Fachbereich 12 - Chemie und Pharmazie
Institut für Pharmazeutische und Medizinische Chemie
Medizinische Chemie

Neue Hemmstoffe der Histon-Deacetylase

Es erfolgt die Synthese und in-vitro-Testung neuer Histon-Deacetylase-Hemmstoffe, die vielversprechende antiproliferative Wirkstoffe sind.

Drittmittelgeber:

CircaGen Pharmaceuticals

Beteiligte Wissenschaftler:

PD Dr. M. Jung (Leiter), Dr. S. Wittich

Veröffentlichungen:

Jung, M.: Inhibitors of histone deacetylase as new anticancer agents. Curr. Med. Chem., 8, 1505-1511, 2001.

Jung, M.: Histone Deacetylases. In: La Thangue, N. B., Bandara L. R. eds. Transcription factors and other nuclear proteins as targets for cancer chemotherapy. Totowa: Humana Press; 2002.

Remiszewski, S. W., L. C. Sambuccetti, P. Atadja, K. W. Bair, W. D. Cornell, M. A. Green, K. L. Howell, M. Jung, P. Kwon, N. Trogani, H. Walker: Inhibitors of human histone deacetylase: synthesis, enzyme and cellular activity of straight chain hydroxamates. J. Med. Chem., 45, 753-757, 2002.

Wittich, S., H. Scherf, C. Xie, G. Brosch, P. Loidl, C. Gerhäuser, M. Jung: Structure-activity relationships on phenylalanine containing inhibitors of histone deacetylase - In-vitro enzyme inhibition, induction of differentiation and inhibition of proliferation in Friend leukemic cells. J. Med. Chem., 45, 3296-3309, 2002.