RESEARCH AREAS
- Carbohydrates and their interactions influencing microbial cells
- Optimised enzymatic hydrolysis of microbial cell walls in disease protection
- Carbohydrate/protein interactions in cell-cell communication
Prof. Dr. Moerschbacher
(Germany)Enzymatic Production, Fingerprinting Analysis, Molecular Recognition, and Biological Activities of Chitosans with Non-Random Patterns of Acetylation
more...Prof. Dr. Goycoolea
(Germany)One of the main research lines of Goycoolea’s group deals with the study of new strategies to interfere with, and hence inhibit, bacterial cell-cell signaling mechanisms that allow bacteria to control the expression of genes a as function of cell density, a series of processes collectively known as quorum sensing (QS).
more...Prof. Dr. Podile
(India) - Carbohydrates and their interactions influencing plant cells
- Generation and perception of elicitors inducing plant disease protection
- Lectins in seed survival and germination
Prof. Dr. Siva Kumar
(India)Research Projects
more...Prof. Dr. K. Seshagirirao
(India)PhD/Research projects can be designed in the area of glyco-biology/science, with special emphasis on lectins, plant gums and carbohydrates. The possible doctoral and post-doctoral research projects in the area of glyco-biology/science...
more...Dr. Ulaganathan
(India)Genome analysis for understudying the role of sugars and sugar transporters in biotic and abiotic stress tolerance of crop plants
more... - Carbohydrates and their interactions influencing mammalian cells
- Requirement for binding of glycosaminoglycans to morphogens and growth factor in development and wound healing
- The use of carbohydrates as therapeutics
- Interaction of exogenous carbohydrates on epidermal cells
Prof. Dr. Hensel
(Germany)Non-cellulosic glucans as inductors for differentiation of human keratinocytes: analytical characterisation and molecular interaction with cell surface structures
more...Dr. Deters
(Germany)Xyloglycans and their interaction with human skin cells:
Influence on extra cellular matrix and signal pathways of
human skin cells leading to an increased cell proliferation
more...Dr. Grobe
(Germany)Research Projects
more...PD Dr. Seidler
(Germany)Characterization of binding affinity and stoichiometry for growth factor and cytokines with chondroitin/dermatan sulfates
more...PD Dr. Götte
(Germany)Role of heparan sulphate in breast cancer pathogenesis
more...Prof. Dr. Goycoolea
(Germany)To understand how “soft” nanobiomaterials harnessed from biocompatible polymers interact with complex biological systems lies among the major current challenges in nanomedicine and nanobiotechnology.
more... - Generic techniques
- Analysis of carbohydrates and glyco-conjugates
- Synthesis of carbohydrates and glyco-conjugates
Prof. Dr. Peter-Katalinić
Dr. Mormann
(Germany)Mass spectrometry of biologically active carbohydrates and their interactions with proteins
more...Prof. Dr. Swamy
(India)Dr. Balamurugan
(India)Dr. Sridhar
(India)Current research projects
more...
Publications of MCGS members:
Hermann A, König S, Lechtenberg M, Sehlbach M, Vakrushev S, Peter-Katalinic J, Hensel A (2012) Proteoglycans from Boswellia serrata Roxb. and B. carteri Birdw. and identification of a proteolytic plant basic secretory protein. Glycobiology. 22, 1424-1439.doi: 10.1093/glycob/cws107
Ohlig S, Pickhinke U, Sirko S, Bandari S, Hoffmann D, Dreier R, Farshi P, Goetz M, Grobe K. An emerging role of Sonic hedgehog shedding as a modulator of heparan sulfate interactions. J Biol Chem. (2012) Dec 21; 287(52):43708-19.doi: 10.1074/jbc.M112.356667.Epub 2012 Nov 1
Jungmann, O., Nikolovska, K., Stock, C., Schulz, J.N., Eckes, B., Riethmüller, C., Owens, R.T., Iozzo, R.V., Seidler, D.G. (2012). The dermatan sulfate proteoglycan decorin stabilizes the vimentin intermediate filament system via α2β1 integrin. PloS ONE
Ibrahim, S.A., Yip, G.W., Stock, C., Pan, J.W., Neubauer, C., Poeter, M., Pupjalis, D., Koo, C.Y., Kelsch, R., Schüle, R., Rescher, U., Kiesel, L., Götte, M. Targeting of syndecan-1 by microRNA miR-10b promotes breast cancer cell motility and invasiveness via a Rho-GTPase- and E-cadherin-dependent mechanism. Int. J. Cancer: 131, E884-96 (2012) VC 2012 UICC
Sofeu Feugaing, D.D., Götte, M., Viola, M. More than matrix: The multifaceted role of decorin in cancer. Eur J Cell Biol. 2012 Oct 8. doi:pii: S0171-9335(12)00126-4. 10.1016/j.ejcb.2012.08.004.
Herzog C., Lippmann I., Grobe K., Zamfir A.D., Echtermeyer F., Seidler D.G. (2011). The amino acid tryptophan prevents dermatan sulfate biosynthesis. Mol. Bio. Syst., DOI:10.1039/c1mb05139c.
Seidler D.G., Mohamed N.A, Bocian C., Stadtmann A., Hermann S., Schäfers K., Schäfers M., Iozzo R.V., Zarbock Z., and Götte M. (2011). The role for decorin in delayed-type hypersensitivity. J. Immunology., 1:187(11), 6108-19.
Ohlig S., Farshi P., Pickhinke U., van den Boom J., Höing S., Jakuschev S., Hoffmann D., Dreier R., Schöler H.R., Dierker T., BordychnC. and Grobe K. (2011). Sonic Hedgehog Shedding Results in Functional Activation of the Solubilized Protein. Dev. Cell., 20, 764-774.
Farshi P., Ohlig S., Pickhinke U., Jochmann K., Höing S., Dierker T. and Grobe K.(2011). Dual Roles of the Heparan Sulfate Binding Cardin-Weintraub-Motif in Multimeric Sonic Hedgehog. J Biol Chem., 286(26), 23608-19.
