Strahlentherapie der Gliomatosis Cerebri

Gliomatosis cerebri is defined as a remarkably diffuse glioma characterized by widespread infiltration of the central nervous system. Clinicopathologic characteristics and imaging findings have been published but valid classification remains controversial. Few reports exist regarding therapeutic options in gliomatosis cerebri. We review data of 17 patients treated with radiation therapy extracted from literature paying attention to available details of irradiation and clinical outcome and present results of 3 additional patients treated at our two institutions. Radiologic-pathologic correlation in gliomatosis cerebri indicated that tumor delineation should be based on T2-weighted MRI. Radiation therapy in gliomatosis cerebri was associated with a temporary improvement or stabilization of clinical symptoms in the majority of cases. Duration of improvement lasted 6 months in 50% of patients. Survival from onset of symptoms was 22.8 months (range 8-42). Substantial variation of the natural course of the disease impedes conclusions regarding the impact of radiation therapy on survival.

Beteiligte Wissenschaftler:

Dr. Eckehard Horst, Dr. Oliver Micke, Dr. M.L. Romppainen, Dr. Juhani Pyhtinen, Prof. Wolfgang Paulus, Dr. Ulrich Schäfer, Prof. Christian Rübe, Prof. Normann Willich

Veröffentlichungen:

Eckehard Horst, Oliver Micke, ML Romppainen, Juhani Pythinen, Wolfgang Paulus, Ulrich Schaefer, Normann Willich: Acta Oncologica 2000; 39: 747-751. Review.