| 02.11.2006 |
Tracking down microtubule binding proteins with atomic force microscopy
Prof. Dr. Christoph F. Schmidt, Universität Göttingen |
We have used atomic force microscopy (AFM) to image microtubules, cytoskeletal protein polymers,
with high resolution. We have further used an AFM tip to measure the elastic properties of these
hollow protein tubes by lateral indentation. Although only 25 nanometers in diameter, with about
5nm large subunits, the linear response of the tubes can be well modeled using a homogeneous
elastic tube. We tested how attached proteins influence this elastic response. We furthermore
imaged kinesin motors attached to the microtubules and used the fact that we could resolve the
individual heads of the dimeric motors to study how the motor tracks along the microtubule.
PD Dr. T. Schäffer
| Ort: |
Wilhelm-Klemm-Str. 10, IG I, HS 2 |
| Zeit: |
donerstags 16 Uhr c.t. |
|
Kolloquiums-Kaffee ab 15:45 Uhr vor dem Hörsaal |
Im Auftrag der Hochschullehrer des Fachbereichs Physik
Apl. Prof. Dr. H. Bracht
