Fachbereich 05 - Medizinische Fakultät
Klinik und Poliklinik für Kinder- und Jugendmedizin - Pädiatrische Hämatologie und Onkologie -
Klinische Studien

Hämostaseologie: Blutungsneigung

Die Arbeitsgruppe Hämostaseologie mit dem Schwerpunkt Diagnostik und Betreuung von Blutungsleiden beschäftigt sich interdisziplinär und multizentrisch mit den ursächlichen Zusammenhängen der angeborenen und erworbenen Blutungsneigung. Zu diesen Themen werden neben der intensiven Patientenbetreuung multizentrische Studien zum Schlaganfall im Kindesalter, Sinusvenenthrombosen im Kindesalter, Thrombosen im Kindesalter sowie zur Hämophilie und Thrombophilie durchgeführt.

Beteiligte Wissenschaftler:

Prof. Dr. Ulrike Nowak-Göttl, Prof. Dr. Heribert Jürgens, Dr. Andrea Kosch, Dr. Katrin Abshagen

Veröffentlichungen:

Escuriola-Ettingshausen,C., Halimeh,S., Kurnik,K., Schobess,R., Wermes,C., Junker,R., Kreuz,W., Pollmann,H., and Nowak-Göttl,U. Symptomatic onset of severe hemophilia A in childhood is dependent on the presence of prothrombotic risk factors. Thromb.Haemost. 85:218-220, 2001

Heller,C., Schobess,R., Kurnik,K., Junker,R., Günther,G., Kreuz,W., and Nowak-Göttl,U. Abdominal venous thrombosis in neonates and infants: role of prothrombotic risk factors - a multicentre case-control study. Br.J Haematol 111:534-539, 2001

Junker,R., Kratz,M., Neufeld,M., Erren,M., Nofer,J.R., Schulte,H., Nowak-Göttl,U., Assmann,G., and Wahrburg,U. Effects of diets containing olive oil, sunflower oil, or rapeseed oil on the hemostatic system. Thromb.Haemost. 85:280-286, 2001

Junker,R., Kotthoff,S., Vielhaber,H., Halimeh,S., Kosch,A., Koch,H., Kassenbohmer,R., Heineking,B., and Nowak-Gottl,U. Infant methylenetetrahydrofolate reductase 677TT genotype is a risk factor for congenital heart disease. Cardiovasc.Res. 51:251-254, 1-8-2001

Nowak-Gottl,U., Junker,R., Kreuz,W., von Eckardstein,A., Kosch,A., Nohe,N., Schobess,R., and Ehrenforth,S. Risk of recurrent venous thrombosis in children with combined prothrombotic risk factors. Blood 97:858-862, 2001

Nowak-Gottl,U., Heinecke,A., von Kries,R., Nürnberger,W., Münchow,N., and Junker,R. Thrombotic events revisited in children with acute lymphoblastic leukemia. Impact of concomitant Escherichia coli asparaginase/prednisone administration. Thromb.Res 103:165-172, 2001

Nowak-Gottl,U., Kotthoff,S., Hagemeyer,E., Junker,R., Kehl,H., Vielhaber,H., and Kececioglu,D. Interaction of fibrinolysis and prothrombotic risk factors in neonates, infants and children with and without thromboembolism and underlying cardiac disease. a prospective study. Thromb.Res 103:93-101, 2001

Nowak-Gottl,U., Strater,R., Kosch,A., von Eckardstein,A., Schobess,R., Luigs,P., Nabel,P., Vielhaber,H., Kurnik,K., and Junker,R. The plasminogen activator inhibitor (PAI)-1 promoter 4G/4G genotype is not associated with ischemic stroke in a population of German children. Childhood Stroke Study Group. Eur.J Haematol. 66:57-62, 2001

Nowak-Gottl,U., Kosch,A., and Schlegel,N. Thromboembolism in newborns, infants and children. Thromb.Haemost. 86:464-474, 2001

Strater,R., Kurnik,K., Heller,C., Schobess,R., Luigs,P., and Nowak-Gottl,U. Aspirin versus low-dose low-molecular-weight heparin: antithrombotic therapy in pediatric ischemic stroke patients: a prospective follow-up study. Stroke 32:2554-2558, 2001

Benze,G., Heinrich,J., Schulte,H., Rust,S., Nowak-Gottl,U., Tataru,M.C., Kohler,E., Assmann,G., and Junker,R. Association of the GPIa C807T and GPIIIa PlA1/A2 polymorphisms with premature myocardial infarction in men. Eur.Heart J 23:325-330, 2002

Bogdanova,N., Markoff,A., Pollmann,H., Nowak-Gottl,U., Eisert,R., Dworniczak,B., Eigel,A., and Horst,J. Prevalence of small rearrangements in the factor VIII gene F8C among patients with severe hemophilia A. Hum.Mutat. 20:236-237, 2002

Ettingshausen,C.E., Kurnik,K., Schobess,R., Kreuz,W.D., Halimeh,S., Pollman,H., and Nowak-Gottl,U. Catheter-related thrombosis in children with hemophilia A: evidence of a multifactorial disease. Blood 99:1499-1500, 2002

Kosch,A., Junker,R., Wermes,C., and Nowak-Gottl,U. Recurrent pulmonary embolism in a 13-year-old male homozygous for the prothrombin G20210A mutation combined with protein S deficiency and increased lipoprotein (a). Thromb.Res 105:49-53, 2002

Manco-Johnson,M.J., Grabowski,E.F., Hellgreen,M., Kemahli,A.S., Massicotte,M.P., Muntean,W., Peters,M., and Nowak-Gottl,U. Laboratory testing for thrombophilia in pediatric patients. On behalf of the Subcommittee for Perinatal and Pediatric Thrombosis of the Scientific and Standardization Committee of the International Society of Thrombosis and Haemostasis (ISTH). Thromb.Haemost. 88:155-156, 2002

Manco-Johnson,M.J., Grabowski,E.F., Hellgreen,M., Kemahli,A.S., Massicotte,M.P., Muntean,W., Peters,M., Schlegel,N., Wang,M., and Nowak-Gottl,U. Recommendations for tPA thrombolysis in children. On behalf of the Scientific Subcommittee on Perinatal and Pediatric Thrombosis of the Scientific and Standardization Committee of the International Society of Thrombosis and Haemostasis. Thromb.Haemost. 88:157-158, 2002

Nowak-Gottl,U., Kosch,A., Schlegel,N., Salem,M., and Manco-Johnson,M. Thromboembolism in children. Curr.Opin.Hematol 9:448-453, 2002

Nowak-Gottl,U., Kosch,A., and Junker,R. DNA- and plasma-based screening for risk factors in infants and children with symptomatic thromboembolism. J Lab Med 26:317-323, 2002

Nowak-Gottl,U., Schobess,R., Kurnik,K., Schwabe,D., Fleischhack,G., and Junker,R. Elevated lipoprotein(a) concentration is an independent risk factor of venous thromboembolism. Blood 99:3476-3477, 2002

Strater,R., Becker,S., von Eckardstein,A., Heinecke,A., Gutsche,S., Junker,R., Kurnik,K., Schobess,R., and Nowak-Gottl,U. Prospective assessment of risk factors for recurrent stroke during childhood--a 5-year follow-up study. Lancet 360:1540-1545, 2002

von Kries,R., Junker,R., Oberle,D., Kosch,A., and Nowak-Gottl,U. Foetal growth restriction in children with prothrombotic risk factors. Thromb Haemost 88:1241-1242, 2002