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Interdisciplinary PhD or MSc thesis | CRG, Barcelona
Research areas:
- Life Sciences
- Chemical & Plant Biology
- Protein Evolution & Engineering
- Functional Genomics
Research summary:
How do proteins evolve to sense environmental chemistry with extreme specificity and sensitivity? Can we decode the molecular determinants by which these structures are tuned and engineered? In our group, we perform large-scale protein library screens to determine proteins' small molecule interaction profiles. We test thousands of hormone receptors, from plants to humans, as well as anti-fungal and 'molecular glue' compounds which chemically modulate their protein targets. With the help of these functional genomics experiments, AI-enhanced evolutionary inference and protein structure modelling, our goal is to design a range of new biosensors for the scalable monitoring of invisible chemicals - this holds key applications for One Health.
Literature:
M.R. Stammnitz & B. Lehner, The genetic architecture of an allosteric hormone receptor. Nature Communications 2026
J. Beltrán et al., Rapid biosensor development using plant hormone receptors as reprogrammable scaffolds. Nature Biotechnology 2022
B.Z. Stanton, E.J. Chory & G.R. Crabtree, Chemically induced proximity in biology and medicine. Science 2018
Project Lead:
Dr. Max Stammnitz
CRG International PhD Deadline: 22.11.2026
Contact:
Email: maximilian.stammnitz@crg.eu
LinkedIn: https://www.linkedin.com/in/maximilian-stammnitz/
CRG Webpage: www.crg.eu/en/content/research/independent-fellow/stammnitz-lab