Name: Chinmoy Kumar Hazra
Diploma / M.Sc degree: IIT Bombay, India
(June 2010)

PhD Project: Copper-catalyzed activation of Si—B and Sn—B bonds in selective bond-forming processes

Abstract of Research Project

Following our main focus on organosilicon and organotin chemistry, we initially aimed at novel C—Si and C—Sn bond forming reactions, for which we choose the versatile chemistry of cuprate-type silicon and tin reagents as a starting point.

Silicon- and tin- substituted allenes are widely used in organic synthesis. These might be prepared from propargylic precursors through SN´ reactions using silicon and tin nucleophiles. Only a handful of selective protocols for the synthesis of silicon- and tin- substituted allenes have been developed so far. Using silicon and tin based nucleophiles it is possible to perform copper-catalyzed regioselective syntheses of desired products.

In this research project, our aim is to develop an efficient method for silyl- and also stannyl- substituted allenes as well as to investigate their application in the synthetic organic chemistry.


Publications

C. K. Hazra, C. Fopp, M. Oestreich
Copper(I)-Catalyzed Regioselective Addition of Nucleophilic Silicon Across Terminal and Internal Carbon-Carbon Triple Bonds
Chem. Asian J. 9 (2014), 3005-3010.

C. K. Hazra, E. Irran, M. Oestreich
Regio- and Diastereoselective Copper(I)-Catalyzed Allylic Substitution of δ-Hydroxy Allylic Chlorides by a Silicon Nucleophile
Eur. J. Org. Chem. (2013), 4903–4908.

C. K. Hazra, M. Oestreich
Copper(I)-Catalyzed Regio- and Chemoselective Single and Double Addition of Nucleophilic Silicon to Propargylic Chlorides and Phosphates
Org. Lett. 14(15) (2012), 4010–4013.

D. J. Vyas, C. K. Hazra, M. Oestreich
Copper(I)-Catalyzed Regioselective Propargylic Substitution Involving Si-B Bond Activation
Org. Lett. 13(16) (2011), 4462-4465.


Chinmoy Kumar Hazra
eMail: Chinmoy Kumar Hazra