoter of the tom-1 gene.
Biochim. Biophys. Acta, 1446, 243-252.S. Mink, S. Jaswal, O. Burk and K.-H. Klempnauer (1999)
The v-myb oncoprotein activates C/EBPβ expression by stimulating an autoregulatory loop at the C/EBPβ promoter.
Biochim. Biophys. Acta, 1446, 175-184.1998
P.B. McIntosh, T.A. Frenkiel, U. Wollborn, J.E. McCormick, K.-H. Klempnauer, J. Feeney and M.D. Carr (1998)
Solution structure of the minimal B-Myb DNA-binding domain: Evidence for a key role for conformational instability in DNA-binding.
Biochemistry, 37, 9619-9629.1997
N. Turque, S. Plaza, K.-H. Klempnauer and S. Saule (1997)
Overexpression of A-myb induces basic fibroblast growth factor dependent proliferation of chicken neuroretina cells.
J. Virol., 71, 9778-9781.S. Mink, B. Haenig and K.-H. Klempnauer (1997)
Interaction and functional collaboration of p300 and C/EBPβ.
Mol. Cell. Biol., 17, 6609-6617.U. Ziebold and K.-H. Klempnauer (1997)
Linking Myb to the cell cycle: Cyclin-dependent phosphorylation and regulation of A-Myb activity.
Oncogene, 15, 1011-1019.S. Worpenberg, O. Burk and K.-H. Klempnauer (1997)
The gene encoding the chicken adenosine receptor 2b is regulated by v-Myb.
Oncogene, 15, 213-221.U. Ziebold, O. Bartsch, R. Marais, S. Ferrari and K.-H. Klempnauer (1997)
Regulation of B-Myb activity by cyclin A.
Curr. Biol. 7, 253-260.O. Burk, S. Worpenberg, B. Haenig and K.-H. Klempnauer (1997)
Tom-1, a novel v-Myb target gene expressed in AMV- and E26-transformed myelomonocytic cells.
EMBO J. 16, 1371-1380.H. Kamano and K.-H. Klempnauer (1997)
B-Myb and Cyclin D1 mediate heat shock element dependent activation of the human HSP70 promoter.
Oncogene 14, 1223-1229.1996
K. Noben-Trauth, N.G.Copeland, D.J. Gilbert, N.A. Jenkins, G. Sonoda, J.R. Testa and K.-H. Klempnauer (1996)
Mybl2(Bmyb) maps to mouse chromosome 2 and human Chromosome 20q13.1.
Genomics 35, 610-612.S. Mink, B. Mutschler, R. Weiskirchen, K. Bister and K.-H. Klempnauer (1996)
A novel function for myc: inhibition of C/EBP-dependent gene activation.
Proc.Natl.Acad.Sci.USA. 93, 6635-6640.J. Sitzmann, K. Noben-Trauth, H. Kamano and K.-H. Klempnauer (1996)
Expression of B-myb during mouse embryogenesis.
Oncogene 12, 1889-1894.S. Mink, U. Kerber and K.-H. Klempnauer (1996)
Interaction of C/EBPβ and v-Myb is required for synergistic activation of the mim-1 gene.
Mol. Cell. Biol. 16, 1316-1325.M.D. Carr, U. Wollborn, P.B. McIntosh, T.A. Frenkiel, J.E. McCormick, C.J. Bauer, K.-H. Klempnauer and J. Feeney (1996)
Structure of the B-Myb DNA-binding domain in solution and evidence for multiple conformations in the region of repeat-2 in DNA-binding: Implications for sequence-specific DNA-binding by Myb proteins.
Eur. J. Biochem. 235, 721-735.1995
H. Kamano, K. Noben-Trauth and K.-H. Klempnauer (1995)
Differential splicing of the mouse B-myb gene.
Oncogene 11, 2575-2582.J. Sitzmann, K. Noben-Trauth and K.-H. Klempnauer (1995)
Expression of mouse c-myb during embryonic development.
Oncogene 11, 2273-2279.1994
K. Trauth, B. Mutschler, N.A. Jenkins, D.J. Gilbert, N.G. Copeland and K.-H. Klempnauer (1994)
Mouse A-myb encodes a trans-activator and is expressed in mitotically active cells of the developing CNS, adult testis and B-lymphocytes.
EMBO J. 13, 5994-6005.G. Foos, S. Grimm and K.-H. Klempnauer (1994)
The chicken A-myb protein is a transcriptional activator.
Oncogene 9, 2481-2488.1993
G. Foos, S. Natour and K.-H. Klempnauer (1993)
TATA-box dependent trans-activation of the human HSP70 promoter by Myb proteins.
Oncogene 8, 1775-1782.O. Burk, S. Mink, M. Dümmer and K.-H. Klempnauer (1993)
Synergistic activation of the chicken mim-1 gene by v-myb and C/EBP transcription factors.
EMBO J. 12, 2027-2038.K.-H. Klempnauer. (1993)
Methylation-sensitive DNA-Binding by v-myb and c-myb proteins.
Oncogene 8, 111-115.1992
G. Foos, S. Natour and K.-H. Klempnauer (1993)
TATA-box dependent trans-activation of the human HSP70 promoter by Myb proteins.
Oncogene 8, 1775-1782.O. Burk, S. Mink, M. Dümmer and K.-H. Klempnauer (1993)
Synergistic activation of the chicken mim-1 gene by v-myb and C/EBP transcription factors.
EMBO J. 12, 2027-2038.K.-H. Klempnauer. (1993)
Methylation-sensitive DNA-Binding by v-myb and c-myb proteins.
Oncogene 8, 111-115.1991
O. Burk and K.-H.Klempnauer (1991)
Estrogen-dependent alterations in differentiation state of myeloid cells caused by a v-myb/estrogen receptor fusion protein.
EMBO J. 10, 3713-3719.E. Kerckhoff, K. Bister and K.-H. Klempnauer (1991)
Sequence-specific DNA-binding by Myc proteins.
Proc.Natl.Acad.Sci.USA 88, 4323-4327.1990
T. Oehler, H. Arnold, H. Biedenkapp and K.-H. Klempnauer (1990)
Characterization of the v-myb DNA-binding domain.
Nucl. Acids. Res. 7, 1703-1710.Reviews
O. Bartsch, U. Ziebold, R. Marais, K.-H. Klempnauer and S. Ferrari (1998)
The transcription factor B-Myb is phosphorylated and activated by cyclin A/CDK2.
In "The biology of tumors", Plenum Press.K.-H. Klempnauer (1994)
Das retrovirale Onkogen myb.
Bioscope 2, 18-23.