Dr. Hermann Pape, Universitätsprofessor a. D.

Mehringweg 36
48159 Münster

pape@uni-muenster.de

Forschungsschwerpunkt: Sekundärstoffwechsel von Actinomyceten

  • Acarbose - ein alpha-Glucosidase-Inhibitor aus Actinoplanes sp.
  • Tylosin und Nonactin - Antibiotika aus Streptomyceten
  • Nikkomycin - ein Antimykotikum aus Streptomyces tendae

Ausgewählte Veröffentlichungen:


Jarling M, Bartkowiak K, Pape H, Meinhardt F (2004) The Genome of phiAsp2, an Actinoplanes Infecting Phage.
Virus Genes 29: 117-129

Jarling M, Bartkowiak K, Robenek H, Pape H, Meinhardt F (2004) Isolation of phages infecting Actinoplanes SN223 and characterization of two of these viruses.
Appl Microbiol Biotechnol 64: 250-254

Jarling M, Cauvet T, Grundmeier M, Kuhnert K, Pape H (2004) Isolation of mak1 from Actinoplanes missouriensis and evidence that Pep2 from Streptomyces coelicolor is a maltokinase.
J Basic Microbiol 44:360-373

Niehues B, Jossek R, Kramer U, Koch A, Jarling M, Schröder W, Pape H (2003) Isolation and characterization of maltokinase (ATP:maltose 1-phosphotransferase) from Actinoplanes missouriensis.
Arch Microbiol 180: 233-239

Hemker M, Stratmann A, Goeke K, Schröder W, Lenz J, Piepersberg W, Pape H (2001) Identification, cloning, expression, and characterization of the extracellular acarbose-modifying glycosyltransferase, AcbD, from Actinoplanes sp. strain SE50.
J Bacteriol 183: 4484-4492

Drepper A, Peitzmann R, Pape H (1996) Maltokinase (ATP: maltose 1-phosphotransferase) from Actinoplanes sp.: demonstration of enzyme activity and characterization of the reaction product.
FEBS Lett 388: 177-179

Drepper A, Pape H (1996) Acarbose 7-Phosphotransferase from Actinoplanes sp.: Purification, Properties, and Possible Physiological Function.
J Antibiot 49: 664-668

Brolle DF, Pape H, Hopwood DA, Kieser T (1993) Analysis of the transfer region of the Streptomyces plasmid SCP2*.
Mol Microbiol 10: 157-170

Degwert U, van Hülst R, Pape H, Herrold RE, Beale JM, Keller PJ, Lee JP, Floss HG (1987) Studies on the Biosynthesis of the alpha-Glucosidase Inhibitor Acarbose: Valienamine, a m-C7N Unit Not Derived from the Shikimate Pathway.
J Antibiot 40: 855-861

Veelken M, Pape H (1984) Production of nikkomycin by immobilized Streptomyces cells - physiological properties.
Appl Microbiol Biotechnol 19: 146-152

Madry N, Pape H (1982) Formation of secondary metabolism enzymes in the tylosin producer Streptomyces T59-235.
Arch Microbiol 131: 170-173

Schindelmeiser J, Pape H (1981) Relationship between macrotetrolide production and specific activity of some hydrolases in a high and a low producing strain of Streptomyces griseus.
Eur J Appl Microbiol Biotechnol 11: 216-221

Bröker M, Schindelmeiser J, Pape H (1979) A Nicotinamide Adenine Dinucleotide (Phosphate) Glycohydrolase [NAD(P)ase, EC 3.2.2.6] from Streptomyces griseus.
FEMS Microbiol Lett 6: 245-247

Pape H, Brillinger GU (1973) Biosynthese von Thymidin-diphospho-mycarose durch ein zellfreies System aus Streptomyces rimosus.
Arch Mikrobiol 88: 25-35

Pape H (1972) Zur Biosynthese der Makrotetrolide. I. Die Grundbausteine des Nonactins.
Arch Mikrobiol 82: 254-264

Pape H, Schmid R, Grisebach H, Achenbach H (1969) Transfer of intact methyl groups of methionine in L-mycarose biosynthesis.
Eur J Biochem 10: 479-483