Name: Sunil Kumar Sunnam
Diploma / M.Sc degree: University of Hyderabad, India (June 2006)

PhD Project: Stereoselective Synthesis of Bicyclic σ Receptor Ligands

Abstract of Research Project

Sigma receptors were postulated in 1976 by Martin et al. Today it is well accepted that σ receptors are unique non-opioid, non NMDA receptors in the brain and also in the periphery. Sigma receptor ligands have antipsychotic, antidepressive, neuroprotective as well as anti cocaine activity.

In order to learn more about the three dimensional structure of σ receptors, novel, highly potent σ receptor ligands with restricted conformational flexibility and defined stereo chemistry are required.

Our aim is to synthesize and to pharmacologically evaluate bicyclic σ receptor ligands (1) stereoselectively.




Publications

S. K. Sunnam, E. Rack, D. Schepmann, B. Wünsch
Synthesis of 7,9-diazabicyclo[4.2.2]decanes as conformationally restricted κ receptor agonists: Fine tuning of the dihedral angle of the ethylenediamine pharmacophore
European Journal of Medicinal Chemistry (2011), 1-11.

S. K. Sunnam, D. Schepmann, E. Rack, R. Fröhlich, K. Korpis, P. J. Bednarski, B. Wünsch
Synthesis and biological evaluation of conformationally restricted σ₁ receptor ligands with 7,9-diazabicyclo[4.2.2]decane scaffold
Org. Biomol. Chem. 8 (2010), 5525-5540.

S. K. Sunnam, D. Schepmann, B. Wibbeling, B. Wünsch
Bicyclic σ-Receptor Ligands by Stereoselective Dieckmann Analogous cyclization of Piperazinebutyrate
Org. Biomol. Chem. 8 (2010), 3715-3722.


Sunil Kumar Sunnam
eMail: Sunil Kumar Sunnam